| Interacting proteins: Q9Y6W6 and P45983 |
Pubmed |
SVM Score :0.0 |
| JAMP association with JNK 1 outcompetes JNK 1 association with mitogen activated protein kinase phosphatase 5 , resulting in increased and prolonged JNK 1 activity following stress . ^^^ |
|
| Interacting proteins: Q9Y6W6 and P45983 |
Pubmed |
SVM Score :0.0 |
| MAP kinase phosphatase 5 ( MKP 5 ) is a member of the mitogen activated protein kinase phosphatase ( MKP ) family and selectively dephosphorylates JNK and p 38 . ^^^ |
|
| Interacting proteins: Q9Y6W6 and P45983 |
Pubmed |
SVM Score :0.0 |
| MKP 5 binds to p 38 and SAPK / JNK , but not to MAPK / ERK , and inactivates p 38 and SAPK / JNK , but not MAPK / ERK . p 38 is a preferred substrate . ^^^ These results suggest that MKP 5 is a novel type of dual specificity phosphatase specific for p 38 and SAPK / JNK . . ^^^ |
|
| Interacting proteins: Q9Y6W6 and P45983 |
Pubmed |
SVM Score :0.0 |
| Forced expression of MKP 5 , a JNK phosphatase , in JNK kinase expressing cells decreased T 81 phosphorylation while reducing p 53 transcriptional activity and p 53 mediated apoptosis . ^^^ |
|
| Interacting proteins: Q9Y6W6 and P45983 |
Pubmed |
SVM Score :0.0 |
| MKP 5 dephosphorylates and inactivates the stress activated MAP kinases JNK and p 38 . ^^^ |
|
| Interacting proteins: Q9Y6W6 and P45983 |
Pubmed |
SVM Score :0.0 |
| JNK activity was selectively increased in Mkp 5 ( also known as Dusp 10 ) deficient mouse cells . ^^^ |
|
| Interacting proteins: Q9Y6W6 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|