| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :1.2527896 |
| BAFF and its close homologue a proliferation inducing ligand ( APRIL ) have both been shown to interact with at least two receptors , B cell maturation antigen ( BCMA ) and transmembrane activator and cyclophilin ligand interactor ( TACI ) , however their relative contribution in transducing BAFF signals in vivo remains unclear . 1.2527896^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.52651324 |
| BAFF binds to three receptors , BAFF R , transmembrane activator and CAML interactor ( TACI ) , and B cell maturation antigen ( BCMA ) , but only BAFF R is required for successful survival and maturation of splenic B cells . 0.52651324^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.79358308 |
| In addition , NHL B cells express BAFF receptor , which binds BAFF , as well as transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag ( BCMA ) , which bind both BAFF and APRIL . 0.79358308^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :1.0603748 |
| Using soluble , monomeric forms of the receptors , we demonstrate that BAFFR binds BAFF with K ( D ) approximately 16 nM , while BCMA binds with K ( D ) approximately 1 . 6 microM , indicating a approximately 100 fold selectivity for binding to BAFFR over BCMA . 1.0603748^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B cell maturation protein is a receptor for the tumor necrosis factor family member TALL 1 . ^^^ Here we show that B cell maturation protein ( BCMA ) , a member of the TNF receptor family that is expressed only by B lymphocytes , specifically binds to TALL 1 . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We have identified two TNF receptor family members , TACI and BCMA , that bind zTNF 4 . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We find that B cell maturation antigen ( BCMA ) , a predicted member of the TNF receptor family expressed primarily in mature B cells , is a receptor for BAFF . ^^^ A soluble form of BCMA , which inhibited the binding of BAFF to a B cell line , induced a dramatic decrease in the number of peripheral B cells when administered in vivo . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI . ^^^ Here we report a novel interaction between BLyS and another TNFR homologue , BCMA ( B cell maturation antigen ) [ 7 ] [ 8 ] . ^^^ Further , the TNF homologue APRIL [ 9 ] , a close relative of BLyS , also bound to BCMA and TACI . ^^^ BLyS or APRIL activated nuclear factor kappaB ( NF kappaB ) through TACI and BCMA , and each ligand stimulated immunoglobulin M ( IgM ) production by peripheral blood B cells . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| APRIL functions via binding to BCMA ( B cell maturation antigen ) and TACI ( transmembrane activator and CAML interactor ) and competes with TALL 1 ( also called BLyS or BAFF ) for receptor binding . ^^^ APRIL and TALL 1 and receptors BCMA and TACI : system for regulating humoral immunity . ^^^ BCMA Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice , indicating that APRIL and / or TALL 1 signaling via BCMA and / or TACI are required for generation of humoral immunity . ^^^ Thus , APRIL TALL 1 and BCMA TACI form a two ligands two receptors pathway involved in stimulation of B and T cell function . . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BCMA binds two TNF family members , BAFF and APRIL , that stimulate cellular proliferation . ^^^ These data suggest a functional redundancy of BCMA in B cell physiology that is probably due to the presence of TACI , another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL . . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Its biology is complex due to the existence of two ligands , BLyS and APRIL , and a homologous receptor , BCMA , that similarly binds both ligands . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Interactions of the tumor necrosis factor superfamily members B lymphocyte stimulator ( BLyS ) and a proliferation inducing ligand ( APRIL ) with their receptors transmembrane activator and CAML interactor ( TACI ) and B cell maturation molecule ( BCMA ) on B cells play an important role in the humoral immune response . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL have similar but distinct biological roles , mediated through two known TNF receptor family members , TACI and BCMA . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BCMA ( TNFRSF 17 ) , along with TACI , has recently been demonstrated to be a receptor for BLyS ( TNFSF13B ) . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| An essential role for BAFF in the normal development of B cells through a BCMA independent pathway . ^^^ The B cell activating factor BAFF ( BlyS / TALL 1 / zTNF4 ) is a tumor necrosis factor ( TNF ) related ligand that promotes B cell survival and binds to three receptors ( BCMA , TACI , and the recently described BAFF R ) . ^^^ BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA . . