| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Glutamate receptor interacting protein ( GRIP ) binds to the C terminus of the glutamate receptor 2 ( GluR 2 ) subunit of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) receptors in vitro and may play an important role in the synaptic organization of these receptors . ^^^ Double labeling revealed that GRIP and GluR 2 were colocalized in Purkinje cells but not in Golgi cells . ^^^ GRIP was especially prominent in a subset of GluR 2 containing cells that also expressed a high level of GluR 1 . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Our immunoprecipitation experiment revealed that the phosphorylation of serine 880 in GluR 2 drastically reduced the affinity for glutamate receptor interacting protein ( GRIP ) , a synaptic PDZ domain containing protein , in vitro and in HEK cells . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| AMPA receptor subunits GluR 2 and GluR 3 interact via their cytoplasmic C termini with PDZ domain containing proteins such as GRIP ( glutamate receptor interacting protein ) , but the functional significance of these interactions is unclear . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| This phosphorylation is accompanied by both a reduction in the affinity of GluR 2 to glutamate receptor interacting protein ( GRIP ) , a molecule known to be critical for AMPA receptor clustering , and a significant disruption of postsynaptic GluR 2 clusters . ^^^ Moreover , GluR 2 protein released from GRIP is shown to be internalized . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Mutagenesis reveals a role for ABP / GRIP binding to GluR 2 in synaptic surface accumulation of the AMPA receptor . ^^^ We studied the role of PDZ proteins GRIP , ABP , and PICK 1 in GluR 2 AMPA receptor trafficking . ^^^ We conclude that the association of GluR 2 with ABP and / or GRIP but not PICK 1 is essential for maintaining the synaptic surface accumulation of the receptor , possibly by limiting its endocytotic rate . . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Here we show that PKC phosphorylation of the AMPA receptor GluR 2 subunit differentially modulates its interaction with the PDZ domain containing proteins GRIP 1 and PICK 1 . ^^^ In vitro binding and coimmunoprecipitation studies show that phosphorylation of serine 880 within the GluR 2 PDZ ligand significantly decreases GluR 2 binding to GRIP 1 but not to PICK 1 . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Because glutamate receptor interacting protein ( GRIP ) may also anchor GluR 2 , we studied the relative distribution of ABP and GRIP . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| We investigated the role of PDZ proteins ( GRIP , ABP , and PICK 1 ) interacting with the C terminal GluR 2 by infusing a ct GluR 2 peptide ( `` pep 2 SVKI ' ' ) into CA 1 pyramidal neurons in hippocampal slices using whole cell recordings . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of this residue causes significant reduction in the affinity of GluR 2 C terminal tail for glutamate receptor interacting protein ( GRIP ) , a molecule known to be crucial for AMPA receptor clustering . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| More importantly , calpain activation resulted in the disruption of GRIP binding to the GluR 2 subunit of alpha amino 3 hydroxy 5 methylisoxazole 4 propionate ( AMPA ) receptors . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| PICK 1 also reduces the plasma membrane levels of the GluR 2 subunit , consistent with a targeting function of PICK 1 and a PKC facilitated release of GluR 2 from the synaptic anchoring proteins ABP and GRIP . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| The multiple PSD 95 , Dlg , and Zo 1 ( PDZ ) domain protein , glutamate receptor interacting protein ( GRIP ) , is involved in the clustering and trafficking of the alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate receptor by directly binding to the cytoplasmic tail of the receptor ' s GluR 2 subunit . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that phosphorylation of Ser 880 on the AMPA receptor GluR 2 subunit differentially regulated the interaction of GluR 2 with the PDZ domain containing proteins GRIP 1 and PICK 1 . ^^^ Here , we show that induction of LTD in hippocampal slices increases phosphorylation of Ser 880 within the GluR 2 C terminal PDZ ligand , suggesting that the modulation of GluR 2 interaction with GRIP 1 and PICK 1 may regulate AMPA receptor internalization during LTD . