| Interacting proteins: O43353 and Q9Y6K9 |
Pubmed |
SVM Score :0.5189439 |
| Similarly , the RICK related kinase RIP associated via its intermediate region with IKKgamma . 0.5189439^^^ |
|
| Interacting proteins: O43353 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43353 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43353 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| The Crohn ' s disease protein , NOD 2 , requires RIP 2 in order to induce ubiquitinylation of a novel site on NEMO . ^^^ We show the NOD 2 dependent ubiquitinylation of NEMO is dependent on the scaffolding protein kinase RIP 2 . ^^^ Crohn ' s disease associated polymorphisms of NOD 2 show a decreased ability to bind RIP 2 , and this decreased ability to bind RIP 2 correlates with a decreased ability to ubiquitinylate NEMO . ^^^ Lastly , we show functionally that RIP 2 induced ubiquitinylation of NEMO is at least in part responsible for RIP 2 mediated NF kB activation . ^^^ |
|
| Interacting proteins: O43353 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that caspase 1 may serve as a scaffolding molecule that promotes RIP 2 interaction with IkappaB kinase gamma thus inducing NF kappaB activation . ^^^ |
|
| Interacting proteins: O43353 and Q9Y6K9 |
Pubmed |
SVM Score :0.0 |
| These results suggest that PKK is a member of the RICK / RIP family of kinases , which is involved in a PKC activated NF kappa B signaling pathway that is independent of Bcl 10 and IKK gamma . . ^^^ |
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