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS ( also called BAFF , TALL 1 , THANK , and zTNF 4 ) , a TNF superfamily member , binds two receptors , TACI and BCMA , and regulates humoral immune responses [ 1 7 ] . ^^^ BLyS ( also called BAFF , TALL 1 , THANK , and zTNF 4 ) , a TNF superfamily member , binds two receptors , TACI and BCMA , and regulates humoral immune responses [ 1 7 ] . ^^^ The results from TACI ( / ) and BCMA ( / ) mice suggest the existence of additional receptor ( s ) for BLyS . ^^^ This receptor is unique in that , in contrast to TACI and BCMA , BR 3 only binds BLyS . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF is known to interact with three receptors , BCMA , TACI and BAFF R , that have distant similarities with other receptors of the TNF family . ^^^ The BAFF structure was further used to generate a homology model of APRIL , a closely related TNF family ligand that also binds to BCMA and TACI , but not BAFF R . ^^^ Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA , TACI and BAFF R . . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The TNF like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TALL 1 is a member of the tumor necrosis factor family that binds to BCMA , TACI , and BAFF R , three receptors mostly expressed by mature B lymphocytes . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL share two receptors , TACI and BCMA , whereas a third receptor , BAFF R , specifically binds BLyS . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Finally , three membrane receptors ( TACI , BCMA , and BAFF R ) which bind a newly discovered member of the tumor necrosis factor family named BAFF . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TALL 1 has three receptors , including BCMA , TACI , and BAFF R , which are mostly expressed by B lymphocytes . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Rescued cDNAs contained Transmembrane Activator and calcium modulator and cyclophilin ligand ( CAML ) Interactor ( TACI ) and B Cell Maturation factor ( BCMA ) sequences , representing two published receptors of BlyS . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLys , a key cytokine that sustains B cell maturation and tolerance , binds three receptors : BR 3 , BCMA , and TACI . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Its biological role is mediated by the specific receptors BCMA , TACI and BAFF R . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF binds three receptors , TACI , BCMA , and BR 3 , with signaling through BR 3 being essential for promoting B cell function . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Comparison of soluble decoy IgG fusion proteins of BAFF R and BCMA as antagonists for BAFF . ^^^ Fc fusion decoy receptors , BCMA Fc and BAFF R Fc , are therapeutic candidates for blocking BAFF . ^^^ While studying their interactions with BAFF , we found that BAFF R Fc is more effective than BCMA Fc for blocking BAFF binding to its receptors . ^^^ We also found that a trimeric BAFF can bind more than one BAFF R Fc but only one BCMA Fc . ^^^ Moreover , we show that , in contrast to monovalent BAFF R Fc , monovalent BCMA does not form stable complexes with BAFF . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF exerts its effect by binding to three receptors transmembrane activator of and CAML interactor ( TACI ) , B cell maturation antigen ( BCMA ) , and BAFF receptor ( BAFF R ) . ^^^ The altered responsiveness of activated memory B cells to CD40L and BAFF correlated with changes in surface phenotype such that expression of CD 40 and BAFF R were reduced on ISCs while BCMA was induced . ^^^ These results suggest BAFF may enhance humoral immunity in vivo by promoting survival of ISCs via a BCMA dependent mechanism . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| They interact with 3 receptors : BAFF R , specific to BAFF ; and TACI and BCMA , which are shared by BAFF and APRIL . ^^^ Conversely , adding soluble BCMA Fc or anti BAFF and anti APRIL antibodies enhanced B CLL apoptosis . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| All MM cells studied expressed one or more of 3 known receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and CAML interactor [ TACI ] , and B cell activating factor receptor [ BAFF R ] ) for BLyS ; however , the pattern of expression was variable . ^^^ Expression of BCMA , TACI , and BAFF R by MM taken together with the ability of BLyS to support MM cell growth and survival has exciting implications because they may be potential therapeutic targets . . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| It binds to three different receptors , BCMA , TACI , and BAFF R , which are all members of the family of TNF receptors . ^^^ Lupus erythematodes prone mice have elevated blood levels of BAFF , and treatment of these mice with the BAFF decoy receptor ( BCMA Ig ) prevents the onset of this systemic autoimmune disease . