| FHL 2 inhibits TRAF 6 induced NF kappaB activity in wild type osteoclast precursors and , in keeping with its role as a suppressor of TRAF 6 mediated RANK signaling , TRAF6 / RANK association is enhanced in FHL 2 / osteoclasts . ^^^ FHL 2 overexpression delays RANK ligand induced ( RANKL induced ) osteoclast formation and cytoskeletal organization . ^^^ FHL 2 is , therefore , an antiosteoclastogenic molecule exerting its effect by attenuating TRAF 6 mediated RANK signaling . . ^^^ |