| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.73944837 |
| Additionally , interactions between the BCL 6 POZ domain and SMRT , N CoR , and BCoR are mutually exclusive . 0.73944837^^^ |
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| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.72212646 |
| Recently , we reported that SMRT also directly associates with LAZ 3 ( BCL 6 ) , a POZ / Zn finger transcriptional repressor involvedin the pathogenesis of non Hodgkin lymphomas . 0.72212646^^^ |
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| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.75100653 |
| The homodimeric BTB domain of BCL 6 ( also known as the POZ domain ) is required for the repression activity of the protein and interacts directly with the SMRT and N CoR corepressors that are found within large multiprotein histone deacetylase containing complexes . 0.75100653^^^ |
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| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF , PLZF RARalpha , and BCL 6 . ^^^ We report here that PLZF , and a structurally similar transcriptional repressor , BCL 6 , can interact with a variety of corepressor proteins in addition to SMRT , including the mSin3A protein and ( for PLZF ) histone deacetylase 1 . ^^^ |
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| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The BCL 6 POZ domain and other POZ domains interact with the co repressors N CoR and SMRT . ^^^ Using a yeast two hybrid screen , we identified N CoR and SMRT as BCL 6 interacting proteins . ^^^ Furthermore , when BCL 6 is bound to its consensus recognition sequence in vivo , it can interact with N CoR and SMRT . ^^^ We find that BCL 6 POZ domain mutations that disrupt the interaction with N CoR and SMRT no longer repress transcription . ^^^ |
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| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In the human B cell lymphoma ( BCL 6 ) and promyelocityc leukemia ( PLZF ) oncoproteins , this domain mediates transcriptional repression through its ability to recruit a silencing mediator of retinoid and thyroid hormone receptor ( SMRT ) / nuclear receptor corepressor ( N CoR ) mSin3A histone deacetylase ( HDAC ) complex , a mechanism shared with numerous transcription factors . ^^^ However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^ |
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| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The interface through which the BCL 6 BTB domain mediates recruitment of the SMRT , NCoR and BCoR corepressors was recently identified . ^^^ |
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| Interacting proteins: P41182 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Apt 48 binds BCL 6 POZ in a manner distinct from the transcriptional corepressor SMRT , yet was found to prevent BCL 6 mediated repression of a luciferase reporter gene . ^^^ |
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