Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.89492605
Recombinant OPGL binds specifically to RANK expressed by transfected cell lines and purified osteoclast progenitors . 0.89492605^^^ Recombinant RANK Fc binds with high affinity to OPGL in vitro and blocks osteoclast differentiation and activation in vitro and in vivo . 0.64028914^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.69342796
The discovery of the role of the receptor to activated NFkappaB ( RANK ) interaction with its ligand RANKL in orchestrating the balance between bone resorption and formation may link mucosal and systemic inflammation with bone remodelling , since RANK RANKL are also involved in lymphopoiesis and T cell apoptosis . 0.69342796^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.51643654
During normal bone remodeling , the receptor activator of nuclear factor kappaB ( RANK ) interacts with its ligand RANKL , which is present on pre osteoclasts , resulting in bone resorption and initiation of new bone formation . 0.51643654^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
This lack of response appeared to result from reduced expression of RANK ligand ( RANKL ) in osteoblasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The interaction between RANKL and RANK was shown to be required for osteoclast formation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In the ST 2 co culture system , XT 611 did not influence the expression of RANKL , osteoprotegerin and RANK mRNAs . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Ocl survival and activity require M CSF and RANK ligand ( RANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL is essential for osteoclast differentiation via its receptor RANK located on the osteoclast membrane . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK Ligand ( RANKL ) is a critical osteoclastogenic factor that is expressed on stromal cells and osteoblasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Opg , RANKl , and RANK in cancer metastasis : expression and regulation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Menaquinone 7 regulates the expressions of osteocalcin , OPG , RANKL and RANK in osteoblastic MC3T3E1 cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL plus AA significantly down regulated the mRNA expression of CAII and RANK by 60 % and 20 % respectively . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin ( OPG ) is a circulating receptor that inhibits osteoclastogenesis by binding to RANK ligand ( RANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The osteoclast differentiation induced by TNF alpha was independent of RANKL binding to its receptor RANK on PBMCs . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast precursors express RANK , a receptor of RANKL , recognized RANKL through cell cell interaction . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Treatment of the PU . 1 reconstituted cells with M CSF and RANKL further augmented the RANK gene expression . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
FHL 2 overexpression delays RANK ligand induced ( RANKL induced ) osteoclast formation and cytoskeletal organization . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Mechanisms of disease : roles of OPG , RANKL and RANK in the pathophysiology of skeletal metastasis . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Pathophysiology of RANK ligand ( RANKL ) and osteoprotegerin ( OPG ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
All clones tested expressed the RANKL receptor RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Soluble form ODF binds directly to osteoclast progenitors , suggesting the presence of a membrane bound receptor for ODF ( ODFR ) on the cells . ^^^ To understand the ODF mediated signal transduction mechanism in osteoclastogenesis , we molecularly cloned ODFR from a mouse macrophage like osteoclast progenitor cell line , C 7 . ^^^ In contrast , both a genetically engineered soluble RANK and Fab fragment of the antibody blocked the binding of ODF to RANK and ODF mediated osteoclastogenesis . ^^^ These results indicate that RANK is the signaling receptor essential for ODF mediated osteoclastogenesis . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast precursors which possess RANK , a TNF receptor family member , recognize ODF / OPGL / TRANCE / RANKL through cell to cell interaction with osteoblasts / stromal cells , and differentiate into osteoclasts in the presence of macrophage colony stimulating factor . ^^^ Mature osteoclasts also express RANK , and their bone resorbingactivity is also induced by ODF / OPGL / TRANCE / RANKL which osteoblasts / stromal cells possess . ^^^ Osteoblasts / stromal cells express a new member of the TNF ligand family `` osteoclast differentiation factor ( ODF ) / osteoprotegerin ligand ( OPGL ) / TNF related activation induced cytokine ( TRANCE ) / receptor activator of NF kB ligand ( RANKL ) ' ' as a membrane associated factor . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast like cells ( OCLs ) formed in cocultures of murine osteoblasts and bone marrow cells expressed mRNA of RANK ( receptor activator of NF kappaB ) , a receptor of ODF . ^^^ A soluble form of RANK as well as osteoprotegerin / osteoclastogenesis inhibitory factor , a decoy receptor of ODF , blocked OCL formation and prevented the survival , multinucleation , and pit forming activity of pOCs induced by sODF . ^^^ These results suggest that ODF regulates not only osteoclast differentiation but also osteoclast function in mice through the receptor RANK . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recent analyses of ODF receptor demonstrated that RANK , a member of the TNF receptor family , is the signaling receptor for ODF in osteoclastogenesis , and that OPG / OCIF acts as a decoy receptor for ODF to compete against RANK . ^^^ The discovery of ODF , OPG / OCIF , and RANK opens a new era in the investigation of the regulation of osteoclast differentiation and function . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recently the osteoclast differentiation factor ( ODF ) , better termed RANKL ( receptor activator of NF kappaB ligand ) , expressed by osteoblasts has been cloned as well as its cognate signaling receptor , receptor activator of NFkappaB ( RANK ) , and a secreted decoy receptor osteoprotegerin ( OPG ) that limits RANKL ' s biological action . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OPG L / ODF is produced by osteoblast lineage cells and exerts its biological effects through binding to its receptor , osteoclast differentiation and activation receptor ( ODAR ) / receptor activator of NF kappa B ( RANK ) , on osteoclast lineage cells , in either a soluble or a membrane bound form , the latter of which requires cell to cell contact . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The osteoclast differentiation factor Rankl ( also known as TRANCE , ODF and OPGL ; refs 8 11 ) induces transcription of Fosl 1 in a c Fos dependent manner , thereby establishing a link between Rank signalling and the expression of Ap 1 proteins in osteoclast differentiation . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In addition , we investigated expression of the ODF receptor on osteoclast precursors , RANK , as well as the ODF inhibitor osteoprotegerin ( OPG ) , and another TNF ligand superfamily member , TRAIL , previously shown to abrogate the inhibitory effects of OPG . ^^^ We report here the novel finding that GCT stromal cells contain abundant ODF mRNA , whereas the giant cell population exclusively expresses RANK mRNA . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Vitamin K ( 2 ) inhibits adipogenesis , osteoclastogenesis , and ODF / RANK ligand expression in murine bone marrow cell cultures . ^^^ MK 4 inhibited the expression of osteoclast differentiation factor ( ODF ) / RANK ligand and the formation of osteoclast like cells induced by 1 , 25 dihydroxyvitamin D ( 3 ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast precursors , which express RANK , a TNF receptor family member , recognize ODF through cell cell interactions with osteoblasts / stromal cells , and differentiate into osteoclasts in the presence of macrophage colony stimulating factor ( M CSF ) . ^^^ These results demonstrate that TNF alpha stimulates osteoclast differentiation through a mechanism independent of the ODF RANK interaction . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK , the receptor activator of NF kappaB , and its ligand RANKL ( initially termed TRANCE , also termed ODF and OPGL ) , are a TNF superfamily receptor ligand pair that govern the development and function of osteoclasts , lymphoid tissue , and mammary epithelium . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappa B ligand ( RANKL , also known as ODF and OPGL ) , a member of the tumor necrosis factor ( TNF ) family , triggers osteoclastogenesis by forming a complex with its receptor , RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The TNF family molecule RANK L ( RANK L , TRANCE , ODF ) and its receptor RANK are key regulators of bone remodeling , and they are essential for the development and activation of osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The tumour necrosis factor family molecule RANKL ( RANKL , TRANCE , ODF ) and its receptor RANK are key regulators of bone remodelling and regulate T cell / dendritic cell communications , and lymph node formation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The relative quantity of the PCR products were determined and the mRNA levels of OPG , ODF , M CSF ( cofactor of ODF ) , and RANK ( receptor of ODF ) were compared with that of the normal bone . ^^^ RESULTS : GCT contained highly expressed mRNA of ODF , OPG , M CSF and RANK . ^^^ There was mRNA expression of OPG , M CSF and RANK and less expression of ODF in normal bone . ^^^ The ODF mRNA and RANK mRNA in GCT were more abundant than that in normal bone . ^^^ CONCLUSIONS : The results suggest that GCT contains all signals including OPG , ODF , M CSF and RANK that are essential for inducing osteoclastogenesis and promoting bone resorption . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
MM increases bone loss by disrupting the checks that normally control signaling by receptor activator of nuclear factor kappaB ligand ( RANK L , also called TRANCE [ tumor necrosis factor related , activation induced cytokine ] , osteoprotegerin ligand [ OPG L ] , osteoclast differentiation factor [ ODF ] , and tumor necrosis factor superfamily member 11 [ TNFSF 11 ] ) , a TNF family cytokine required for osteoclast differentiation and activation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The TNF family molecule receptor activator of nuclear factor kappa B ( NFkappaB ) ligand ( RANKL ) ( OPGL , TRANCE , ODF ) and its receptor activator of NFkappaB ( RANK ) are key regulators of bone remodeling and regulate T cell / dendritic cell communications , and lymph node formation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recently , the TNF family molecule , RANKL ( also called TRANCE , ODF , and OPGL ) , and its receptors , RANK and OPG , were found to be regulators of the development and activation of osteoclasts in bone remodeling . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Furthermore , vitamin K 2 also inhibits the expression of the osteoclast differentiation factor ( ODF ) / RANK ligand , tartrate resistant acid phosphatase activity , and mononuclear cell formation , and induces osteoclast apoptosis in vitro . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The minimum ODF was strongly correlated with mean deviation ( Spearman rank r = 0 . 475 , P < 0 . 0001 ) . ^^^ There was a strong association between differences in hemifield sensitivity loss and in hemivein ODF ( rank r = 0 . 369 , P < 0 . 0001 , n = 80 ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The processes governing both the differentiation and activation of osteoclasts involve signals induced by osteoprotegerin ligand ( OPGL ) , a member of tumor necrosis factor ( TNF ) superfamily , and its cognate receptor RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Furthermore , we show that antibodies raised against the OPGL receptor , RANK , also induce actin ring formation . ^^^ Together , these findings indicate that , in addition to their effects on OC precursors , OPGL and OPG have profound and direct effects on mature OCs and indicate that the OC receptor , RANK , mediates OPGL ' s effects . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The OPGL receptor , RANK , is expressed on chondrocytes , osteoclast precursors and mature osteoclasts . ^^^ OPGL expression in T cells is induced by antigen receptor engagement , which suggests that activated T cells may influence bone metabolism through OPGL and RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Using fluorescence in situ hybridization , we sought to determine mRNA expression of OPGL , its receptor RANK , and its decoy receptor OPG in three major cell types of GCT . ^^^ We demonstrated that OPG mRNA was expressed in all three cell types of GCT , OPGL transcripts were mainly detected in spindle shaped stromal like tumor cells , whereas RANK was expressed only in macrophage like mononuclear cells and multinuclear osteoclast like giant cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Although OPG is normally expressed in arteries , OPG ligand ( OPGL ) and receptor activator of NF kappaB ( RANK ) are not detected in the arterial walls of wild type adult mice . ^^^ Interestingly , OPGL and RANK transcripts are detected in the calcified arteries of OPG ( / ) mice . ^^^ These findings indicate that the OPG / OPGL / RANK signaling pathway may play an important role in both pathological and physiological calcification processes . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We report that mice lacking OPGL or its receptor RANK fail to form lobulo alveolar mammary structures during pregnancy , resulting in death of newborns . ^^^ Transplantation and OPGL rescue experiments in opgl / and rank / pregnant females showed that OPGL acts directly on RANK expressing mammary epithelial cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The discovery of osteoprotegerin ( OPG ) , osteoprotegerin ligand ( OPGL ) , and RANK has elucidated the mechanism by which osteoblasts and stromal cells regulate osteoclastic differentiation and function and mediate the effects exerted by other hormones and cytokines . ^^^ RANK was detectable in FLG 29 . 1 and the number of positive cells was increased by OPGL / CSF 1 treatment while reduced by calcitonin . ^^^ We propose that calcitonin could interact with the OPG / OPGL , and its effects on RANK may explain in part the action of this hormone in suppressing bone resorption . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin ligand ( OPGL , TNFS 11 ) and its receptor RANK ( TNFRS11A ) are essential for the development and activation of osteoclasts and critical regulators of physiological bone remodeling and osteoporosis . ^^^ Inhibition of OPGL binding to RANK via the natural decoy receptor osteoprotegerin ( OPG ) prevents bone loss in postmenopausal osteoporosis and cancer metastases and completely blocks crippling in a rat model of arthritis . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Previous studies suggest that the receptor activator for NF kappaB ( RANK ) on cytokine treated OCPs in mouse bone marrow interacts with osteoprotegerin ligand ( OPGL / TRANCE / RANKL / ODF ) to initiate osteoclast differentiation . ^^^ Hence , we used a fluorescent form of human OPGL ( Hu OPGL F ) to identify possible RANK expressing OCPs in untreated peripheral blood mononuclear cells ( PBMCs ) using fluorescence activated cell sorting analysis . ^^^ Thus , all freshly isolated monocytes demonstrate displaceable Hu OPGL F binding , suggesting the presence of RANK on OCPs in PB ; also , OCPs within a purified PB monocyte population form osteoclast like cells in the complete absence of other cell types in OPGL and CSF 1 containing medium . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
This binding prevents OPGL from activating its cognate receptor RANK , which is the osteoclast receptor vital for osteoclast differentiation , activation and survival . ^^^ Ablation of OPGL or RANK also produces profound osteopetrosis , indicating the important physiological role of these proteins in regulating bone resorption . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
These multinucleated , tartrate resistant acid phosphatase positive cells were positive for receptor activator of NF kappaB ( RANK ) , the receptor for osteoprotegerin ligand ( OPGL ) , also known as RANK ligand ( RANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The marrow microenvironment appears critical for osteoclast formation due to production of RANK ligand , a recently described osteoclast differentiation factor , by marrow stromal cells in response to a variety of osteotropic factors . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The receptor activator of nuclear factor ( NF ) kappaB ligand [ RANKL ; also known as tumor necrosis factor related activation induced cytokine , osteoprotegerin ligand , and osteoclast differentiation factor ] is known to bind with the receptor activator of NF kappaB ( RANK ) and act not only as a key factor for osteoclastogenesis but also as a regulator of lymphocyte development . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin ligand , also called Osteoclast Differentiation Factor or RANK ligand , its receptor RANK and its decoy receptor Osteoprotegerin are key molecules regulating osteoclast differentiation and activation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OBJECTIVE : This study investigated the involvement of the recently identified regulators of osteoclast formation RANKL [ receptor activator of nuclear factor kappaB ( RANK ) ligand , osteoclast differentiation factor , TRANCE , osteoprotegerin ligand ] and its natural inhibitor , osteoprotegerin ( OPG ) , in the bone erosion of rheumatoid arthritis ( RA ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin deficiency could explain juvenile Paget ' s disease because osteoprotegerin suppresses bone turnover by functioning as a decoy receptor for osteoclast differentiation factor ( also called RANK ligand ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
It is now apparent that receptor activator for NFkappaB ( RANK ) , its ligand RANKL ( also known as TRANCE , osteoclast differentiation factor and osteoprotegerin ( OPG ) ligand ) and the RANKL inhibitor OPG , are the major factors regulating osteoclast formation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Packaged retroviral vector was detected in culture supernatants only where the osteoclast differentiation factor receptor activator for NF kappaB ligand ( RANKL ) induced fusion between these two cell types . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
It is now apparent that receptor activator NFkappaB ( RANK ) , its ligand , RANKL ( also known as TRANCE , osteoclast differentiation factor and osteoprotegerin ( OPG ) ligand ) and the natural RANKL inhibitor , OPG , are the key factors regulating osteoclast formation in normal bone physiology . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin ( OPG ) is an osteoclastogenesis inhibitory factor that we have cloned , and is a decoy receptor that inhibits the binding of an osteoclast differentiation factor , RANKL and its receptor RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
