| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.55670463 |
| Unlike agonist bound PR that interacts only with coactivators such as steroid receptor coactivator 1 ( SRC 1 ) , RU 486 bound PR binds to both coactivator SRC 1 and corepressor silencing mediator for retinoid and thyroid hormone receptor ( SMRT ) in vitro . 0.55670463^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Candidate factors have been identified by the observation that changes in glucocorticoid induction parameters in CV 1 cells could be reproduced by varying the cellular levels of coactivators [ transcriptional intermediary factor 2 ( TIF 2 ) , steroid receptor coactivator 1 ( SRC 1 ) , and amplified in breast cancer 1 ( AIB 1 ) ] , comodulator [ CREB binding protein ( CBP ) ] , or corepressor [ silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) ] without concomitant increases in GR . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| To obtain some clue to these roles , we screened the expression levels of ER alpha , ER beta , coactivators ( SRC 1 , TIF 2 , AIB 1 , CBP , and P / CAF ) and corepressors ( N CoR and SMRT ) in 6 normal mammary glands , 6 intraductal carcinomas , 22 invasive ductal carcinomas , and 7 breast cancer cell lines using a multiplex reverse transcription PCR . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Expression levels of oestrogen receptors ( ERalpha , ERbeta ) , cofactors AIB 1 , RIP 140 , SMRT and the Fas associated protein tyrosine phophatase 1 ( FAP 1 ) genes were evaluated in breast , endometrial and ovarian cancer cell lines and in three ERalpha positive and three ERalpha negative breast cancer tumours . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| METHODS : Multiprobe ribonuclease protection assay and real time reverse transcriptase polymerase chain reaction were used to quantitate mRNA levels of steroid receptors , vitamin D receptor ( VDR ) , retinoic acid receptors ( RAR ) , and cofactors AIB 1 ( amplified in breast cancer 1 ) , CBP ( cyclic adenosine monophosphate response element binding protein ) , pCAF ( p300 / CBP associated factor ) , TIF 2 ( transcription intermediary factor 2 ) , N CoR ( nuclear receptor corepressor ) , and SMRT ( silencing mediator of repressed transcription ) . ^^^ Cofactors N CoR , SMRT , pCAF , CBP , TIF 2 , AIB 1 , and p 300 mRNAs were expressed in all samples in both endometrium and myometrium . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| CHO K 1 cells transfected with ERalpha or ERbeta show ERE sequence dependent differences in the functional interaction of ERalpha and ERbeta with coactivators steroid receptor coactivator 1 ( SRC 1 ) , SRC 2 ( glucocorticoid receptor interacting protein 1 ( GRIP 1 ) ) , SRC 3 amplified in breast cancer 1 ( AIB 1 ) and ACTR , cyclic AMP binding protein ( CBP ) , and steroid receptor RNA activator ( SRA ) , corepressors nuclear receptor co repressor ( NCoR ) and silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) , and secondary coactivators coactivator associated arginine methyltransferase 1 ( CARM 1 ) and protein arginine methyltransferase 1 ( PRMT 1 ) . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Progesterone receptor ( PR ) expression was decreased and silencing mediator for retinoid acid and thyroid hormone receptors ( SMRT ) and amplified in breast cancer 1 ( AIB 1 ) expression increased in anti estrogen resistant cells . ^^^ |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In particular , ligand induced binding to the coactivator ACTR correlated better with transcriptional activation of RA response elements than the ligand induced release of the corepressor SMRT . ^^^ |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The PXR SMRT interaction is sensitive to species specific ligands , and Rif causes an exchange of the corepressor SMRT with the p 160 coactivator known as receptor associated coactivator 3 ( RAC 3 ) . ^^^ |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Ten of the 12 cofactors tested were expressed in all cells analyzed ( AIB 1 , ARA 54 , ARA 70 , CBP , cyclin D 1 , Her2 / neu / erbB2 , BAG 1 / M / L , SRC 1 , SMRT , and TIF 2 ) . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Candidate genes were then evaluated for their possible involvement in the RTH phenotype in these 4 families : 2 coactivators [ NCoA 1 ( SRC 1 ) and NCoA 3 ( AIB 1 ) ] , 2 corepressors ( NCoR and SMRT ) , and a coregulator ( RXRgamma ) . ^^^ |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The expression of 11 nuclear receptor co regulatory factors ( SRC 1 , AIB 1 , ARA 24 , ARA 54 , ARA 55 , ARA 70 , ARA 160 , FHL 2 , PDEF , NCoR 1 , SMRT ) was compared in these cell lines by semi quantitative RT PCR to determine if the pattern of receptor co activators or repressors expressed in these cells might explain the differential regulation of KLK 2 and KLK 3 . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| To examine this hypothesis , we cloned rat complementary DNA fragments corresponding to coactivators ( SRC 1 , TIF 2 and TRAM 1 ) and corepressors ( N CoR and SMRT ) , and studied the ontogenic changes in their corresponding messenger RNAs in rat cerebellum of normal and hypothyroid rats during postnatal development , using a RNase protection assay . ^^^ We found an increased expression of SRC 1 and TIF 2 , as well as of N CoR , during rat cerebellar development but no change in the expression of SMRT and TRAM 1 genes . