| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| Conservation of coding and transcriptional control sequences within the snRNP E protein gene . ^^^ The snRNP E protein is one of several proteins associated with the U family of small nuclear RNAs that are involved in RNA processing . ^^^ Isolation and characterization of the snRNP E protein cDNA sequences from mouse and chicken revealed a 100 % conservation of the predicted amino acid sequence when compared to that of the human homologue . ^^^ Further characterization of a genomic clone for the mouse snRNP E protein gene revealed that the 5 ' untranslated region and the immediate 5 ' upstream region have also been highly conserved : 72 and 70 % , respectively . ^^^ Conserved 5 ' regions include multiple copies of the CTTCCG hexamer sequence which are involved in regulating transcription of the human snRNP E protein gene . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| Specifically , the seventh intron of the human Gi 3 alpha gene contains a fusion of a partial snRNP E protein pseudogene to a variant U 6 snRNA gene . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| The 5 ' upstream region of the small nuclear ribonucleoprotein E protein ( snRNP E ) gene has multiple sequence similarities to elements found to be integral in the transcriptional regulation of some mouse ribosomal protein genes ( G + C block , CTTCCG motifs ) as well as U 1 snRNA genes ( U 1 `` B , ' ' U 1 `` D , ' ' and SPH enhancers ) . ^^^ Furthermore , the immediate upstream region of the snRNP E protein gene lacks typical TATA and CAAT sequence motifs but contains one copy of a GC box characteristic of a housekeeping promoter . ^^^ By transfection of constructs containing various amounts of the 5 ' upstream region of the snRNP E protein gene linked to the bacterial gene for chloramphenicol acetyl transferase ( CAT ) , we determined that the 5 ' boundary of sequence needed for transcription was within the first 153 nucleotides upstream of the transcription start site . ^^^ This suggests that the direct repeats of the CTTCCG hexamer sequence play a key role in transcriptional regulation of the snRNP E protein gene . . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| In addition to the snRNP E protein gene , two other snRNP components the U 1 RNA true multigene family and a group of class 1 U 1 pseudogenes are located on human chromosome 1 . . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| The complete primary structure of the human snRNP E protein . ^^^ The snRNP E protein is one of four `` core ' ' proteins associated with the snRNAs of the U family ( U 1 , U 2 , U 4 , U 5 , and U 6 ) . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| Two of the genes , U 6 and S 13 , overlap while another two genes , snRNP E and clpP , are cotranscribed in a single mRNA . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| Genes for the snRNP proteins U 1 70K , U 1 A , Sm B ' / B , Sm D 1 and Sm E have been isolated from various metazoan species . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| Analysis of genes for human snRNP Sm D 1 protein and identification of the promoter sequence which shows segmental homology to the promoters of Sm E and U 1 snRNA genes . ^^^ Sequence comparison of the 0 . 38 kb promoter sequence with the promoters of the Sm E gene and U 1 snRNA genes revealed several homologous motifs , suggesting that genes encoding the snRNP components may be coordinately regulated . . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| Despite the large size of the GFP tag , GFP fusions to both the core snRNP SmE and U 1 specific U1A proteins assemble into snRNP particles and give an identical nuclear localization pattern to their endogenous counterparts . ^^^ |
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| Interacting proteins: Q9Y333 and P62304 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Gemin 5 interacts with several of the snRNP core proteins including SmB , SmD 1 , SmD 2 , SmD 3 , and SmE , suggesting that it participates in the activities of the SMN complex in snRNP assembly . ^^^ |
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