| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| FIP 3 also was shown to bind to other cell proteins , RIP and NIK , which previously had been described as essential components of TNF alpha induced NF kappaB activation . ^^^ In addition , FIP 3 inhibited activation of NF kappaB induced by TNF alpha , the TNFR 1 receptor , RIP , NIK , and IKKbeta , as well as basal levels of endogenous NF kappaB in 293 cells . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Recruitment of the IKK signalosome to the p 55 TNF receptor : RIP and A 20 bind to NEMO ( IKKgamma ) upon receptor stimulation . ^^^ Here we show that triggering of the p 55 TNF receptor induces binding of RIP to NEMO ( IKKgamma ) , a component of the 1 kappa B kinase ( IKK ) `` signalosome ' ' complex , as well as recruitment of RIP to the receptor together with the three major signalosome components , NEMO , IKK 1 and IKK 2 , and some kind of covalent modification of the recruited RIP molecules . ^^^ The findings suggest that the signaling activities of the IKK signalosome are regulated through binding of NEMO to RIP and A 20 within the p 55 TNF receptor complex . . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Similarly , the RICK related kinase RIP associated via its intermediate region with IKKgamma . ^^^ A mutant form of IKKgamma deficient in binding to IKKalpha and IKKbeta inhibited NF kappaB activation induced by RICK or RIP . ^^^ Enforced oligomerization of RICK or RIP as well as of IKKgamma , IKKalpha , or IKKbeta was sufficient for induction of NF kappaB activation . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Activation of the Ikappa B kinases by RIP via IKKgamma / NEMO mediated oligomerization . ^^^ Substitution of the C terminal region of IKKgamma , which interacts with RIP , with a truncated DR 4 lacking its cytoplasmic death domain , produced a molecule that could induce IKK and NF kappaB activation in cells in response to TRAIL . ^^^ These data suggest that IKKgamma functions as a signaling adaptor between the upstream regulators such as RIP and the IKKs and that oligomerization of the IKK complex by upstream regulators is a critical step in activation of this complex . . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Using TRAF 2 ( / ) cells , we demonstrated that the TNF induced interaction between IKKgamma and the death domain kinase RIP is TRAF 2 dependent and that one possible function of this interaction is to stabilize the IKK complex when it interacts with TRAF2 . . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| These results suggest that PKK is a member of the RICK / RIP family of kinases , which is involved in a PKC activated NF kappa B signaling pathway that is independent of Bcl 10 and IKK gamma . . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| We show here that the zinc finger protein A 20 is an NF kappaB inducible gene that can protect the IKKgamma deficient cells from TNF induced apoptosis by disrupting the recruitment of the death domain signaling molecules TRADD and RIP to the receptor signaling complex . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Of note , TNF induced NF kappaB DNA binding activity and activation of IkappaB kinases ( IKKs ) were markedly impaired in FAK / cells , whereas the expression of TNF receptor 1 or other signaling molecules such as receptor interacting protein ( RIP ) , tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , IKKalpha , IKKbeta , and IKKgamma was unchanged . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| In the present paper , we demonstrate that ABIN 2 exerts its inhibitory function by blocking the interaction of RIP ( receptor interacting protein ) with the downstream effector IKKgamma , a non kinase component of the IkappaB ( inhibitory kappaB ) kinase complex . ^^^ When overexpressed in cells , ABIN 2 bound to IKKgamma and prevented the association of IKKgamma with RIP . ^^^ Strikingly , a portion of RIP , which is similar to this 50 residue domain of ABIN 2 , is also essential for RIP interaction with IKKgamma . ^^^ The RIP mutant with deletion of this similar region did not associate with IKKgamma and had substantial reduction of its ability to mediate NF kappaB activation . ^^^ Taken together , these conserved 50 residues of ABIN 2 and RIP define a novel structural domain in mediating a key step in the NF kappaB signalling pathway through the interaction with IKKgamma . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Similar to A 20 , ZNF 216 interacted with IKKgamma , RIP , and TRAF 6 in co immunoprecipitation experiments . ^^^ Domain mapping experiments indicated that the ZnF A 20 domain was responsible for interacting with IKKgamma and RIP , whereas the ZnF AN 1 domain interacted with TRAF 6 . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| In contrast , expression of a fusion protein composed of NEMO , a component of the IkappaB kinase complex , and the death domain of RIP ( NEMO DD ) can not restore TNF alpha induced NF kappaB activation in RIP deficient cells . ^^^ These results indicate that the role of RIP is to specifically recruit MEKK 3 to the TNF alpha receptor complex , whereas the forced recruitment of NEMO to the TNF alpha receptor complex is insufficient for TNF alpha induced NF kappaB activation . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Here , we show that NEMO binds to Lys 63 but not Lys 48 linked polyubiquitin , and that single point mutations in NEMO that prevent binding to Lys 63 linked polyubiquitin also abrogates the binding of NEMO to RIP in tumour necrosis factor ( TNF ) alpha stimulated cells , the recruitment of IKK to TNF receptor ( TNF R ) 1 , and the activation of IKK and NF kappaB . ^^^ RIP is also destabilized in the absence of NEMO binding and undergoes proteasomal degradation in TNF alpha treated cells . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| The secondary complex retained the DISC components FADD and caspase 8 , but recruited several factors involved in kinase activation by TNF , namely , RIP 1 , TRAF 2 , and NEMO / IKKgamma . ^^^ Apo2L / TRAIL stimulation of JNK and p 38 further depended on RIP 1 and TRAF 2 , whereas IKK activation required NEMO . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Upon genotoxic stress , a complex between PIDD , the kinase RIP 1 , and a component of the NF kappaB activating kinase complex , NEMO , is formed . ^^^ Depletion of PIDD and RIP 1 , but not caspase 2 , abrogates DNA damage induced NEMO modification and NF kappaB activation . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Activation of IKK by TNFalpha requires site specific ubiquitination of RIP 1 and polyubiquitin binding by NEMO . ^^^ Interestingly , polyubiquitinated RIP 1 recruits IKK through the binding between the polyubiquitin chains and NEMO , a regulatory subunit of the IKK complex . ^^^ These results reveal the biochemical mechanism underlying the essential signaling function of NEMO and provide direct evidence that signal induced site specific ubiquitination of RIP 1 is required for IKK activation . . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Recruitment of the NF kappaB activating IKK signaling complex to the TNF receptor is shown to be driven by induced binding of NEMO , a regulatory component of this complex , to K 63 linked polyubiquitin chains attached to RIP 1 , a receptor associated adaptor protein ( Ea et al . , 2006 [ in a recent issue of Molecular Cell ] ; Li et al . , 2006 ; Wu et al . , 2006a ) . . ^^^ |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15311 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
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