| Interacting proteins: Q03181 and Q9Y618 |
Pubmed |
SVM Score :0.51445928 |
| This inhibition is achieved , in part , by binding of PPARdelta to a peroxisome proliferator response element and the association of nonliganded PPARdelta with corepressors SMRT ( silencing mediator for retinoid and thyroid hormone receptors ) , SHARP ( SMRT and histone deacetylase associated repressor protein ) , and class 1 histone deacetylases . 0.51445928^^^ |
|
| Interacting proteins: Q03181 and Q9Y618 |
Pubmed |
SVM Score :0.68593952 |
| Glutathione S transferase ( GST ) pull down assays show that PPARdelta physically interacts with SRC 1 3 , RIP 140 , PPAR binding protein , N CoR , and SMRT in the absence of ligands , suggesting their potent interactions with PPARdelta . 0.68593952^^^ |
|
| Interacting proteins: Q03181 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In transient transfection experiments , NCoR and the related silencing mediator for retinoid and thyroid hormone receptor ( SMRT ) were shown to exert a marked dose dependent repression of ligand induced PPAR delta mediated transactivation ; in addition , transactivation induced by the cAMP elevating agent forskolin was efficiently reduced to basal levels by NCoR as well as SMRT coexpression . ^^^ Our results suggest that the transactivation potential of liganded PPAR delta can be fine tuned by interaction with NCoR and SMRT in a manner determined by the expression levels of corepressors and coactivators . . ^^^ |
|
| Interacting proteins: Q03181 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|