| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :1.0161617 |
| Binding studies performed in vitro , however , reveal that recombinant SMRT can interact with PR in a manner which is not influenced by the nature of the bound ligand . 1.0161617^^^ Thus , the inability of SMRT or NCoR to interact with agonist activated PR when assayed in vivo may relate more to the increased affinity of PR for coactivators , with a subsequent displacement of corepressors , than to an inherent low affinity for the corepressor proteins . 0.59502399^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.97445805 |
| Unlike agonist bound PR that interacts only with coactivators such as steroid receptor coactivator 1 ( SRC 1 ) , RU 486 bound PR binds to both coactivator SRC 1 and corepressor silencing mediator for retinoid and thyroid hormone receptor ( SMRT ) in vitro . 0.97445805^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| METHODS : Northern analysis , Western analysis , and polymerase chain reaction were used to examine expression of estrogen receptor ( ER ) , progesterone receptor ( PR ) , the nuclear receptor corepressors N CoR and SMRT , and the steroid receptor coactivator BRG 1 in ovarian cancer cell lines and primary cancers . ^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In this study we assessed the effect of SMRT and DAX 1 on AR and PR activity in the presence of both agonists and partial antagonists . ^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| METHODS : Gene expression of SRC 1 , SRC 2 , SRC 3 , N CoR , SMRT , ERalpha , and PR was measured in 26 samples of normal endometrium and 30 primary endometrial carcinomas using real time RT PCR . ^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In this work we determined the content of PR isoforms , ER beta , one coactivator ( SRC 1 ) , and one corepressor ( SMRT ) in the lung of both female rats during the estrous cycle and intact males by Western blot . ^^^ In the lung of adult male rats the content of PR isoforms , ER beta and SMRT was lower than in that of females , whereas the content of SRC 1 was similar in both sexes . ^^^ Our results suggest a sexual dimorphism in the content of PR , ER beta , and SMRT in the rat lung as well as a relation of their content to the physiological levels of progesterone and estradiol . . ^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Therefore , events other than histone deacetylation and stability of SMRT and NCoR must also play a role in inhibition of PR mediated transcription . . ^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Progesterone receptor ( PR ) expression was decreased and silencing mediator for retinoid acid and thyroid hormone receptors ( SMRT ) and amplified in breast cancer 1 ( AIB 1 ) expression increased in anti estrogen resistant cells . ^^^ Estrogen independent cells were still estrogen responsive and PR , nuclear receptor corepressor ( N CoR ) and SMRT expression was increased whereas steroid receptor coactivator 1 ( SRC 1a ) and CBP related protein p 300 ( p 300 ) expression decreased . ^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In this work we have determined the role of the 26S proteasome in the regulation of the content of progesterone receptors ( PR A and PR B ) , estrogen receptors ( ER alpha and ER beta ) , the coactivator SRC 1 and the corepressor SMRT in the rat brain during the estrous cycle . ^^^ The 26S proteasome inhibitor MG 132 was injected once into the lateral ventricle on proestrous day ; and 24h later , on estrous day we evaluated the content of PR and ER isoforms , SRC 1 and SMRT in the hypothalamus , the preoptic area and the hippocampus by Western blot . ^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Treatment of cultured human uterine smooth muscle cells ( UtSMC ) with TNF alpha significantly reduced mRNA for the coactivators , SRC 1 ( 42 % , P < 0 . 01 ) and 2 ( 47 % , P < 0 . 03 ) , and diminished the respective protein levels , but did not significantly alter the mRNAs encoding SRC 3 , CBP and the corepressors , NCoR and SMRT ; or progesterone receptor protein levels . ^^^ |
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| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| NA |
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