| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.71142631 |
| Although only a minute fraction of total cellular Cul 1 is modified by Nedd 8 , the Cul 1 associated with ectopically expressed betaTrCP was highly enriched for the Nedd 8 conjugated form . 0.71142631^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| We have found that one human Fbp , beta Trcp ( beta Transducin repeat containing protein ) , does indeed form a novel SCF with human Skp 1 and Cul 1 . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| ROC 1 , a novel SCF associated protein , is recruited by cullin 1 to form a quatemary SCFHOS ROC 1 holenzyme ( with Skp 1 and the beta TRCP homolog HOS ) . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| The SCF complex containing Skp 1 , Cul 1 , and the F box protein FWD 1 ( the mouse homologue of Drosophila Slimb and Xenopus beta TrCP ) functions as the ubiquitin ligase for IkappaBalpha . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| The IkappaB alpha ubiquitin ligase activity associated with phosphorylated IkappaB alpha ( pIkappaB alpha ) in HeLa cells was almost completely lost by washing under stringent conditions including 1 M NaCl ; nevertheless , an SCF ( betaTrCP ) complex containing Skp 1 , Cullin 1 , and F box / WD40 protein betaTrCP was still bound to pIkappaB alpha , suggesting the existence of a putative factor that is loosely associated with pIkappaB alpha and may collaborate with SCF ( betaTrCP ) . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Following CK 2 dependent phosphorylation both UBC3B and UBC 3 bind to the F box protein beta TrCP , the substrate recognition subunit of an SCF ( Skp 1 , Cul 1 , F box ) ubiquitin ligase . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| An activated SCF complex , a heterotetramer ( Skp 1 , Cul 1 , beta TrCP [ F box protein ] , and ROC 1 ) involved with ubiquitination , is also required for iNOS NO ( . ) induction . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| By engineering a chimeric protein with the beta catenin binding domain of E cadherin fused to betaTrCP ubiquitin protein ligase , the stable beta catenin mutant was recruited to the cellular SCF ( Skp 1 , Cullin 1 , and F box containing substrate receptor ) ubiquitination machinery for ubiquitination and degradation . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Here we show that the engineered Skp 1 , Cullin 1 , and F box containing betaTrCP substrate receptor ubiquitin proteolytic system , designated protein knockout , could achieve not only total elimination but also rapid and systematic reduction of a given cellular protein . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| IkappaB alpha ubiquitination is catalyzed by the E 3 SCF ( betaTrCP ) ubiquitin ligase , which is itself regulated via covalent modification of the cullin 1 subunit by the ubiquitin like protein NEDD 8 . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Considered with evidence that the distinct Cullin 1 based SCF ( beta TrCP ) complex regulates beta catenin stability , our data on the stability of Dishevelled demonstrates that two distinct ubiquitin ligase complexes regulate the Wnt beta catenin pathway . . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| An E 3 ubiquitin ligase complex ROC 1 SCF ( Fbw1a ) consisting of ROC 1 , Skp 1 , Cullin 1 , and Fbw1a ( also termed betaTrCP 1 ) induces ubiquitination of Smad 3 . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| In addition , SKP 1 and CUL 1 of the SCF ( FWD 1 ) complex are also unstable in the mutant . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Other components of the SCF ( FWD 1 ) complex , SKP 1 and CUL 1 are also unstable in the mutant . ^^^ |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y297 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|