| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.76346342 |
| Intriguingly , tyrosine kinase signaling similarly disrupted the interactions of SMRT with 5 Erb A , with retinoic acid receptors , and with PLZF , a nonreceptor transcriptional repressor . 0.76346342^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The SMRT ( silencing mediator of retinoic acid and thyroid hormone receptor ) corepressor participates in the repression of target gene expression by a variety of transcription factors , including the nuclear hormone receptors , promyelocytic leukemia zinc finger protein , and B cell leukemia protein 6 . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| SMRT corepressor interacts with PLZF and with the PML retinoic acid receptor alpha ( RARalpha ) and PLZF RARalpha oncoproteins associated with acute promyelocytic leukemia . ^^^ Unexpectedly , the PLZF moiety itself can interact with SMRT corepressor . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that both PML RARalpha and PLZF RARalpha fusion proteins can act as transcriptional repressors and are able to interact with nuclear receptor transcriptional co repressors , such as SMRT . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Rev erbAalpha / beta ) , Mxi 1 and Mad bHLH zip proteins and the oncoproteins PLZF and LAZ3 / BCL6 is mediated by the corepressors N CoR and SMRT . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF , PLZF RARalpha , and BCL 6 . ^^^ We and others have previously implicated the SMRT corepressor in the actions of the PLZF transcription factor and in the function of its oncogenic derivative , PLZF retinoic acid receptor ( RARalpha ) , in promyelocytic leukemia . ^^^ We report here that PLZF , and a structurally similar transcriptional repressor , BCL 6 , can interact with a variety of corepressor proteins in addition to SMRT , including the mSin3A protein and ( for PLZF ) histone deacetylase 1 . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We find , in vitro , that POZ domains from a variety of other POZ domain containing proteins , including the transcriptional repressor PLZF , as well as ZID , GAGA and a vaccinia virus protein , SalF17R , also interact with varying affinities with N CoR and SMRT . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Dissociation of SMRT from different receptors was observed at ATRA concentrations of 0 . 01 microM , 0 . 1 microM , and 1 . 0 microM for RARalpha RXRalpha , NPM RARalpha , and PML RARalpha , respectively , but not observed for PLZF RARalpha even in the presence of 10 microM ATRA . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Rev erbAalpha / beta ) , Mad / Max bHLH ( basic helix loop helix ) LZ proteins , and oncoproteins , PLZF and LAZ3 / BCL6 , bind DNA and silence transcription by recruiting a repressor complex that contains N CoR ( nuclear receptor corepressor ) / SMRT ( silencing mediator of retinoic acid and thyroid hormone receptor ) , Sin3A / B , and HDAc 1 / 2 proteins . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In the human B cell lymphoma ( BCL 6 ) and promyelocityc leukemia ( PLZF ) oncoproteins , this domain mediates transcriptional repression through its ability to recruit a silencing mediator of retinoid and thyroid hormone receptor ( SMRT ) / nuclear receptor corepressor ( N CoR ) mSin3A histone deacetylase ( HDAC ) complex , a mechanism shared with numerous transcription factors . ^^^ However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The difference in response to ATRA therapy between acute promyelocytic leukemia ( APL ) patients with PML RARalpha fusion and PLZF RARalpha fusion has recently been found to be partially due to the strong association of the transcriptional co repressor , SMRT / N CoR , with PLZF domain . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The N terminal portion of ETO forms complexes with PLZF , while the C terminal region , which was shown to bind to N CoR and SMRT , is required for the ability of ETO to augment transcriptional repression by PLZF . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We found that mutations of the BTB domain that neutralize key charged pocket residues did not disrupt dimerization , yet abrogated the ability of PLZF to repress transcription and led to the loss of interaction with N CoR , SMRT , and histone deacetylases ( HDACs ) . ^^^ |
|
| Interacting proteins: Q05516 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The silencing mediator of retinoic and thyroid hormone receptors ( SMRT ) corepressor mediates transcriptional repression by interacting with transcription factors such as the promyelocytic leukemia zinc finger ( PLZF ) protein . ^^^ In the presence of Flt 3 ITD , PLZF SMRT interaction was reduced , transcriptional repression by PLZF was inhibited , and PLZF mediated growth suppression of leukemia cells was partially blocked . ^^^ |
|