| Interacting proteins: Q9Y618 and O15111 |
Pubmed |
SVM Score :0.0 |
| SMRT derepression by the IkappaB kinase alpha : a prerequisite to NF kappaB transcription and survival . ^^^ Here , we demonstrate that NF kappaB transcription requires IKKalpha to phosphorylate SMRT on chromatin , stimulating the exchange of corepressor for coactivator complexes . ^^^ IKKalpha induced phosphorylation coincides with a loss of chromatin associated SMRT and HDAC 3 and with nuclear export of the SMRT corepressor , events required for expression of the NF kappaB regulated cIAP 2 and IL 8 genes . ^^^ Using a nonphosphorylatable SMRT protein , we demonstrate that IKKalpha induced phosphorylation is required to recruit 14 3 3epsilon and Ubc 5 for SMRT derepression . ^^^ Failure of IKKalpha to stimulate the removal of SMRT from chromatin inhibits the recruitment of NF kappaB to promoters , blocking transcription and sensitizing cells to apoptosis . ^^^ |
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| Interacting proteins: Q9Y618 and O15111 |
Pubmed |
SVM Score :0.0 |
| IkappaB kinase alpha mediated derepression of SMRT potentiates acetylation of RelA / p65 by p 300 . ^^^ In the initial phase , IKKalpha is responsible for derepressing the silencing mediator for retinoic acid and thyroid hormone receptor ( SMRT ) histone deacetylase 3 ( HDAC 3 ) corepressor complex from the p 50 homodimer . ^^^ However , in the latter phase , chromatin bound IKKalpha coordinates the simultaneous phosphorylation of RelA / p65 ( S 536 ) and SMRT ( S 2410 ) as detected by chromatin immunoprecipitation ( ChIP ) assays . ^^^ |
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