| Interacting proteins: Q9Y297 and P84022 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta facilitates beta TrCP mediated degradation of Cdc25A in a Smad 3 dependent manner . ^^^ Here we demonstrate that the transforming growth factor beta ( TGF beta ) Smad 3 pathway promotes SCF ( beta TrCP ) mediated Cdc25A ubiquitination . ^^^ TGF beta induced ubiquitination is associated with Cdc25A phosphorylation at the beta TrCP docking site ( DS82G motif ) and physical association of Cdc25A with Smad 3 and beta TrCP . ^^^ Smad 3 siRNA inhibits beta TrCP Cdc25A interaction and Cdc25A degradation in response to TGF beta . beta TrCP 2 siRNA also inhibits Smad 3 induced Cdc25A degradation . ^^^ |
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| Interacting proteins: Q9Y297 and P84022 |
Pubmed |
SVM Score :0.0 |
| An E 3 ubiquitin ligase complex ROC 1 SCF ( Fbw1a ) consisting of ROC 1 , Skp 1 , Cullin 1 , and Fbw1a ( also termed betaTrCP 1 ) induces ubiquitination of Smad 3 . ^^^ Smad 3 bound to ROC 1 SCF ( Fbw1a ) is then exported from the nucleus to the cytoplasm for proteasomal degradation . ^^^ |
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