| IKK gamma / NEMO was demonstrated to shuttle between the cytoplasm and the nucleus and to interact with the nuclear coactivator cAMP responsive element binding protein binding protein ( CBP ) . ^^^ Using both in vitro and in vivo analysis , we demonstrated that IKK gamma / NEMO competed with p 65 and IKK alpha for binding to the N terminus of CBP , inhibiting CBP dependent transcriptional activation . ^^^ These results indicate that , in addition to the key role of IKK gamma / NEMO in regulating cytokine induced IKK activity , its ability to shuttle between the cytoplasm and the nucleus and to bind to CBP can lead to transcriptional repression of the NF kappa B pathway . . ^^^ |