These cytokines may induce resorption indirectly by affecting the production of the essential osteoclast differentiation factor , receptor activator of NF kB ligand , and / or its soluble decoy receptor , osteoprotegerin , by osteoblast / stromal cells or directly by enhancing proliferation and / or activity of cells in the osteoclast lineage . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We have generated RANK ( receptor activator of NF kappaB ) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin , osteoprotegerin ligand , and RANK during bone resorption and remodeling processes . ^^^ Together these data indicate that RANK is the intrinsic cell surface determinant that mediates osteoprotegerin ligand effects on bone resorption and remodeling as well as the physiological and pathological effects of calciotropic hormones and proresorptive cytokines . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Here we report the characterization of RANK ( for receptor activator of NF kappaB ) , a new member of the TNFR family derived from dendritic cells , and the isolation of a RANK ligand ( RANKL ) by direct expression screening . ^^^ Thus RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The receptor activator of NF kappaB ( RANK ) , a recently described TNF receptor family member , and its ligand , RANKL , promote survival of dendritic cells and differentiation of osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Because OPG / FDCR 1 shares some properties with RANK , the first RANKL / TRANCE receptor , we discuss how the balance between RANK and OPG / FDCR 1 expression could influence immune responses and , ultimately , germinal center formation . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast precursors express RANK , a TNF receptor family member , recognize RANKL through cell to cell interaction with osteoblasts / stromal cells , and differentiate into pOCs in the presence of M CSF . ^^^ OPG , which has also been called OCIF or TR 1 , is a soluble receptor for RANKL and acts as a decoy receptor in the RANK RANKL signaling system ( Fig . 8 ) . ^^^ RANKL , RANK , and OPG are three key molecules that regulate osteoclast recruitment and function . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Although M CSF and RANKL ( ligand ) induced commitment of late stage precursor cells ( c Fms ( + ) RANK ( + ) ) into osteoclasts , even late stage precursors have the potential to differentiate into macrophages without RANKL . ^^^ Pretreatment of precursors with M CSF and delayed addition of RANKL showed that timing of RANK expression and subsequent binding of RANKL are critical for osteoclastogenesis . ^^^ Thus , the RANK RANKL system determines the osteoclast differentiation of bipotential precursors in the default pathway of macrophagic differentiation . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Although the important roles of RANK / RANKL in osteoclastogenesis have been established , their roles in the regulation of mature osteoclasts remain uncertain . ^^^ We have shown that RANK is highly expressed in mature osteoclasts and that its stimulation by RANKL results in activation of NF kappaB and calcium signalling . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In this report we demonstrate that granulocyte macrophage colony forming unit ( CFU GM ) derived cells represent an easily obtainable highly purified source of human OCL precursors that form OCLs at very high efficiency ( greater than 90 % ) when cultured with RANK ligand ( RANKL ) , macrophage colony stimulating factor ( M CSF ) , and dexamethasone . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
On the other hand , no receptor activator of NF KB ligand ( RANKL ) mRNA was detectable in any of the samples , suggesting that anti FRP 1 mAb can induce osteoclast like cells from blood monocytes without RANKL . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The inhibitory effects of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide on osteoclast formation are associated with upregulation of osteoprotegerin and downregulation of RANKL and RANK . ^^^ By using semiquantitative RT PCR , it was found that D 3 upregulated the mRNA expressions of receptor activator of NF kappaB ligand ( RANKL ) and receptor activator of NF kappaB ( RANK ) , whereas the expression of osteoprotegerin ( OPG ) was downregulated in mouse bone marrow cultures stimulated by D 3 for 7 days . ^^^ Both VIP and PACAP 38 decreased the stimulatory effects of D 3 on RANKL and RANK expression , whereas the inhibitory effect of D 3 on OPG expression was reversed by VIP and PACAP 38 . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Led first by the discovery of osteoprotegerin ( OPG ) , a naturally occurring protein with potent osteoclastogenesis inhibitory activity , rapid progress was made to the isolation of RANKL , a transmembrane ligand expressed on osteoblasts / stromal cells , that binds to RANK , a transmembrane receptor on hemopoietic osteoclast precursor cells . ^^^ The interaction of RANK and RANKL initiates a signaling and gene expression cascade that results in differentiation and maturation of osteoclast precursor cells to active osteoclasts capable of resorbing bone . ^^^ Osteoprotegerin acts as a decoy receptor ; it binds to RANKL and blocks its interaction with RANK , thus inhibiting osteoclast development . ^^^ The new understanding provided by the RANK / RANKL / OPG paradigm for both differentiation and activation of osteoclasts has had tremendous impact on the field of bone biology and has opened new avenues for development of possible treatments of diseases characterized by excessive bone resorption . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
To examine these possibilities , we compared RANK ligand ( RANKL ) mRNA expression in a marrow stromal cell line developed from a pagetic lesion ( PSV 10 ) with that in a normal stromal cell line ( Saka ) , and expression in marrow samples from affected bones of Paget ' s patients with that in normal marrow . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ligand ( RANKL ) expressed on osteoblast / stromal lineage cells plays a pivotal role to transduce an essential differentiation signal to osteoclast lineage cells through binding to its receptor , RANK , expressed on the latter cell population ; however , the difficulty to detect RANKL protein expression hampers us in investigating the regulation of RANKL expression by humoral factors . ^^^ To determine protein expression of RANKL , we have established a new method , named as a ligand receptor precipitation ( LRP ) Western blot analysis , which can specifically concentrate the target protein by the use of specific binding characteristic between RANKL and RANK / osteoprotegrin ( OPG ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF ) stimulates RANKL induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways . ^^^ Finally , we found that TNF and RANKL synergistically up regulate RANK expression in wild type precursors , whereas basal and stimulated levels of RANK are significantly lower in TNFr 1 knockout cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Of these factors , receptor activator of NF kappaB ( RANK ) ligand ( RANKL ) has been recently cloned as an essential inducer of osteoclastogenesis in the presence of M CSF . ^^^ Translocation of NF kappaB into nuclei induced by sRANKL in TGF beta pretreated M / Mphi like hemopoietic cells was greater than that in untreated cells , whereas TGF beta did not up regulate the expression of RANK , the receptor of RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL mediates bone homeostasis through binding to the cognate ligand on osteoclasts , RANK , and a soluble decoy receptor , osteoprotegerin ( OPG ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
New members of the TNF receptor ligand family ( namely receptor activator of nuclear factor kappa B [ RANK ] and RANK ligand [ RANKL ] ) have been discovered whose cross interaction is mandatory for the differentiation of osteoclasts from hemopoietic precursors , in both physiological and pathological situations . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Identification of receptor activator of nuclear factor kappaB ( RANK ) and RANK ligand ( RANKL ) has provided new insights into the osteoclast differentiation pathway . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
After considerable deliberation and after vetting by workers in the field , the Committee recommends the names of receptor activator of NF kappaB ( RANKL ) for the membrane receptor , RANK ligand ( RANK ) for the ligand , and osteoprotegerin ( OPG ) for the decoy receptor . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Here we show that T cell production of interferon ( IFN ) gamma strongly suppresses osteoclastogenesis by interfering with the RANKL RANK signalling pathway . ^^^ IFN gamma induces rapid degradation of the RANK adapter protein , TRAF 6 ( tumour necrosis factor receptor associated factor 6 ) , which results in strong inhibition of the RANKL induced activation of the transcription factor NF kappaB and JNK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
After considerable deliberation and after vetting by workers in the field , the Committee recommends the names of receptor activator of NF kappaB ( RANK ) for the membrane receptor , RANK ligand ( RANKL ) for the ligand , and osteoprotegerin ( OPG ) for the decoy receptor . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Mice rendered null for the genes encoding receptor activator of nuclear factor kappa B ligand ( RANKL ) or its receptor , RANK , are osteopetrotic because of failure of osteoclast development . ^^^ The breast phenotype in RANKL / ( but not in RANK / ) mice is rescued by treatment of pregnant mice with RANKL , indicating a key role for these tumour necrosis factor ( TNF ) ligand and receptor family members in a crucial terminal step in breast development and lactation . ^^^ Both RANKL and RANK are synthesized by mammary epithelial cells , with both prolactin and parathyroid hormone related protein ( PTHrP ) able to enhance production of mRNA for RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
One of the main mechanisms of osteoclast formation and activation involves the receptor activator of nuclear factor kappaB ( RANK ) / RANK ligand ( RANKL ) / osteoprotegerin ( OPG ) pathway , where binding of RANKL to RANK results in the differentiation of osteoclast precursors . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Led first by the discovery of osteoprotegerin ( OPG ) , a naturally occurring protein with potent osteoclastogenesis inhibitory activity , rapid progress was made to the isolation of RANKL , a transmembrane ligand expressed on osteoblasts / stromal cells that binds to RANK , a transmembrane receptor on hematopoietic osteoclast precursor cells . ^^^ The interaction of RANK and RANKL initiates a signaling and gene expression cascade that results in differentiation and maturation of osteoclast precursor cells to active osteoclasts capable of resorbing bone . ^^^ OPG acts as a decoy receptor , binding to RANKL and blocking its interaction with RANK , inhibiting osteoclast development . ^^^ The new understanding provided by the RANK / RANKL / OPG paradigm for both differentiation of osteoclasts and their activation has had tremendous impact on the field and opened new avenues for development of possible treatments of diseases characterized by excessive bone resorption . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the expression of osteoprotegerin ( OPG ) and RANK ligand ( RANKL ) in human prostatic tissues . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The recent discovery of key regulators of osteoclast formation and activity , including receptor activator of nuclear factor of kappaB ligand ( RANKL ) , RANK , and osteoprotegerin ( OPG ) , may facilitate new treatment regimes for certain tumors associated with excessive bone loss . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
To further examine the pathway by which osteoclastic resorption was stimulated , we used osteoprotegerin , a specific inhibitor of the receptor activator of NF kappaB ( RANK ) / receptor activator of the NF kappaB ligand ( RANKL ) pathway . ^^^ Neither NO production nor NF kappaB signaling , and only partly the RANK / RANKL pathway , were involved in the stimulatory effect of the cytokine combination on osteoblastic bone resorption in these long bones , suggesting the existence of other pathways by which osteoclastic resorption can be stimulated . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OBJECTIVE : To elucidate the direct role of human T cells in the induction of osteoclastogenesis in rheumatoid arthritis ( RA ) , by studying human monocytes and the pathogenetic roles of receptor activator of nuclear factor kappaB ligand ( RANKL ) , RANK , and osteoprotegerin ( OPG ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of nuclear factor kappaB ligand ( RANKL ) is a newly described regulator of osteoclast formation and function , the activity of which appears to be a balance between interaction with its receptor RANK and with an antagonist binding protein osteoprotegerin ( OPG ) . ^^^ Therefore , we have examined the relationship between the expression of RANKL , RANK , and OPG and indices of bone structure and turnover in human cancellous bone from the proximal femur . ^^^ RANKL , OPG , and RANK messenger RNA ( mRNA ) were abundant in human cancellous bone , with significant differences between control and OA individuals . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL , expressed in osteoblasts , activates osteoclast differentiation and osteoclast function by binding the ' receptor activator of NF kB ' ( RANK ) , expressed in ostoclast precursors and mature osteoclasts . ^^^ OBJECTIVE : Osteoprotegerin ( OPG ) and its ligand ' receptor activator of NF kB ligand ' ( RANKL ) are important regulators of bone metabolism . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Experimental models and human diseases demonstrated that T lymphocytes may produce many bone cell regulatory cytokines , including two essential stimulators of osteoclastogenesis : receptor for activation of nuclear factor kappa b ( NF kappa B ) ( RANK ) ligand ( RANKL ) and macrophage colony stimulating factor . ^^^ Both B and T lymphocytes may act through the RANKL / RANK / osteoprotegerin cytokine system , which has been independently discovered within immune and bone systems . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The modulation of osteoclastogenesis by immature cells of the osteoblastic lineage is mediated through receptor activator of NF kappa B ( RANK ) , its ligand RANKL , and osteoprotegerin ( OPG ) , a natural decoy receptor for RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of nuclear factor ( NF kappaB ) ligand ( RANKL ) , its cellular receptor , receptor activator of NF kappaB ( RANK ) , and the decoy receptor osteoprotegerin ( OPG ) constitute a novel cytokine system . ^^^ RANKL activates its specific receptor , RANK located on osteoclasts and dendritic cells , and its signaling cascade involves stimulation of the c jun , NF kappaB , and serine / threonine kinase PKB / Akt pathways . ^^^ Transgenic and knock out mice with excessive or defective production of RANKL , RANK , and OPG display the extremes of skeletal phenotypes , osteoporosis and osteopetrosis . ^^^ The discovery and characterization of RANKL , RANK , and OPG and subsequent studies have changed the concepts of bone and calcium metabolism , have led to a detailed understanding of the pathogenesis of metabolic bone diseases , and may form the basis of innovative therapeutic strategies . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OAFs implicated in myeloma bone disease include tumor necrosis factor beta ( TNFbeta ) , RANK ligand ( RANKL ) , interleukin 1 ( IL 1 ) , parathyroid hormone related protein ( PTHrP ) , hepatocyte growth factor ( HGH ) , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNFalpha ) , and macrophage inflammatory protein 1 alpha ( MIP 1alpha ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OPG , a decoy receptor for RANKL , also binds to RANKL , and competitive binding of RANKL with RANK or OPG is thought to regulate bone metabolism . ^^^ To investigate roles of the RANKL / RANK / OPG system in pathophysiological conditions , the expression of RANKL , RANK , and OPG messenger RNA ( mRNA ) was analyzed in bones of aged and ovariectomized rats by means of in situ hybridization . ^^^ In the 2 . 5 year old rat bones , the expression of RANKL , RANK , and OPG mRNA tended to decrease except for the endosteal region . ^^^ In the ovariectomized rat bones , the expression of RANKL , RANK , and OPG mRNA increased , and high expression of OPG mRNA was induced in resting chondrocytes and osteocytes . ^^^ These results suggest that estrogen deficiency stimulates the RANKL / RANK / OPG system and induces OPG in cells that have been thought to be less important for bone metabolism . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
BACKGROUND : The current review summarizes the roles of the ligand , receptor activator of nuclear factor kappaB ligand ( RANKL ) , its receptor , receptor activator of nuclear factor kappaB ( RANK ) , and its decoy receptor , osteoprotegerin ( OPG ) , on osteoclast biology and bone resorption . ^^^ METHODS : After its discovery and cloning , the biologic effects of RANKL , RANK , and OPG have been characterized by in vitro experiments and in vivo studies . ^^^ RANKL , RANK , and OPG form an essential cytokine system that is capable of regulating all aspects of osteoclast functions , including proliferation , differentiation , fusion , activation , and apoptosis . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In the current studies , we examined the ability of 5 alpha dihydrotestosterone to suppress osteoclast formation induced by receptor activator of NF kB ligand ( RANKL ) and macrophage colony stimulating factor in vitro . 5 alpha Dihydrotestosterone suppressed the differentiation of bone marrow monocytes into osteoclasts from both sham operated and orchidectomized mice . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis . ^^^ Cells isolated from periprosthetic tissues containing wear particles expressed mRNA encoding for the pro osteoclastogenic molecules , RANKL , its receptor RANK , monocyte colony stimulating factor ( M CSF ) , interleukin ( IL ) 1beta , tumour necrosis factor ( TNF ) alpha , IL 6 , and soluble IL 6 receptor , as well as OPG . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In both Paget ' s disease and bone metastases the increased OCL formation and the increased osteoclastogenic nature of the bone microenvironment are mediated by common factors , namely interleukin ( IL ) 6 and RANK ligand ( RANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