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| RESULTS : LymphoStat B bound with high affinity to human BLyS and inhibited the binding of BLyS to its 3 receptors , TACI , BCMA , and BLyS receptor 3 / BAFF R . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Soluble recombinant chBAFF produced by human 293T cells interacted with the mammalian cell surface receptors TACI , BCMA and BAFF R . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Heightened expression of B cell maturation antigen ( BCMA ) , and lowered expression of transmembrane activator and cyclophilin ligand interactor and BAFF receptor in PCs relative to resting B cells suggests a vital role of BCMA in PC survival . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we have found that the Expi accelerated apoptosis is mediated via BAFF receptor among three known BAFF receptors : BAFF receptor , tumor necrosis factor ( TNF ) receptor homologue TACI ( transmembrane activator and CAML interactor ) , and BCMA ( another TNFR homologue , B cell maturation antigen ) . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| APRIL shares two TNF receptor family members , TACI and BCMA , with another TNF homolog , BLyS / BAFF . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The tumour necrosis factor ( TNF ) ligand TALL 1 and its cognate receptors , BCMA , TACI and BAFF R , were recently identified as members of the TNF superfamily , which are essential factors contributing to B cell maturation . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BCMA has been implicated as a receptor for both a proliferation inducing ligand ( APRIL ) and B cell activating factor ( BAFF ) , tumor necrosis factor ligands that bind to multiple tumor necrosis factor receptor and have been reported to play a role in autoimmune disease and cancer . ^^^ The results presented herein provide a dual perspective analysis of BCMA binding to both APRIL and BAFF . ^^^ First , we characterized the binding affinity of monomeric BCMA for its ligands ; BAFF binding affinity ( IC 50 = 8 + / 5 microm ) is about 1000 fold reduced compared with the high affinity interaction of APRIL ( IC 50 = 11 + / 3 nm ) . ^^^ Second , shotgun alanine scanning of BCMA was used to map critical residues for either APRIL or BAFF binding . ^^^ Incorporation of the Q25D and R27Y substitutions into BCMA produced a dual specificity variant , since it has comparable binding affinity for both APRIL and BAFF , IC 50 = 350 and 700 nm , respectively . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We confirmed the expression of BAFF and APRIL receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and calcium modulator and cyclophilin ligand interactor [ TACI ] , and BAFF R ) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors ( BCMA , TACI , and BAFF R ) for BLyS ; however , the pattern of expression was variable . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to three receptors , BR 3 , TACI and BCMA . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Three receptors have been identified that bind to BAFF : transmembrane activator , calcium modulator , and cyclophilin ligand interactor ( TACI ) ; B cell maturation Ag ( BCMA ) ; and BAFF R . ^^^ This finding , together with normal or enhanced B cell generation in mice deficient for BCMA or TACI , respectively , suggested that the interaction of BAFF with BAFF R triggers signals essential for the generation and maintenance of mature B cells . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The TNF related ligand , B cell activating factor belonging to the TNF family ( BAFF ) , is necessary for normal B cell development and survival , and specifically binds the receptors transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , B cell maturation Ag ( BCMA ) , and BAFF R . ^^^ Also , mice lacking both TACI and BCMA simultaneously exhibit no B cell loss , thus confirming that BAFF R is the primary receptor for transmitting the BAFF dependent B cell survival signal . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Increased expression of BCMA , a weak TNFSF receptor for B lymphocyte stimulator ( BLyS ) , on CD 21 ( low ) B cells was associated with a concomitant reduction in the expression of the more potent BLyS receptor , BAFF R , that resulted in reduced BLyS binding and BLyS mediated survival . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| APRIL binds the receptors B cell maturation antigen ( BCMA ) and TACI with high affinity ; both of these receptors have also been shown to bind BAFF , although BCMA has significantly higher affinity for APRIL than BAFF . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Increased expression of BCMA , a weak TNFSF receptor for B lymphocyte stimulator ( BLyS ) , on CD 21 ( low ) B cells was associated with a concomitant reduction in the expression of the more potent BLyS receptor , BAFF R , that resulted in reduced BLyS binding and BLyS mediated survival . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TACI binds two ligands , APRIL and BAFF , with high affinity and contains two cysteine rich domains ( CRDs ) in its extracellular region ; in contrast , BCMA and BR 3 , the other known high affinity receptors for APRIL and BAFF , respectively , contain only a single or partial CRD . ^^^ BCMA complexes that together reveal the mechanism by which TACI engages high affinity ligand binding through a single CRD , and we highlight sources of ligand receptor specificity within the APRIL / BAFF system . . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| APRIL and BAFF each engage two receptors , transmembrane activator and calcium modulator and cytophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) , on B cells . ^^^ To determine the role of these receptors in isotype switching , we examined B cells from mice deficient in TACI , BCMA , and BAFF R . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Also , the viability of CLL B cells cultured with NLCs was significantly reduced when CLL B cells were cultured with decoy receptor of B cell maturation antigen ( BCMA ) , which can bind both BAFF and APRIL , but not with BAFF receptor : Fc ( BAFF R : Fc ) , which binds only to BAFF . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , BAFF R , TACI and BCMA , whereas APRIL interacts with TACI , BCMA and proteoglycans . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ BAFF R expression increased initially and then decreased with a corresponding induction of TACI and BCMA expression during differentiation to plasma cells ( PCs ) . ^^^ B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Generation and characterization of C 305 , a murine neutralizing scFv antibody that can inhibit BLyS binding to its receptor BCMA . ^^^ Neutralizing single chain fragment variable ( scFv ) antibody against BLyS binding to its receptor BCMA has the potential to play a prominent role in autoimmune disease therapy . ^^^ The results indicated that C 305 is the neutralizing scFv antibody that can inhibit BLyS binding to its receptor BCMA . . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B cell maturation Ag ( BCMA ) , a member of the TNFR superfamily expressed on B cells , binds to a proliferation inducing ligand ( APRIL ) and B cell activating factor of the TNF family ( BAFF ) but the specific B cell responses regulated by BCMA remain unclear . ^^^ A comparative analysis of hybrid receptors of TNFR 2 fused to the cytoplasmic domains of APRIL / BAFF receptors found that only BCMA , but not transmembrane activator and calcium modulator and cyclophilin ligand interactor or BAFF R , is capable of activating Ag presentation . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Here we review approaches to antagonise members of the CD 28 B7 superfamily as well as the TNF receptor ligand superfamily members , BAFF and APRIL , and their corresponding receptors on B cells ( BAFF R , TACI and BCMA ) . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| PURPOSE OF REVIEW : The complex system of the tumour necrosis factor ligands BAFF and APRIL and their three receptors BCMA , TACI and BAFF receptor and its role in B cell development and function is the objective of extensive research . ^^^ SUMMARY : In this review we will discuss recent progress made in the understanding of the BAFF / APRIL TACI / BCMA / BAFF receptor system in relation to the recent discovery that mutations in human TACI cause a primary humoral immunodeficiency . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Antibodies to the receptors BAFF R , BCMA , and TACI were used to define expression of the individual BLyS receptors on subsets of B cells in blood , spleen , and tonsils . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI , BCMA , and BAFF R , which are expressed by mature B cells . ^^^ Syndecan 2 bound TACI but bound neither BAFF R nor BCMA . ^^^ This is the first identification of ligands that selectively activate TACI without simultaneously triggering BCMA or BAFF R . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to 3 TNF R receptors , TACI , BCMA , BAFF R , to regulate B cell survival , differentiation , and proliferation . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| A novel BLyS antagonist peptide designed based on the 3 D complex structure of BCMA and BLyS . ^^^ In this study , a novel BLyS antagonist peptide , PT , was designed based on the modeling 3 D complex structure of BCMA and BLyS . ^^^ The results of competitive ELISA demonstrated that PT could inhibit the binding of BCMA Fc and anti BLyS antibody to BLyS in vitro . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS , a TNF family member , is crucial for B cell proliferation and differentiation by acting through its three receptors , TACI , BCMA and BAFF R . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF is a ligand for three TNF receptor superfamily members : B cell maturation antigen ( BCMA ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , and BAFF receptor ( BAFF R ) . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Malignant B cells were found to bind soluble BLyS and variably express the receptors BAFF R , TACI , and BCMA . ^^^ |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02223 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :1.2527896 |