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Two papers in this issue of Neuron add a new dimension to our understanding of liprin and LAR RPTP function during synapse formation . present evidence that Dliprin alpha interacts with Dlar to regulate presynaptic morphogenesis of the Drosophila neuromuscular junction . demonstrate that mammalian liprin alpha 1 forms a complex with the PDZ protein GRIP and LAR in both pre and postsynaptic compartments of hippocampal neurons and is required for the clustering of the GluR 2 glutamate receptor in dendritic spines . . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| AMPA receptor binding protein ( ABP ) and glutamate receptor interacting protein ( GRIP ) are two similar PDZ ( postsynaptic density 95 / Discs large / zona occludens 1 ) proteins that interact with glutamate receptors 2 and 3 ( GluR 2 and GluR 3 ) subunits . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Here , we study the roles of proteins [ N ethylmaleimide sensitive fusion protein ( NSF ) , glutamate receptor AMPAR binding protein ( ABP ) interacting protein ( GRIP ) / ( ABP ) , and protein interacting with C kinase 1 ( PICK 1 ) that interact with the GluR 2 subunit in the control of the surface expression and cycling of AMPARs . ^^^ Conversely , the behavior of the GluR 2 mutants incapable of binding to GRIP / ABP suggests that these PDZ proteins play a role in the stabilization of an intracellular pool of AMPARs that have been internalized on stimulation , thus inhibiting their recycling to the synaptic membrane . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Purification of small synaptic vesicles through controlled pore glass chromatography , revealed that both GluR 2 and GluR 1 , but not the GluR 2 interacting protein GRIP , copurify with synaptic vesicles . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| The GluR 2 subunit of the AMPA receptor binds to a number of intracellular adapter proteins including GRIP , PICK 1 and NSF , which may link the receptor to proteins with signalling , scaffolding and other roles . ^^^ We implicate for the first time a possible role for GRIP , PICK 1 and NSF in neuropathic sensitisation from experiments with cell permeable blocking peptides mimicking their GluR 2 interaction motifs and also demonstrate differential changes in expression of these proteins following peripheral nerve injury . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| The data also demonstrated significant differences in the abundances of mRNAs encoding GluR 1 4 subunits ( GluR 2 > GluR 3 > GluR 1 > GluR 4 ) and of AMPAR binding proteins ( SAP 97 > PICK 1 > GRIP > ABP ) in both diagnostic groups . ^^^ Small but significant differences in the amounts of GluR 2 , GluR 3 , and GRIP mRNAs were detected between the two cortical areas : more GluR 3 and GRIP but less GluR 2 were detected in the DLPFC than in the occipital cortex . . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Interactions between NEEP 21 , GRIP 1 and GluR 2 regulate sorting and recycling of the glutamate receptor subunit GluR 2 . ^^^ Here we show by biochemical and atomic force microscopy analyses that NEEP 21 , a neuronal endosomal protein necessary for receptor recycling including AMPAR , is associated with the scaffolding protein GRIP 1 and the AMPAR subunit GluR 2 . ^^^ Expression of a NEEP 21 fragment containing the GRIP 1 binding site decreases surface GluR 2 levels and delays recycling of internalized GluR 2 , which accumulates in early endosomes and lysosomes . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| Co immunoprecipitation from rat brains showed that transgenic GRIP 1 is in complex with the endogenous GluR 2 subunit of AMPA receptors . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| AMPAR surface expression involves interactions between the GluR 2 carboxy tail and various proteins including glutamate receptor interacting protein ( GRIP ) , AMPA receptor binding protein ( ABP ) , protein interacting with C kinase 1 ( PICK 1 ) , N ethyl maleimide sensitive fusion protein ( NSF ) . ^^^ Internalization of pep 2 SVKI to prevent GluR 2 GRIP / ABP / PICK1 interactions potentiated the AMPA evoked release of [ 3H ] NA but left unmodified that of [ 3H ] ACh . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| GRIP 1 is known to bind to the GluRB subunit of the AMPA glutamate receptor expressed by subpopulations of neurons and immature glial cells . ^^^ A complex of NG 2 , GRIP 1 , and GluRB can be precipitated from transfected mammalian cells and from cultures of primary oligodendrocytes . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| A recently identified intracellular partner of AN2 / NG2 is the glutamate receptor interacting protein GRIP , which binds to the GluRB subunit of the AMPA subclass of glutamate receptors . ^^^ |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42262 and Q9Y3R0 |
Pubmed |
SVM Score :0.0 |
| NA |
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