| Interacting proteins: P56524 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In contrast , SMRT does not activate the class 2 HDAC 4 , with which it also interacts . ^^^ |
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| Interacting proteins: P56524 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Here we show that these RDs are nonredundant , and that one RD , which is conserved in N CoR and SMRT , represses transcription by interacting directly with class 2 HDAC 4 and HDAC 5 . ^^^ Endogenous N CoR and SMRT each associate with HDAC 4 in a complex that does not contain mSin3A or HDAC 1 . ^^^ |
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| Interacting proteins: P56524 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| SMRTE inhibits MEF2C transcriptional activation by targeting HDAC 4 and 5 to nuclear domains . ^^^ Intriguingly , although HDAC 4 is located primarily in the cytoplasm , coexpression of SMRTe dramatically translocates HDAC 4 from the cytoplasm into the nucleus , where HDAC 4 prevents MEF2C from activating muscle differentiation . ^^^ Accordingly , SMRTe synergizes with HDAC 4 and 5 to inhibit MEF2C transactivation of target promoter , suggesting that nuclear domain targeting of HDAC4 / 5 may be important in preventing muscle cell differentiation . ^^^ |
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| Interacting proteins: P56524 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Different class 2 HDACs reside in the cell nucleus in stable and autonomous complexes with enzymatic activity , but the enzymatic activities associated with HDAC 7 and HDAC 4 rely on shared cofactors , including HDAC 3 and SMRT / N CoR . . ^^^ |
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| Interacting proteins: P56524 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In addition , endogenous HDAC 4 and at least one of its binding partners , the corepressor protein SMRT ( for silencing mediator of retinoid and thyroid receptor ) , undergo changes in their nuclear distribution in ICP 0 transfected cells . ^^^ |
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