| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.57775993 |
| Interactions of BAFF ( B cell activating factor ) with BAFF R , one of three BAFF binding receptors that are preferentially expressed on B cells , are essential for B cell development , because defects in either the ligand or the receptor arrest progression from immature type 1 B cells to type 2 cells and mature cells ; B 1 B cells are unaffected . 0.57775993^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :1.0658769 |
| In addition , NHL B cells express BAFF receptor , which binds BAFF , as well as transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag ( BCMA ) , which bind both BAFF and APRIL . 1.0658769^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.83245957 |
| In addition , BAFF specifically binds BAFF receptor , whereas the nature of a postulated APRIL specific receptor remains elusive . 0.83245957^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.97051477 |
| Using soluble , monomeric forms of the receptors , we demonstrate that BAFFR binds BAFF with K ( D ) approximately 16 nM , while BCMA binds with K ( D ) approximately 1 . 6 microM , indicating a approximately 100 fold selectivity for binding to BAFFR over BCMA . 0.97051477^^^ |
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| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| In a Perspective , Waldschmidt and Noelle discuss new findings showing that the TNF family ligand BAFF and its receptor BAFF R are crucial for selecting transitional B cells into the mature B cell pool ( Thompson et al . , Schiemann et al . ) . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The B cell activating factor BAFF ( BlyS / TALL 1 / zTNF4 ) is a tumor necrosis factor ( TNF ) related ligand that promotes B cell survival and binds to three receptors ( BCMA , TACI , and the recently described BAFF R ) . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF is known to interact with three receptors , BCMA , TACI and BAFF R , that have distant similarities with other receptors of the TNF family . ^^^ The BAFF structure was further used to generate a homology model of APRIL , a closely related TNF family ligand that also binds to BCMA and TACI , but not BAFF R . ^^^ Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA , TACI and BAFF R . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TALL 1 is a member of the tumor necrosis factor family that binds to BCMA , TACI , and BAFF R , three receptors mostly expressed by mature B lymphocytes . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We show here that B cell activating factor ( BAFF ) activates this second pathway and that this requires the BAFF receptor ( BAFF R ) , the NF kappa B inducing kinase ( NIK ) and protein synthesis , but not NEMO . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL share two receptors , TACI and BCMA , whereas a third receptor , BAFF R , specifically binds BLyS . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Finally , three membrane receptors ( TACI , BCMA , and BAFF R ) which bind a newly discovered member of the tumor necrosis factor family named BAFF . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TALL 1 has three receptors , including BCMA , TACI , and BAFF R , which are mostly expressed by B lymphocytes . ^^^ Gene knockout studies have indicated that BAFF R is the major stimulatory receptor for TALL 1 signaling and is required for normal B cell development . ^^^ Coimmunoprecipitation experiments indicated that BAFF R interacts with TRAF 3 in B lymphoma cells and this interaction is stimulated by TALL 1 treatment . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Crystal structure of the BAFF BAFF R complex and its implications for receptor activation . ^^^ Its biological role is mediated by the specific receptors BCMA , TACI and BAFF R . ^^^ We have determined the crystal structure of the extracellular domain of BAFF R bound to BAFF at a resolution of 3 . 3 A . ^^^ The cysteine rich domain ( CRD ) of the BAFF R extracellular domain adopts a beta hairpin structure and binds to the virus like BAFF cage in a 1 : 1 molar ratio . ^^^ The conserved DxL motif of BAFF R is located on the tip of the beta turn and is indispensable in the binding of BAFF . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF is a critical survival / maturation factor for peripheral B cells and this activity is mediated through a BAFF specific receptor , BAFF R . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Comparison of soluble decoy IgG fusion proteins of BAFF R and BCMA as antagonists for BAFF . ^^^ Fc fusion decoy receptors , BCMA Fc and BAFF R Fc , are therapeutic candidates for blocking BAFF . ^^^ While studying their interactions with BAFF , we found that BAFF R Fc is more effective than BCMA Fc for blocking BAFF binding to its receptors . ^^^ We also found that a trimeric BAFF can bind more than one BAFF R Fc but only one BCMA Fc . ^^^ Moreover , we show that , in contrast to monovalent BAFF R Fc , monovalent BCMA does not form stable complexes with BAFF . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , only one of which , BAFF R , does not cross react with the BAFF related ligand APRIL . ^^^ The survival function of BAFF on B cells is mediated mainly by BAFF R and is particularly effective in transitional B cells . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF exerts its effect by binding to three receptors transmembrane activator of and CAML interactor ( TACI ) , B cell maturation antigen ( BCMA ) , and BAFF receptor ( BAFF R ) . ^^^ The altered responsiveness of activated memory B cells to CD40L and BAFF correlated with changes in surface phenotype such that expression of CD 40 and BAFF R were reduced on ISCs while BCMA was induced . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Two signaling pathways known to be essential for progression from immature to mature B cells are BAFF receptor ( BAFF R ) and the B cell receptor ( BCR ) . ^^^ Here , we first show that phospholipase C ( PLC ) gamma 2 is required for a BAFF R mediated survival signal . ^^^ Then , we have examined the question of whether the reduced number of mature B cells in PLC gamma 2 / mice is caused by a defect in either BCR or BAFF R signaling . ^^^ Therefore , our data suggest that the BAFF R mediated survival signal , provided by PLC gamma 2 , is not sufficient to promote B cell maturation , and that , in addition , activation of PLC gamma 2 by BCR is required for B cell development . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| They interact with 3 receptors : BAFF R , specific to BAFF ; and TACI and BCMA , which are shared by BAFF and APRIL . ^^^ TACI and BAFF R mRNAs were found in leukemic B cells . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| All MM cells studied expressed one or more of 3 known receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and CAML interactor [ TACI ] , and B cell activating factor receptor [ BAFF R ] ) for BLyS ; however , the pattern of expression was variable . ^^^ Expression of BCMA , TACI , and BAFF R by MM taken together with the ability of BLyS to support MM cell growth and survival has exciting implications because they may be potential therapeutic targets . