| Interacting proteins: Q9Y618 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y618 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y618 and P19838 |
Pubmed |
SVM Score :0.0 |
| SMRT derepression by the IkappaB kinase alpha : a prerequisite to NF kappaB transcription and survival . ^^^ Here , we demonstrate that NF kappaB transcription requires IKKalpha to phosphorylate SMRT on chromatin , stimulating the exchange of corepressor for coactivator complexes . ^^^ IKKalpha induced phosphorylation coincides with a loss of chromatin associated SMRT and HDAC 3 and with nuclear export of the SMRT corepressor , events required for expression of the NF kappaB regulated cIAP 2 and IL 8 genes . ^^^ Failure of IKKalpha to stimulate the removal of SMRT from chromatin inhibits the recruitment of NF kappaB to promoters , blocking transcription and sensitizing cells to apoptosis . ^^^ Our work provides evidence that IKKalpha orchestrates SMRT derepression , a prerequisite for NF kappaB transcription and survival . . ^^^ |
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| Interacting proteins: Q9Y618 and P19838 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated recruitment of coactivators ( SRC 1 , SRC 2 , and SRC 3 ) and corepressors ( HDAC 1 , HDAC 2 , HDAC 3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after NF kappaB activation by tumor necrosis factor alpha . ^^^ |
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| Interacting proteins: Q9Y618 and P19838 |
Pubmed |
SVM Score :0.0 |
| Although phosphorylated SMRT remains bound to the active p 50 RelA / p65 heterodimer of NF kappaB , derepression of SMRT is evidenced by the loss of chromatin associated HDAC 3 activity . ^^^ Introduction of nonphosphorylatable mutants of RelA / p65 and SMRT proteins or the inhibition of IKK activity results in active repression of NF kappaB promoters by tethering the SMRT HDAC 3 complex . ^^^ |
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