| Interacting proteins: Q06455 and Q9Y618 |
Pubmed |
SVM Score :0.7596818 |
| ETO interacts with nuclear receptor corepressors SMRT and N CoR , which recruit histone deacetylase to the AML 1 ETO oncoprotein . 0.7596818^^^ |
|
| Interacting proteins: Q06455 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We report here that ETO ( eight twenty one or MTG 8 ) , which is fused to the acute myelogenous leukemia 1 ( AML 1 ) transcription factor in t ( 8 ; 21 ) AML , interacts via its zinc finger region with a conserved domain of the corepressors N CoR and SMRT and recruits HDAC in vivo . ^^^ The fusion protein AML 1 ETO retains the ability of ETO to form stable complexes with N CoR / SMRT and HDAC . ^^^ |
|
| Interacting proteins: Q06455 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The resulting AML 1 ETO fusion is an aberrant transcriptional regulator due to the ability of ETO , which does not bind DNA itself , to recruit the transcriptional corepressors N CoR , SMRT , and Sin3A and histone deacetylases . ^^^ The N terminal portion of ETO forms complexes with PLZF , while the C terminal region , which was shown to bind to N CoR and SMRT , is required for the ability of ETO to augment transcriptional repression by PLZF . ^^^ |
|
| Interacting proteins: Q06455 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|