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| It binds to three different receptors , BCMA , TACI , and BAFF R , which are all members of the family of TNF receptors . ^^^ Defects in the genes encoding BAFF or BAFF R abolish the generation of mature B cells . ^^^ BAFF is made by myeloid cells whereas BAFF R is expressed preferentially on B cells . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Normal induction but attenuated progression of germinal center responses in BAFF and BAFF R signaling deficient mice . ^^^ A BAFF receptor expressed by B cells ( BAFF R / BR3 ) is defective in A / WySnJ mice which exhibit a phenotype similar to BAFF deficient ( BAFF / ) animals . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Both GTPases were required to transduce BCR signals leading to proliferation , survival and up regulation of BAFF R , a receptor for BAFF , a key survival molecule required for B cell development and maintenance . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Soluble recombinant chBAFF produced by human 293T cells interacted with the mammalian cell surface receptors TACI , BCMA and BAFF R . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Since CD21 / 35 and CD 23 are inadequate for delineating B cell subpopulations in BAFF null mice , we used expression of BAFF R and several B cell markers to identify more mature splenic B cells in these mice . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The tumour necrosis factor ( TNF ) ligand TALL 1 and its cognate receptors , BCMA , TACI and BAFF R , were recently identified as members of the TNF superfamily , which are essential factors contributing to B cell maturation . ^^^ Sequence alignments , structural modelling and mutagenesis revealed that one disulphide bridge in BAFF R is critical for determining the binding specificity of the extracellular domain eBAFF R to TALL 1 instead of APRIL , a closely related ligand of TALL 1 , which was confirmed by binding experiments in vitro . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , BAFF R , transmembrane activator and CAML interactor ( TACI ) , and B cell maturation antigen ( BCMA ) , but only BAFF R is required for successful survival and maturation of splenic B cells . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors ( BCMA , TACI , and BAFF R ) for BLyS ; however , the pattern of expression was variable . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Three receptors have been identified that bind to BAFF : transmembrane activator , calcium modulator , and cyclophilin ligand interactor ( TACI ) ; B cell maturation Ag ( BCMA ) ; and BAFF R . ^^^ Recently , it was shown that A / WySnJ mice , which contain a dramatically reduced peripheral B cell compartment due to decreased B cell life span , express a mutant BAFF R . ^^^ This finding , together with normal or enhanced B cell generation in mice deficient for BCMA or TACI , respectively , suggested that the interaction of BAFF with BAFF R triggers signals essential for the generation and maintenance of mature B cells . ^^^ Residual signaling through the mutant BAFF R could account for these differences . ^^^ Alternatively , dominant negative interference by the mutant receptor could lead to an overestimation of the importance of BAFF R . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The TNF related ligand , B cell activating factor belonging to the TNF family ( BAFF ) , is necessary for normal B cell development and survival , and specifically binds the receptors transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , B cell maturation Ag ( BCMA ) , and BAFF R . ^^^ Similarities between mice completely lacking BAFF and A / WySnJ strain mice that express a naturally occurring mutant form of BAFF R suggest that BAFF acts primarily through BAFF R . ^^^ However , the nearly full length BAFF R protein expressed by A / WySnJ mice makes unambiguous interpretation of receptor function in these animals impossible . ^^^ Using homologous recombination we created mice completely lacking BAFF R and compared them directly to A / WySnJ mice and to mice lacking BAFF . ^^^ BAFF R null mice exhibit loss of mature B cells similar to that observed in BAFF ( / ) and A / WySnJ mice . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Increased expression of BCMA , a weak TNFSF receptor for B lymphocyte stimulator ( BLyS ) , on CD 21 ( low ) B cells was associated with a concomitant reduction in the expression of the more potent BLyS receptor , BAFF R , that resulted in reduced BLyS binding and BLyS mediated survival . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF binding to T cell expressed BAFF R costimulates T cell proliferation and alloresponses . ^^^ Binding of the TNF family member , B cell activating factor ( BAFF ) , to its receptor ( BAFF R , TNFRSF13C ) is required for generation and maintenance of mature B cells , but there are no data as to any role for the BAFF / BAFF R pathway in T cell functions . ^^^ We report that the binding of BAFF to BAFF R expressed by a subset of primarily CD 4 ( + ) T cells costimulates T cell activation and allo proliferation in vitro and in vivo , and that mice with a mutation in the BAFF R , or with a targeted deletion of BAFF , show prolonged cardiac allograft survival as compared to wild type or transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) ( / ) controls . ^^^ Taken together , these data indicate the BAFF / BAFF R pathway contributes to both T and B cell responses and may be an attractive target for control of acute and chronic allograft rejection . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Increased expression of BCMA , a weak TNFSF receptor for B lymphocyte stimulator ( BLyS ) , on CD 21 ( low ) B cells was associated with a concomitant reduction in the expression of the more potent BLyS receptor , BAFF R , that resulted in reduced BLyS binding and BLyS mediated survival . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| A BAFF specific receptor ( BAFF R ; BR 3 ) appears to mediate these functions via activation of the NF kappaB 2 pathway . ^^^ Signaling by the BAFF R is also required to sustain the germinal center ( GC ) reaction . ^^^ Engagement of this receptor results in the induction of Bcl 2 , suggesting that this antiapoptotic factor acts downstream of the BAFF R and NF kappaB 2 pathway to promote peripheral B cell survival during primary and Ag driven development . ^^^ To test this idea , we created lines of mice coexpressing a Bcl 2 transgene and a signaling deficient form of the BAFF R derived from the B lymphopenic A / WySnJ strain . ^^^ These results suggest that the BAFF R and Bcl 2 regulate key and nonoverlapping aspects of peripheral B cell survival and development . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor belonging to the TNF family receptor ( BAFF R ) , a member of the TNFR superfamily , plays a role in autoimmunity after ligation with BAFF ligand ( also called TALL 1 , BLyS , THANK , or zTNF 4 ) . ^^^ BAFF / BAFF R interactions are critical for B cell regulation , and signaling from this ligand receptor complex results in NF kappaB activation . ^^^ However , BAFF R binds only one TRAF adaptor , TRAF 3 , and this interaction negatively regulates activation of NF kappaB . ^^^ In this study , we report the crystal structure of a 24 residue fragment of the cytoplasmic portion of BAFF R bound in complex with TRAF 3 . ^^^ The recognition motif ( 162 ) PVPAT ( 166 ) in BAFF R is accommodated in the same binding crevice on TRAF 3 that binds two related TNFRs , CD 40 and LTbetaR , but is presented in a completely different structural framework . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TACI and BAFF R mediate isotype switching in B cells . ^^^ In addition , BAFF engages a third receptor on B cells , BAFF R . ^^^ To determine the role of these receptors in isotype switching , we examined B cells from mice deficient in TACI , BCMA , and BAFF R . ^^^ The results obtained indicate that both TACI and BAFF R are able to transduce signals that result in isotype switching . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The enhanced protection of B cells afforded by IFN gamma / TNF alpha treated FLS was inhibited by the addition of BAFF R : Fc fusion protein . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF also affects T cell function through binding to one of the BAFF receptors , BAFF R . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Also , the viability of CLL B cells cultured with NLCs was significantly reduced when CLL B cells were cultured with decoy receptor of B cell maturation antigen ( BCMA ) , which can bind both BAFF and APRIL , but not with BAFF receptor : Fc ( BAFF R : Fc ) , which binds only to BAFF . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , BAFF R , TACI and BCMA , whereas APRIL interacts with TACI , BCMA and proteoglycans . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of human BAFF receptor TNFRSF13C ( BAFF R ) in patients with common variable immunodeficiency . ^^^ BAFF receptor ( BAFF R / BR3 / TNFRSF13C ) is a recently identified molecule that specifically binds BLyS , a protein belonging to the tumor necrosis factor ( TNF ) family , and is involved in survival and maturation of B cells . ^^^ Recent studies have demonstrated that mice defective in BAFF R gene exhibit an altered profile of the B cell pool , a phenotype observed in BLyS knockout mice as well . ^^^ To test this hypothesis , we sequenced the BAFF R gene in 48 patients with common variable immunodeficiency ( CVID ) along with 57 healthy controls . ^^^ These variants do not affect the expression of BAFF R neither at the mRNA nor at the protein level , suggesting that these variants represent novel polymorphic variants of the BAFF R gene . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Here we review approaches to antagonise members of the CD 28 B7 superfamily as well as the TNF receptor ligand superfamily members , BAFF and APRIL , and their corresponding receptors on B cells ( BAFF R , TACI and BCMA ) . ^^^ Thus , the recent discovery of deletions in the ICOS , BAFF R and TACI genes leading to disturbances in late B cell differentiation and hypogammaglobulinaemia underline the potential impact of targeting these molecules for therapeutic strategies in autoimmune disorders . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ Using specific antibodies , we have investigated the expression of BAFF R on human tonsillar B cells and their functional roles in naive and germinal center ( GC ) B cell differentiation . ^^^ Our studies show that BAFF R is the dominant receptor on naive B cells . ^^^ BAFF R expression increased initially and then decreased with a corresponding induction of TACI and BCMA expression during differentiation to plasma cells ( PCs ) . ^^^ Consistently , blocking of BAFF R alone with specific mAb inhibited GC B cell proliferation and PC generation in the early period of their differentiation , whereas depletion of BAFF with TACI Ig exhibited consistent inhibition throughout the differentiation . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| A comparative analysis of hybrid receptors of TNFR 2 fused to the cytoplasmic domains of APRIL / BAFF receptors found that only BCMA , but not transmembrane activator and calcium modulator and cyclophilin ligand interactor or BAFF R , is capable of activating Ag presentation . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF R , the major B cell activating factor receptor , is expressed on most mature B cells and B cell lymphoproliferative disorders . ^^^ B cell activating factor receptor ( BAFF R ) is one of three known receptors for BAFF , a critical regulator of B and T cell function . ^^^ In mice , BAFF R is required for B cell maturation and survival , and in mice and humans , the overproduction of BAFF is associated with autoimmune disease . ^^^ We sought to determine the normal pattern of BAFF R expression at specific stages of B and T cell development and whether this pattern of expression corresponds with related B and T cell neoplasms . ^^^ Most circulating human B cells and a small subset of T cells are BAFF R positive . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF is a ligand for three TNF receptor superfamily members : B cell maturation antigen ( BCMA ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , and BAFF receptor ( BAFF R ) . ^^^ Among them , BAFF R plays the central role in the BAFF system , whereas TACI plays the inhibitory role . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Malignant B cells were found to bind soluble BLyS and variably express the receptors BAFF R , TACI , and BCMA . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Antibodies to the receptors BAFF R , BCMA , and TACI were used to define expression of the individual BLyS receptors on subsets of B cells in blood , spleen , and tonsils . ^^^ Targeting BLyS as a therapeutic strategy will require overcoming the persistent binding of BLyS to BAFF R . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI , BCMA , and BAFF R , which are expressed by mature B cells . ^^^ Syndecan 2 bound TACI but bound neither BAFF R nor BCMA . ^^^ This is the first identification of ligands that selectively activate TACI without simultaneously triggering BCMA or BAFF R . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Although A strain mice have been reported to have an insertion in BAFF R , the receptor for BAFF ( B cell activation factor from the tumor necrosis factor family ) , which could explain our results , A . ^^^ SW mice have no mutations in BAFF R . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| It also requires signaling through BAFF and the BAFF receptor ( BAFF R ) , and is negatively regulated by protein kinase Cdelta ( PKCdelta ) . ^^^ In PKCdelta deficient mice , B cell maturation occurs independently of the BAFF receptor ( BAFF R ) , indicating that BAFF R signaling promotes maturation by inhibiting the negative function of PKCdelta . ^^^ This indicates that BASH mediated BCR signaling primarily controls B cell survival and maturation , with BAFF R signaling and its inhibition of PKCdelta acting as a secondary regulator . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to 3 TNF R receptors , TACI , BCMA , BAFF R , to regulate B cell survival , differentiation , and proliferation . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Although human APRIL does not interact with BAFF R , the shorter variant of mouse APRIL exhibits weak but detectable binding to mouse BAFF R . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND AND OBJECTIVES : We explored the expression of LCK and BAFF R ( B cell activating factor receptor ) both of which are known to play a role in signaling and apoptosis , in routine tissue biopsies . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor belonging to the TNF family ( BAFF ) and its receptor BAFF R play critical roles in the maturation and survival of conventional peripheral B cells . ^^^ However , they appeared to be dispensable for the generation and maintenance of CD 5 ( + ) B 1 cells as BAFF ( / ) and BAFF R ( / ) mice have normal B 1 cell populations . ^^^ We show here that BAFF R and transmembrane activator and CAML interactor ( TACI ) are the major receptors expressed by B 1 cells . ^^^ This costimulatory effect is achieved primarily through BAFF R as BAFF failed to costimulate B 1 cells obtained from A / WySnJ mice which have defective BAFF R signaling . ^^^ B cell activating factor belonging to the TNF family ( BAFF ) and its receptor BAFF R play critical roles in the maturation and survival of conventional peripheral B cells . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| In hyperplastic thymi , macrophages expressed APRIL and BAFF , and germinal center B cells , BAFF R . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS , a TNF family member , is crucial for B cell proliferation and differentiation by acting through its three receptors , TACI , BCMA and BAFF R . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The maintenance of mature B cells hinges on signals emitted from the BAFF R cell surface receptor , but the nature of these signals is incompletely understood . ^^^ Inhibition of canonical NF kappaB transcription factor activity through ablation of the essential scaffold protein NEMO arrests B cell development at the same stage as BAFF R deficiency . ^^^ Correspondingly , activation of this pathway by constitutively active IkappaB Kinase 2 renders B cell survival independent of BAFF R : BAFF interactions and prevents proapoptotic PKCdelta nuclear translocation . ^^^ In addition , canonical NF kappaB activity mediates differentiation and proper localization of follicular and marginal zone B cells in the absence of BAFF R , but not CD 19 . ^^^ By replacing BAFF R signals , constitutive canonical NF kappaB signaling , a hallmark of various B cell lymphomas , causes accumulation of resting B cells and promotes their proliferation and survival upon activation , but does not per se induce lymphomagenesis . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The expression of BAFF receptor appeared to be restricted to B cells . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Recent studies on BAFF , a member of the tumor necrosis factor family , and the discovery of a new BAFF receptor have revealed that this ligand receptor pair is essential for B cell survival and differentiation , holding promise for a better understanding and treatment of some autoimmune diseases and lymphomas . . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Heightened expression of B cell maturation antigen ( BCMA ) , and lowered expression of transmembrane activator and cyclophilin ligand interactor and BAFF receptor in PCs relative to resting B cells suggests a vital role of BCMA in PC survival . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we have found that the Expi accelerated apoptosis is mediated via BAFF receptor among three known BAFF receptors : BAFF receptor , tumor necrosis factor ( TNF ) receptor homologue TACI ( transmembrane activator and CAML interactor ) , and BCMA ( another TNFR homologue , B cell maturation antigen ) . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| When placed in a diverse B cell compartment , BAFF receptor engagement and signaling are reduced and the autoantigen binding cells are unable to protect themselves from Bim and possibly other death promoting factors induced by chronic BCR signaling . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We , therefore , analyzed the effect of B cell antigen receptor ( BCR ) and BAFF receptor ( BAFF R ) engagement on the regulation of A 1 in total B 220 ( + ) cells but also FACS sorted immature T 1 , T 2 and M B cells . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF receptor ( BAFFR ) is a member of the TNF receptor ( TNFR ) superfamily that regulates the survival and maturation of B cells . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TACItly changing tunes : farewell to a yin and yang of BAFF receptor and TACI in humoral immunity . ^^^ PURPOSE OF REVIEW : The complex system of the tumour necrosis factor ligands BAFF and APRIL and their three receptors BCMA , TACI and BAFF receptor and its role in B cell development and function is the objective of extensive research . ^^^ Whereas the importance of BAFF / BAFF receptor interactions for B cell survival could be clearly demonstrated , TACI is believed to counteract BAFF activity as a negative regulator in the murine model . ^^^ The recent discovery of genetic defects in the tumour necrosis factor receptor superfamily members TACI and BAFF receptor in patients with common variable immunodeficiency denotes further advances in this field . ^^^ SUMMARY : In this review we will discuss recent progress made in the understanding of the BAFF / APRIL TACI / BCMA / BAFF receptor system in relation to the recent discovery that mutations in human TACI cause a primary humoral immunodeficiency . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The expression of BAFF receptor ( BAFFR ) on CD19+ B cells was assessed by flow cytometry . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Biacore measurements established that the affinity of Ala 134 BAFF for the BAFF receptor BAFFR / BR3 is similar to that of myc Gln 136 BAFF , which is exclusively trimeric in solution . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF and APRIL bind to BAFF receptor and TACI and are major B cell survival factors . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| In contrast to CD 40 , BAFF receptor , TLR 4 , and TLR 9 mediated signaling , stimulation of splenic B cells via the BCR was not observed to induce expression of HSH 2 unless the cells had been stimulated previously through CD 40 . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Here we report the identification of a third BLyS receptor ( BR 3 ; BLyS receptor 3 ) . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Signaling through one of the BLyS receptors , BLyS receptor 3 ( BR 3 ) , controls B cell numbers in two ways : by varying the proportion of cells that complete transitional B cell development and by serving as the primary determinant of mature B cell longevity . ^^^ |
|
| Interacting proteins: Q96RJ3 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Decreased survival is accompanied by hyporesponsiveness to the B cell survival factor BLyS ( also termed BAFF ) , decreased expression of the BLyS receptor 3 ( BR 3 ) , and altered regulation of PKCdelta nuclear accumulation . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.57775993 |
