| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.59961266 |
| In addition , MafB forms heterodimers with 5 Maf and Fos through its zipper structure . 0.59961266^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Comparison of the sequence homologies of the proteins encoded by maf 1 and maf 2 with those of c maf and chicken mafB indicated that maf 1 and maf 2 are the rat homologues of mafB and c maf , respectively . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| We isolated two cellular maf related cDNAs , maf 1 ( mafB ) and maf 2 ( c maf ) , from rat and determined the specificities of DNA binding and heterodimer formation . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| MafA is able to bind to MARE sequence and to heterodimerize with 5 Maf , MafB , Jun and Fos , but not with the small MafF and MafK proteins . ^^^ |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| To elucidate the regulatory mechanisms underlying lens development , we searched for members of the large Maf family , which are expressed in the mouse lens , and found three , c Maf , MafB , and Nrl . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| In this study , the distribution of maf 1 genes , the rat homologues of mafB , was examined in rat kidneys at the embryonic stages from 13 days , gestation ( E 13 ) through E 21 and then 1 , 2 , 4 , and 8 weeks after birth by in situ hybridization with ( 35 ) S labeled antisense riboprobes . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Reflecting the high similarity of the bZip domain , all other Maf family members tested ( c / v Maf , MafB , MafK , MafF , and MafG ) also associated with the Hox proteins . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| We also analyzed the expression patterns of SMaf 1 and SMaf 2 ( Somite Maf 2 ) / Krml2 as well as MafB / Val and c Maf during zebrafish embryogenesis . ^^^ In addition , the expression patterns of SMaf 2 and MafB in the blood forming regions , and those of c Maf and MafB in the lens cells showed spatial redundancy , although the temporal appearance of these genes at these sites differed . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Among the transcribed sequences in the vicinity of the breakpoints , an ectopic expression of the MAFB gene , which is located at 450 680 kb telomeric to one of the breakpoints and encodes a member of the MAF family basic region / leucine zipper transcription factor , was demonstrated to be associated with t ( 14 ; 20 ) . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Characterization of the chicken L Maf , MafB and c Maf in crystallin gene regulation and lens differentiation . ^^^ BACKGROUND : Members of the Maf family , including L Maf , MafB and c Maf , are `` basic region / leucine zipper ' ' ( bZIP ) transcription factors . ^^^ Recent studies reveal that L Maf , c Maf and MafB play key roles in vertebrate lens development . ^^^ In transient transfection assays with a reporter gene containing Maf responsive elements , MafB and c Maf activated higher levels of the reporter gene than L Maf . ^^^ However , L Maf transactivated the alphaA crystallin promoter as effectively as MafB and c Maf , and induced the expression of the endogenous delta crystallin gene more efficiently than the other two proteins . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| We have studied the expression of a human homologue of mafB ( maf 1 ) , a member of the family of large maf transcription factors . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| However , reverse transcription PCR analysis demonstrated that mouse islets express not only MafA but also other members of the large Maf family , specifically c Maf and MafB . ^^^ Because MafA , MafB , and c Maf were each capable of specifically binding to and activating insulin C 1 element mediated expression , our results suggest that all of these factors play a role in islet beta cell function . . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| The corresponding cellular protein , c Maf belongs to a family of related bZip proteins together with MafA and MafB . ^^^ In this paper , we compare the transactivation and cell transforming abilities of MafA and MafB along with two forms of the c Maf protein . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Expression of c maf and mafB genes in the skin during rat embryonic development . ^^^ The present study was performed to analyze expression of c maf 1 and mafB genes in skin of embryonic stages from 15 days onwards using in situ hybridization . ^^^ MafB showed similar expression patterns as c maf . ^^^ Our findings indicate that c maf and mafB are involved in embryonic development of epidermis and hair follicles . . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Here , we report studies on transcriptional regulation of mouse alphaB and gammaF crystallin promoters by specific combinations of Pax6 / Pax6 ( 5a ) , large Mafs ( MafA , MafB , c Maf , and NRL ) , Sox 1 , Sox 2 , Six 3 , and RARbeta / RXRbeta . ^^^ Regulation of alphaB crystallin was studied in the presence of lens epithelial factors Pax 6 , MafB , and RARbeta / RXRbeta , and lens fiber factors Pax 6 , MafA , c Maf , and NRL . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Distinct gene expression patterns have been found to be associated with different lesions : the overexpression of CCND 2 and genes involved in cell adhesion pathways was observed in cases with deregulated MAF and MAFB , whereas genes upregulated in cases with the t ( 4 ; 14 ) showed apoptosis related functions . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Translocations can directly dysregulate CCND 1 ( 11q13 ) or CCND 3 ( 6p21 ) , or MAF ( 16q23 ) or MAFB ( 20q11 ) transcription factors that target CCND 2 . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Our phylogenetic analysis shows that , in osteichthyans , the large Maf family contains four orthology classes , MafA , MafB , c Maf and Nrl , which have emerged in vertebrates prior to the split between actinopterygians and sarcopterygians . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that p 38 also phosphorylates MafB and c Maf . ^^^ |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Nearly half of tumors are nonhyperdiploid , and mostly have one of five recurrent IgH translocations : 16 % 11q13 ( CCN D 1 ) , 3 % 6p21 ( CCN D 3 ) , 5 % 16q23 ( MAF ) , 2 % 20q12 ( MAFB ) , and 15 % 4p16 ( FGFR 3 and MMSET ) . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| We show that MafA and c Maf are potent oncogenes in chicken embryo fibroblasts , while MafB appears weaker . ^^^ Unlike 5 Jun , MafA , MafB and c Maf did not show oncogenic activity in these cells . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| We previously found that c maf and mafB are strongly expressed in hypertrophic chondrocytes during cartilage development . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Ectopically expressed large Maf factors , MafA , MafB , or cMaf , induced expression from insulin and glucagon reporter constructs , demonstrating a redundancy in their function . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| MafA and c maf positive cells were more diffusely localized in pancreatic tissue with fewer mafB positive cell clusters scattered throughout . ^^^ MafA , mafB , and c maf coexpressed with insulin positive cells , and c maf coexpressed with glucagon positive cells in adult porcine pancreas based on the results of a double staining study . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| Other large Maf transcription factors , MafB and c Maf , also express and activate insulin transcription in beta cells . ^^^ |
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| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| MafB is a member of the large Maf family of transcription factors that share similar basic region / leucine zipper DNA binding motifs and N terminal activation domains . ^^^ |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Q3 and O75444 |
Pubmed |
SVM Score :0.0 |
| NA |
|