| Myosin motor Myo1c and its receptor NEMO / IKK gamma promote TNF alpha induced serine 307 phosphorylation of IRS 1 . ^^^ This intracellular trafficking of NEMO requires insulin , an intact actin cytoskeletal network , and the motor protein Myo1c . ^^^ Increased Myo1c expression enhanced the NEMO IRS 1 interaction , which is essential for TNF alpha induced phosphorylation of Ser 307 IRS 1 . ^^^ Thus , motor protein Myo1c and its receptor protein NEMO act cooperatively to form the IKK IRS 1 complex and function in TNF alpha induced insulin resistance . . ^^^ |