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| To determine the molecular mechanisms of myeloid leukemogenesis and maturation arrest in STAT5b RARalpha ( + ) APL and its unresponsiveness to ATRA , we examined the effect of STAT5b RARalpha on the activity of myeloid transcription factors including RARalpha / retinoid 10 receptor ( RXR ) alpha , STAT 3 , and STAT 5 as well as its molecular interactions with the nuclear receptor corepressor , SMRT , and nuclear receptor coactivator , TRAM 1 . ^^^ SMRT was released from STAT5b RARalpha / SMRT complexes by ATRA at 10 ( 6 ) M , whereas TRAM 1 became associated with STAT5b RARalpha at 10 ( 7 ) M . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In GST pull down experiments , NuMA RARalpha formed a complex with the corepressor SMRT , was released from the NuMA RARalpha / SMRT complexes by all trans retinoic acid ( ATRA ) at 10 ( 7 ) 10 ( 6 ) M and became associated with the coactivator TRAM 1 at 10 ( 8 ) M ATRA . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| METHODS : Gene expression of SRC 1 , SRC 2 , SRC 3 , N CoR , SMRT , ERalpha , and PR was measured in 26 samples of normal endometrium and 30 primary endometrial carcinomas using real time RT PCR . ^^^ CONCLUSION : The nuclear receptor coregulators SRC 1 , SRC 2 , SRC 3 , N CoR , and SMRT were found to be up regulated in malignant endometrium . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Treatment of cultured human uterine smooth muscle cells ( UtSMC ) with TNF alpha significantly reduced mRNA for the coactivators , SRC 1 ( 42 % , P < 0 . 01 ) and 2 ( 47 % , P < 0 . 03 ) , and diminished the respective protein levels , but did not significantly alter the mRNAs encoding SRC 3 , CBP and the corepressors , NCoR and SMRT ; or progesterone receptor protein levels . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| This study examines the expression of the co activators SRC 1a / e , SRC 2 , SRC 3 , SRA , and the corepressors NCoR and SMRT in GCT , epithelial ovarian tumours and normal ovary . ^^^ No significant difference in the expression of SRC 1 , SRC 2 , SRC 3 or NCoR and SMRT was found . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated recruitment of coactivators ( SRC 1 , SRC 2 , and SRC 3 ) and corepressors ( HDAC 1 , HDAC 2 , HDAC 3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after NF kappaB activation by tumor necrosis factor alpha . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We conclude that ( 1 ) TRalpha is the major TR regulating Hr expression in the cerebellum of young mouse pups ; ( 2 ) TH upregulates Hr and SMRT and downregulates SRC 1 ; ( 3 ) NcoR and SRC 3 may not be regulated by TH in the cerebellum at the transcriptional level ; and ( 4 ) autoregulation of TH action may be mediated through TH dependent expression of the cofactors necessary for TH action in the cerebellum and may be developmentally specific . . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| By using a real time RT PCR assay , we showed that SRC 1 , N CoR and SMRT mRNA are expressed in human endometrium during all phases of the menstrual cycle , as well as in inactive endometrium . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Moreover , the repression is not affected by the silencing mediator for retinoic acid receptor and thyroid hormone receptor ( SMRT ) and steroid receptor coactivator 1 ( SRC 1 ) . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| To determine whether coactivators and corepressors have the capacity to modulate the relative agonist / antagonist activity of 4HT , ER dependent gene expression was measured in the absence or presence of expression vectors for SRC 1 ( steroid receptor coactivator 1 ) or SMRT ( silencing mediator of retinoic acid and thyroid hormone receptors ) . ^^^ In Hep G 2 cells in which 4HT is an agonist , exogenous SRC 1 enhanced estradiol ( E 2 ) and 4HT stimulated transcription in a dose dependent manner , while SMRT overexpression strongly reduced basal and 4HT stimulated gene expression with no effect on E 2 activity . ^^^ To assess whether relative coactivator and corepressor expression within a given cell could modulate the balance of 4HT agonist / antagonist activity , SRC 1 and SMRT were coexpressed . ^^^ SMRT overexpression blocked SRC 1 coactivation of 4HT stimulated gene expression and preferentially inhibited 4HT agonist activity whether or not exogenous SRC 1 was present . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Transcriptional repression by COUP TFI is mediated by corepressors , N CoR ( nuclear receptor corepressor ) and SMRT ( silencing mediator for retinoid and thyroid hormone receptor ) , whereas transcriptional activation by SF 1 is mediated by coactivator SRC 1 ( steroid receptor coactivator 1 ) . ^^^ We therefore examined the expression of COUP TFI , SF 1 , SRC 1 , N CoR , and SMRT in a variety of adrenocortical adenomas and compared the results with CYP 17 mRNA levels . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We showed that for SRC 1 , CBP , TIF1alpha , RIP 140 , N CoR , and SMRT , no significant differences in the expression levels were observed between breast and endometrial cells . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Using quantitative RT PCR , we , therefore , measured the levels of transcripts encoding these coregulators , as well as the corepressor SMRT , and the coactivator SRC 1 , in a small cohort of tamoxifen resistant and sensitive breast tumors . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Using quantitative RT PCR we therefore measured the levels of transcripts encoding these coregulators , as well as the corepressor SMRT , and the coactivator SRC 1 , in a small cohort of tamoxifen resistant and sensitive breast tumors . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Interestingly , rifampicin also increased the interaction of SXR with SMRT as well as with coactivator SRC 1 . ^^^ On the other hand , the anti fungal agent ketoconazole decreased SXR interaction with both SRC 1 and SMRT . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In this work , we determined the variations in the content of the steroid receptor coactivator ( SRC 1 ) and the silencing mediator for retinoic acid and thyroid hormone receptors corepressor ( SMRT ) in the hypothalamus , the preoptic area , and the hippocampus of adult intact rats during the estrous cycle by Western blot . ^^^ SRC 1 content was higher than that of SMRT in the hypothalamus throughout the estrous cycle , whereas SMRT content was higher in the preoptic area . ^^^ These results demonstrate that SRC 1 and SMRT content change in a tissue specific manner in the rat brain during the estrous cycle , and suggest that the transcriptional activity of steroid hormone receptors in the rat brain in physiological conditions is regulated by changes in SRC 1 and SMRT content . . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to test the hypothesis that expression of retinoid receptors ( RARalpha , RARbeta , RARgamma ) , rexinoid receptors ( RXRalpha , RXRbeta ) , thyroid hormone receptors ( TRalpha , TRbeta ) , estrogen receptors ( ERalpha , ERbeta ) , nuclear receptor coregulators ( N CoR , SRC 1 , SMRT ) , and in addition type 1 iodothyronine 5 ' deiodinase ( 5 ' DI ) , EGFR and erb B2 / neu would be different in mammary postlactating tissue in comparison with that of nonlactating mammary gland . ^^^ Using RT PCR , we have shown that expression of RARalpha , RXRalpha , TRalpha , ERalpha , ERbeta , N CoR , SRC 1 , SMRT and EGFR in rat was significantly increased in postlactating mammary gland when compared to that of nonlactating mammary tissue . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : To examine the steroid hormone dependent growth mechanism of human endometrial hyperplasia and carcinoma , expression levels of steroid receptor cofactors , such as coactivators ( steroid receptor coactivator 1 [ SRC 1 ] and p300 / cyclic AMP response element binding protein ( p300 / CBP ] ) and corepressors ( nuclear receptor corepressor [ NCoR ] and silencing mediator for retinoid and thyroid hormone receptors [ SMRT ] ) , were investigated . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| SRC 1 and SMRT were identified at the ER ERE complex , and interactions between ER isoforms and coregulatory proteins were determined using immunoprecipitation . ^^^ Differential recruitment of SRC 1 and SMRT by ER alpha and ER beta in the presence of beta estradiol and 4 OHT may be central to the response of the tumor to endocrine treatment . . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Here we show by a modified mammalian two hybrid system that both the AR interacting domains of the coactivator SRC 1 and of the corepressor SMRT compete for interaction with the AR N terminus . ^^^ We show that the Qr region of SRC 1 is able to inhibit the interaction of SMRT with AR . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Elevated levels of MR , the co activators TIF 2 and SRC 1 , and the co repressor SMRT do modulate the dose response curve and partial agonist activity of MR complexes . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Both coregulatory proteins , steroid receptor coactivator ( SRC 1 ) and silencing mediator for retinoid and thyroid hormones ( SMRT ) , were found to be expressed in the zona fasciculata and reticularis in the human adrenal cortex , but were largely absent from the zona glomerulosa . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| By contrast , the retinoid receptors associated transcriptional co factors , including the co repressors of N CoR and SMRT , and the co activators of SRC 1 and P / CAF , were ubiquitously expressed in the developing telencephalon . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Regulation of the content of progesterone and estrogen receptors , and their cofactors SRC 1 and SMRT by the 26S proteasome in the rat brain during the estrous cycle . ^^^ In this work we have determined the role of the 26S proteasome in the regulation of the content of progesterone receptors ( PR A and PR B ) , estrogen receptors ( ER alpha and ER beta ) , the coactivator SRC 1 and the corepressor SMRT in the rat brain during the estrous cycle . ^^^ The 26S proteasome inhibitor MG 132 was injected once into the lateral ventricle on proestrous day ; and 24h later , on estrous day we evaluated the content of PR and ER isoforms , SRC 1 and SMRT in the hypothalamus , the preoptic area and the hippocampus by Western blot . ^^^ |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y6Q9 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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