These cells require the presence of RANK ligand ( RANKL ) expressing osteoblastic cells and human macrophage colony stimulating factor ( M CSF ) to form osteoclasts in vitro . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Expression of RANK , the receptor of RANKL , induced by macrophage colony stimulating factor , was reduced markedly in D PDMP treated cells . d PDMP also inhibited the phosphorylation of the inhibitor of nuclear factor kappa B and extracellular signal regulated kinase 1 / 2 induced by RANKL . ^^^ Moreover , exogenous LacCer recovered the reduced expression of RANK and the phosphorylation of inhibitor of NF kappa B and extracellular signal regulated kinase 1 / 2 after stimulation by RANKL at the same level of cells without D PDMP treatment . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In this article , we describe the new concepts from the identification of OPG , a protein with potent osteoclastogenesis inhibitory activity , to the isolation of RANKL , a transmembrane ligand expressed on osteoblasts / stromal cells that bind to RANK , a transmembrane receptor on osteoclast cells and its precursors . ^^^ The interaction between RANK and RANKL triggers a series of mechanisms that result in differentiation , maturation and activation of osteoclasts . ^^^ OPG inhibits osteoclastogenesis binding to RANKL and blocks its interaction with RANK . ^^^ The knowledge of the RANK / RANKL / OPG system and the understanding of osteoclast differentiation and activation has had a great impact on the field of bone metabolism , with new possible treatment strategies for diseases characterized by excessive bone resorption . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We have shown that chick macrophages express RANK at their surface and human RANKL ( hRANKL ) triggers the formation of osteoclasts able to degrade dentine . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
FL appeared to substitute for M CSF by supporting the differentiation of adherent cells that express mRNA for RANK and responsiveness to RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Minireview : the OPG / RANKL / RANK system . ^^^ The identification of the OPG / RANKL / RANK system as the dominant , final mediator of osteoclastogenesis represents a major advance in bone biology . ^^^ RANKL , in turn , was shown to bind its receptor , RANK , on osteoclast lineage cells . ^^^ Over the past several years , work has focused on identifying the factors regulating this system , the signaling mechanisms involved in the RANKL / RANK pathway , and finally , potential alterations in this system in metabolic bone disorders , from the extremely common ( i . e . postmenopausal osteoporosis ) to the rare ( i . e . familial expansile osteolysis ) . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
It is activated by the secreted or cell surface bound RANK ligand ( RANKL ) . ^^^ Osteoprotegerin ( OPG ) is a soluble nonsignaling receptor for RANKL and interferes with RANK activation . ^^^ Expression of RANK , RANKL , and OPG was analyzed by immunohistochemistry , Western blotting , or reverse transcription polymerase chain reaction . ^^^ RESULTS : RANK , RANKL , and OPG messenger RNA ( mRNA ) were expressed in normal cartilage . ^^^ By immunohistochemistry , RANK , RANKL , and OPG were detected in the superficial zone of normal cartilage . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
ATL cells from patients with hypercalcemia , which highly expressed the transcripts of the RANK ligand ( RANKL ) gene , induced the differentiation of human hematopoietic precursor cells ( HPCs ) into OCLs in vitro in the presence of macrophage colony stimulating factor ( M CSF ) . ^^^ Cell differentiation was suppressed by osteoprotegerin / Fc , an inhibitor of RANKL , indicating that such differentiation occurred through the RANK RANKL pathway . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
When blood monocytes were indirectly cocultured with HSOS 1 cells or cloned no . 9 cells in the presence of OCIF for 14 days , HOS cell mediated osteoclastogenesis was suppressed , indicating that RANK RANKL system is involved in the HOS cell mediated osteoclastogenesis . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ligand ( RANKL ) activates TAK 1 mitogen activated protein kinase kinase kinase through a signaling complex containing RANK , TAB 2 , and TRAF 6 . ^^^ The receptor activator of NF kappaB ( RANK ) and its ligand RANKL are key molecules for differentiation and activation of osteoclasts . ^^^ In 293 cells stably transfected with full length RANK , RANKL stimulation facilitates the formation of a complex containing RANK , TRAF 6 , TAB 2 , and TAK 1 , leading to the activation of TAK 1 . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Studies on recently discovered members of the tumor necrosis factor receptor ligand family have demonstrated a crucial role of RANKL ( receptor activator of nuclear factor kappa B [ RANK ] ligand ) expressed by osteoblast / stromal cells and of its receptor RANK expressed by OCs during OC differentiation and activation . ^^^ We used immunohistochemical analysis to study RANKL and RANK expression in 5 GCTBs . ^^^ Multinucleated cells and some mononuclear cells showed strong positive staining with anti RANK antibodies ; RANKL was present in a subset of mononuclear cells that did not express the hematopoietic lineage cell marker CD 45 , a feature that identified them as mesenchymal tumor cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoblast differentiation requires the transcription factor Cbfa 1 , whereas osteoclastogenesis results from the interaction between receptor activator of NF kappa B ligand ( RANKL ) , expressed on stromal / osteoblastic cells , and RANK , a surface receptor on hematopoietic precursors . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
To elucidate the mechanism of osteoclastogenesis and bone destruction in autoimmune arthritis , we investigated the expression of RANK ligand ( RANKL ) , RANK , and osteoprotegerin ( OPG ) mRNA in a mouse type 2 collagen induced arthritis ( CIA ) model by in situ hybridization . ^^^ In the inflamed synovium and pannus of the mouse CIA model , synovial fibroblastic cells around these RANK positive cells were strongly positive for RANKL . ^^^ These data indicated that the RANKL RANK system plays an important role for osteoclastogenesis in both local and systemic osteolytic lesions in autoimmune arthritis , and can therefore be a good target for therapeutic intervention . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK ( receptor activator of nuclear factor kappaB ) and RANKL expression in multiple myeloma . ^^^ The new members of the tumour necrosis factor ( TNF ) receptor ligand family , receptor activator of nuclear factor kappaB ligand ( RANKL ) and its receptor RANK , play a crucial role in osteoclast differentiation and activation . ^^^ An increased expression of RANKL and / or RANK may be involved in the excessive bone resorption observed in multiple myeloma ( MM ) . ^^^ We used immunohistochemistry to study RANK and RANKL expression in bone marrow ( BM ) biopsies obtained at diagnosis in 15 MM patients , six patients with monoclonal gammopathy of undetermined significance ( MGUS ) and 10 normal BM biopsies . ^^^ Plasma cells were not labelled with anti RANKL or anti RANK antibodies . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
As expected , M CSF alone induced the receptor for RANKL ( RANK ) , but also , unexpectedly , other RANK / NFkappaB pathway components ( TRAF2A , PI 3 kinase , MEKK 3 , RIPK 1 ) , providing a molecular explanation for the synergy of M CSF and RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Induction of osteoclast formation requires upregulation of receptor activator of nuclear factor kappaB ligand ( RANKL ) on cells of the osteoblastic lineage , which then binds to the RANK receptor on cells of the osteoclast lineage . ^^^ Osteoprotegerin ( OPG ) is a decoy receptor for RANKL that can block its interaction with RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Previous studies reported that receptor activator of nuclear factor kappaB ( NF kappaB ) ( RANK ) , a member of the TNF receptor family , is expressed on DCs , and that RANK ligand ( RANKL ) enhances DC survival and induces them to secrete cytokines . ^^^ RANKL increased IL 8 and IL 13 levels in the supernatants of H / RS cell lines , an effect that was blocked by soluble RANK . ^^^ Furthermore , soluble RANK decreased the basal level of IL 8 in one cell line , suggesting that IL 8 was induced by an autocrine RANKL / RANK loop . ^^^ The coexpression of RANK and RANKL in H / RS cells suggests that they may regulate cytokine and chemokine secretion in H / RS cells by an autocrine mechanism . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Immunohistochemical localization of receptor activator of nuclear factor kappaB ( RANK ) and its ligand ( RANKL ) in human deciduous teeth . ^^^ RANK and RANKL [ receptor activator of nuclear factor kappaB ( ligand ) ] , two cytokine like proteins of the tumor necrosis factor superfamily , are localized on these bone cells and are crucial for the regulation of osteoclastic cell differentiation from hematopoietic precursors and also for the upregulation of mature osteoclasts mediated by cell to cell contact and a subsequent cascade of diverse intracellular signaling processes in the osteoclasts . ^^^ It was the aim of this study to examine the sites of expression of RANKL and RANK in the corresponding cells of human dental hard and periodontal tissues using immunohistochemical light microscopical methods on tissue sections of 15 paraffin embedded human deciduous teeth undergoing root resorption . ^^^ These findings indicate that human dental cells express key mediators of hard tissue resorption and , though the RANK / RANKL system may not be the sole regulator of tooth root resorption , these factors could at least contribute to this complex process under both physiological and pathological conditions . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Expression of RANKL by stromal cells and of RANK and both NF kappaB p 50 and p 52 by osteoclast precursors is essential for osteoclast formation . ^^^ To examine further the role of RANKL , RANK , and NF KB signaling in this process , we used NF kappaB p 50 / ; p 52 / double knockout ( dKO ) and wild type ( WT ) mice . ^^^ Thus , NF kappaB p 50 and p 52 expression is not required for formation of RANK expressing osteoclast progenitors but is essential for RANK expressing osteoclast precursors to differentiate into TRAP+ osteoclasts in response to RANKL and other osteoclastogenic cytokines . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
LPS inhibits RANKL activity by reducing the expression of RANK and M CSF receptor and stimulates osteoclastogenesis in RANKL pretreated cells via TNF alpha . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK , RANKL , and OPG have well established regulatory effects on bone metabolism . ^^^ The ligand , RANKL binds to its receptor RANK to induce bone resorption . ^^^ Osteoprotegerin decoy receptor ( OPG ) , a member of the TNF receptor family expressed by osteoblasts , strongly inhibits bone resorption by binding with high affinity to its ligand RANKL , thereby preventing RANKL from engaging its receptor RANK . ^^^ Conversely , the effects of RANKL , RANK , and OPG on inflammatory processes , most notably on the bone resorption associated with inflammation , remain to be defined . ^^^ This suggests that the bone erosion seen in rheumatoid arthritis may result from RANKL / RANK system activation by activated T cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Also , the recent discovery of receptor activator of NF kappaB ligand ( RANKL ) RANK interaction confirms the well known hypothesis that osteoblasts play an essential role in osteoclast differentiation . ^^^ Osteoclast precursors that express RANK , a receptor for RANKL , recognize RANKL through the cell cell interaction and differentiate into osteoclasts . ^^^ Recent studies have shown that lipopolysaccharide and inflammatory cytokines such as tumor necrosis factor receptor alpha and interleukin 1 directly regulate osteoclast differentiation and function through a mechanism independent of the RANKL RANK interaction . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
This cytokine induces rapid degradation of the RANK ( receptor activator of nuclear factor kappaB ) adapter protein TRAF 6 ( TNF receptor associated factor 6 ) , resulting in strong inhibition of the RANKL induced activation of NF kappaB and JNK ( c Jun N terminal kinase ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Real time , quantitative polymerase chain reaction ( PCR ) analysis ( TaqMan PCR ) and semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) demonstrated that IL 11 caused concentration dependent enhancements of receptor activator of nuclear factor kappaB ligand ( RANKL ) and osteoprotegerin ( OPG ) mRNA , without affecting the mRNA expression of RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The discovery of osteoprotegerin ( OPG ) , the receptor activator of nuclear factor kappa b ligand ( RANKL ) , and its receptor ( RANK ) has elucidated these phenomena . ^^^ OPG and RANKL are produced by osteoblasts , whereas RANK is located to the osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
No modulation of RANK mRNA expression was observed and mRNA for RANKL and OPG were not detected in this culture system , suggesting that bLF inhibits osteoclastogenesis and reduces bone resorption through a mechanism independent of OPG / RANKL / RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We , therefore , examined the gene expression pattern of the TGF beta family members ( inhibin / activin betaA subunit ( activin betaA ) , inhibin alpha subunit , and bone morphogenetic protein 2 ( BMP 2 ) ) , the TNF family members ( receptor activator of NF KB ligand ( RANKL ) and osteoprotegerin ( OPG ) ) , and osteopontin ( OPN ) in normal , non invasive , invasive , and metastatic human breast cancer specimens . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ( RANK ) ligand ( RANKL ) and osteoprotegerin ( OPG ) play essential roles in bone metabolism and immune responses . ^^^ RANKL activates RANK , which is expressed by osteoclasts and dendritic cells ( DC ) , whereas OPG acts as its decoy receptor . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In this study , we hypothesized that IGF 1 modulates bone resorption by regulating expression of osteoprotegerin ( OPG ) and receptor activator of nuclear factor kappaB ( RANK ) ligand ( RANKL ) in bone cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In the present study , the resorptive effects of these agents and their regulation of receptor activator of NF kappaB ligand ( RANKL ) , RANK , and osteoprotegerin ( OPG ) were studied in neonatal mouse calvaria . ^^^ Semiquantitative RT PCR showed that hIL 6 plus shIL 6R enhanced the expression of RANKL and OPG in calvarial bones , but decreased RANK expression . ^^^ Human LIF , hOSM , and mouse OSM ( mOSM ) also stimulated 45Ca release and enhanced the mRNA expression of RANKL and OPG in mouse calvaria , but had no effect on the expression of RANK . ^^^ These experiments demonstrated stimulation of calvarial bone resorption and regulation of mRNA and protein expression of RANKL and OPG by D 3 and IL 6 family cytokines as well as regulation of RANK expression in preosteoclasts / osteoclasts of mouse calvaria by D 3 and hIL 6 plus shIL 6R . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
To further investigate the DC : T cell signals involved in regulating the homeostatic balance between mucosal immunity and tolerance , we have examined the expression and function of the TNFR family member receptor activator of NF kappaB ( RANK ) and its cognate ligand , RANKL , in vitro and in vivo . ^^^ Our data show that although DC isolated from mucosal lymphoid tissues expressed similar levels of surface RANK compared with DC isolated from peripheral lymphoid tissues , DC from the distinct anatomical sites displayed differential responsiveness to RANK engagement with soluble RANKL . ^^^ These studies underscore the functional differences between mucosal and peripheral DC and highlight a novel role for RANK / RANKL interactions during the induction of mucosal immune responses . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK ligand ( RANKL ) expressed by stromal cells and T cells , and its cognate receptor , RANK , were identified as a critical ligand receptor pair for osteoclast differentiation and survival . ^^^ In arthritic joints OPG mRNA was highly expressed and co localized with RANK ligand , and treatment with Fc OPG did not affect the expression of endogenous RANKL or OPG mRNA . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin , RANK , RANKL . ^^^ Osteoprotegerin , RANK ( Receptor Activator of Nuclear factor kappa B ) and RANKL ( Receptor Activator of Nuclear faktor kappa B ligand ) became the aim of intensive research . ^^^ The present paper summarizes the most significant data in osteoprotegerin , RANK and RANKL problems obtained . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OBJECTIVE : The receptor activator of nuclear factor kappaB ( RANK ) / RANK ligand ( RANKL ) pathway is critical in osteoclastogenesis and bone resorption and has been implicated in the process of focal bone erosion in arthritis . ^^^ RANK and RANKL expression were analyzed using specific immunohistochemistry , and tartrate resistant acid phosphatase ( TRAP ) staining was performed . ^^^ Sites of RANK expression also correlated well with sites of RANKL expression , and there was a close correlation of the temporal expression of the receptor ligand pair . ^^^ CONCLUSION : Cells expressing RANK increased in abundance with the progression of arthritis in evolving CIA , and sites of RANK expressing cells correlated with sites of TRAP positive , multinucleated osteoclast like cells as well as with sites of RANKL expression . ^^^ These data support the hypothesis that the RANK / RANKL pathway plays an important role in the process of bone erosion in CIA . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast ( OC ) differentiation requires that precursors , such as macrophage colony stimulating factor ( M CSF ) dependent bone marrow macrophages , receive signals transduced by receptor activator of nuclear factor kappaB ( RANK ) and c Fms , receptors for RANK ligand ( RANKL ) and M CSF , respectively . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
