We also observed that 12 TNFR family members ( p75TNFR , LTbetaR , RANK , HVEM , CD 40 , CD 30 , CD 27 , 4 1BB , GITR , BCMA , OX 40 , and TACI ) are each capable of activating the alternative NF kappaB pathway and conclude that TRAF 3 serves as a negative regulator of this pathway for all tested receptors . . ^^^