| Interacting proteins: O75469 and Q9Y618 |
Pubmed |
SVM Score :1.0117344 |
| We show that SMRT interacts with PXR in glutathione S transferase pull down , yeast two hybrid , and mammalian two hybrid assays . 1.0117344^^^ |
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| Interacting proteins: O75469 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| We thus examined transcriptional repression of SXR and its interaction with corepressors , NCoR ( nuclear receptor corepressor ) and SMRT ( silencing mediator for retinoid and thyroid receptors ) using reporter assays in the absence and presence of ligand . ^^^ Cotransfection of SMRT , but not NCoR , inhibited not only basal but also rifampicin induced transcriptional activity of SXR on the CYP3A4 promoter through specific SMRT SXR interaction in HepG 2 cells . ^^^ Interestingly , rifampicin also increased the interaction of SXR with SMRT as well as with coactivator SRC 1 . ^^^ On the other hand , the anti fungal agent ketoconazole decreased SXR interaction with both SRC 1 and SMRT . ^^^ |
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| Interacting proteins: O75469 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| Expression of SMRT ( corepressor ) but not NCoR suppressed the drug induced activation of SXR by approximately 50 % , indicating a selectivity in corepressor interaction with hPXR . ^^^ |
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| Interacting proteins: O75469 and Q9Y618 |
Pubmed |
SVM Score :0.0 |
| In the absence of ligands , PXR can also repress gene expression by interacting with transcriptional corepressors , such as the silencing mediator for retinoid and thyroid hormone receptor ( SMRT ) . ^^^ Here , we propose structural models of the PXR LBD / SMRT ID 1 and PXR LBD / SMRT ID 2 complexes to understand their molecular interactions and potential inhibitory mechanism . . ^^^ |
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