| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| RIP 140 foci do not correspond to PML bodies but partly colocalize with domains harboring the corepressor SMRT . ^^^ |
|
| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| SMRT corepressor interacts with PLZF and with the PML retinoic acid receptor alpha ( RARalpha ) and PLZF RARalpha oncoproteins associated with acute promyelocytic leukemia . ^^^ |
|
| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that both PML RARalpha and PLZF RARalpha fusion proteins can act as transcriptional repressors and are able to interact with nuclear receptor transcriptional co repressors , such as SMRT . ^^^ |
|
| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| This chimeric protein has been strongly implicated in APL pathogenesis because of its interactions with growth suppressors ( PML ) , retinoid signaling molecules ( RXRalpha ) , and nuclear hormone transcriptional co repressors ( N CoR and SMRT ) . ^^^ |
|
| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Dissociation of SMRT from different receptors was observed at ATRA concentrations of 0 . 01 microM , 0 . 1 microM , and 1 . 0 microM for RARalpha RXRalpha , NPM RARalpha , and PML RARalpha , respectively , but not observed for PLZF RARalpha even in the presence of 10 microM ATRA . ^^^ |
|
| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The difference in response to ATRA therapy between acute promyelocytic leukemia ( APL ) patients with PML RARalpha fusion and PLZF RARalpha fusion has recently been found to be partially due to the strong association of the transcriptional co repressor , SMRT / N CoR , with PLZF domain . ^^^ We demonstrate that SMRT association , as with PML RARalpha , can be released from NPM RARalpha at pharmacological concentration of ATRA ( 10 6 M ) . ^^^ |
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| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In these cases , the aberrant 5 type PML RAR ( alpha ) protein displayed increased affinity to the nuclear corepressor protein SMRT , providing further evidence that RA exerts the therapeutic effect on APL through modulation of the RAR corepressor interaction . ^^^ |
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| Interacting proteins: P29590 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Distinct nuclear body components , PML and SMRT , regulate the trans acting function of HTLV 1 Tax oncoprotein . ^^^ Coexpression of SMRT and PML resulted in an additive activation of Tax trans acting function . ^^^ |
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