IL 7R ( alpha ) ( + ) cells harvested from TRAF 6 ( / ) embryos expressed LTalphabeta in response to IL 7 but not RANKL , demonstrating that the RANK TRAF 6 signaling pathway regulates LT ( alpha ) beta expression in LN but not in PP . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK ligand ( RANKL ) induces activation of NFkappaB , enhancing the formation , resorptive activity , and survival of osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OPG acts as a decoy receptor , binding to RANK ligand ( RANKL ) , thus preventing the interaction between receptor activator of NF kappaB ( RANK ) and RANKL . ^^^ Dendritic cells ( DCs ) express RANK and T cells express RANKL . ^^^ The ligation of RANK by RANKL can activate both T cells and DCs . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast precursors which express receptor activator of NF kappaB ( RANK ) recognize RANKL through cell to cell interaction with osteoblasts / stromal cells , and differentiate into osteoclasts in the presence of macrophage colony stimulating factor ( M CSF ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Surprisingly , the expression of a subset of such genes including RANKL , stromal derived factor ( SDF 1 ) , B cell lymphotactin chemokine ( BLC ) , and RANK was dramatically enhanced in the mi marrow . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The recent discovery of receptor activator of NF kappa B ligand ( RANKL ) RANK interaction confirms the well known hypothesis that osteoblasts play an essential role in osteoclast differentiation . ^^^ Osteoclast precursors that express RANK , a receptor for RANKL , recognize RANKL through the cell cell interaction and differentiate into osteoclasts . ^^^ Recent Studies have shown that lipopolysaccharide and inflammatory cytokines such as TNF alpha and interleukin 1 directly regulate osteoclast differentiation and function through a mechanism independent of the RANKL RANK interaction . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
This treatment slightly up regulated the mRNA expressions of receptor activator of NF ( B ligand ( RANKL ) , RANK and osteoprotegerin ( OPG ) . ^^^ In contrast , high Ca treatment at the later stage of osteoclastogenesis ( the last 2 days of culture ) stimulated the formation of TRAP ( + ) MNCs , increased RANKL and RANK mRNA expressions and decreased OPG mRNA . ^^^ In conclusion , high Ca affects osteoclastogenesis in a manner depending on the stage of osteoclastogenesis , which is partly mediated via the RANKL RANK OPG regulatory system . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OBJECTIVES : To analyse the expression of receptor activator of NF kappaB ( RANK ) and RANK ligand ( RANKL ) in the joints of children with juvenile idiopathic arthritis ( JIA ) , to characterize the phenotype of RANK ( + ) cells and to test the hypothesis that some RANK ( + ) cells are of the dendritic type . ^^^ METHODS : Paired samples of peripheral blood mononuclear cells ( PBMC ) and synovial fluid mononuclear cells ( SFMC ) from children with oligoarticular ( n=14 ) or polyarticular ( n=4 ) JIA and PBMC from 10 control subjects were studied for expression of RANK , RANKL and dendritic cell specific ICAM ( intercellular adhesion molecule ) grabbing non integrin ( DC SIGN ) by the reverse transcriptase polymerase chain reaction and three colour flow cytometry . ^^^ RESULTS : mRNA for RANK was detected in both adherent cells and T cells from PBMC and SFMC of patients with JIA and in control PBMC , while mRNA for RANKL was detectable in the T cell fraction from JIA patients but not in that from controls . ^^^ CONCLUSIONS : There is increased expression of RANKL and RANK in the juvenile arthritic joint . ^^^ RANK / RANKL interactions may contribute to the survival of inflammatory cells within the joint , as well as to erosions and osteoporosis in juvenile arthritis . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
By contrast , after continuous treatment , gene expression of RANK ligand ( RANKL ) was increased and that of osteoprotegerin ( OPG ) was decreased , resulting in a 25 fold increase in the RANKL / OPG ratio . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recently , RANK ( receptor activator of nuclear factor kappaB ) and its ligand ( RANKL ) have been identified and their essential roles in osteoclastogenesis have been demonstrated , which has provided new insights into the osteoclast differentiation pathway . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Cellular responses to RANK ligand ( RANKL ) and the signal transduction pathways of RANK have been well characterized in osteoclasts and osteoclast precursor cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
For example , the discovery of osteoprotegerin , the decoy receptor and inhibitor of receptor activator of NF kappaB ligand ( RANKL ) , and the RANKL / receptor activator of NF kappaB ( RANK ) signaling pathway that is essential for osteoclastogenesis , has helped clarify the mechanisms regulating osteoclast formation , activation , and survival . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
As Cbfa 1 binding site ( s ) have been located in the promoter of the receptor activator of nuclear factor kappaB ( RANK ) ligand ( RANKL ) gene , we also examined RANKL expression . rmShh N treatment upregulated RANKL and RANK mRNA expression levels in chondrocytes . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In situ hybridization was also carried out to detect the mRNA expression of the receptor activator of NF kappaB ligand ( RANKL ) , a newly identified cytokine that is shown to be essential in the osteoclastogenesis , its receptor RANK ( receptor activator of NF kappaB ligand ) , and its decoy receptor OPG ( osteoprotegerin ) in these four types of lesions . ^^^ RANKL , OPG , and RANK expressed in these lesions may play important roles in the formation of the MGCs . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recent discoveries of novel cytokines in the pathology of arthritis such as IL 17 , IL 18 and RANK ligand ( RANKL ) will help us better understand the pathogenesis of chronic arthritis and may contribute to improvement of current therapies . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
About 1 . 3 3 . 5 % of murine marrow cells expressed surface RANK ( the receptor for RANKL ) while about 11 . 9 15 % of murine bone marrow cells expressed c Fms ( the receptor for M CSF ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In the induced HL 60 cells expressing both c Fms and RANK , RANK mRNA expression was further enhanced by RANKL , but not by macrophage colony stimulating factor . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In situ hybridization revealed the expression of receptor activator of nuclear factor kappa B ( RANK ) in the giant cells and receptor activator of nuclear factor kappa B ligand ( RANKL ) in the tumor cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Commitment of pre osteoclasts to osteoclasts is induced by the interaction of the osteoclastic cell surface receptor RANK with a ligand expressed by osteoblasts , RANKL . ^^^ The RANK / RANKL interaction not only initiates a differentiation cascade that culminates in mature bone resorbing osteoclasts but also increases osteoclastic resorptive capacity and survival . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Although important roles of receptor activator of NF kappaB ligand ( RANKL ) and its receptor ( RANK ) have been established for osteoclastogenesis and bone resorption , their expression and roles during physiological root resorption remain uncertain . ^^^ In this study , we examined the expression of RANKL and osteoprotegerin ( OPG ) , a decoy receptor that prevents RANKL from binding to RANK in human periodontal ligament ( PDL ) cells during physiological root resorption using immunocytochemistry and reverse transcriptase polymerase chain reaction . ^^^ Human odontoclasts derived from resorbing deciduous teeth expressed both RANKL and RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin / RANKL / RANK system and postmenopausal osteoporosis . ^^^ The osteoprotegerin / RANKL / RANK system seems to be an essential signalling pathway by which osteoblasts control the pool size of active osteoclasts . ^^^ The role of OPG as the decoy receptor is to bind RANKL that prevents RANKL from activating its receptor RANK in osteoclast lineage cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Accumulating evidences indicate that receptor activator of NF kB ligand ( RANKL ) is the ultimate extracellular mediator that stimulates osteoclast differentiation into mature osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL stimulation of RANK / TRAF6 signaling increases nuclear factor kappaB ( NFkappaB ) nuclear translocation and activates the Akt / PKB cell survival pathway . ^^^ Our data suggest that activin A enhances osteoclastogenesis treated with RANKL and M CSF via stimulation of RANK , thereby increasing the RANKL stimulation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Here we report that RANKL expression in the mammary gland is developmentally regulated and dependent on PRL and progesterone , whereas its receptor RANK ( receptor activator of NF kappaB ) and decoy receptor osteoprotegerin ( OPG ) are constitutively expressed at all stages in both normal ( PRL+ / ) and prolactin knockout ( PRL / ) mice . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Several studies suggested that receptor activator of NF kappaB ( RANK ) and its ligand ( RANKL ) could be involved in endothelial physiology . ^^^ Using immunofluorescence and reverse transcriptase polymerse chain reaction , we found that RANK was expressed by endothelial cells , and RANKL was expressed by arterial smooth muscle cells . ^^^ Tumor necrosis factor alpha , which causes endothelial cell apoptosis , induced endothelial cells to express osteoprotegerin , a decoy receptor that inhibits RANK RANKL signaling . ^^^ These findings indicate that RANK , in response to the paracrine stimulus of RANKL , may play an important role in maintaining endothelial cell integrity through the PI 3 ' kinase / Akt signal transduction pathway . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Furthermore compared with controls , RANKL induces enhanced association of TRAF 6 and RANK in both RAW264 . 7 cells expressing SHP 1 ( C453S ) and bone marrow macrophages from Me ( 5 ) / Me ( 5 ) mice . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In the present work , we studied the expression of NMDA receptors ( NMDAR ) by osteoclast precursors and their role in osteoclastogenesis using two in vitro models , the murine myelomonocytic RAW 264 . 7 cell line and mouse bone marrow cells , both of which differentiate into osteoclasts in the presence of macrophage colony stimulating factor ( M CSF ) and Rank ligand ( RankL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ligand ( RANKL ) is an important cytokine for bone resorption that acts through its osteoclastic receptor , receptor activator of NF kappaB ( RANK ) , while osteoprotegerin serves as a decoy receptor that binds RANKL and prevents activation of RANK . ^^^ Modulation of the RANKL / RANK / OPG system in animals results in a skeletal and vascular phenotype , and administration of OPG may prevent osteoporosis and vascular calcification . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Since enhanced osteoclastogenesis is recognized as a hallmark of bone loss in prosthetic loosening , we have now investigated the gene expression of receptor activator of nuclear factor kappaB ( RANK ) and receptor activator of nuclear factor kappaB ligand ( RANKL ) during the inflammatory response to different shapes of UHMWPE particles . ^^^ Gene levels of RANK , RANKL , TNFalpha , IL 1beta , and cathepsin K ( CK ) were quantified by real time RT PCR , and TRAP staining of pouch membrane was used to evaluate osteoclastogenesis . ^^^ We found that ( 1 ) elongated particles generated significantly higher RANK and RANKL gene expression than globular particles in pouch tissue ; ( 2 ) elongated particles provoked significantly higher IL 1beta and TNFalpha gene expression ; ( 3 ) a positive association was found between tissue inflammation status and the gene level of RANK / RANKL ; and ( 4 ) elongated particles stimulated significantly higher CK gene expression in comparison with globular particles . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In this study , we used adenoviral vectors to express a model tumor Ag ( the E 7 oncoprotein of human papillomavirus 16 ) with or without coexpression of receptor activator of NF kappaB ( RANK ) / RANK ligand ( RANKL ) or CD40 / CD40L costimulatory molecules , and used these transgenic DCs to immunize mice for the generation of E 7 directed CD 8 ( + ) T cell responses . ^^^ We show that coexpression of RANK / RANKL , but not CD40 / CD40L , in E 7 expressing DCs augmented E 7 specific IFN gamma secreting effector and memory T cells and E 7 specific CTLs . ^^^ These responses were also augmented by coexpression of T cell costimulatory molecules ( RANKL and CD40L ) or DC costimulatory molecules ( RANK and CD 40 ) in the E 7 expressing DC immunogens . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ligand ( RANKL ) is essential for osteoclast ( OC ) differentiation / activation and functions through its receptor RANK at the surface of the osteoclastic cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
This study investigates the expression of key regulators of osteoclast formation , receptor activator NFkappaB ( RANK ) , Receptor activator of NFkappaB ligand ( RANKL ) and osteoprotegerin ( OPG ) , in the peri implant tissues of patients with osteolysis compared with levels in synovial tissues from osteoarthritic and healthy subjects . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The incapacity of Dap 12 null cells to undergo normal osteoclast differentiation is not due to blunted stimulation of major RANK ligand ( RANKL ) or M CSF induced signaling pathways . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Suppression of interaction of RANK with TRAF 6 by TRAF 6 binding peptide abrogated the anti proliferative effects of RANKL , suggesting the critical role of TRAF 6 . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Imbalance of RANKL / RANK / OPG system in interface tissue in loosening of total hip replacement . ^^^ In the differentiation of osteoclasts the differentiation factor ( RANKL ) interacts with the receptor activator of NF kappaB ( RANK ) in a direct cell to cell contact between osteoblast and ( pre ) osteoclast . ^^^ The mRNA levels of both RANKL ( p < 0 . 01 ) and RANK ( p < 0 . 05 ) were high in peri implant tissue and RANKL+ and RANK+ cells were found in such tissue . ^^^ We were unable to stimulate fibroblasts to express RANKL in vitro , but monocyte activation with LPS gave a fivefold increase in RANK mRNA levels . ^^^ In contrast to RANKL and RANK expression in peri implant tissue , expression of OPG was restricted to vascular endothelium . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The inhibition of inflammatory osteoclastogenesis by EM treatment was further confirmed by an osteoclast ( OC ) formation assay using primary cultures of mouse bone marrow progenitor cells stimulated with macrophage colony stimulating factor and RANK ligand ( RANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL acting via its receptor , receptor activator of NFkappaB ( RANK ) , increases bone turnover and promotes intestinal dendritic cell ( DC ) survival in vivo . ^^^ Modulation of RANKL RANK interactions with exogenous recombinant osteoprotegerin ( Fc OPG ) reverses skeletal abnormalities and reduces colitis by decreasing colonic DC numbers . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In situ expression of RANKL , RANK , osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue . ^^^ OBJECTIVES : This study examined the in situ expression of receptor activator of nuclear factor kappaB ligand ( RANKL ) , receptor activator of nuclear factor kappaB ( RANK ) , osteoprotegerin , interleukin 1beta ( IL 1beta ) and tumor necrosis factor alpha ( TNFalpha ) in the osteoclasts of rat periodontal tissue . ^^^ Furthermore , various kinds of molecules such as RANKL , RANK , osteoprotegerin , IL 1beta and TNFalpha are known to be related to the osteoclasts differentiation and function . ^^^ It is therefore important to observe the expression of RANKL , RANK , osteoprotegerin and cytokines in osteoclasts and PDLs . ^^^ In situ hybridization was performed to detect RANKL , RANK , osteoprotegerin , IL 1beta , and TNFalpha mRNAs in osteoclasts and other cells using the specific RNA probes , respectively . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
METHODS : The presence and distribution of RANKL , its receptor RANK and OPG in the periprosthetic interface of septically ( n = 5 ) and aseptically ( n = 6 ) loosened prostheses was examined by immunohistochemistry and immunoblotting . ^^^ However , in all cases RANKL and RANK could be demonstrated in macrophages and giant cells . ^^^ They might be responsible for periprosthetic bone loss in aseptic loosening as a result of their RANKL and RANK expression . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The interaction between receptor activator of nuclear factor kappaB ligand ( RANKL ) and RANK has been reported to regulate immunity in addition to bone metabolism . ^^^ The aim of this study was to determine if osteoprotegerin ( OPG ) , an inhibitor of the RANKL RANK interaction and possibly a new drug against osteoporosis , would adversely affect immunity . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast precursors express RANK , and the interaction between RANKL and RANK ( which is inhibited by OPG ) is the major determinant of osteoclast formation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RAW 264 . 7 cells plated at 10 ( 4 ) cells / cm ( 2 ) and cultured for 4 days in the presence of RANKL represent the optimal culture conditions for osteoclast differentiation , with an up regulation of all parameters related to bone resorption : tartrate resistant acid phosphatase ( TRAP ) , calcitonin receptor ( CTR ) , RANK , cathepsin K , matrix metalloproteinase ( MMP ) 9 mRNA expressions . ^^^ RANKL and OPG biological effects vary according to the differentiation state of the cells : in undifferentiated RAW 264 . 7 cells , TRAP expression was decreased by OPG and RANKL , RANK expression was inhibited by OPG , while MMP 9 and cathepsin K mRNA expressions were not modulated . ^^^ Receptor activator of NF kB Ligand ( RANKL ) is an essential requirement for osteoclastogenesis and its activity is neutralized by binding to the soluble decoy receptor osteoprotegerin ( OPG ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The differentiation and activation of osteoclasts specialized cells that degrade the bone matrix are decisively regulated by the osteoprotegerin ( OPG ) RANK ligand ( RANKL ) paracrine system . ^^^ The biologic activity of OPG counteracts the effects of RANKL by competing with the receptor activator of the nuclear factor * B ( RANK ) ; subsequently , the differentiation and activation of osteoclasts is inhibited and bone resorption reduced . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin ( OPG ) is a decoy receptor for receptor activator of nuclear factor kappaB ligand ( RANKL ) , an inducer of osteoclastogenesis via its receptor RANK . ^^^ Surface plasmon resonance experiments revealed that RANK , RANKL and OPG are able to form a tertiary complex . ^^^ These results suggested a potential formation of a tertiary complex RANK RANKL OPG on osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Here , we present the involvement of three groups of cytokines which seem to be of particular importance in bone physiology : interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) ( TNF alpha ) / IL 1 , and the more recently known triad osteoprotegerin ( OPG ) / receptor activator of NF kappaB ( RANK ) / RANK ligand ( RANKL ) . ^^^ The central role of the OPG / RANK / RANKL triad is pointed out . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OPG inhibits bone resorption and binds with strong affinity to its ligand RANKL , thereby preventing RANKL from binding to its receptor RANK . ^^^ Thus , the bony erosions seen in RA may result from RANKL / RANK system activation by activated T cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
