| Interacting proteins: Q9Y2Y9 and Q92793 |
Pubmed |
SVM Score :0.89025578 |
| FKLF 2 interacts with both CBP and PCAF through specific domains , and CBP and PCAF acetylate FKLF 2 . 0.89025578^^^ |
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| Interacting proteins: Q9Y2Y9 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF 13 activity . ^^^ We have shown that both CBP / p300 and PCAF stimulate the transcriptional activation by KLF 13 , a member of the KLF / Sp1 family , either individually or cooperatively . ^^^ Here we further investigated how CBP and PCAF acetylation regulate KLF 13 activity , and how these two co activators functionally interplay in the regulation of KLF 13 activity . ^^^ We found that CBP and PCAF acetylated KLF 13 at specific lysine residues in the zinc finger domain of KLF 13 . ^^^ The acetylation by CBP , however , resulted in disruption of KLF 13 DNA binding . ^^^ |
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| Interacting proteins: Q9Y2Y9 and Q92793 |
Pubmed |
SVM Score :0.0 |
| To further investigate the functional roles of these protein interaction domains in CBP / p300 regulation , we have identified multiple domains of CBP that interact with FKLF 2 and the CH 2 domain as a new p 53 interacting domain of CBP . ^^^ Functional studies demonstrate that several domains of CBP are capable of stimulating FKLF 2 and p 53 DNA binding . ^^^ |
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