| Interacting proteins: Q96T58 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In cotransfection experiments , SHARP mediated repression was sensitive to the HDAC inhibitor TSA and facilitated by SKIP , a highly conserved SMRT and RBP Jkappa interacting protein . ^^^ |
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| Interacting proteins: Q96T58 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| A yeast two hybrid screen using the conserved carboxyl terminus of the nuclear receptor corepressor SMRT as a bait led to the isolation of a novel human gene termed SHARP ( SMRT / HDAC1 Associated Repressor Protein ) . ^^^ SHARP is a potent transcriptional repressor whose repression domain ( RD ) interacts directly with SMRT and at least five members of the NuRD complex including HDAC 1 and HDAC 2 . ^^^ |
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| Interacting proteins: Q96T58 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| This inhibition is achieved , in part , by binding of PPARdelta to a peroxisome proliferator response element and the association of nonliganded PPARdelta with corepressors SMRT ( silencing mediator for retinoid and thyroid hormone receptors ) , SHARP ( SMRT and histone deacetylase associated repressor protein ) , and class 1 histone deacetylases . ^^^ |
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| Interacting proteins: Q96T58 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| OTT 3 is a new member of the Spen ( split end ) family of proteins ( huSHARP , huOTT 1 , DmSpen , and muMINT ) , which are characterized by several N terminal RNA recognition motifs and a highly conserved C terminal SPOC ( Spen Paralog and Ortholog C terminal ) domain that , in the case of SHARP , has been shown to interact with SMRT / NCoR corepressors . ^^^ Furthermore , we demonstrated that the capacity of the OTT 3 and OTT 1 SPOC domains to interact with SMRT and repress transcription is far weaker than that of SHARP . ^^^ |
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