To address the controversy of whether TNFalpha can compensate for RANKL in osteoclastogenesis in vivo , we used a TNFalpha induced animal model of inflammatory arthritis and blocked RANKL / RANK signaling . ^^^ INTRODUCTION : Although critical roles of TNFalpha in inflammatory arthritis and RANKL in bone resorption have been firmly established , a central controversy remains about the extent to which TNFalpha can compensate for RANKL during osteoclastogenesis and the stage at which RANK signaling is required for osteoclastogenesis . ^^^ MATERIALS AND METHODS : Osteoclastogenesis and osteoclast precursor ( OCP ) frequency were analyzed using histology , fluorescence activated cell sorting ( FACS ) , and cell culture from ( 1 ) TNF Tg mice treated with the RANKL antagonist , RANK : Fc , or ( 2 ) TNF Tg 10 RANK / mice generated by crossing TNF Tg mice with RANK / mice . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Opg , Rank , and Rankl in tooth development : co ordination of odontogenesis and osteogenesis . ^^^ Osteoprotegerin ( OPG ) , receptor activator of nuclear factor kappaB ( RANK ) , and RANK ligand ( RANKL ) are mediators of various cellular interactions , including bone metabolism . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
These results indicate that a defect of Src homology 2 domain phosphatase 1 function not only accelerates physiological osteoclast development by RANKL / RANK , but also acquires a novel pathway for osteoclastogenesis by LPS . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
This approach is illustrated here in conjunction with the multi locus TDT in determining whether common alleles of the immune regulatory genes RANK and its ligand TRANCE ( RANKL ) are associated with type 1 diabetes ( T1D ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recently , novel members of the TNF / TNF receptor superfamily , receptor activator of nuclear factor kappa B ligand ( RANKL ) , its receptor RANK , and the decoy receptor osteoprotegerin ( OPG ) , have been identified as paracrine mediators of both the immune system and bone functions . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recently , the signaling of receptor activator of nuclear factor KappaB ( RANK ) and its ligand ( RANKL ) was reported to play a pivotal role in osteoclast formation and activation . ^^^ The aim of this study was to examine the expression of RANKL and the contribution of RANK RANKL signaling to the process of tooth germ and alveolar bone development . ^^^ To elucidate the function of RANKL , mouse mandibular explants on embryonic day 14 were subjected to organ culture with osteoprotegerin ( OPG ) , an inhibitor of RANK RANKL signaling as a decoy receptor of RANKL . ^^^ These observations suggest that osteoclastogenesis in the alveolar bone , which is essential for the accommodation of normal tooth development , is mediated by RANK RANKL signaling . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
This system consists of a ligand , receptor activator of NF kappaB ligand ( RANKL ) , a receptor , RANK , and its soluble decoy receptor , osteoprotegerin ( OPG ) . ^^^ RANKL , a member of the tumor necrosis factor ( TNF ) family , triggers osteoclastogenesis by forming a complex with RANK , a member of the TNF receptor family . ^^^ Further structural and mutational studies on the RANKL / RANK / OPG system will provide useful information for developing drug candidates that inhibit osteoclastogenesis and mediate problems of bone metabolism . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin ( OPG ) belongs to the tumor necrosis factor receptor superfamily and acts as a decoy receptor for the receptor activator of NF kappaB ligand ( RANKL ) , preventing its binding to RANK . ^^^ Since 1997 , the RANKL / RANK / OPG system has been intensively investigated in the fields of bone , immune and cardiovascular system pathophysiology . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
As osteoclastogenesis is regulated by some T cell cytokines and osteotropic factors , we examined the effect of DBT on the receptor activator of NF kappa B ( RANK ) , RANK ligand ( RANKL ) , osteoprotegerin ( OPG ) and M CSF mRNAs , which were induced by arthritis induction . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Expression of RANKL , RANK , osteoprotegerin ( OPG ) , IL 6 , IL 11 , osteocalcin ( OCN ) , and calcitonin receptor ( CTR ) messenger RNA ( mRNA ) species were analyzed and the data were nonparametrically distributed . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK , RANKL , OPG , and M CSF expression in stromal cells during corneal wound healing . ^^^ RANKL , RANK , M CSF , and OPG proteins were detected in unwounded and wounded mouse corneas by immunocytochemistry . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The receptor activator of NF kappaB ligand ( RANKL ) and its receptor RANK are critical regulators for immune responses as well as bone remodeling . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Clinical implications of the osteoprotegerin / RANKL / RANK system for bone and vascular diseases . ^^^ Moreover , alterations of the OPG / RANKL / RANK system have been implicated in vascular diseases . ^^^ RANKL blockade ( using OPG or RANK fusion proteins or RANKL antibodies ) has prevented bone loss caused by osteoporosis , chronic inflammatory disorders , and malignant tumors in animal models and may emerge as a therapy in humans based on studies in postmenopausal osteoporosis , myeloma bone disease , and osteolytic metastases . ^^^ This review summarizes the clinical implications of the OPG / RANKL / RANK system for bone and vascular diseases . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Proliferation and differentiation of osteoclasts are regulated by a cytokine system that includes RANKL , which binds 2 receptors : RANK , which activates osteoclast differentiation , and osteoprotegerin ( OPG ) , a decoy receptor that limits RANKL action . ^^^ We investigated the role of the OPG / RANKL / RANK network in the pathogenesis of skeletal metastasis in neuroblastoma . ^^^ SH SY5Y showed the lowest OPG to RANKL ratio and promoted osteoclastic differentiation of FLG29 . 1 and peripheral mononuclear cells , inducing expression of the osteoclast markers RANK , c src , c fos , cathepsin K and TRAP . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We also found that tumor necrosis factor ( TNF ) receptor associated factor 6 ( TRAF 6 ) , which mediates RANKL signaling , was constitutively bound to RANK in TNF receptor deleted cells but not in wild type cells , and this binding was enhanced by RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclastogenesis may be determined by its receptor RANK and the relative ratio of RANKL to its decoy receptor osteoprotegerin ( OPG ) , and alterations in this ratio may be a major cause of bone loss in many metabolic and immunologic disorders . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
First , reverse transcriptase polymerase chain reactions ( RT PCR ) were carried out to detect the mRNA encoding receptor activator of NF kappaB ( RANK ) , RANK ligand ( RANKL ) , osteoprotegerin ( OPG ) , tumour necrosis factor alpha ( TNF alpha ) , interleukin ( IL ) 1beta , IL 6 and the osteoclast markers tartrate resistant acid phosphatase ( TRAP ) and cathepsin K . ^^^ In real time PCR , the expression levels of TNF alpha , IL 1beta , IL 6 , RANKL , TRAP and cathepsin K mRNA increased , whereas the expression levels of RANK and OPG were unchanged and decreased respectively . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The phenotype , including a block in RANKL dependent osteoclast differentiation and lymph node agenesis , copies that of Rank ( / ) mice , which have been produced by targeted recombination . ^^^ INTRODUCTION : Commitment of osteoclast progenitors to the osteoclast lineage requires RANKL / RANK mediated intercellular signals . ^^^ Gene targeted defects in this signaling pathway resulted in osteoclast deficiency and severe osteopetrosis in mice , but to date , there have been no reports of spontaneous mutations in Rankl or Rank resulting in osteopetrosis . ^^^ RESULTS : The inheritance pattern was consistent with autosomal recessive inheritance , and the phenotype resembled that of either Rankl or Rank knockout mice with the exception of as yet unexplained death of most mice 2 3 weeks after weaning . ^^^ Osteoclast precursors from the spleens of affected pups failed to form osteoclasts in vitro when stimulated with macrophage colony stimulating factor ( M CSF ) and RANKL , unless they were forced to express wildtype Rank cDNA . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
These factors could act primarily via a common final pathway involving the recently described members of the TNF receptor ligand family : RANKL ( Receptor Activator of NK kappaB Ligand ) and its corresponding RANK receptor that play a crucial role in osteoclast differentiation and activation , and osteoprotegerin ( OPG ) , the physiological inhibitor of RANKL . ^^^ A therapeutic approach targeting the RANKL RANK signaling pathway could be of great value , as RANKL inhibitors are potent anti resorptive agents , affecting both myeloma induced bone resorption and the tumor burden . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL / RANK / OPG : new therapeutic targets in bone tumours and associated osteolysis . ^^^ The emergence of the molecular triad osteoprotegerin ( OPG ) / Receptor Activator of NF kB ( RANK ) / RANK Ligand ( RANKL ) has helped elucidate a key signalling pathway between stromal cells and osteoclasts . ^^^ The interaction between RANK and RANKL plays a critical role in promoting osteoclast differentiation and activation leading to bone resorption . ^^^ OPG is a soluble decoy receptor for RANKL that blocks osteoclast formation by inhibiting RANKL binding to RANK . ^^^ The OPG / RANK / RANKL system has been shown to be abnormally regulated in several malignant osteolytic pathologies such as multiple myeloma [ MM , where enhanced RANKL expression ( directly by tumour cells or indirectly by stromal bone cells or T lymphocytes ) ] plays an important role in associated bone destruction . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We investigated time course changes in the expression of receptor activator of nuclear factor kappaB ( RANK ) , its ligand ( RANKL ) , osteoprotegerin ( OPG ) , bone type alkaline phosphatase ( BAP ) , and tartrate resistant acid phosphatase ( TRAP ) in ovariectomized ( OVX ) rats . ^^^ The expression profiles of TRAP , RANK , and RANKL proteins in the coccyx specimens were similar to the pattern of serum TRAP activity , while the profiles of the BAP and OPG proteins were similar to the pattern of serum BAP activity in OVX rats . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
To further investigate the role of RANKL in the pathophysiology of MM we evaluated the expression of its receptor RANK in MM cells and in the BM environment and the potential role of RANKL in the interaction of myeloma cells with the microenvironment . ^^^ The presence of the RANK Fc that blocks the RANK / RANKL interaction significantly inhibited HMCL induced secretion of IL 6 and IL 11 . ^^^ BACKGROUND AND OBJECTIVES : The receptor activator of NF kB ligand ( RANKL ) has a critical role in osteoclast activation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclastogenesis is primarily a RANK / RANKL dependent event and occurs in an environment governed by both hematopoietic and mesenchymal compartments . ^^^ Thus , we reasoned that TNF / TNFr1 may regulate RANKL and possibly RANK expression by stromal cells and osteoclast precursors ( OCPs ) , respectively . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclasts and osteoclast precursors from patients with Paget ' s disease contain paramyxoviral transcripts and appear hyperresponsive to 1 , 25 ( OH ) 2D3 and RANK ligand ( RANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The receptor activator of nuclear factor kappa B ( RANK ) / RANK ligand ( RANKL ) / osteoprotegerin ( OPG ) pathway has been recently recognized as the final , dominant mediator of osteoclast proliferation and activation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The marrow stromal cell is the principal source of the key osteoclastogenic cytokine receptor activator of NF kappaB ( RANK ) ligand ( RANKL ) . ^^^ The direct induction of osteoclast recruitment by TNF alpha is characterized by enhanced RANK expression and sensitization of precursor cells to RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In addition , PAR inhibited NF kappaB activation induced by osteoclastogenic factors RANKL , interleukin ( IL ) 1beta , or TNF alpha to varying degrees and reduced the gene expression of RANK and TRAF 6 . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
A more profound defect in osteoclastogenesis was observed in vitro using IKK alpha ( / ) hematopoietic cells treated with colony stimulating factor 1 and RANK ligand ( RANKL ) , as the cells failed to form large , multinucleated osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappa B ligand ( RANKL ) and its receptor activator of NF kappa B ( RANK ) play pivotal roles in osteoclast differentiation and function . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
BACKGROUND : Parathyroid hormone related protein ( PTHrP ) promotes osteoclastogenesis by inhibiting expression of osteoprotegerin ( OPG ) , a decoy receptor for the receptor activator of nuclear factor kappa B ( RANK ) , and by enhancing production of RANK ligand ( RANKL ) by osteoblasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of nuclear factor kappaB ligand ( RANKL ) transduces a differentiation signal appropriate to osteoclasts likely through induction a receptor homotrimer ; however , biological importance of RANK trimerizarion is unknown . ^^^ However , dimerized RANK induced osteoclasts showed relatively low levels of multinucleation , pit forming activity , and expression of calcitonin receptor and cathepsin K , compared with osteoclasts which were induced in the presence of RANKL . ^^^ As expression of nuclear factor of activated T cells 1 ( NFATc 1 ) was also reduced in dimerized RANK induced osteoclasts , RANK oligomerization by RANKL is a critical event to generate fully matured osteoclasts through upregulation of NFATc1 . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL , a member of tumor necrosis factor ( TNF ) superfamily , regulates the differentiation , activation , and survival of osteoclasts through binding to its cognate receptor , RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
All three chemokines also directly and dramatically enhanced OC formation in marrow cultures , through a pathway dependent on the presence of RANKL but without altering RANK expression . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Increased expression of receptor activator of NF kappaB ligand ( RANKL ) , its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn ' s disease patients . ^^^ Receptor activator of NF kappaB ligand ( RANKL ) , its receptor RANK and its decoy receptor osteoprotegerin ( OPG ) are potentially involved in this process as they regulate osteoclastogenesis and are influenced by pro inflammatory cytokines . ^^^ The aim of this study was to determine the levels of soluble RANKL ( sRANKL ) , RANK and OPG expression both in the serum and in the colon of CD patients . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ( RANK ) ligand ( RANKL ) , expressed by cells of the osteoblast lineage binds to RANK , induces signaling and a gene expression cascade that leads to osteoclast differentiation and activation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The molecular triad OPG / RANK / RANKL : involvement in the orchestration of pathophysiological bone remodeling . ^^^ The recent identification of the receptor activator of nuclear factor kappaB ligand ( RANKL ) , its cognate receptor RANK , and its decoy receptor osteoprotegerin ( OPG ) has led to a new molecular perspective on osteoclast biology and bone homeostasis . ^^^ Specifically , the interaction between RANKL and RANK has been shown to be required for osteoclast differentiation . ^^^ The third protagonist , OPG , acts as a soluble receptor antagonist for RANKL that prevents it from binding to and activating RANK . ^^^ In this context , the OPG / RANK / RANKL triad opens novel therapeutic areas in diseases characterized by excessive bone resorption . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The receptor activator of NF kappaB ( RANK ) is a member of the tumor necrosis factor ( TNF ) receptor family and acts to cause osteoclastgenesis through the interaction with its ligand , RANKL . ^^^ When the aptamer binding to RANK was challenged by RANKL , there was no competition between the aptamer and RANKL . ^^^ Instead , the formation of a ternary complex , aptamer RANK RANKL , was detected by a spin down assay and by BIAcore surface plasmon resonance analysis . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Bone marrow cells from wild type and CD 44 k . o . mice were analyzed for their capacity to form osteoclasts on plastic and on bone in the presence of macrophage colony stimulating factor ( M CSF ) and receptor activator of NF kB ligand ( RANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recently , receptor activator of nuclear factor kappaB ( RANK ) , its ligand ( RANKL ) , and soluble decoy receptor osteoprotegerin ( OPG ) have been identified as a pivotal cytokine system in the bone remodeling control . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OBJECTIVE : To demonstrate the effects of disease modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through their effects on receptor activator of nuclear factor kappaB ( RANK ) , osteoprotegerin ( OPG ) , and RANK ligand ( RANKL ) . ^^^ RANKL expression in RA FLS and RANK expression in PBMCs were assayed by Western blotting , reverse transcription polymerase chain reaction ( RT PCR ) , and real time PCR . ^^^ CONCLUSION : MTX , SSZ , infliximab , and IL 4 inhibit human osteoclastogenesis by modulating the interaction of RANKL , RANK , and OPG . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ligand ( RANKL ) is the type 2 membrane protein in cells of the osteoblastic lineage which interacts with its receptor , RANK , on hemopoietic precursors to promote osteoclast formation and maintain their viability and activity . ^^^ With a number of identifiable milestones from the early 1980s on , a highly convincing case was made for the existence of what turned out to be RANKL and RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Heritable disorders of the RANKL / OPG / RANK signaling pathway . ^^^ Figure 7 summarizes the heritable disorders identified to date that directly involve the RANKL / OPG / RANK signaling pathway in humans . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK , RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis . ^^^ Elucidation of the receptor activator of nuclear factor kappa B ( RANK ) , its ligand ( RANKL ) and osteoprotegerin ( OPG ) as the final effectors of bone resorption has transformed our understanding of metabolic bone diseases and revealed novel therapeutic targets . ^^^ Activation of the RANK RANKL signaling pathway is directly responsible for dramatic focal erosions that are observed in inflammatory arthritis and aseptic loosening of orthopaedic implants . ^^^ Herein , we provide a review of the role of RANK , RANKL and OPG in erosive arthritis and periprosthetic osteolysis and discuss the potential of anti RANKL therapy for these conditions . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The osteoprotegerin ( OPG ) / receptor activator of nuclear factor kappaB ligand ( RANKL ) / receptor activator of nuclear factor kappaB ( RANK ) system is the dominant and final mediator of osteoclastogenesis . ^^^ Although interactions between the COX 2 / PGE ( 2 ) and IL 6 systems have been described in bone cells , the mechanisms underlying these cooperative signaling pathways and the possible involvement of the OPG / RANKL / RANK system have not been fully elucidated . ^^^ Effects on osteoclast differentiation , particularly with IL 6 , were most marked when osteoclast precursor cells were grown in coculture with osteoblasts , indicating a possible role of the RANK / RANKL / OPG system . ^^^ COX 2 and PGE ( 2 ) stimulated osteoclastogenesis through inhibition of OPG secretion , stimulation of RANKL production by osteoblasts , and up regulation of RANK expression in osteoclasts . ^^^ These findings provide evidence for cross talk between the PGE ( 2 ) and IL 6 signaling enhance osteoclast differentiation via effects on the OPG / RANKL / RANK system in bone cells . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We examined the direct effect of SC 19220 , an EP 1 prostaglandin ( PG ) E 2 receptor antagonist , on osteoclastogenesis induced by RANK / RANKL signaling in mouse cell cultures . ^^^ We found that SC 19220 inhibited RANKL induced osteoclastogenesis by suppression of the RANK / RANKL signaling pathway in osteoclast precursors . ^^^ INTRODUCTION : Bone growth is accomplished by a dynamic equilibrium between formation by osteoblasts and resorption by osteoclasts , which are regulated by many systemic and local osteotropic factors that induce osteoclast formation from hematopoietic precursors through RANK / RANKL signaling . ^^^ In this study , we investigated the inhibitory effects of SC 19220 on osteoclastogenesis induced by RANK / RANKL signaling in mouse cell cultures and analyzed the mechanism involved . ^^^ We also examined the effects of SC 19220 on the macrophage colony stimulating factor ( M CSF ) receptor ( c Fms ) and RANK expression in osteoclast precursors as well as RANK / RANKL signaling using RT PCR and Western blotting analyses . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
