| Interacting proteins: Q9Y3R0 and P35222 |
Pubmed |
SVM Score :0.74839219 |
| While beta catenin can bind directly to both AR and Lef 1 , GRIP 1 can only bind directly to AR ; the ability of GRIP 1 to associate with and function as a coactivator for Lef 1 is entirely dependent on the presence of beta catenin . 0.74839219^^^ |
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| Interacting proteins: Q9Y3R0 and P35222 |
Pubmed |
SVM Score :1.1962288 |
| The multifunctional oncoprotein beta catenin interacts with the activation function 2 domain of androgen receptor ( AR ) to stimulate androgen receptor transcriptional activity , increase sensitivity , and broaden specificity of ligand interactions . beta Catenin interacts with androgen receptor in close proximity to the binding groove for P 160 coactivators such as transcriptional intermediary factor 2 ( TIF 2 ) / glucocorticoid receptor interacting protein 1 ( GRIP 1 ) . beta Catenin can also bind directly to TIF2 / GRIP1 . 1.1962288^^^ |
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| Interacting proteins: Q9Y3R0 and P35222 |
Pubmed |
SVM Score :0.0 |
| Cadherin , beta catenin and GluR2 / 3 are tyrosine phosphoproteins that coimmunoprecipitate with liprin alpha and GRIP from rat brain extracts . ^^^ |
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| Interacting proteins: Q9Y3R0 and P35222 |
Pubmed |
SVM Score :0.0 |
| Differential use of functional domains by coiled coil coactivator in its synergistic coactivator function with beta catenin or GRIP 1 . beta Catenin , a pivotal component of the Wnt signaling pathway , binds to and serves as a transcriptional coactivator for the T cell factor / lymphoid enhancer factor ( TCF / LEF ) family of transcriptional activator proteins and for the androgen receptor ( AR ) , a nuclear receptor . ^^^ Three components of the p 160 nuclear receptor coactivator complex , including CARM 1 , p300 / CBP , and GRIP 1 ( one of the p 160 coactivators ) , bind to and cooperate with beta catenin to enhance transcriptional activation by TCF / LEF and AR . ^^^ CoCoA uses different domains to bind GRIP 1 and beta catenin , and it uses different domains to transmit the activating signal to the transcription machinery , depending on whether it is bound to GRIP 1 or beta catenin . ^^^ |
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| Interacting proteins: Q9Y3R0 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
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