| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| We have now mapped a gene , Snrpn , encoding a brain enriched small nuclear ribonucleoprotein ( snRNP ) associated polypeptide SmN , to mouse chromosome 7 in a region of homology with human chromosome 15q11 13 and demonstrated that Snrpn is a maternally imprinted gene in mouse . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The snRNP core protein SmB and tissue specific SmN protein are differentially distributed between snRNP particles . ^^^ To investigate the function of SmN , its localisation within different snRNP particles was investigated using a range of anti snRNP monoclonal antibodies . ^^^ SmN and SmB were found to exhibit different patterns of association with snRNP particles in two cell lines , ND 7 and F 9 which express SmN . ^^^ In both cases , SmN was found to be present in the U 2 snRNP but was excluded from the U 1 snRNPs whereas SmB was present in both U 1 and U 2 snRNPs . ^^^ Taken together , the results suggest that the pre U 1 snRNP particle has a lower affinity for SmN than for SmB . ^^^ |
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| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| These findings suggest a role for SMN and SIP 1 in spliceosomal snRNP biogenesis and function and provide a likely molecular mechanism for the cause of SMA . . ^^^ The spinal muscular atrophy disease gene product , SMN , and its associated protein SIP 1 are in a complex with spliceosomal snRNP proteins . ^^^ We found that SMN is tightly associated with a novel protein , SIP 1 , and together they form a specific complex with several spliceosomal snRNP proteins . ^^^ SMN interacts directly with several of the snRNP Sm core proteins , including B , D 1 3 , and E . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Defects in spliceosomal snRNP biogenesis may , therefore , be the cause of SMA . . ^^^ The SMN SIP 1 complex has an essential role in spliceosomal snRNP biogenesis . ^^^ The SMN protein is tightly associated with a novel protein , SIP 1 , and together they form a complex with several spliceosomal snRNP proteins . ^^^ Antibodies directed against the SMN SIP 1 complex strongly interfere with the cytoplasmic assembly of the common ( Sm ) snRNP proteins with spliceosomal snRNAs and with the import of the snRNP complex into the nucleus . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The SMN protein has a role in spliceosomal snRNP biogenesis and has therefore been implicated indirectly in general cellular RNA processing due to its unique sub nuclear localization within structures termed ' gems ' , which co localize with spliceosomal factors within coiled bodies . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN interacts with spliceosomal snRNP proteins and is critical for snRNP assembly in the cytoplasm . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In addition to La and Ro 52 , proteins in the small nuclear ribonucleoprotein ( snRNP ) particles such as SmA , SmB , SmD , and 70 kD U 1 RNP were unexpectedly identified as targeted antigens . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Recent work indicates the involvement of the SMN protein and its associated protein SIP 1 in spliceosomal snRNP biogenesis . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Furthermore , pICln prevents the interaction of Sm proteins with the survival of motor neurons ( SMN ) protein , an interaction that has been shown to be critical for snRNP biogenesis . ^^^ These findings lead us to propose a model in which pICln participates in the regulation of snRNP biogenesis , at least in part by interfering with Sm protein interaction with SMN protein . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In the nucleus , SMN is present in large foci called gems , the function of which is not yet known , while cytoplasmic SMN has been implicated in snRNP biogenesis . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Moreover , we show that SMN , but not mutants found in SMA patients , can form large oligomers and that SMN oligomerization is required for high affinity binding to spliceosomal snRNP Sm proteins . ^^^ These findings directly link the impaired interaction between SMN and Sm proteins to a defect in snRNP metabolism and to SMA . . ^^^ SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins . ^^^ The SMN protein interacts with itself , with SMN interacting protein 1 , and with several spliceosomal small nuclear ribonucleoprotein ( snRNP ) Sm proteins . ^^^ A complex containing SMN plays a critical role in spliceosomal snRNP assembly and in pre mRNA splicing . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Thus , our data show that SMN is an essential U snRNP assembly factor and establish a direct correlation between defects in the biogenesis of U snRNPs and SMA . . ^^^ Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly : implications for spinal muscular atrophy . ^^^ Although it is clear that SIP 1 as a component of this complex is essential for spliceosomal uridine rich small ribonucleoprotein ( U snRNP ) assembly , the role of SMN and its functional interactions with SIP 1 and Sm proteins are poorly understood . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The spinal muscular atrophy disease gene product , SMN : A link between snRNP biogenesis and the Cajal ( coiled ) body . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In the cytoplasm , SMN and SIP 1 interact with the Sm core proteins of spliceosomal small nuclear ribonucleoproteins ( snRNPs ) , and they play a critical role in snRNP assembly . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In the cytoplasm , the SMN complex is associated with snRNP Sm core proteins and plays a critical role in spliceosomal snRNP assembly . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN has been shown previously to play a role in both snRNP biogenesis and mRNA processing , although direct evidence for the relationship between SMN and disease pathology has not been elucidated . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The spinal muscular atrophy protein , SMN , is a cytoplasmic protein that is also found in distinct nuclear structures called `` gems . ' ' Gems are closely associated with nuclear coiled bodies and both may have a direct role in snRNP maturation and pre RNA splicing . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The spinal muscular atrophy disease gene product ( SMN ) is crucial for small nuclear ribonuclear protein ( snRNP ) biogenesis in the cytoplasm and plays a role in pre mRNA splicing in the nucleus . ^^^ SMN oligomers interact avidly with the snRNP core proteins SmB , D 1 , and D 3 . ^^^ This suggests that SMN also functions in the assembly of the U 6 snRNP in the nucleus and in the assembly of other Lsm containing complexes . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The survival motor neuron ( SMN ) protein and the SMN interacting protein 1 ( SIP 1 ) are part of a 300 kD protein complex with a crucial role in snRNP biogenesis and pre mRNA splicing . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The SMN protein plays a crucial role in the assembly of spliceosomal uridine rich small nuclear ribonucleoprotein ( U snRNP ) complexes via binding to the spliceosomal Sm core proteins . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN is part of an 800 kDa macromolecular complex that plays an essential role in snRNP biogenesis and pre mRNA splicing . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In addition , overexpression of a truncated form of SMN shown to induce a modified subcellular localization and to exert a dominant negative effect on snRNP biogenesis and RNA splicing in HeLa cells was ineffective in modifying both localization and survival in motoneurons . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN , the affected protein in spinal muscular atrophy ( SMA ) , is a cytoplasmic protein that also occurs in nuclear structures called `` gems ' ' and is involved in snRNP maturation . ^^^ SMN , the affected protein in spinal muscular atrophy ( SMA ) , is a cytoplasmic protein that also occurs in nuclear structures called `` gems ' ' and is involved in snRNP maturation . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN binds the arginine and glycine rich ( RG ) domains of the snRNP proteins SmD 1 and SmD 3 . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Confocal microscopy demonstrated colocalization of ZNF 265 with the motor neuron gene product SMN , the snRNP protein U 1 70K , the SR protein SC 35 , and with the transcriptosomal components p 300 and YY 1 . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Our data demonstrate that full length coilin is essential for proper formation and / or maintenance of CBs and that recruitment of snRNP and SMN complex proteins to these nuclear subdomains requires sequences within the coilin COOH terminus . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN and its associated proteins Gemin 2 , Gemin 3 , and Gemin 4 form a large complex that plays a role in snRNP assembly , pre mRNA splicing , and transcription . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Tudor domain missense mutations , including one found in an SMA patient , impair the interaction between SMN and fibrillarin ( as well as the common snRNP protein SmB ) . ^^^ Our results suggest a function for SMN in small nucleolar RNP biogenesis ( akin to its known role as an snRNP assembly factor ) and reveal a potential link between small nucleolar RNP biogenesis and SMA . . ^^^ SMN has been shown to function in spliceosomal small nuclear ribonucleoprotein ( snRNP ) biogenesis and pre mRNA splicing . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN is in a complex with several proteins , including Gemin 2 , Gemin 3 and Gemin 4 , and it plays important roles in small nuclear ribonucleoprotein ( snRNP ) biogenesis and in pre mRNA splicing . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Recently , biochemical studies resulted in identification of the 38kDa survival motor neuron ( SMN ) protein , probably involved in the biogenesis of spliceosomal snRNP . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The survival motor neuron ( SMN ) protein , the spinal muscular atrophy disease gene product , is crucial for snRNP core particle assembly in vivo . ^^^ Together with previous results , these data indicate that methylation of Sm proteins by the methylosome directs Sm proteins to the SMN complex for assembly into snRNP core particles and suggest that the methylosome can regulate snRNP assembly . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Gemin 5 interacts with several of the snRNP core proteins including SmB , SmD 1 , SmD 2 , SmD 3 , and SmE , suggesting that it participates in the activities of the SMN complex in snRNP assembly . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The methylosome functions to modify specific arginines to dimethylarginines in the arginine and glycine rich domains of several spliceosomal Sm proteins , and this modification targets these proteins to the survival of motor neurons ( SMN ) complex for assembly into small nuclear ribonucleoprotein ( snRNP ) core particles . ^^^ Interestingly , all of the known components of the methylosome bind Sm proteins , suggesting that in addition to producing properly methylated substrates for the SMN complex , the methylosome may be involved in Sm protein rearrangements or pre assembly required for snRNP biogenesis . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| These data indicate that the level of snRNP protein expression and snRNP assembly , rather than the expression levels of p 80 coilin or SMN , may be a key trigger for Cajal body formation . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Substitution of three nucleotides in the SL 1 loop ( SL1A3 ) abolishes SMN interaction , and the corresponding U 1 snRNA ( U1A3 ) is impaired in U 1 snRNP biogenesis . ^^^ Microinjection of excess SL 1 but not SL1A3 into Xenopus oocytes inhibits SMN complex binding to U 1 snRNA and U 1 snRNP assembly . ^^^ These findings indicate that SMN complex interaction with SL 1 is sequence specific and critical for U 1 snRNP biogenesis , further supporting the direct role of the SMN complex in RNP biogenesis . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Reduced Smn / Gemin2 protein levels lead to disturbed U snRNP assembly as indicated by reduced nuclear accumulation of Sm proteins . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN , the spinal muscular atrophy protein , forms a pre import snRNP complex with snurportin 1 and importin beta . ^^^ Therefore , we conclude that , following Sm protein assembly , the SMN complex persists until the final stages of cytoplasmic snRNP maturation and may provide somatic cell RNPs with an alternative NLS . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Here , we identify three distinct cytoplasmic SMN complexes , each representing a defined intermediate in the snRNP biogenesis pathway . ^^^ Finally , the SMN complex is associated with a preimport complex containing m ( 3 ) G capped snRNP cores bound to the snRNP nuclear import mediator snurportin 1 . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The SMN protein is important in small nuclear ribonucleoprotein ( snRNP ) assembly and interacts with snRNP proteins via arginine / glycine rich domains . ^^^ Finally , we have found that unlike the interaction of SMN with the Sm snRNP proteins , interaction with GAR 1 and fibrillarin is not enhanced by arginine dimethylation . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Essential role for the SMN complex in the specificity of snRNP assembly . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN 1 interacts with multiple proteins with functions in snRNP biogenesis , pre mRNA splicing and presumably neural transport . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In most cell types , CBs coincide with nuclear gems , which contain the survival of motor neurons ( SMN ) complex , an essential snRNP assembly factor . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| RNAs contain specific SMN binding domains that are essential for snRNP assembly . ^^^ A specific domain unique to U 1 snRNA , stem loop 1 ( SL 1 ) , is required for SMN complex binding and U 1 snRNP Sm core assembly . ^^^ Furthermore , the SMN complex binding domain and the Sm site are both necessary and sufficient for Sm core assembly and their relative positions are critical for snRNP assembly . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Through its binding to specific sequences in the snRNAs , the SMN complex surveys the correct identity of the target RNAs and facilitates snRNP assembly . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| A large macromolecular complex containing the survival of motor neurons ( SMN ) protein is required for proper snRNP assembly in vivo . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Moreover this structure has important consequences for snRNP assembly that is mediated by two complexes containing the PRMT 5 methyltransferase and the SMN ( survival of motor neurons ) protein , respectively . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Despite the presence of SMN in both the nucleus and cytoplasm , we find that only the latter promotes efficient SMN mediated U snRNP assembly activity . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Biochemical studies have established that the SMN protein plays an important role in spliceosomal small nuclear ribonucleoprotein ( snRNP ) biogenesis and that the SMN complex can interact with the zinc finger protein ZPR 1 . ^^^ Specifically , SMN localization to Cajal bodies and gems was not observed in cells derived from Zpr 1 / embryos and the amount of cytoplasmic snRNP detected in Zpr 1 / embryos was reduced compared with that in wild type embryos . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| We show that the reduction of SMN leads to a decrease in snRNP assembly , the disappearance of Gems , and to a drastic reduction in the amounts of several Gemins . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Unrip is a component of SMN complexes active in snRNP assembly . ^^^ These results demonstrate that unrip functions in the pathway of snRNP biogenesis and is a marker of cellular SMN complexes active in snRNP assembly . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Coilin , the CB marker protein , may participate in snRNP biogenesis given that it can interact with snRNPs and SMN . ^^^ SMN is crucial for snRNP assembly and is the protein mutated in the neurodegenerative disease Spinal Muscular Atrophy . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Complete depletion of the SMN complex from cell extracts abolishes snRNP assembly , the formation of heptameric Sm cores on snRNAs . ^^^ To address this , we developed a sensitive and quantitative assay for snRNP assembly , the formation of high salt and heparin resistant stable Sm cores , that is strictly dependent on the SMN complex . ^^^ Consistent with this , pulse labeling experiments demonstrate a significant reduction in the rate of snRNP biogenesis in low SMN cells . ^^^ Furthermore , extracts of cells from spinal muscular atrophy patients have a lower capacity for snRNP assembly that corresponds directly to the reduced amount of SMN . ^^^ Thus , SMN determines the capacity for snRNP biogenesis , and our findings provide evidence for a measurable deficiency in a biochemical activity in cells from patients with spinal muscular atrophy . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| SMN is involved in snRNP transport and nuclear RNA splicing , but axonal transport of SMN has also been shown to occur in motor neurons . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| The marker protein for CBs , coilin , may play a role in snRNP biogenesis given that it can interact with snRNPs and SMN , the protein mutated in Spinal Muscular Atrophy . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Nuclear transport assays showed that this IBB mutant is deficient for snRNP import but that import can be rescued by addition of purified survival of motor neurons ( SMN ) protein complexes . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Spliceosomal Uridine rich small ribonucleo protein ( U snRNP ) assembly is an active process mediated by the macromolecular survival motor neuron ( SMN ) complex . ^^^ Our data identify unrip as the first component of the U snRNP assembly machinery that associates with the SMN complex in a compartment specific way . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In HeLa cells , we show that reduction of SMN to levels found in SMA patients impairs U snRNP assembly . ^^^ Previous studies have assigned SMN to uridine rich small nuclear ribonucleoprotein particle ( U snRNP ) assembly , splicing , transcription , and RNA localization . ^^^ Here , we have used gene silencing to assess the effect of SMN protein deficiency on U snRNP metabolism in living cells and organisms . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Although the SMN complex has the potential to control the pathway of snRNP biogenesis , it is not known whether SMN function in snRNP assembly is regulated . ^^^ Strikingly , however , SMN function in snRNP assembly in extracts does not correlate with its expression levels and it varies greatly both among tissues and during development . ^^^ Using model cell systems and pulse labeling experiments , we further show that SMN activity and snRNP synthesis are strongly downregulated upon neuronal as well as myogenic differentiation , and linked to the rate of global transcription of postmitotic neurons and myotubes . ^^^ These results demonstrate that the SMN complex activity in snRNP assembly is regulated and point to a differential requirement for SMN function during development and cellular differentiation . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Our results also demonstrate that Cajal body homeostasis requires SMN and ongoing snRNP biogenesis . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| These findings demonstrate that the SMN complex is the identifier , as well as assembler , of the abundant class of snRNAs in cells because it is able to recognize an snRNP code that they contain . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Gemin 8 is also associated with Sm proteins , and Gemin 8 containing SMN complexes are competent to carry out snRNP assembly . ^^^ Importantly , RNA interference experiments indicate that Gemin 8 knock down impairs snRNP assembly , and Gemin 8 expression is down regulated in cells with low levels of SMN . ^^^ These results demonstrate that Gemin 8 is a novel integral component of the SMN complex and extend the repertoire of cellular proteins involved in the pathway of snRNP biogenesis . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In this article , we have used an RNA interference approach in order to analyse the effects of SMN depletion on snRNP assembly in HeLa cells . ^^^ Although snRNP profiles are not perturbed in SMN depleted cells , we found that SMN depletion gives rise to cytoplasmic accumulation of a GFP SmB reporter protein . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| Gemin 5 therefore functions as the factor that allows the SMN complex to distinguish snRNAs from other cellular RNAs for snRNP biogenesis . . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| In cultured motor neurons , SMN granules colocalized with ribonucleoprotein Gemin proteins but not spliceosomal Sm proteins needed for snRNP assembly . ^^^ |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y333 and Q16637 |
Pubmed |
SVM Score :0.0 |
| NA |
|