| Interacting proteins: Q9Y6Q6 and O00463 |
Pubmed |
SVM Score :0.0 |
| From this deletion analysis , we determined that TRAF 2 , TRAF 5 , and TRAF 6 interact with RANK at its C terminal 85 amino acid tail ; the binding affinity appeared to be in the order of TRAF 2 > TRAF 5 > TRAF 6 . ^^^ |
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| Interacting proteins: Q9Y6Q6 and O00463 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that the cytoplasmic domain of receptor activator of NF kappaB ( RANK ) interacts with TRAF 2 , TRAF 5 , and TRAF 6 and that its overexpression activates NF kappaB and JNK pathways . ^^^ Through a detailed mutational analysis of the cytoplasmic domain of RANK , we demonstrate that TRAF 2 and TRAF 5 bind to consensus TRAF binding motifs located in the C terminus at positions 565 568 and 606 611 , respectively . ^^^ Furthermore , transfection experiments with RANK and its deletion mutants in human embryonic 293 cells revealed that the TRAF 6 binding region ( 340 358 ) , but not the TRAF 2 or TRAF 5 binding region , is necessary and sufficient for RANK induced NF kappaB activation . ^^^ |
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| Interacting proteins: Q9Y6Q6 and O00463 |
Pubmed |
SVM Score :0.0 |
| When overexpressed , PIAS 3 inhibits NF kappaB dependent transcription induced by treatment with tumor necrosis factor alpha ( TNF alpha ) or interleukin 1beta or by overexpression of TNF family receptors such as RANK , TNFR 1 , and CD 30 or signal transducers of TNF receptor associated factors ( TRAFs ) , including TRAF 2 , TRAF 5 , and TRAF 6 . ^^^ |
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| Interacting proteins: Q9Y6Q6 and O00463 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation experiments suggested potential interactions between the cytoplasmic tail of TRANCE R with TRAF 1 , TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 . ^^^ Dominant negative forms of TRAF 2 , TRAF 5 , and TRAF 6 and an endogenous inhibitor of TRAF 2 , TRAF interacting protein ( TRIP ) , substantially inhibited TRANCE R mediated NF kappaB activation , suggesting a role of TRAFs in regulating DC and osteoclast function . ^^^ Analysis of TRANCE R deletion mutants suggested that the TRAF 2 and TRAF 5 interaction sites were restricted to the C terminal 93 amino acids ( C region ) . ^^^ |
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| Interacting proteins: Q9Y6Q6 and O00463 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q6 and O00463 |
Pubmed |
SVM Score :0.0 |
| NA |
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