| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Here we report the crystal structure of a ternary complex containing the peroxisome proliferator activated receptor alpha ligand binding domain bound to the antagonist GW 6471 and a SMRT co repressor motif . ^^^ |
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| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Using multiple biophysical techniques , we find that peptides derived from one of the nuclear receptor interacting motifs of the corepressors nuclear receptor corepressor ( NCoR ) and silencing mediator of retinoid and thyroid receptors ( SMRT ) are able to bind the ligand binding domains ( LBD ) of all three PPAR ( peroxisome proliferator activated receptor ) subtypes . ^^^ |
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| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Further studies demonstrated that the PPARalpha ligand 8 ( S ) hydroxyeicosatetraenoic acid strongly promotes the interaction of PPARalpha with the co activator RIP 140 but decreases the interaction of PPARalpha with the co repressor SMRT . ^^^ In contrast , TAK 1 interacts with RIP 140 but not with SMRT and competes with PPARalpha for RIP 140 binding . ^^^ |
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| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Stable expression of PPARdelta inhibits the expression of endogenous PPARalpha target gene expression in 3T3 PPARalpha cells , whereas a PPARdelta mutant that does not interact with the corepressor SMRT loses its ability to repress the induction of PPARalpha target gene . ^^^ |
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| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Interestingly , N CoR and SMRT potently repress PPARdelta induced transcriptional activation but fail to repress PPARalpha activity . ^^^ |
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| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In contrast to PPARgamma , wild type PPARalpha failed to recruit the transcriptional corepressors NCoR and SMRT . ^^^ |
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| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In transient transfection experiments , NCoR and the related silencing mediator for retinoid and thyroid hormone receptor ( SMRT ) were shown to exert a marked dose dependent repression of ligand induced PPAR delta mediated transactivation ; in addition , transactivation induced by the cAMP elevating agent forskolin was efficiently reduced to basal levels by NCoR as well as SMRT coexpression . ^^^ Our results suggest that the transactivation potential of liganded PPAR delta can be fine tuned by interaction with NCoR and SMRT in a manner determined by the expression levels of corepressors and coactivators . . ^^^ |
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| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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