| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.66885637 |
| RAR alpha strongly interacts with SMRT and can repress target gene transcription , whereas RAR beta and gamma interact with SMRT only weakly and fail to repress . 0.66885637^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.86726527 |
| These differing transcriptional properties appear to reflect the differing abilities of the three RAR isotypes to interact with the SMRT ( silencing mediator of retinoic acid and thyroid hormone receptor ) corepressor protein : RARalpha binds to SMRT strongly both in vitro and in vivo , whereas RARbeta and RARgamma interact only weakly with SMRT . 0.86726527^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.72956879 |
| We demonstrate that SMRT association , as with PML RARalpha , can be released from NPM RARalpha at pharmacological concentration of ATRA ( 10 6 M ) . 0.72956879^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.65088904 |
| In GST pull down experiments , NuMA RARalpha formed a complex with the corepressor SMRT , was released from the NuMA RARalpha / SMRT complexes by all trans retinoic acid ( ATRA ) at 10 ( 7 ) 10 ( 6 ) M and became associated with the coactivator TRAM 1 at 10 ( 8 ) M ATRA . 0.65088904^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Cell specific inhibition of retinoic acid receptor alpha silencing by the AF2 / tau c activation domain can be overcome by the corepressor SMRT , but not by N CoR . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Retinoid isomers differ in the ability to induce release of SMRT corepressor from retinoic acid receptor alpha . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Similarly , co repressors , such as SMRT and N CoR , for TR and retinoic acid receptors ( RAR ) have been identified . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Recently , transcriptional repression ( basal silencing ) by TR and RAR was shown to be mediated by nuclear receptor corepressors ( CoRs ) , such as NCoR and SMRT . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We demonstrate in this report that the proximal ID in NCoR and SMRT , which share only 23 % homology , allows preferential recognition of nuclear receptors , such that TR prefers to recruit NCoR , and RAR prefers to recruit SMRT , to DNA response elements . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We also show that different residues of the RAR coactivator pocket are used differently for interactions with the corepressor silencing mediator for retinoid and thyroid hormone receptor ( SMRT ) and coactivator . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We investigated the expression of the co repressor ( SMRT ) and co activator ( Trip 1 ) for retinoid and thyroid hormone receptors in several neuroectodermal tumour cell lines , and its modulation by all trans retinoic acid , as well as by synthetic agonists , for RAR alpha , RAR beta , RAR gamma and RXR . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| SMRT corepressor interacts with PLZF and with the PML retinoic acid receptor alpha ( RARalpha ) and PLZF RARalpha oncoproteins associated with acute promyelocytic leukemia . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that both PML RARalpha and PLZF RARalpha fusion proteins can act as transcriptional repressors and are able to interact with nuclear receptor transcriptional co repressors , such as SMRT . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF , PLZF RARalpha , and BCL 6 . ^^^ We and others have previously implicated the SMRT corepressor in the actions of the PLZF transcription factor and in the function of its oncogenic derivative , PLZF retinoic acid receptor ( RARalpha ) , in promyelocytic leukemia . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Dissociation of SMRT from different receptors was observed at ATRA concentrations of 0 . 01 microM , 0 . 1 microM , and 1 . 0 microM for RARalpha RXRalpha , NPM RARalpha , and PML RARalpha , respectively , but not observed for PLZF RARalpha even in the presence of 10 microM ATRA . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Both NPM RAR and PML RAR interact with the co repressor protein SMRTe in a manner that is less sensitive than RARalpha to dissociation by retinoic acid . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Indirect immunofluorescence studies with anti SMRTe antibody reveal discrete cytoplasmic and nuclear speckles , which contain RARalpha in an RA sensitive manner . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In these cases , the aberrant 5 type PML RAR ( alpha ) protein displayed increased affinity to the nuclear corepressor protein SMRT , providing further evidence that RA exerts the therapeutic effect on APL through modulation of the RAR corepressor interaction . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| First , corepressor SMRT [ for silencing mediator of thyroid hormone receptor ( TR ) and retinoic acid receptor ( RAR ) ] inhibits the interaction of coactivator steroid receptor coactivator 1 with liganded TR / RAR . ^^^ Second , SMRT enables receptors to adopt apo form even in the presence of ligand , as demonstrated with limited proteolyses and decreased binding of radiolabeled retinoid to RAR . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| METHODS : Multiprobe ribonuclease protection assay and real time reverse transcriptase polymerase chain reaction were used to quantitate mRNA levels of steroid receptors , vitamin D receptor ( VDR ) , retinoic acid receptors ( RAR ) , and cofactors AIB 1 ( amplified in breast cancer 1 ) , CBP ( cyclic adenosine monophosphate response element binding protein ) , pCAF ( p300 / CBP associated factor ) , TIF 2 ( transcription intermediary factor 2 ) , N CoR ( nuclear receptor corepressor ) , and SMRT ( silencing mediator of repressed transcription ) . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Moreover , a physical interaction between AhR and the RAR corepressor SMRT has been described in vitro . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to test the hypothesis that expression of retinoid receptors ( RARalpha , RARbeta , RARgamma ) , rexinoid receptors ( RXRalpha , RXRbeta ) , thyroid hormone receptors ( TRalpha , TRbeta ) , estrogen receptors ( ERalpha , ERbeta ) , nuclear receptor coregulators ( N CoR , SRC 1 , SMRT ) , and in addition type 1 iodothyronine 5 ' deiodinase ( 5 ' DI ) , EGFR and erb B2 / neu would be different in mammary postlactating tissue in comparison with that of nonlactating mammary gland . ^^^ Using RT PCR , we have shown that expression of RARalpha , RXRalpha , TRalpha , ERalpha , ERbeta , N CoR , SRC 1 , SMRT and EGFR in rat was significantly increased in postlactating mammary gland when compared to that of nonlactating mammary tissue . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| AhR was shown to be involved in a mutual antagonism with RARalpha corepressor SMRT ( silencing mediator of retinoid and thyroid receptors ) . ^^^ This , and the documented physical interaction between AhR and SMRT suggested that SMRT sequestration by AhR might activate RARalpha in the absence of ligand . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| The ability to recruit SMRT appears to play a crucial role in leukemogenesis by the PML retinoic acid receptor alpha ( RARalpha ) oncoprotein , an aberrant nuclear hormone receptor implicated in human acute promyelocytic leukemia ( APL ) . ^^^ We report here that arsenite is a potent inhibitor of the interaction of SMRT with its transcription factor partners , including PML RARalpha . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| To determine the molecular mechanisms of myeloid leukemogenesis and maturation arrest in STAT5b RARalpha ( + ) APL and its unresponsiveness to ATRA , we examined the effect of STAT5b RARalpha on the activity of myeloid transcription factors including RARalpha / retinoid 10 receptor ( RXR ) alpha , STAT 3 , and STAT 5 as well as its molecular interactions with the nuclear receptor corepressor , SMRT , and nuclear receptor coactivator , TRAM 1 . ^^^ SMRT was released from STAT5b RARalpha / SMRT complexes by ATRA at 10 ( 6 ) M , whereas TRAM 1 became associated with STAT5b RARalpha at 10 ( 7 ) M . ^^^ The coiled coil domain of STAT5b was required for formation of STAT5b RARalpha homodimers , for the inhibition of RARalpha / RXRalpha transcriptional activity , and for stability of the STAT5b RARalpha / SMRT complex . ^^^ Thus , STAT5b RARalpha contributes to myeloid maturation arrest by binding to RARE as either a homodimer or as a heterodimer with RXRalpha resulting in the recruitment of SMRT and inhibition of RARalpha / RXRalpha transcriptional activity . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Oligomerization of this domain in the Stat 5 RARalpha fusion protein leads to stable binding of the corepressor SMRT independent of all trans retinoic acid ( ATRA ) stimulation and is accompanied by an impaired response to differentiation signals in hematopoietic cells . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Moreover , this retinoid discriminates between the nuclear corepressors SMRT and NCoR , since it efficiently dissociates SMRT but not NCoR from the RARalpha LBD . . ^^^ |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|