| Interacting proteins: P19793 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19793 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19793 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19793 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| This chimeric protein has been strongly implicated in APL pathogenesis because of its interactions with growth suppressors ( PML ) , retinoid signaling molecules ( RXRalpha ) , and nuclear hormone transcriptional co repressors ( N CoR and SMRT ) . ^^^ |
|
| Interacting proteins: P19793 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In contrast , cotransfection of SMRT repressed PPARgamma2 / RXRalpha mediated LPL transcription in the absence or presence of COUP TFII ( ARP 1 ) . ^^^ |
|
| Interacting proteins: P19793 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Proteasome mediated degradation of RARgamma or RXRalpha in vitro was significantly reduced by the corepressor SMRT , which binds unliganded retinoid receptors . ^^^ Ligand failed to relieve protection from degradation by SMRT of a mutant form of RXRalpha that binds SMRT in the presence and absence of ligand . ^^^ |
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| Interacting proteins: P19793 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The coiled coil domain of STAT5b was required for formation of STAT5b RARalpha homodimers , for the inhibition of RARalpha / RXRalpha transcriptional activity , and for stability of the STAT5b RARalpha / SMRT complex . ^^^ Thus , STAT5b RARalpha contributes to myeloid maturation arrest by binding to RARE as either a homodimer or as a heterodimer with RXRalpha resulting in the recruitment of SMRT and inhibition of RARalpha / RXRalpha transcriptional activity . ^^^ |
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| Interacting proteins: P19793 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to test the hypothesis that expression of retinoid receptors ( RARalpha , RARbeta , RARgamma ) , rexinoid receptors ( RXRalpha , RXRbeta ) , thyroid hormone receptors ( TRalpha , TRbeta ) , estrogen receptors ( ERalpha , ERbeta ) , nuclear receptor coregulators ( N CoR , SRC 1 , SMRT ) , and in addition type 1 iodothyronine 5 ' deiodinase ( 5 ' DI ) , EGFR and erb B2 / neu would be different in mammary postlactating tissue in comparison with that of nonlactating mammary gland . ^^^ Using RT PCR , we have shown that expression of RARalpha , RXRalpha , TRalpha , ERalpha , ERbeta , N CoR , SRC 1 , SMRT and EGFR in rat was significantly increased in postlactating mammary gland when compared to that of nonlactating mammary tissue . ^^^ |
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