| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| The degree of c src expression depends on the taxonomic rank of the Eumetazoa tested , and is organ specific with nervous tissues displaying the highest kinase activities . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| A series of proprietary c src inhibitors was evaluated in competition assays , and demonstrated a rank order of potency which was identical to that determined by other assay methods . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| Signed rank test univariate analysis revealed a statistically significant difference in c Src expression between NM / AD ( p = 0 . 0001 ) , NM / CA ( p = 0 . 0001 ) , NM / MT ( p = 0 . 0006 ) , AD / CA ( p = 0 . 0001 ) , and AD / MT ( p = 0 . 0002 ) . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| We recently demonstrated that TRANCE activates Akt via a mechanism involving TRANCE receptor ( TRANCE R ) / RANK , TRAF 6 , and c Src . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| Similarly , for all ligands tested , the rank order of EC ( 50 ) for peptide recruitment was CBP < PGC 1 < SRC 1 . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| Expression of raft component flotillin greatly increased during osteoclast differentiation , whereas engagement of RANK induced the translocation of tumor necrosis factor receptor associated factor 6 to rafts where Src was constitutively resident . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| These include key signals mediating osteoclast differentiation , including PU . 1 , RANK , CSF 1 / c fms , and src , and key specializations of the osteoclast including HCl secretion driven by H+ ATPase and the secretion of collagenolytic enzymes including cathepsin K and matrix metalloproteinases ( MMPs ) . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| The RANK signaling mechanisms involved in these responses include the recruitment of TNF receptor associated factor proteins , the activation of transcription factors ( NF kappaB , AP 1 , and NFAT 2 ) , the cascades of mitogen activated protein kinases ( ERK , JNK , and p 38 ) , and the induction of Src and phosphatidylinositol 3 kinase dependent Akt activation . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although placenta growth factor specific to VEGF receptor 1 had no significant effect on RANK expression , inhibition of downstream signaling molecules of the VEGF receptor 2 ( Flk 1 / KDR ) such as Src , phospholipase C , protein kinase C , and phosphatidylinositol 3 ' kinase suppressed VEGF stimulated RANK expression in HUVECs . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| Monoclonal antibodies to RANK ligand and parathyroid hormone related protein , as well as Src kinase inhibitors , are also currently under clinical evaluation . . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| These results indicate that a defect of Src homology 2 domain phosphatase 1 function not only accelerates physiological osteoclast development by RANKL / RANK , but also acquires a novel pathway for osteoclastogenesis by LPS . . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| SH SY5Y showed the lowest OPG to RANKL ratio and promoted osteoclastic differentiation of FLG29 . 1 and peripheral mononuclear cells , inducing expression of the osteoclast markers RANK , c src , c fos , cathepsin K and TRAP . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| The expression of genes involved in osteoclast differentiation and activation was evaluated , i . e . c fms , RANK , c src , c fos , cathepsin K ( CATK ) , TRAP , and calcitonin R ( CTR ) . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| In RANK signaling networks , SC 19220 inhibited c Src and NFAT 2 expression . ^^^ Our findings indicated that SC 19220 inhibits RANKL induced osteoclastogenesis through the suppression of RANK , c Fms , c Src , and NFAT 2 , suggesting that this EP 1 specific antagonist inhibits osteoclast formation induced by RANKL from the early stage of osteoclastogenesis . . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| This enhancement of c Src and RANK proteins induced by LMW HA was inhibited by CD 44 function blocking monoclonal antibody . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| A deficiency in c Src or addition of Src family kinase inhibitors blocks TRANCE mediated PKB activation in osteoclasts . c Src and TRAF 6 interact with each other and with TRANCE R upon receptor engagement . ^^^ |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|