| Interactions of BAFF ( B cell activating factor ) with BAFF R , one of three BAFF binding receptors that are preferentially expressed on B cells , are essential for B cell development , because defects in either the ligand or the receptor arrest progression from immature type 1 B cells to type 2 cells and mature cells ; B 1 B cells are unaffected . 0.57775993^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :1.0658769 |
| In addition , NHL B cells express BAFF receptor , which binds BAFF , as well as transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag ( BCMA ) , which bind both BAFF and APRIL . 1.0658769^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.97051477 |
| Using soluble , monomeric forms of the receptors , we demonstrate that BAFFR binds BAFF with K ( D ) approximately 16 nM , while BCMA binds with K ( D ) approximately 1 . 6 microM , indicating a approximately 100 fold selectivity for binding to BAFFR over BCMA . 0.97051477^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.83245957 |
| In addition , BAFF specifically binds BAFF receptor , whereas the nature of a postulated APRIL specific receptor remains elusive . 0.83245957^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| The expression of BAFF receptor appeared to be restricted to B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| In a Perspective , Waldschmidt and Noelle discuss new findings showing that the TNF family ligand BAFF and its receptor BAFF R are crucial for selecting transitional B cells into the mature B cell pool ( Thompson et al . , Schiemann et al . ) . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| The B cell activating factor BAFF ( BlyS / TALL 1 / zTNF4 ) is a tumor necrosis factor ( TNF ) related ligand that promotes B cell survival and binds to three receptors ( BCMA , TACI , and the recently described BAFF R ) . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Recent studies on BAFF , a member of the tumor necrosis factor family , and the discovery of a new BAFF receptor have revealed that this ligand receptor pair is essential for B cell survival and differentiation , holding promise for a better understanding and treatment of some autoimmune diseases and lymphomas . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF is known to interact with three receptors , BCMA , TACI and BAFF R , that have distant similarities with other receptors of the TNF family . ^^^ The BAFF structure was further used to generate a homology model of APRIL , a closely related TNF family ligand that also binds to BCMA and TACI , but not BAFF R . ^^^ Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA , TACI and BAFF R . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| We show here that B cell activating factor ( BAFF ) activates this second pathway and that this requires the BAFF receptor ( BAFF R ) , the NF kappa B inducing kinase ( NIK ) and protein synthesis , but not NEMO . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Finally , three membrane receptors ( TACI , BCMA , and BAFF R ) which bind a newly discovered member of the tumor necrosis factor family named BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Crystal structure of the BAFF BAFF R complex and its implications for receptor activation . ^^^ Its biological role is mediated by the specific receptors BCMA , TACI and BAFF R . ^^^ We have determined the crystal structure of the extracellular domain of BAFF R bound to BAFF at a resolution of 3 . 3 A . ^^^ The cysteine rich domain ( CRD ) of the BAFF R extracellular domain adopts a beta hairpin structure and binds to the virus like BAFF cage in a 1 : 1 molar ratio . ^^^ The conserved DxL motif of BAFF R is located on the tip of the beta turn and is indispensable in the binding of BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF is a critical survival / maturation factor for peripheral B cells and this activity is mediated through a BAFF specific receptor , BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , only one of which , BAFF R , does not cross react with the BAFF related ligand APRIL . ^^^ The survival function of BAFF on B cells is mediated mainly by BAFF R and is particularly effective in transitional B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF exerts its effect by binding to three receptors transmembrane activator of and CAML interactor ( TACI ) , B cell maturation antigen ( BCMA ) , and BAFF receptor ( BAFF R ) . ^^^ The altered responsiveness of activated memory B cells to CD40L and BAFF correlated with changes in surface phenotype such that expression of CD 40 and BAFF R were reduced on ISCs while BCMA was induced . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Two signaling pathways known to be essential for progression from immature to mature B cells are BAFF receptor ( BAFF R ) and the B cell receptor ( BCR ) . ^^^ Here , we first show that phospholipase C ( PLC ) gamma 2 is required for a BAFF R mediated survival signal . ^^^ Then , we have examined the question of whether the reduced number of mature B cells in PLC gamma 2 / mice is caused by a defect in either BCR or BAFF R signaling . ^^^ Therefore , our data suggest that the BAFF R mediated survival signal , provided by PLC gamma 2 , is not sufficient to promote B cell maturation , and that , in addition , activation of PLC gamma 2 by BCR is required for B cell development . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF and APRIL bind to BAFF receptor and TACI and are major B cell survival factors . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| They interact with 3 receptors : BAFF R , specific to BAFF ; and TACI and BCMA , which are shared by BAFF and APRIL . ^^^ TACI and BAFF R mRNAs were found in leukemic B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| It binds to three different receptors , BCMA , TACI , and BAFF R , which are all members of the family of TNF receptors . ^^^ Defects in the genes encoding BAFF or BAFF R abolish the generation of mature B cells . ^^^ BAFF is made by myeloid cells whereas BAFF R is expressed preferentially on B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Comparison of soluble decoy IgG fusion proteins of BAFF R and BCMA as antagonists for BAFF . ^^^ Fc fusion decoy receptors , BCMA Fc and BAFF R Fc , are therapeutic candidates for blocking BAFF . ^^^ While studying their interactions with BAFF , we found that BAFF R Fc is more effective than BCMA Fc for blocking BAFF binding to its receptors . ^^^ We also found that a trimeric BAFF can bind more than one BAFF R Fc but only one BCMA Fc . ^^^ Moreover , we show that , in contrast to monovalent BAFF R Fc , monovalent BCMA does not form stable complexes with BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| When placed in a diverse B cell compartment , BAFF receptor engagement and signaling are reduced and the autoantigen binding cells are unable to protect themselves from Bim and possibly other death promoting factors induced by chronic BCR signaling . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| We , therefore , analyzed the effect of B cell antigen receptor ( BCR ) and BAFF receptor ( BAFF R ) engagement on the regulation of A 1 in total B 220 ( + ) cells but also FACS sorted immature T 1 , T 2 and M B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Normal induction but attenuated progression of germinal center responses in BAFF and BAFF R signaling deficient mice . ^^^ A BAFF receptor expressed by B cells ( BAFF R / BR3 ) is defective in A / WySnJ mice which exhibit a phenotype similar to BAFF deficient ( BAFF / ) animals . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Both GTPases were required to transduce BCR signals leading to proliferation , survival and up regulation of BAFF R , a receptor for BAFF , a key survival molecule required for B cell development and maintenance . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Soluble recombinant chBAFF produced by human 293T cells interacted with the mammalian cell surface receptors TACI , BCMA and BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Since CD21 / 35 and CD 23 are inadequate for delineating B cell subpopulations in BAFF null mice , we used expression of BAFF R and several B cell markers to identify more mature splenic B cells in these mice . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Heightened expression of B cell maturation antigen ( BCMA ) , and lowered expression of transmembrane activator and cyclophilin ligand interactor and BAFF receptor in PCs relative to resting B cells suggests a vital role of BCMA in PC survival . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we have found that the Expi accelerated apoptosis is mediated via BAFF receptor among three known BAFF receptors : BAFF receptor , tumor necrosis factor ( TNF ) receptor homologue TACI ( transmembrane activator and CAML interactor ) , and BCMA ( another TNFR homologue , B cell maturation antigen ) . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , BAFF R , transmembrane activator and CAML interactor ( TACI ) , and B cell maturation antigen ( BCMA ) , but only BAFF R is required for successful survival and maturation of splenic B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Three receptors have been identified that bind to BAFF : transmembrane activator , calcium modulator , and cyclophilin ligand interactor ( TACI ) ; B cell maturation Ag ( BCMA ) ; and BAFF R . ^^^ Recently , it was shown that A / WySnJ mice , which contain a dramatically reduced peripheral B cell compartment due to decreased B cell life span , express a mutant BAFF R . ^^^ This finding , together with normal or enhanced B cell generation in mice deficient for BCMA or TACI , respectively , suggested that the interaction of BAFF with BAFF R triggers signals essential for the generation and maintenance of mature B cells . ^^^ Residual signaling through the mutant BAFF R could account for these differences . ^^^ Alternatively , dominant negative interference by the mutant receptor could lead to an overestimation of the importance of BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| The TNF related ligand , B cell activating factor belonging to the TNF family ( BAFF ) , is necessary for normal B cell development and survival , and specifically binds the receptors transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , B cell maturation Ag ( BCMA ) , and BAFF R . ^^^ Similarities between mice completely lacking BAFF and A / WySnJ strain mice that express a naturally occurring mutant form of BAFF R suggest that BAFF acts primarily through BAFF R . ^^^ However , the nearly full length BAFF R protein expressed by A / WySnJ mice makes unambiguous interpretation of receptor function in these animals impossible . ^^^ Using homologous recombination we created mice completely lacking BAFF R and compared them directly to A / WySnJ mice and to mice lacking BAFF . ^^^ BAFF R null mice exhibit loss of mature B cells similar to that observed in BAFF ( / ) and A / WySnJ mice . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF binding to T cell expressed BAFF R costimulates T cell proliferation and alloresponses . ^^^ Binding of the TNF family member , B cell activating factor ( BAFF ) , to its receptor ( BAFF R , TNFRSF13C ) is required for generation and maintenance of mature B cells , but there are no data as to any role for the BAFF / BAFF R pathway in T cell functions . ^^^ We report that the binding of BAFF to BAFF R expressed by a subset of primarily CD 4 ( + ) T cells costimulates T cell activation and allo proliferation in vitro and in vivo , and that mice with a mutation in the BAFF R , or with a targeted deletion of BAFF , show prolonged cardiac allograft survival as compared to wild type or transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) ( / ) controls . ^^^ Taken together , these data indicate the BAFF / BAFF R pathway contributes to both T and B cell responses and may be an attractive target for control of acute and chronic allograft rejection . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF also affects T cell function through binding to one of the BAFF receptors , BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Also , the viability of CLL B cells cultured with NLCs was significantly reduced when CLL B cells were cultured with decoy receptor of B cell maturation antigen ( BCMA ) , which can bind both BAFF and APRIL , but not with BAFF receptor : Fc ( BAFF R : Fc ) , which binds only to BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| A BAFF specific receptor ( BAFF R ; BR 3 ) appears to mediate these functions via activation of the NF kappaB 2 pathway . ^^^ Signaling by the BAFF R is also required to sustain the germinal center ( GC ) reaction . ^^^ Engagement of this receptor results in the induction of Bcl 2 , suggesting that this antiapoptotic factor acts downstream of the BAFF R and NF kappaB 2 pathway to promote peripheral B cell survival during primary and Ag driven development . ^^^ To test this idea , we created lines of mice coexpressing a Bcl 2 transgene and a signaling deficient form of the BAFF R derived from the B lymphopenic A / WySnJ strain . ^^^ These results suggest that the BAFF R and Bcl 2 regulate key and nonoverlapping aspects of peripheral B cell survival and development . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor belonging to the TNF family receptor ( BAFF R ) , a member of the TNFR superfamily , plays a role in autoimmunity after ligation with BAFF ligand ( also called TALL 1 , BLyS , THANK , or zTNF 4 ) . ^^^ BAFF / BAFF R interactions are critical for B cell regulation , and signaling from this ligand receptor complex results in NF kappaB activation . ^^^ However , BAFF R binds only one TRAF adaptor , TRAF 3 , and this interaction negatively regulates activation of NF kappaB . ^^^ In this study , we report the crystal structure of a 24 residue fragment of the cytoplasmic portion of BAFF R bound in complex with TRAF 3 . ^^^ The recognition motif ( 162 ) PVPAT ( 166 ) in BAFF R is accommodated in the same binding crevice on TRAF 3 that binds two related TNFRs , CD 40 and LTbetaR , but is presented in a completely different structural framework . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| TACI and BAFF R mediate isotype switching in B cells . ^^^ In addition , BAFF engages a third receptor on B cells , BAFF R . ^^^ To determine the role of these receptors in isotype switching , we examined B cells from mice deficient in TACI , BCMA , and BAFF R . ^^^ The results obtained indicate that both TACI and BAFF R are able to transduce signals that result in isotype switching . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| The enhanced protection of B cells afforded by IFN gamma / TNF alpha treated FLS was inhibited by the addition of BAFF R : Fc fusion protein . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF receptor ( BAFFR ) is a member of the TNF receptor ( TNFR ) superfamily that regulates the survival and maturation of B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , BAFF R , TACI and BCMA , whereas APRIL interacts with TACI , BCMA and proteoglycans . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ Using specific antibodies , we have investigated the expression of BAFF R on human tonsillar B cells and their functional roles in naive and germinal center ( GC ) B cell differentiation . ^^^ Our studies show that BAFF R is the dominant receptor on naive B cells . ^^^ BAFF R expression increased initially and then decreased with a corresponding induction of TACI and BCMA expression during differentiation to plasma cells ( PCs ) . ^^^ Consistently , blocking of BAFF R alone with specific mAb inhibited GC B cell proliferation and PC generation in the early period of their differentiation , whereas depletion of BAFF with TACI Ig exhibited consistent inhibition throughout the differentiation . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| A comparative analysis of hybrid receptors of TNFR 2 fused to the cytoplasmic domains of APRIL / BAFF receptors found that only BCMA , but not transmembrane activator and calcium modulator and cyclophilin ligand interactor or BAFF R , is capable of activating Ag presentation . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of human BAFF receptor TNFRSF13C ( BAFF R ) in patients with common variable immunodeficiency . ^^^ BAFF receptor ( BAFF R / BR3 / TNFRSF13C ) is a recently identified molecule that specifically binds BLyS , a protein belonging to the tumor necrosis factor ( TNF ) family , and is involved in survival and maturation of B cells . ^^^ Recent studies have demonstrated that mice defective in BAFF R gene exhibit an altered profile of the B cell pool , a phenotype observed in BLyS knockout mice as well . ^^^ To test this hypothesis , we sequenced the BAFF R gene in 48 patients with common variable immunodeficiency ( CVID ) along with 57 healthy controls . ^^^ These variants do not affect the expression of BAFF R neither at the mRNA nor at the protein level , suggesting that these variants represent novel polymorphic variants of the BAFF R gene . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Decreased survival is accompanied by hyporesponsiveness to the B cell survival factor BLyS ( also termed BAFF ) , decreased expression of the BLyS receptor 3 ( BR 3 ) , and altered regulation of PKCdelta nuclear accumulation . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Here we review approaches to antagonise members of the CD 28 B7 superfamily as well as the TNF receptor ligand superfamily members , BAFF and APRIL , and their corresponding receptors on B cells ( BAFF R , TACI and BCMA ) . ^^^ Thus , the recent discovery of deletions in the ICOS , BAFF R and TACI genes leading to disturbances in late B cell differentiation and hypogammaglobulinaemia underline the potential impact of targeting these molecules for therapeutic strategies in autoimmune disorders . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF R , the major B cell activating factor receptor , is expressed on most mature B cells and B cell lymphoproliferative disorders . ^^^ B cell activating factor receptor ( BAFF R ) is one of three known receptors for BAFF , a critical regulator of B and T cell function . ^^^ In mice , BAFF R is required for B cell maturation and survival , and in mice and humans , the overproduction of BAFF is associated with autoimmune disease . ^^^ We sought to determine the normal pattern of BAFF R expression at specific stages of B and T cell development and whether this pattern of expression corresponds with related B and T cell neoplasms . ^^^ Most circulating human B cells and a small subset of T cells are BAFF R positive . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| TACItly changing tunes : farewell to a yin and yang of BAFF receptor and TACI in humoral immunity . ^^^ PURPOSE OF REVIEW : The complex system of the tumour necrosis factor ligands BAFF and APRIL and their three receptors BCMA , TACI and BAFF receptor and its role in B cell development and function is the objective of extensive research . ^^^ Whereas the importance of BAFF / BAFF receptor interactions for B cell survival could be clearly demonstrated , TACI is believed to counteract BAFF activity as a negative regulator in the murine model . ^^^ The recent discovery of genetic defects in the tumour necrosis factor receptor superfamily members TACI and BAFF receptor in patients with common variable immunodeficiency denotes further advances in this field . ^^^ SUMMARY : In this review we will discuss recent progress made in the understanding of the BAFF / APRIL TACI / BCMA / BAFF receptor system in relation to the recent discovery that mutations in human TACI cause a primary humoral immunodeficiency . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BAFF is a ligand for three TNF receptor superfamily members : B cell maturation antigen ( BCMA ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , and BAFF receptor ( BAFF R ) . ^^^ Among them , BAFF R plays the central role in the BAFF system , whereas TACI plays the inhibitory role . ^^^ Furthermore , inhibition of BAFF by TACI Ig and BAFFR Ig has been successful in treating murine models of SLE and rheumatoid arthritis . ^^^ Thus , the dysregulation of BAFF / BAFF receptor system may contribute to induction and development of autoimmune diseases and become one of important therapeutic targets . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Biacore measurements established that the affinity of Ala 134 BAFF for the BAFF receptor BAFFR / BR3 is similar to that of myc Gln 136 BAFF , which is exclusively trimeric in solution . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| It also requires signaling through BAFF and the BAFF receptor ( BAFF R ) , and is negatively regulated by protein kinase Cdelta ( PKCdelta ) . ^^^ In PKCdelta deficient mice , B cell maturation occurs independently of the BAFF receptor ( BAFF R ) , indicating that BAFF R signaling promotes maturation by inhibiting the negative function of PKCdelta . ^^^ This indicates that BASH mediated BCR signaling primarily controls B cell survival and maturation , with BAFF R signaling and its inhibition of PKCdelta acting as a secondary regulator . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Although human APRIL does not interact with BAFF R , the shorter variant of mouse APRIL exhibits weak but detectable binding to mouse BAFF R . