| Interacting proteins: P10589 and Q9Y618 |
Pubmed |
SVM Score :0.65261159 |
| To determine which corepressor is involved in the COUP TF silencing activity , we used a yeast two hybrid and in vitro GST pull down assays to demonstrate that COUP TFI can interact with the fragment of N CoR ( nuclear receptor corepressor ) encoding amino acids 921 2453 and the fragments of SMRT ( silencing mediator for retinoic acid receptor and TR ) encoding amino acids 29 564 and 565 1289 , respectively . 0.65261159^^^ |
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| Interacting proteins: P10589 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Transcriptional repression by COUP TFI is mediated by corepressors , N CoR ( nuclear receptor corepressor ) and SMRT ( silencing mediator for retinoid and thyroid hormone receptor ) , whereas transcriptional activation by SF 1 is mediated by coactivator SRC 1 ( steroid receptor coactivator 1 ) . ^^^ We therefore examined the expression of COUP TFI , SF 1 , SRC 1 , N CoR , and SMRT in a variety of adrenocortical adenomas and compared the results with CYP 17 mRNA levels . ^^^ Interestingly , the pattern of COUP TFI expression was similar to the profile of N CoR expression , but not of SMRT expression . ^^^ |
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| Interacting proteins: P10589 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We have shown that transcriptional repression by COUP TFI is mediated by corepressors , N CoR ( nuclear receptor corepressor ) and SMRT ( silencing mediator for retinoid and thyroid hormone receptor ) . ^^^ Therefore , we compared the expression of COUP TFI , N CoR and SMRT in non hyperfunctioning adrenocortical adenomas and normal adrenal glands . ^^^ Interestingly , the pattern of N CoR and SMRT expression was different compared with COUP TFI expression . ^^^ These data suggest that COUP TFI , N CoR , and SMRT may play a differential role in steroid biosynthesis of non hyperfunctioning adenomas . . ^^^ |
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