A model of inflammatory arthritis highlights a role for oncostatin M in pro inflammatory cytokine induced bone destruction via RANK / RANKL . ^^^ Furthermore , there was increased expression of RANK and its ligand RANKL in the inflammatory cells , in inflamed synovium and in articular cartilage of knee joints treated with the cytokine combinations compared with expression in joints treated with the cytokines alone or the control . ^^^ The model also provides further evidence that increased osteoclast like , tartrate resistant acid phosphatase positive staining multinucleate cells and upregulation of RANK / RANKL in joint tissues are key factors in pathological bone destruction . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL induced degradation of 1 kappa B alpha and phosphorylation of p 38 MAPK and c Jun N terminal kinase in RAW264 . 7 cells were up regulated by PGE 2 in a cAMP dependent protein kinase A ( PKA ) dependent manner , suggesting that EP 2 and EP 4 signals cross talk with RANK signals . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The expression of receptor activator of NF kappa B ligand ( RANKL ) and receptor activator of NF kappa B ( RANK ) , as assessed by quantitative reverse transcription polymerase chain reaction ( RT PCR ) , was also increased significantly during endochondral ossification in TNFR 1 ( / ) mice . ^^^ BMPs and RANKL and its receptor RANK may be involved in the change of local environment in the absence of TNFR 1 signalling . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) family member , RANK ligand ( RANKL ) expressed on marrow stromal / osteoblast cells in response to several osteotropic factors , is critical for osteoclast precursor differentiation to form multinucleated osteoclasts , which resorb bone . ^^^ The interaction of RANKL RANK results in activation of various signaling cascades during osteoclast development and activation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL is expressed on the bone marrow derived stromal cell membrane and induces the differentiation of osteoclasts by binding to RANK expressed on the osteoclast precursor cell membrane . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Other tyrosine kinase receptors including kit and met can augment fms signalling , and TNFs other than RANKL , including TNFalpha and TRAIL , modify RANK signalling , which is also susceptible to interference by interferons . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The direct expression and production of the critical osteoclastogenic factor , the receptor activator of NF kB ligand ( RANKL ) , is a matter of controversy . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Peripheral blood monocytes ( PBMC ) were cultured on bone slices or plastic culture dishes with human recombinant RANK ligand ( RANKL ) and recombinant human macrophage colony stimulating factor ( M CSF ) for 16 21 days . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ( RANK ) and its ligand RANKL have been identified as essential factors involved in osteoclast development and bone remodeling , but their mechanism and interacting factors have not been fully characterized . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The increased osteoclast motility and activation in response to SDF 1alpha was associated with an increase in the expression of a number of osteoclast activation related genes , including RANKL , RANK , TRAP , MMP 9 , CA 2 , and Cathepsin K . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
These results indicate that LMW HA plays an important role in osteoclast differentiation and function through the interaction of RANKL and RANK . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator NF kappa B ( RANK : the receptor for RANKL ) , IL 1 receptor and integrin alpha ( 5 ) beta ( 3 ) act as positive regulators of osteoclastic bone resorption . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
There was no difference in RANK and osteoprotegerin expression between iNOS KO and WT bone marrow cultures after M CSF and RANKL treatment , while Traf 6 expression was significantly lower in the absence of iNOS . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Suramin interacts with RANK and inhibits RANKL induced osteoclast differentiation . ^^^ Receptor activator of NF kB ( RANK ) ligand ( RANKL ) is a key regulator of osteoclast differentiation and function and this study evaluated the ability of suramin , which has been shown to disrupt protein protein interactions , to interfere with RANKL functional activity and binding to RANK . ^^^ The ability of RANKL to bind to recombinant human RANK Fc ( rhRANK Fc ) was reduced 50 % by suramin in an in vitro binding assay . ^^^ Receptor activator of NF kB ( RANK ) ligand ( RANKL ) is a key regulator of osteoclast differentiation and function and this study evaluated the ability of suramin , which has been shown to disrupt protein protein interactions , to interfere with RANKL functional activity and binding to RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK , RANKL and osteoprotegerin in arthritic bone loss . ^^^ In fact , osteoclasts are markedly activated after RANKL binding to the cognate RANK expressed on the surface of these cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
BACKGROUND : There is a potential interface between osteoporosis and the chronic inflammation of inflammatory bowel disease ( IBD ) , and the osteoprotegerin ( OPG ) / receptor for activated nuclear factor kappaB ( RANK ) / RANK ligand ( RANKL ) signaling pathway may be an important mediator , although data are limited . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
BACKGROUND : Interleukin 17 ( IL 17 ) is exclusively produced by activated T cells , and this cytokine can induce inflammatory responses , support immune responses ( Th 1 ) , and stimulate osteoclastic bone resorption in combination with receptor activator of NF kappaB ( RANK ) and RANK ligand ( RANKL ) . ^^^ The IL 17 mRNA positive samples simultaneously expressed mRNAs encoding interferon ( IFN ) gamma , IL 2 , RANK , and RANKL , but not IL 4 . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The tumors were analyzed by RT PCR to determine the mRNA expression of interleukin 6 ( IL 6 ) , parathyroid hormone related protein ( PTHrP ) , tumor necrosis factor alpha ( TNF alpha ) , receptor activator of nuclear factor kappaB ( RANK ) , RANK ligand ( RANKL ) , and osteoprotegerin . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Multiple myeloma has recently been found to induce considerable imbalance in the newly identified system of osteoprotegerin ( OPG ) , receptor activator of nuclear factor KB ligand ( RANKL ) and RANK . ^^^ The binding of RANKL to RANK on the surface of osteoclastic precursors in the presence of m CSF activates the signalling pathways for differentiation and proliferation of an osteoclastic line . ^^^ OPG is a decoy circulating receptor for RANKL which blocks its binding to RANK . ^^^ There are at least three mechanisms by which myeloma cells affects the OPG / RANKL / RANK system : 1 : The adhesion between the myeloma / stromal cells and the osteoblastic precursors stimulates the system by increasing the production of RANKL . 2 : Some myeloma lines produce independently membrane bound or free RANKL . 3 : The normal and mutated plasma cells bind , degrade and block the OPG production from the stromal cells . ^^^ The OPG / RANKL / RANK system is the latest therapeutic target in the treatment of myeloma bone disease . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RESULTS AND CONCLUSIONS : Osteoclast progenitors from normal fetal liver , which were cultured with M CSF , expressed surface molecules c fms , Mac 1 , and RANK , and could differentiate into TRACP ( + ) multinucleate cells in the presence of soluble RANKL or TNF alpha . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoprotegerin ( OPG ) , the receptor activator of nuclear factor kappaB ( RANK ) , and RANK ligand ( RANKL ) are newly discovered members of the tumor necrosis factor superfamily that are critical regulators in bone metabolism but appear also to be involved in immune responses . ^^^ We hypothesized that the OPG / RANK / RANKL axis could be involved in the pathogenesis of heart failure ( HF ) , and this hypothesis was investigated in both experimental and clinical studies . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recent studies have revealed that new molecules such as the receptor activator of nuclear factor kappa B ( RANK ) , its ligand ( RANKL ) , osteoprotegerin ( OPG ) , and macrophage inflammatory protein 1alpha are implicated in osteoclast activation and differentiation , while proteins such as dickkopf 1 inhibit osteoblastic bone formation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
When cultured in the presence of M CSF and RANKL , CBMs formed multinucleated cells that expressed RANK and calcitonin receptor , and were able to resorb bone . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Inhibition of the RANKL pathway with concentrations of OPG up to 25 ng / ml , far greater than physiological , did not significantly decrease the robust acid induced Ca efflux from bone nor did incubation of the calvariae with a different inhibitor , RANK / Fc ( up to 50 ng / ml ) . ^^^ Thus acid induced net Ca efflux appears to involve mechanisms in addition to the RANK / RANKL pathway . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
BMMs were cultured with or without M CSF , and analyzed for expression of OPG and receptor activator of NF kappaB ( RANK ; receptor for RANKL ) mRNAs by real time polymerase chain reaction and secretion of OPG by enzyme linked immunosorbent assay . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Changes in RANKL / OPG / RANK gene expression in peripheral mononuclear cells following treatment with estrogen or raloxifene . ^^^ The RANKL / OPG / RANK pathway is the key mediator of osteoclastogenesis . ^^^ The effect of estrogen or raloxifene on bone resorption and the expression of RANKL / OPG / RANK in peripheral blood mononuclear cells ( PBMCs ) was examined . ^^^ PBMCs were isolated from 17 women and changes in RANKL , OPG and RANK mRNA were determined . ^^^ RANKL , OPG and RANK gene expression decreased ( 6 months : RANKL 50 . 0 % [ 24 . 8 ] p < 0 . 001 , OPG : 21 . 7 % [ 28 ] p < 0 . 001 , RANK : 76 . 6 % [ 10 . 2 ] p=0 . 015 ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL exerts the effects by binding RANK , the receptor activator of NF kappaB , in osteoclasts and its precursors . ^^^ Upon binding RANKL , RANK activates six major signaling pathways : NFATc 1 , NF kappaB , Akt / PKB , JNK , ERK and p 38 , which play distinct roles in osteoclast differentiation , function and survival . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The multinucleated giant cells have characters as osteoclast like cells , indicating that a soluble osteoclast inducing factor ( s ) is secreted from GCTSC expressing RANK , RANKL / ODF / OPGL and TACE mRNA . ^^^ Furthermore , OCIF / OPG inhibited GCTSC induced osteoclastogenesis , showing that the RANK RANKL system is involved in GCTSC induced osteoclastogenesis and that soluble form of ODF / RANKL induces osteoclasts from monocytes . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANK and RANKL expression as markers of dendritic cell T cell interactions in paired samples of rheumatoid synovium and lymph nodes . ^^^ OBJECTIVE : The RANK / RANKL pathway is critical in bone destruction in conditions such as rheumatoid arthritis ( RA ) . ^^^ Since RANK / RANKL deficient mice show major lymph node ( LN ) abnormalities , undertook this study to investigate the expression of RANK / RANKL in paired samples of synovium and LNs from RA patients . ^^^ METHODS : Using immunohistochemistry , RANK / RANKL expression by dendritic cell ( DC ) and T cell subsets was studied in this unique set of samples and in RA synoviocytes stimulated with interleukin 1beta ( IL 1beta ) , tumor necrosis factor alpha ( TNFalpha ) , and IL 17 . ^^^ Double staining of paired RA synovium and LN sections showed that some immature CD1a+ DCs expressed RANK and RANKL , while some mature DC LAMP+ DCs expressed only RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Alterations of the key regulators of osteoclastogenesis , receptor activator of NF kappaB ( RANK ) , RANK ligand ( RANKL ) , and osteoprotegerin ( OPG ) have been implicated in wear particle induced osteolysis , the most common cause for implant failure in total joint replacements . ^^^ This important finding underscores the crucial significance of the OPG RANKL RANK signaling in wear particle induced osteolysis . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The effects of RANKL are counteracted by the decoy receptor osteoprotegerin ( OPG ) , which protects against bone resorption by preventing RANKL from coupling to its receptor RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
CONTEXT : The discovery of the receptor activator for nuclear factor kappaB ( RANK ) ligand ( RANKL ) / RANK signaling pathway has marked a major advance in our understanding of the mechanisms controlling osteoclastogenesis . ^^^ RANKL , expressed by preosteoblasts and stromal cells , binds to RANK , expressed by cells of the osteoclast lineage , inducing a signaling cascade leading to the differentiation and fusion of osteoclast precursor cells and stimulating the activity of the mature osteoclast . ^^^ Search terms osteoprotegerin , OPG , RANK , RANKL , and RANK ligand were used alone and in combination with bone , osteoporosis , and disease . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The final pathway of osteoclastogenesis involves three constituents of a cytokine system : receptor activator of nuclear factor kB ligand ( RANKL ) ; its receptor , receptor activator of nuclear factor kB ( RANK ) ; and its soluble decoy receptor , osteoprotegerin ( OPG ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL / RANK signaling inhibitor ] . ^^^ We tested the ability of a peptide mimic ( WP9QY ) of a critical contact site on the TNF receptor to inhibit RANK ligand induced osteoclastogenesis and discuss whether it could work as both TNF alpha and RANKL antagonists , and the possibility of the drug development using the techniques in the structural biology . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Identification of RANKL / ODF ( receptor activator of NF kappaB ligand / osteoclast differentiation factor ) , RANK ( receptor activator of NF kappaB ) and OPG / OCIF ( osteoprotegerin / osteoclastogenesis inhibitory factor ) revealed the mechanisms regulating osteoclast differentiation and function . ^^^ RANKL RANK signaling is essential for the physiological osteoclast development and plays a major role in the pathological bone destruction . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Insight into the molecular mechanisms of osteoclastogenesis has been provided by the detection of receptor activator of NF kappaB ligand ( RANKL ) , its specific receptor ( RANK ) and its decoy receptor antagonist osteoprotegerin ( OPG ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Previously , we demonstrated that the marrow of such mice over express receptor activator of nuclear factor kappaB ( RANK ) ligand ( RANKL ) . ^^^ We hypothesized that the loss of B cells in the marrow of mi mice was due to the over expression of IFN beta as a result of heightened RANK RANKL signaling . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Although the pathway using receptor and activator of NF kappa B ( RANK ) and its ligand , RANKL , is known to be essential for osteoclast differentiation , their precise mechanisms are not fully understood . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We have studied the expression of different mediators implicated in bone homeostasis , such as inducible nitric oxide synthase ( iNOS ) , cyclooxygenase 2 ( COX 2 ) , receptor activator of nuclear factor kappaB ( RANK ) , receptor activator of nuclear factor kappaB ligand ( RANKL ) , osteoprotegerin ( OPG ) , IL 1 , IL 4 , IL 6 , IL 10 , IL 11 and IL 17 . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL / RANK , OPG and OPT in a group of patients affected by chronic arthritis . ^^^ Recently , receptor activator of nuclear factor kappaB ligand ( RANKL ) , its receptor RANK , and the decoy receptor osteoprotegerin ( OPG ) , have been identified as paracrine mediator of bone functions . ^^^ The balance of RANKL / RANK and OPG is critical for osteoclastogenesis modulation and physiological bone remodeling . ^^^ These results suggest that RANKL / RANK system , OPG and OPN have important role in patients with chronic arthritis . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Self assembly of mouse RANK was examined by immunoprecipitation assay using 293T cells that had been transfected with the full length RANK ( Full ) fused to FLAG tag ( Full FLAG ) and Full fused to HA tag ( Full HA ) without soluble RANKL ( sRANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Downstream signaling molecules of the receptor of RANKL , RANK , modulate the differentiation and the activation of osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Variation in genes involved in the RANKL / RANK / OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men . ^^^ In order to assess the contribution of polymorphisms in the RANKL ( TNFSF 11 ) , RANK ( TNFRSF11A ) and OPG ( TNFRSF11B ) genes to variations in bone mineral density ( BMD ) , a population based cohort with 1 , 120 extreme low hip BMD cases or extreme high hip BMD controls was genotyped on five SNPs . ^^^ Significantly positive associations were found for A163G polymorphisms in the promoter regions of the OPG gene , a missense substitution in exon 7 ( Ala192Val ) of the RANK gene and rs 9594782 SNP in the 5 ' UTR of the RANKL gene with BMD in men only . ^^^ Significant gene gene interactions were also observed among the OPG , RANK and RANKL genes . ^^^ Our findings suggest that genetic variation in genes involved in the RANKL / RANK / OPG bone remodeling pathway are strongly associated with BMD at different skeletal sites in adult men , but not in women . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Inhibition of hormone and cytokine stimulated osteoclastogenesis and bone resorption by interleukin 4 and interleukin 13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT 6 dependent pathway . ^^^ IL 4 and IL 13 decreased receptor activator of nuclear factor kappaB ligand ( RANKL ) and RANK mRNA and increased osteoprotegerin ( OPG ) mRNA in calvariae . ^^^ No effects by IL 4 on bone resorption and osteoclast formation or on RANKL and RANK mRNA expression were seen in Stat 6 / mice . ^^^ The data indicate that IL 4 and IL 13 , via a STAT 6 dependent pathway , inhibit osteoclast differentiation and bone resorption by activating receptors on osteoblasts and osteoclasts that affect the RANKL / RANK / OPG system . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL exerts its effect by activating its receptor RANK ( receptor activator of NF kappaB ) , which recruits various intracellular signaling molecules via specific motifs in its cytoplasmic tail . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Role of the RANKL / RANK system in the induction of interleukin 8 ( IL 8 ) in B chronic lymphocytic leukemia ( B CLL ) cells . ^^^ Moreover , unlike primary normal B cells , leukemic B CLL cells showed surface expression of RANK , the cognate transmembrane receptor of RANKL . ^^^ On the other hand , treatment with RANK Fc chimera potently upregulated the release of IL 8 in the B CLL culture supernatants , suggesting involvement of reverse signaling through transmembrane RANKL in IL 8 induction . ^^^ Since IL 8 has been implicated in progression of B CLL disease , our findings suggest that , by upregulating IL 8 , the RANKL / RANK system may contribute to the pathogenesis of B CLL . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL binds to its functional receptor , receptor activator of NF B ( RANK ) , expressed as a transmembrane heterotrimer on the surface of hematopoietic osteoclasts progenitors and mature osteoclasts . ^^^ RANKL RANK interaction is inhibited by soluble receptor osteoprotegerin . ^^^ OSTEOPROTEGERIN : Osteoprotegerin ( OPG ) , a member of the tumor necrosis factor receptor superfamily , acts as a natural decoy receptor that blocks the interaction between RANKL and RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The tumour necrosis factor ( TNF ) family of cytokines and receptors specifically TNF alpha , RANKL , RANK and OPG are dominant regulators of osteoclastic bone resorption in rheumatoid arthritis . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The discovery and characterization of the RANKL / RANK / OPG signaling pathway and the identification of its role in the pathogenesis of bone loss have provided the rationale for the development of drugs with the ability to modulate RANK induced osteoclastogenesis . ^^^ In vivo studies have identified interfering with the RANKL / RANK interaction as a potential therapeutic target in the management of osteoporosis . ^^^ Two agents capable of blocking the binding of RANKL to RANK have been so far tested in clinical studies osteoprotegerin ( Fc OPG fusion molecule ) and the RANKL antibody ( AMG 162 ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The data support a model in which tumor cells cause osteolytic bone destruction independently of the RANK ligand ( RANKL ) pathway . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL directly induces bone morphogenetic protein 2 expression in RANK expressing POS 1 osteosarcoma cells . ^^^ Thereby , experiments were performed to determine whether RANK was functional , by studying the biological activity of murine RANKL through the receptor RANK expressed on POS 1 cells . ^^^ Moreover , a 2 fold molar excess of soluble RANK blocks the RANKL induced BMP 2 expression , demonstrating that the biological effects of RANKL observed in POS 1 cells are mediated by RANK . ^^^ This is the first report describing a functional RANK expressed on osteosarcoma cells , as shown by its ability to induce signal transduction pathways and biological activity when stimulated by RANKL . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RANKL RANK signaling in osteoclastogenesis and bone disease . ^^^ In particular , genetic experiments showing that the receptor activator of NF kappaB ( RANK ) , its ligand RANKL , and the decoy receptor OPG are essential , central regulators of osteoclast development and osteoclast function were significant turning points in our understanding of bone diseases . ^^^ RANKL RANK signaling activates a variety of downstream signaling pathways required for osteoclast development . ^^^ Moreover , molecular cross talk between RANKL RANK and other ligand receptor systems fine tunes bone homeostasis in normal physiology and disease . ^^^ Designing novel drugs that target RANKL RANK and their signaling pathways in osteoclasts could potentially revolutionize the treatment of many diseases associated with bone loss such as arthritis , tooth loss , cancer metastases or osteoporosis . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We have recently demonstrated a functional role for heat shock factor 2 ( HSF 2 ) in fibroblast growth factor 2 ( FGF 2 ) induced RANK ligand ( RANKL ) , a critical osteoclastogenic factor expression on stromal / preosteoblast cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ( RANK ) ligand ( RANKL ) and its receptor RANK play an essential role in osteoclastogenesis and osteoclast function by activating several signaling pathways . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
For example , the receptor activator of NF kappaB ligand ( RANKL ) / osteoprotegerin ( OPG ) / receptor activator of NF kappaB ( RANK ) signaling axis plays a critical role in dendritic cell ( DC ) function as well as bone remodeling . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OBJECTIVE : Based on its role in inflammation and matrix degradation , we hypothesized a role for osteoprotegerin ( OPG ) , RANK , and RANK ligand ( RANKL ) in coronary artery disease . ^^^ METHODS AND RESULTS : We examined the expression of various members of the OPG / RANKL / RANK axis in patients with stable and unstable angina and in the atherosclerotic lesions of apolipoprotein E deficient ( apoE ( / ) ) mice . ^^^ CONCLUSIONS : We show enhanced expression of the OPG / RANKL / RANK system both in clinical and experimental atherosclerosis , with enhanced T cell expression of RANKL as an important feature of unstable disease . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Using osteoprotegerin deficient mice , which exhibit severe osteoporosis due to excessive receptor activator of NF kappaB ligand / receptor activator of NF kappaB ( RANKL / RANK ) stimulation , we show herein that oral treatment of these mice with 1alpha , 25 dihydroxyvitamin D 3 [ 1alpha , 25 ( OH ) 2D3 ] inhibited bone resorption and prevented bone loss , suggesting that VDR counters RANKL / RANK signaling . ^^^ Among signaling molecules downstream of RANK , 1alpha , 25 ( OH ) 2D3 inhibited the induction of c Fos protein after RANKL stimulation , and retroviral expression of c Fos protein abrogated the suppressive effect of 1alpha , 25 ( OH ) 2D3 on osteoclast development . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
After 3 5 days , both flavonols robustly inhibited RANKL induced expression of the osteoclastic differentiation markers , RANK and calcitonin receptor . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Our findings indicate that : ( 1 ) EM reduced UHMWPE induced tissue inflammation , including the diminished pouch membrane thickness , reduced inflammatory cellular infiltration , and lowered IL 1beta and TNF alpha expression ( mRNA and protein ) ; ( 2 ) EM inhibited UHMWPE induced osteoclastogenesis , with reduced gene activation of RANK , RANKL , and CPK , and diminished RANKL expression in UHMWPE stimulated pouches , and ( 3 ) EM markedly reduced the number of TRAP ( + ) cells in pouch tissues , and protected against bone collagen depletion . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Furthermore , analysis of the bone regulatory proteins that control bone resorption showed that receptor activator of nuclear factor kappaB ligand ( RANKL ) , receptor activator of nuclear factor kappaB ( RANK ) and osteoprotegerin ( OPG ) were differentially expressed in calcified VA and normal valves . ^^^ RANKL and RANK were not detected in normal valves , whereas calcified VA expressed RANKL and RANK . ^^^ The expression pattern of the RANKL / RANK / OPG system suggests that it may have a regulatory role not only in osteoclastogenesis but also in the calcification of human VA . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
No expression of IL 1beta , IL 6 , IL 8 , TNF alpha , receptor activator of NF lambdaB ( RANK ) , receptor activator of NF lambdaB ligand ( RANKL ) , or osteoprotegerin mRNA was observed in the control cells under atmospheric pressure , whereas , in hPDL cells treated with HP , a pressure dependent enhancement of IL 6 , IL 8 , RANKL , and OPG mRNA expression was observed between 10 and 60 min after the exposure to HP . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
METHODS : Expression of osteoprotegerin ( OPG ) , receptor activator of nuclear factor kappa B ( RANK ) , and RANK ligand ( RANKL ) were assayed in samples of bone obtained from the otic capsule , calvarium , and femur , and from the soft tissue within the cochlea using semiquantitative reverse transcriptase polymerase chain reaction ( RT PCR ) in mice . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The present study was undertaken to further elucidate the contribution of this cytokine system to osteoclastogenesis and subsequent bone erosion in RA by examining the pattern of protein expression for RANKL , OPG and the receptor activator of NF kappaB ( RANK ) in RA at sites of articular bone erosion . ^^^ Immunohistochemistry was used to characterize the cellular pattern of RANKL , RANK and OPG protein expression immediately adjacent to and remote from sites of bone erosion . ^^^ CONCLUSIONS : The pattern of RANKL and OPG expression and the presence of RANK expressing osteoclast precursor cells at sites of bone erosion in RA contributes to the generation of a local microenvironment that favours osteoclast differentiation and activity . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The osteoprotegerin / soluble receptor activator of NF kappa beta ligand / receptor activator of NF kappa beta ( OPG / RANKL / RANK ) triumvirate has been implicated in control of bone resorption under various circumstances . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Furthermore , receptor activator of nuclear factor kappaB ( RANK ) induced the recruitment of tumor necrosis factor ( TNF ) associated factors 2 and 6 ( TRAF 2 and 6 , respectively ) to the cytoplasmic tail of RANKL with activated IkappaB kinase and IkappaB phosphorylation , while D PDMP treatment inhibited RANKL and induced IkappaB phosphorylation , and that inhibition was recovered by LacCer . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Here we show that the cytokine RANKL ( receptor activator of NF kappaB ligand ) triggers migration of human epithelial cancer cells and melanoma cells that express the receptor RANK . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ligand ( RANKL ) , its receptor RANK , and osteoprotegerin ( OPG ) , the physiological inhibitor of RANKL , were discovered using a genomics based approach . ^^^ The study of the RANK / RANKL / OPG axis in animal models has firmly established the central importance of this pathway in bone mass regulation and provided the initial rationale for the design of a mechanism based targeted approach to inhibit RANKL in pathologic bone loss settings , including cancer induced bone disease . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The osteoprotegerin ( OPG ) / receptor activator of nuclear factor kappaB ligand ( RANKL ) / receptor activator of nuclear factor kappaB ( RANK ) system was evaluated as a potential target of CGRP anabolic activity on bone . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In the present study , dexamethasone treatment of neonatal mouse calvarial bones increased mRNA expression of tartrate resistant acid phosphatase , calcitonin receptor ( CTR ) , cathepsin K , carbonic anhydrase 2 , osteoprotegerin ( OPG ) , and receptor activator of nuclear factor kappaB ( RANK ) as well as mRNA and protein expression of RANK ligand ( RANKL ) . ^^^ Stimulation of RANKL , RANK , OPG , and CTR mRNA expression by dexamethasone in calvariae was blocked by the glucocorticoid receptor antagonist RU 38 , 486 . ^^^ The data demonstrate that dexamethasone induced bone resorption in calvarial bones is associated with increased differentiation of osteoclasts and regulation of the RANKL RANK OPG system . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Consequently , quantitative real time polymerase chain reaction ( PCR ) analysis demonstrated that CBX downregulated the expression of osteoclast phenotypic markers , but without having any significant effects on RANK , RANKL , and osteoprotegerin ( OPG ) mRNA expression . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
RESULTS : In the presence and absence of RANKL , LIGHT induced osteoclast formation from both human peripheral blood mononuclear cells and murine macrophage precursors , in a dose dependent manner , whereas no inhibition was observed by adding osteoprotegerin , RANK : Fc , TNFalpha , or interleukin 8 or by blocking the LIGHT receptors herpesvirus entry mediator or lymphotoxin beta receptor . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We found that the expression of osteoprotegerin ( OPG ) was induced by genistein and inhibited by docetaxel , whereas genistein significantly down regulated the expression and secretion of receptor activator of nuclear factor kappaB ( RANK ) ligand ( RANKL ) and inhibited osteoclast formation . ^^^ These results suggest that the observed potentiation of antitumor activity of docetaxel by genistein in the SCID human model of experimental bone metastasis could be mediated by regulation of OPG / RANK / RANKL / MMP 9 signaling , resulting in the inhibition of osteoclastic bone resorption and prostate cancer bone metastasis . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Surface plasmon resonance studies showed that a peptide ( WP9QY ) that mimics this TNFR contact site and inhibits TNF alpha induced activity bound to RANK ligand ( RANKL ) . ^^^ WP9QY , but not the altered control peptide , inhibited the RANKL induced activation of RANK dependent signaling in RAW 264 . 7 cells but had no effect on M CSF induced activation of some of the same signaling events . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Key components of RANKL signal transduction including RANKL , its receptor RANK , and the downstream remodeling enzyme cathepsin K ( Ctsk ) are expressed in the heart during valve remodeling and colocalize with NFATc 1 in developing valve endocardium . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Serum OPG as well as myocardial gene expression of RANK and OPG , but not RANKL , were highest early after HTx and declined progressively . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Finally , the presence of apigenin inhibited osteoclast differentiation from the RAW 264 . 7 cell line by reducing receptor activator of nuclear factor kappa ligand ( RANKL ) induced expression of tartrate resistant acid phosphatase ( TRAP ) , RANK , and calcitonin receptor but not CCR 1 , resulting in the inhibition of multinucleated osteoclast formation . ^^^ Similarly , apigenin inhibited expression of the osteoclast differentiation markers TRAP , RANK , and c Fms in osteoclast precursor cells obtained from mouse bone marrow following treatment with RANKL and macrophage colony stimulating factor ( MCSF ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
