| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| The ligand for AITR ( AITRL ) was found to be an undescribed member of the TNF family , which is expressed in endothelial cells . ^^^ Thus , AITR and AITRL seem to be important for interactions between activated T lymphocytes and endothelial cells . . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| We have identified a new TNF related ligand , designated human GITR ligand ( hGITRL ) , and its human receptor ( hGITR ) , an ortholog of the recently discovered murine glucocorticoid induced TNFR related ( mGITR ) protein [ 4 ] . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| We investigated the role of GITR / GITRL interaction during disseminated candidiasis in GITR knockout ( GITR / ) mice . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| This study reveals a novel function of GITR / GITRL in pDC mediated coactivation of NK cells . . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| Multimeric soluble GITR ligand ( GITRL ) augmented the CD 8 ( + ) T cell , CD 4 ( + ) T cell , and antibody responses to DNA vaccination . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| This abrogation of immunosuppression by GITRL RPE was dependent on GITR GITRL interaction and could not be mimicked by anti CD 28 antibody . ^^^ GITR GITRL interaction provides a unique proinflammatory costimulation that may signal through a different pathway than that of CD 28 B7 costimulation . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid induced tumour necrosis factor receptor ( GITR ) and its ligand ( GITRL ) in atopic dermatitis . ^^^ Binding of the GITR ligand ( GITRL ) leads to downregulation of the regulatory function of Tregs . ^^^ GITR also exists in a soluble form , and increased levels of this lead to decreased levels of GITRL and thereby increased Treg activity . ^^^ We have measured the levels of GITR and GITRL in plasma from atopic dermatitis patients and found it not to be increased . ^^^ Furthermore , plasma levels of GITR and GITRL did not correlate with SCORAD . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| We isolated a cDNA encoding GITR ligand ( GITRL ) from mouse endothelioma cells . ^^^ Consistent with this , soluble GITRL bound to the cell surface of the GITR expressing HEK 293 cells . ^^^ Coexpression of GITR with GITRL or stimulation of the GITR expressing cells with soluble GITRL led to activation of NF kappaB , which was significantly reduced by anti GITR . ^^^ More importantly , GITRL was expressed by both immature and mature dendritic cells , suggesting that the interaction between GITR and GITRL may contribute to immune regulation of Tregs by dendritic cells . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| The putative GITR ligand ( GITRL ) is composed of 173 amino acids with features resembling those of type 2 membrane proteins and is 51 % identical to the human activation inducible TNF receptor ( AITR ) ligand , TL 6 . ^^^ GITRL binds GITR expressed on HEK 293 cells and triggers NF kappaB activation . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid induced TNFR related gene ( GITR ; TNFRSF 18 ) , a receptor belonging to the TNFR superfamily ( TNFRSF ) , is activated by GITRL . ^^^ The GITR GITRL system appears crucial in regulating immunity and warrants further study . . ^^^ |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UNG2 and Q9Y5U5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| The ligand for AITR ( AITRL ) was found to be an undescribed member of the TNF family , which is expressed in endothelial cells . ^^^ Thus , AITR and AITRL seem to be important for interactions between activated T lymphocytes and endothelial cells . . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| The putative GITR ligand ( GITRL ) is composed of 173 amino acids with features resembling those of type 2 membrane proteins and is 51 % identical to the human activation inducible TNF receptor ( AITR ) ligand , TL 6 . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| We have identified a new TNF related ligand , designated human GITR ligand ( hGITRL ) , and its human receptor ( hGITR ) , an ortholog of the recently discovered murine glucocorticoid induced TNFR related ( mGITR ) protein [ 4 ] . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| We isolated a cDNA encoding GITR ligand ( GITRL ) from mouse endothelioma cells . ^^^ Consistent with this , soluble GITRL bound to the cell surface of the GITR expressing HEK 293 cells . ^^^ Coexpression of GITR with GITRL or stimulation of the GITR expressing cells with soluble GITRL led to activation of NF kappaB , which was significantly reduced by anti GITR . ^^^ More importantly , GITRL was expressed by both immature and mature dendritic cells , suggesting that the interaction between GITR and GITRL may contribute to immune regulation of Tregs by dendritic cells . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid induced TNFR related gene ( GITR ; TNFRSF 18 ) , a receptor belonging to the TNFR superfamily ( TNFRSF ) , is activated by GITRL . ^^^ The GITR GITRL system appears crucial in regulating immunity and warrants further study . . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| We investigated the role of GITR / GITRL interaction during disseminated candidiasis in GITR knockout ( GITR / ) mice . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| This study reveals a novel function of GITR / GITRL in pDC mediated coactivation of NK cells . . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| Multimeric soluble GITR ligand ( GITRL ) augmented the CD 8 ( + ) T cell , CD 4 ( + ) T cell , and antibody responses to DNA vaccination . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| This abrogation of immunosuppression by GITRL RPE was dependent on GITR GITRL interaction and could not be mimicked by anti CD 28 antibody . ^^^ GITR GITRL interaction provides a unique proinflammatory costimulation that may signal through a different pathway than that of CD 28 B7 costimulation . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid induced tumour necrosis factor receptor ( GITR ) and its ligand ( GITRL ) in atopic dermatitis . ^^^ Binding of the GITR ligand ( GITRL ) leads to downregulation of the regulatory function of Tregs . ^^^ GITR also exists in a soluble form , and increased levels of this lead to decreased levels of GITRL and thereby increased Treg activity . ^^^ We have measured the levels of GITR and GITRL in plasma from atopic dermatitis patients and found it not to be increased . ^^^ Furthermore , plasma levels of GITR and GITRL did not correlate with SCORAD . ^^^ |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5U5 and Q9UNG2 |
Pubmed |
SVM Score :0.0 |
| NA |
|