| Interacting proteins: O95999 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Finally , substitution of the C terminal region of IKKgamma , which interacts with vCLAP , with the CARD of vCLAP or Bcl 10 produced a molecule that was able to activate NF kappaB when ectopically expressed in IKKgamma deficient cells . ^^^ |
|
| Interacting proteins: O95999 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| These results suggest that PKK is a member of the RICK / RIP family of kinases , which is involved in a PKC activated NF kappa B signaling pathway that is independent of Bcl 10 and IKK gamma . . ^^^ |
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| Interacting proteins: O95999 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Bcl 10 overexpression is sufficient to activate NF kappaB , a process that requires the NF kappaB essential modulator NEMO ( also known as IKK gamma ) , which is the regulatory subunit of the IkappaB kinase complex . ^^^ Bcl 10 activates the NF kappaB pathway through ubiquitination of NEMO . ^^^ Here we show that Bcl 10 targets NEMO for lysine 63 linked ubiquitination . ^^^ Notably , a mutant form of NEMO that can not be ubiquitinated inhibited Bcl 10 induced NF kappaB activation . ^^^ Paracaspase and a ubiquitin conjugating enzyme ( UBC 13 ) were both required for Bcl 10 induced NEMO ubiquitination and subsequent NF kappaB activation . ^^^ |
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| Interacting proteins: O95999 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| PDK 1 associated PKC recruits the IKK complex , whereas PDK 1 associated CARD 11 recruits the Bcl 10 MALT1 complex , thereby allowing activation of the IKK complex through Bcl 10 MALT1 dependent ubiquitination of the IKK complex subunit known as NEMO ( NF kappaB essential modifier ) . ^^^ |
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| Interacting proteins: O95999 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| Further , upon engagement of IKKbeta / Malt1 / Bcl10 with Carma 1 , IKKbeta phosphorylates Bcl 10 in the C terminus and thereby interferes with Bcl10 / Malt1 association and Bcl 10 mediated IKKgamma ubiquitination . ^^^ |
|
| Interacting proteins: O95999 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|