| Interacting proteins: Q9Y297 and P48729 |
Pubmed |
SVM Score :0.0 |
| In spite of the fact that CKI epsilon was found as a positive regulator of the Wnt pathway , mutational analysis suggests that mutation of Ser 45 regulates beta catenin stability by inhibiting the ability of GSK 3 to phosphorylate Ser 33 and 37 , thereby disrupting the interaction between beta catenin , beta TRCP and Axin . 1 propose that phosphorylation of Ser 45 by CKI epsilon plays an important role in regulating beta catenin stability . . ^^^ |
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| Interacting proteins: Q9Y297 and P48729 |
Pubmed |
SVM Score :0.0 |
| It is established that Ser 45 phosphorylation by casein kinase 1 ( CKI ) initiates phosphorylation at Thr 41 , Ser 37 , and Ser 33 by glycogen synthase kinase 3 ( GSK 3 ) and that phosphorylated Ser 37 and Ser 33 are recognized by the F box protein beta TrCP , a component of a ubiquitin ligase complex that mediates beta catenin degradation . ^^^ |
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| Interacting proteins: Q9Y297 and P48729 |
Pubmed |
SVM Score :0.0 |
| Our results support a simple model whereby PKA triggers a cascade of Gli 3 phosphorylation by GSK3beta and CK 1 that leads to direct betaTrCP binding and ubiquitination by SCFbetaTrCP . ^^^ |
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| Interacting proteins: Q9Y297 and P48729 |
Pubmed |
SVM Score :0.0 |
| NA |
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