| Interacting proteins: P42229 and Q9Y618 |
Pubmed |
SVM Score :0.79729399 |
| SMRT binds to both STAT5A and 5B , and strongly repressed STAT 5 dependent transcription in vitro . 0.79729399^^^ |
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| Interacting proteins: P42229 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| To determine the molecular mechanisms of myeloid leukemogenesis and maturation arrest in STAT5b RARalpha ( + ) APL and its unresponsiveness to ATRA , we examined the effect of STAT5b RARalpha on the activity of myeloid transcription factors including RARalpha / retinoid 10 receptor ( RXR ) alpha , STAT 3 , and STAT 5 as well as its molecular interactions with the nuclear receptor corepressor , SMRT , and nuclear receptor coactivator , TRAM 1 . ^^^ |
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| Interacting proteins: P42229 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Oligomerization of this domain in the Stat 5 RARalpha fusion protein leads to stable binding of the corepressor SMRT independent of all trans retinoic acid ( ATRA ) stimulation and is accompanied by an impaired response to differentiation signals in hematopoietic cells . ^^^ |
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