| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Of note , TNF induced NF kappaB DNA binding activity and activation of IkappaB kinases ( IKKs ) were markedly impaired in FAK / cells , whereas the expression of TNF receptor 1 or other signaling molecules such as receptor interacting protein ( RIP ) , tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , IKKalpha , IKKbeta , and IKKgamma was unchanged . ^^^ |
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| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| We now use cells lacking expression of TRAF 2 , TRAF 5 , TRAF 6 , IKKalpha , IKKbeta , IKKgamma , TAB 2 , IL 1 receptor associated kinase ( IRAK ) 1 , or IRAK 4 to assess their roles in LMP 1 mediated NF kappaB activation . ^^^ More surprisingly , NF kappaB responses were near normal in TRAF 2 and TRAF 5 double KO MEFs , IKKgamma KO MEFs , TAB 2 KO MEFs , and IRAK 4 KO MEFs but were highly deficient in TRAF 6 KO MEFs and IRAK 1 KO HEK 293 cells . ^^^ |
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| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Here we identify TANK ( TRAF family member associated NF kappa B activator ) as a NEMO / IKK gamma interacting protein via yeast two hybrid analyses . ^^^ The TANK binding domain within NEMO / IKK gamma is required for proper functioning of this IKK subunit . ^^^ Association of the adaptor TANK with the 1 kappa B kinase ( IKK ) regulator NEMO connects IKK complexes with IKK epsilon and TBK 1 kinases . ^^^ |
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| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| TNFalpha and IKKbeta mediated TANK / I TRAF phosphorylation : implications for interaction with NEMO / IKKgamma and NF kappaB activation . ^^^ Moreover , we show that TANK is phosphorylated by IKKbeta upon TNFalpha stimulation and that this modification negatively regulates TANK binding to NEMO ( NF kappaB essential modulator ) . ^^^ |
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| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| The TFG protein , involved in oncogenic rearrangements , interacts with TANK and NEMO , two proteins involved in the NF kappaB pathway . ^^^ In this study by yeast two hybrid screening we identified NEMO and TANK , two proteins modulating the NF kappaB pathway , as novel TFG interacting proteins . ^^^ |
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| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Using TRAF 2 ( / ) cells , we demonstrated that the TNF induced interaction between IKKgamma and the death domain kinase RIP is TRAF 2 dependent and that one possible function of this interaction is to stabilize the IKK complex when it interacts with TRAF2 . . ^^^ |
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| Interacting proteins: Q6NW12 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| The secondary complex retained the DISC components FADD and caspase 8 , but recruited several factors involved in kinase activation by TNF , namely , RIP 1 , TRAF 2 , and NEMO / IKKgamma . ^^^ Apo2L / TRAIL stimulation of JNK and p 38 further depended on RIP 1 and TRAF 2 , whereas IKK activation required NEMO . ^^^ |
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