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| In contrast to CD 40 , BAFF receptor , TLR 4 , and TLR 9 mediated signaling , stimulation of splenic B cells via the BCR was not observed to induce expression of HSH 2 unless the cells had been stimulated previously through CD 40 . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI , BCMA , and BAFF R , which are expressed by mature B cells . ^^^ Syndecan 2 bound TACI but bound neither BAFF R nor BCMA . ^^^ This is the first identification of ligands that selectively activate TACI without simultaneously triggering BCMA or BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| The expression of BAFF receptor ( BAFFR ) on CD19+ B cells was assessed by flow cytometry . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Although A strain mice have been reported to have an insertion in BAFF R , the receptor for BAFF ( B cell activation factor from the tumor necrosis factor family ) , which could explain our results , A . ^^^ SW mice have no mutations in BAFF R . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor belonging to the TNF family ( BAFF ) and its receptor BAFF R play critical roles in the maturation and survival of conventional peripheral B cells . ^^^ However , they appeared to be dispensable for the generation and maintenance of CD 5 ( + ) B 1 cells as BAFF ( / ) and BAFF R ( / ) mice have normal B 1 cell populations . ^^^ We show here that BAFF R and transmembrane activator and CAML interactor ( TACI ) are the major receptors expressed by B 1 cells . ^^^ This costimulatory effect is achieved primarily through BAFF R as BAFF failed to costimulate B 1 cells obtained from A / WySnJ mice which have defective BAFF R signaling . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| In hyperplastic thymi , macrophages expressed APRIL and BAFF , and germinal center B cells , BAFF R . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| All MM cells studied expressed one or more of 3 known receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and CAML interactor [ TACI ] , and B cell activating factor receptor [ BAFF R ] ) for BLyS ; however , the pattern of expression was variable . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND AND OBJECTIVES : We explored the expression of LCK and BAFF R ( B cell activating factor receptor ) both of which are known to play a role in signaling and apoptosis , in routine tissue biopsies . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Increased expression of BCMA , a weak TNFSF receptor for B lymphocyte stimulator ( BLyS ) , on CD 21 ( low ) B cells was associated with a concomitant reduction in the expression of the more potent BLyS receptor , BAFF R , that resulted in reduced BLyS binding and BLyS mediated survival . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Increased expression of BCMA , a weak TNFSF receptor for B lymphocyte stimulator ( BLyS ) , on CD 21 ( low ) B cells was associated with a concomitant reduction in the expression of the more potent BLyS receptor , BAFF R , that resulted in reduced BLyS binding and BLyS mediated survival . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Here we report the identification of a third BLyS receptor ( BR 3 ; BLyS receptor 3 ) . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL share two receptors , TACI and BCMA , whereas a third receptor , BAFF R , specifically binds BLyS . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Signaling through one of the BLyS receptors , BLyS receptor 3 ( BR 3 ) , controls B cell numbers in two ways : by varying the proportion of cells that complete transitional B cell development and by serving as the primary determinant of mature B cell longevity . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| We found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors ( BCMA , TACI , and BAFF R ) for BLyS ; however , the pattern of expression was variable . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Malignant B cells were found to bind soluble BLyS and variably express the receptors BAFF R , TACI , and BCMA . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| The maintenance of mature B cells hinges on signals emitted from the BAFF R cell surface receptor , but the nature of these signals is incompletely understood . ^^^ Inhibition of canonical NF kappaB transcription factor activity through ablation of the essential scaffold protein NEMO arrests B cell development at the same stage as BAFF R deficiency . ^^^ Correspondingly , activation of this pathway by constitutively active IkappaB Kinase 2 renders B cell survival independent of BAFF R : BAFF interactions and prevents proapoptotic PKCdelta nuclear translocation . ^^^ In addition , canonical NF kappaB activity mediates differentiation and proper localization of follicular and marginal zone B cells in the absence of BAFF R , but not CD 19 . ^^^ By replacing BAFF R signals , constitutive canonical NF kappaB signaling , a hallmark of various B cell lymphomas , causes accumulation of resting B cells and promotes their proliferation and survival upon activation , but does not per se induce lymphomagenesis . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| Antibodies to the receptors BAFF R , BCMA , and TACI were used to define expression of the individual BLyS receptors on subsets of B cells in blood , spleen , and tonsils . ^^^ Targeting BLyS as a therapeutic strategy will require overcoming the persistent binding of BLyS to BAFF R . . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to 3 TNF R receptors , TACI , BCMA , BAFF R , to regulate B cell survival , differentiation , and proliferation . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| BLyS , a TNF family member , is crucial for B cell proliferation and differentiation by acting through its three receptors , TACI , BCMA and BAFF R . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| TALL 1 is a member of the tumor necrosis factor family that binds to BCMA , TACI , and BAFF R , three receptors mostly expressed by mature B lymphocytes . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| TALL 1 has three receptors , including BCMA , TACI , and BAFF R , which are mostly expressed by B lymphocytes . ^^^ Gene knockout studies have indicated that BAFF R is the major stimulatory receptor for TALL 1 signaling and is required for normal B cell development . ^^^ Coimmunoprecipitation experiments indicated that BAFF R interacts with TRAF 3 in B lymphoma cells and this interaction is stimulated by TALL 1 treatment . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| The tumour necrosis factor ( TNF ) ligand TALL 1 and its cognate receptors , BCMA , TACI and BAFF R , were recently identified as members of the TNF superfamily , which are essential factors contributing to B cell maturation . ^^^ Sequence alignments , structural modelling and mutagenesis revealed that one disulphide bridge in BAFF R is critical for determining the binding specificity of the extracellular domain eBAFF R to TALL 1 instead of APRIL , a closely related ligand of TALL 1 , which was confirmed by binding experiments in vitro . . ^^^ |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and Q96RJ3 |
Pubmed |
SVM Score :0.0 |
| NA |
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