OPG acts as a soluble decoy receptor that inhibits the binding of receptor activator of NF kappaB ligand ( RANKL ) to its receptor RANK and thus inhibits the proliferation and activation of osteoclasts . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Identification of RANKL ( receptor activator of NF kappaB ligand ) , RANK ( receptor activator of NF kappaB ) and OPG ( osteoprotegerin ) revealed the mechanisms regulating osteoclast differentiation and function . ^^^ RANKL RANK signaling is essential for the physiological osteoclast development and plays a major role in the pathological bone destruction . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Expression of RANKL / RANK / OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation . ^^^ In this regard , the role of a novel cytokine system belonging to the tumor necrosis factor ( TNF ) family that is critical for osteoclastic osteolysis and that consists of receptor activator of NF kappaB ligand ( RANKL ) , its receptor ( RANK ) , and decoy receptor osteoprotegerin ( OPG ) is of potential interest . ^^^ METHODS : Reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemical analysis was used to examine the expression of RANKL , RANK , and OPG in human prostate cancer cell lines and in 89 archival samples of primary and metastatic ( lymph nodes , skeleton ) prostate cancer patients . ^^^ RESULTS : Expression of RANKL / RANK / OPG was low in normal but markedly higher in prostate cancer cell lines . ^^^ Analysis of surgical biopsy specimens showed the expression of RANKL ( 31 % ) , RANK ( 38 % ) , and OPG ( 19 % ) in primary carcinoma . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Signaling of RANK ( receptor activator of nuclear factor kappa B ) through its ligand RANKL appears critical in osteolysis associated with aseptic loosening ( AL ) . ^^^ Results showed that UHMWPE stimulation induced strong pouch tissue inflammation in RANK ( / ) mice , as manifested by inflammatory cellular infiltration , pouch tissue proliferation , and increased gene expression of IL 1beta , TNFalpha , and RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Recent characterization of osteoclast activating factors ( OAFs ) , receptor activator of nuclear factor kappaB ( RANK ) ligand ( RANKL ) osteoprotegerin RANK system , and inhibitors of Wnt signaling have provided a better understanding of myeloma bone disease in molecular level . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The correlation of RANK , RANKL and TNFalpha expression with bone loss volume and polyethylene wear debris around hip implants . ^^^ This study investigates receptor activator NF kappaB ( RANK ) , RANK ligand ( RANKL ) and tumour necrosis factor ( TNFalpha ) , key factors regulating bone turnover , present in the tissues near peri prosthetic osteolysis . ^^^ Immunohistochemical analysis of formalin fixed tissue sections demonstrated that RANK , RANKL and TNFalpha were strongly expressed by large multinucleated cells containing polyethylene wear debris in revision tissues . ^^^ Control tissue stained weakly for RANK , RANKL and TNFalpha . ^^^ A strong statistical correlation ( p < 0 . 02 ) was found between the five parameters , volume of bone loss , polyethylene wear debris , RANK , RANKL and TNFalpha expression . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The purpose of this study is to investigate the association of ultra high molecular weight polyethylene ( UHMWPE ) particle induced inflammatory osteoclastogenesis and expression of RANK / RANKL and VEGF / VEGF receptors ( Flt 1 and Flk 1 ) using a mouse osteolysis model . ^^^ Both RANK and RANKL gene transcripts were significantly increased by UHMWPE stimulation , which was subsequently reduced by VEGF inhibitor treatment ( p < 0 . 05 ) . ^^^ This study suggests that VEGF has a role in the regulation of RANK / RANKL mediated osteoclastogenesis , and warrant future investigations to elucidate the role of VEGF signaling in the pathogenesis of prosthetic loosening . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of NF kappaB ( RANK ) and its ligand ( RANKL ) are pivotal regulators of osteoclast differentiation . ^^^ RANK and RANKL also mediate T cell / dendritic cell ( DC ) interaction . ^^^ Previous study has shown that RANK / RANKL interaction induces prolonged DC survival and antigen presentation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Moreover , EMD peak 2 enhanced the levels of phosphorylation of ERK p 38 and RANK in RAW 264 . 7 cells stimulated with RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance : role in the interactions with receptor activator of nuclear factor kappaB ligand ( RANKL ) and RANK . ^^^ Osteoprotegerin ( OPG ) is a decoy receptor for receptor activator of nuclear factor kappaB ligand ( RANKL ) , a key inducer of osteoclastogenesis via its receptor RANK . ^^^ We previously showed that RANK , RANKL , and OPG are able to form a tertiary complex and that OPG must be also considered as a direct effector of osteoclast functions . ^^^ Kinetic data demonstrated that OPG binds to heparin with a high affinity ( KD : 0 . 28 nM ) and that the pre incubation of OPG with heparin inhibits in a dose dependent manner the OPG binding to the complex RANK RANKL . ^^^ Moreover , a decasaccharide is the minimal structure that totally inhibits the OPG binding to the complex RANK RANKL . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
These include growth factors , such as macrophage colony simulating factor , which simulates the proliferation and prevents apoptosis of early OCL precursors , and RANK ligand ( RANKL ) , which is the primary mediator of OCL formation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Interactive effect of interleukin 6 and prostaglandin E 2 on osteoclastogenesis via the OPG / RANKL / RANK system . ^^^ The OPG / RANKL / RANK system regulates osteoclastogenesis . ^^^ The mechanisms underlying these signaling pathways on the OPG / RANKL / RANK system are not fully understood . ^^^ We herein demonstrate that COX 2 and PGE 2 stimulated osteoclastogenesis through inhibition of OPG secretion , stimulation of RANKL production by osteoblasts , and upregulation of RANK expression in osteoclasts . ^^^ These findings provide evidence of interactive effect of PGE 2 and IL 6 signaling pathways in osteoclastogenesis via effect on the OPG / RANKL / RANK system . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Several mechanisms of action have been proposed to account for these effects : TNF directly inhibits osteoblast differentiation ; TNF augments osteoclast formation by inducing stromal cells to increase expression of RANKL and macrophage colony stimulating factor ( M CSF ) and decrease that of osteoprotegerin ( OPG ) ; and TNF serves to synergize with pathways downstream of RANK to directly increase osteoclast differentiation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Eosinophil chemotactic factor L ( ECF L ) is a novel stimulator of osteoclast ( OCL ) formation that acts at the differentiation / fusion stage of OCL formation , and is a cofactor for RANK ligand ( RANKL ) . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The signaling axis constituted by osteoprotegerin ( OPG ) , receptor activator nuclear factor kB ( RANK ) and its ligand ( RANKL ) , along with the monocyte colony stimulating factor ( M CSF ) and the transcription factor core Binding protein ( Cbfa 1 ) , play a pivotal role in the control of VC . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Receptor activator of nuclear factor kappaB ( RANK ) is activated by its ligand , RANKL , an essential molecule for osteoclast development : in the absence of RANKL or RANK , osteoclast differentiation from monocyte precursors does not occur . ^^^ In animal models of arthritis , blockade of RANKL RANK interactions , or a genetic absence of RANKL or RANK , protects against joint damage despite the presence of joint inflammation . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
One MAb ( 80736 ) immunoprecipitated RANK RANKL complexes from surface biotinylated GCT lysates . ^^^ Importantly , sorted CD 14 ( + ) RANK ( high ) PBMNCs treated with recombinant RANKL and macrophage colony stimulating factor ( M CSF ) gave rise to approximately twice the number of osteoclasts than RANK ( mid ) or RANK ( low ) cells . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
In the long bones from IGF 1 ( / ) mice , mRNA levels of RANKL , RANK , M CSF , and c fms were 55 % , 33 % , 60 % , and 35 % of that from IGF 1 ( + / + ) mice , respectively . ^^^ IGF 1 is required for maintaining the normal interaction between the osteoblast and osteoclast to support osteoclastogenesis through its regulation of RANKL and RANK expression . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclastic differentiation is also regulated by numerous factors : osteoprotegerin ( OPG ) ; RANK L ( receptor activator of nuclear factor kappa B ligand , a transmembrane protein related to tumour necrosis factor [ TNF ] , the binding of which to its RANK receptor induces osteoclastic differentiation ) ; and soluble TNF receptors . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Identification of the RANKL / OPG / RANK / NF kB ( receptor activator of nuclear factor kappa B ligand / osteoprotegerin ) signaling pathway as the major regulatory system for osteoclastogenesis began with discovery of these ligands and receptors in the tumor necrosis factor ( TNF ) superfamily . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
TRANCE ( tumor necrosis factor [ TNF ] related activation induced cytokine ) is a new member of the TNF family that is induced upon T cell receptor engagement and activates c Jun N terminal kinase ( JNK ) after interaction with its putative receptor ( TRANCE R ) . ^^^ Here , we show that high levels of TRANCE R are detected on mature dendritic cells ( DCs ) but not on freshly isolated B cells , T cells , or macrophages . ^^^ Signaling by TRANCE R appears to be dependent on TNF receptor associated factor 2 ( TRAF 2 ) , since JNK induction is impaired in cells from transgenic mice overexpressing a dominant negative TRAF 2 protein . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Thus , TRANCE expression by osteoblasts appears to be both necessary and sufficient for hormone mediated activation of mature osteoclasts , and TRANCE R is likely to be a receptor for signal transduction for activation of the osteoclast and its survival . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The TRANCE receptor ( TRANCE R ) , recently identified as receptor activator of NF kappabeta ( RANK ) , activates NF kappaB , a transcription factor critical in the differentiation and activation of those cells . ^^^ In this report we identify the TNF receptor associated factor ( TRAF ) family of signal transducers as important components of TRANCE R mediated NF kappaB activation . ^^^ Coimmunoprecipitation experiments suggested potential interactions between the cytoplasmic tail of TRANCE R with TRAF 1 , TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 . ^^^ Dominant negative forms of TRAF 2 , TRAF 5 , and TRAF 6 and an endogenous inhibitor of TRAF 2 , TRAF interacting protein ( TRIP ) , substantially inhibited TRANCE R mediated NF kappaB activation , suggesting a role of TRAFs in regulating DC and osteoclast function . ^^^ Overexpression of combinations of TRAF dominant negative proteins revealed competition between TRAF proteins for the TRANCE R and the possibility of a TRAF independent NF kappaB pathway . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Here we show that CD 4 ( + ) T cell responses to viral infection were greatly diminished in CD 40 deficient mice by administration of a soluble form of TNF related activation induced cytokine receptor ( TRANCE R ) to inhibit the function of another TNF family member , TRANCE . ^^^ Thus , the TRANCE / TRANCE R interaction provides costimulation required for efficient CD 4 ( + ) T cell priming during viral infection in the absence of CD40L / CD40 . ^^^ Moreover , the data suggest that TRANCE / TRANCE R may be a novel and important target for immune intervention . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We studied the effects of PTH on the expression of tumor necrosis factor related activation induced cytokine ( TRANCE ) , osteoprotegerin ( OPG ) , and receptor activator of NF kappaB ( RANK ) messenger RNA ( mRNA ) in cultured murine bone marrow , calvaria , and osteoblasts . ^^^ TRANCE , OPG , and RANK are recently identified regulators of osteoclast formation . ^^^ TRANCE , OPG , and RANK mRNA were measured by RT PCR . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
TRANCE , a TNF family member , and its receptor , TRANCE R , are critical regulators of dendritic cell and osteoclast function . ^^^ A deficiency in c Src or addition of Src family kinase inhibitors blocks TRANCE mediated PKB activation in osteoclasts . c Src and TRAF 6 interact with each other and with TRANCE R upon receptor engagement . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Thus , in addition to its role in activating dendritic cells by binding to the receptor RANK , TRANCE itself can signal the augmentation of IFN gamma secretion via a p 38 dependent pathway , and this provides yet another example of reverse signaling by a member of TNF superfamily . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We recently demonstrated that TRANCE activates Akt via a mechanism involving TRANCE receptor ( TRANCE R ) / RANK , TRAF 6 , and c Src . ^^^ Here , we show that TRANCE R and CD 40 recruit TRAF 6 , Cbl family scaffolding proteins , and the phospholipid kinase phosphatidylinositol 3 kinase in a ligand dependent manner . ^^^ The recruitment of Cbl b and c Cbl to TRANCE R is dependent upon the activity of Src family kinases . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
However , OPG also blocks TRAIL and may not be sufficiently specific in long term therapy , but it is hoped that inhibitors of the interaction of TRANCE and its specific signalling receptor , RANK , can be rationally designed . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Long lived immature dendritic cells mediated by TRANCE RANK interaction . ^^^ We have identified int DCs that express both TRANCE ( tumor necrosis factor related activation induced cytokine ) and RANK ( receptor activator of NF kappaB ) and have generated these cells from CD 34 ( + ) human progenitor cells using macrophage colony stimulating factor ( M CSF ) . ^^^ This suggests that constitutive TRANCE RANK interaction is responsible for CD 34 ( + ) derived int DC longevity . ^^^ These findings provide evidence that TRANCE and RANK play important roles in the homeostasis of DCs . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The recently identified TNF superfamily cytokine , TRANCE ( RANKL / OPGL / ODF / TNFSF11 ) , which interacts with two receptors one functional , TRANCE R ( RANK / TNFRSF11A ) , and one decoy , OPG ( TNFRSF11B ) is a survival factor for activated dendritic cells , and may also be important for the maintenance of immune tolerance . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Here we report that VEGF up regulates expression of receptor activator of NF kappa B ( RANK ) and increases angiogenic responses of endothelial cells to TRANCE . ^^^ VEGF potentiated TRANCE induced ERK activation and tube formation via RANK up regulation in HUVECs . ^^^ Together , these results show that VEGF enhances RANK expression in endothelial cells through Flk 1 / KDR protein kinase C ERK signaling pathway , suggesting that VEGF plays an important role in modulating the angiogenic action of TRANCE under physiological or pathological conditions . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
TRANCE RANK costimulation is required for IL 12 production and the initiation of a Th 1 type response to Leishmania major infection in CD40L deficient mice . ^^^ Blockade of TNF related activation induced cytokine ( TRANCE ) receptor activator of NF kappaB ( RANK ) interaction reverses healing in CD40L ( / ) mice infected with Leishmania major . ^^^ These results demonstrate that CD40L ( / ) mice use the TRANCE RANK costimulatory pathway to promote IL 12 production and the activation of a protective Th 1 type response . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The tumor necrosis factor family ligand , tumor necrosis factor related activation induced cytokine ( TRANCE ) , and its receptors , receptor activator of nuclear factor kappaB ( RANK ) and osteoprotegerin ( OPG ) , are known to be regulators of development and activation of osteoclasts in bone remodeling . ^^^ Sustained osteoclast activation that occurs through TRANCE RANK causes osteopenic disorders such as osteoporosis and contributes to osteolytic metastases . ^^^ Unlike soluble OPG receptors , which preclude TRANCE binding to RANK , OP 3 4 shows the ability to modulate RANK TRANCE signaling pathways and alters the biological functions of the RANK TRANCE receptor complex by facilitating a defective receptor complex . ^^^ These features suggest that OPG derived small molecules can be used as a probe to understand complex biological functions of RANK TRANCE OPG receptors and also can be used as a platform to develop more useful therapeutic agents for inflammation and bone disease . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We analyzed the role of TNF related activation induced cytokine ( TRANCE ) , a member of the TNF family expressed on activated T cells that shares functional properties with CD40L , and its receptor activating NF kappaB ( RANK ) which is mostly expressed on mature dendritic cells , during allogenic responses in vivo using a rodent heart allograft model . ^^^ TRANCE mRNA was strongly up regulated in acutely rejected allografts on days 4 and 5 posttransplantation whereas RANK was detected as early as day 1 but did not show further up regulation during the first week . ^^^ Immunofluoresence analyses of heart allografts showed that 80 and 100 % of TRANCE and RANK expressing cells were T cells and APCs , respectively . ^^^ We conclude that TRANCE RANK interactions play an important role during acute allograft rejection and that CD40L independent allogeneic immune responses can be , at least in part , dependent on the TRANCE pathway of costimulation . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Only the TRANCE receptor ( TRANCE R ) has been shown to induce osteoclastogenesis , even though other immune receptors , including CD 40 and IL 1R / Toll like receptor , use TRAF 6 to activate overlapping signalling cascades . ^^^ Our results suggest that differences in the osteoclastogenesis inducing capacity of TRANCE R versus other TRAF 6 associated receptors may in part stem from a quantitative difference in the TRAF 6 mediated signals . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
We found that adult but not neonatal inducer cells expressed high levels of OX40L and CD30L , whereas their expression of TNF related activation induced cytokine ( TRANCE ) and receptor activator of NF kappaB ( RANK ) was comparable . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
CONCLUSION : The PD 1 / PD L 1 , CD27 / CD70 , CD134 / CD134L , CD30 / CD153 , and tumor necrosis factor ( TNF ) related activation induced cytokine ( TRANCE ) / RANK interactions are independently required for generation of regulatory cells by intratracheal delivery of alloantigen . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
Osteoclast differentiation independent of the TRANCE RANK TRAF 6 axis . ^^^ Genetic deletion of TRANCE or its receptor , receptor activator of nuclear factor kappaB ( RANK ) , results in severely osteopetrotic mice with no osteoclasts in their bones . ^^^ Hence , the current paradigm holds that TRANCE RANK interaction and subsequent signaling via TRAF 6 are essential for the generation of functional osteoclasts . ^^^ Surprisingly , we show that hematopoietic precursors from TRANCE , RANK , or TRAF 6 null mice can become osteoclasts in vitro when they are stimulated with TNF alpha in the presence of cofactors such as TGF beta . ^^^ We provide direct evidence against the current paradigm that the TRANCE RANK TRAF 6 pathway is essential for osteoclast differentiation and suggest the potential existence of alternative routes for osteoclast differentiation . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
The requirements for organized lymph nodes vary according to anatomic location , but most rely on Id 2 ( Idb 2 ) and Rorc , in addition to lymphotoxins and Tnfrsf11a , Tnfsf 11 , Relb , Map3k14 , Cxcl 13 , and Blr 1 genes . ^^^ Here we review abnormalities of lymphoid organ development in immunodeficient mutant mice , including spontaneous and targeted mutations of Id 2 , Rorc , Tnf , Tnfrsf1a , Lta , Ltb , Ltbr , Tnfrsf11a , Tnfsf 11 , Relb , Map3k14 , IL7r , Blr 1 , and Cxcl 13 genes . . ^^^
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14788 and Q9Y6Q6	Pubmed	SVM Score :0.0
NA