| Interacting proteins: Q9Y672 and Q9Y673 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y672 and Q9Y673 |
Pubmed |
SVM Score :0.0 |
| Elaborating on the analogy of this finding with the phenotype of alg 5 and alg 6 Saccharomyces cerevisiae strains , we have cloned and analyzed the human orthologs to the ALG 5 dolichyl phosphate glucosyltransferase and ALG 6 dolichyl pyrophosphate Man9GlcNAc2 alpha 1 , 3 glucosyltransferase in four novel CDGS patients . ^^^ |
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| Interacting proteins: Q9Y672 and Q9Y673 |
Pubmed |
SVM Score :0.0 |
| The alg 1 mutant accumulated lipid linked GlcNAc 2 , alg 2 mutants accumulated Man 1 2GlcNAc2 , alg 3 mutants accumulated Man5GlcNAc2 , alg 4 mutants accumulated Man 1 8GlcNAc2 , and alg 5 and alg 6 mutants accumulated Man9GlcNAc2 . ^^^ These aberrant protein linked oligosaccharides were processed by the addition of outer chain residues in the alg 3 , alg 5 , and alg 6 mutants . ^^^ |
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| Interacting proteins: Q9Y672 and Q9Y673 |
Pubmed |
SVM Score :0.0 |
| These mutants synthesize and transfer to nascent proteins truncated oligosaccharides lacking two ( alg 8 ) or three ( alg 5 and alg 6 ) glucoses . ^^^ As compared with alg 5 and alg 6 , alg 8 secreted a higher proportion of ExgII , which was paralleled by a significant drop in the proportion of ExgTuni and , to a lesser extent , of ExgII1 / 2 . ^^^ |
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| Interacting proteins: Q9Y672 and Q9Y673 |
Pubmed |
SVM Score :0.0 |
| Monoglucosylated protein linked oligosaccharides were detected in alg 6 or alg 5 mutant cells , which transfer Man9GlcNAc2 to protein ; glucosylation was dependent on the inhibition of glucosidase 2 or the disruption of the gene encoding this enzyme . ^^^ |
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| Interacting proteins: Q9Y672 and Q9Y673 |
Pubmed |
SVM Score :0.0 |
| In genes alg 5 , alg 8 and swp 1 of Saccharomyces cerevisiae , gpt of Schizosaccharomyces pombe and human gene alg 6 , encoding the dolichol cycle enzymes , a mirror type internal symmetry was found . ^^^ |
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