| BAFF and its close homologue a proliferation inducing ligand ( APRIL ) have both been shown to interact with at least two receptors , B cell maturation antigen ( BCMA ) and transmembrane activator and cyclophilin ligand interactor ( TACI ) , however their relative contribution in transducing BAFF signals in vivo remains unclear . 1.2527896^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.52651324 |
| BAFF binds to three receptors , BAFF R , transmembrane activator and CAML interactor ( TACI ) , and B cell maturation antigen ( BCMA ) , but only BAFF R is required for successful survival and maturation of splenic B cells . 0.52651324^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.79358308 |
| In addition , NHL B cells express BAFF receptor , which binds BAFF , as well as transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag ( BCMA ) , which bind both BAFF and APRIL . 0.79358308^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :1.0603748 |
| Using soluble , monomeric forms of the receptors , we demonstrate that BAFFR binds BAFF with K ( D ) approximately 16 nM , while BCMA binds with K ( D ) approximately 1 . 6 microM , indicating a approximately 100 fold selectivity for binding to BAFFR over BCMA . 1.0603748^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| We find that B cell maturation antigen ( BCMA ) , a predicted member of the TNF receptor family expressed primarily in mature B cells , is a receptor for BAFF . ^^^ A soluble form of BCMA , which inhibited the binding of BAFF to a B cell line , induced a dramatic decrease in the number of peripheral B cells when administered in vivo . ^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| APRIL functions via binding to BCMA ( B cell maturation antigen ) and TACI ( transmembrane activator and CAML interactor ) and competes with TALL 1 ( also called BLyS or BAFF ) for receptor binding . ^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BCMA binds two TNF family members , BAFF and APRIL , that stimulate cellular proliferation . ^^^ These data suggest a functional redundancy of BCMA in B cell physiology that is probably due to the presence of TACI , another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BAFF exerts its effect by binding to three receptors transmembrane activator of and CAML interactor ( TACI ) , B cell maturation antigen ( BCMA ) , and BAFF receptor ( BAFF R ) . ^^^ The altered responsiveness of activated memory B cells to CD40L and BAFF correlated with changes in surface phenotype such that expression of CD 40 and BAFF R were reduced on ISCs while BCMA was induced . ^^^ These results suggest BAFF may enhance humoral immunity in vivo by promoting survival of ISCs via a BCMA dependent mechanism . ^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| An essential role for BAFF in the normal development of B cells through a BCMA independent pathway . ^^^ The B cell activating factor BAFF ( BlyS / TALL 1 / zTNF4 ) is a tumor necrosis factor ( TNF ) related ligand that promotes B cell survival and binds to three receptors ( BCMA , TACI , and the recently described BAFF R ) . ^^^ BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA . . ^^^ |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BLyS ( also called BAFF , TALL 1 , THANK , and zTNF 4 ) , a TNF superfamily member , binds two receptors , TACI and BCMA , and regulates humoral immune responses [ 1 7 ] . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BAFF is known to interact with three receptors , BCMA , TACI and BAFF R , that have distant similarities with other receptors of the TNF family . ^^^ The BAFF structure was further used to generate a homology model of APRIL , a closely related TNF family ligand that also binds to BCMA and TACI , but not BAFF R . ^^^ Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA , TACI and BAFF R . . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Finally , three membrane receptors ( TACI , BCMA , and BAFF R ) which bind a newly discovered member of the tumor necrosis factor family named BAFF . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Its biological role is mediated by the specific receptors BCMA , TACI and BAFF R . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BAFF binds three receptors , TACI , BCMA , and BR 3 , with signaling through BR 3 being essential for promoting B cell function . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Comparison of soluble decoy IgG fusion proteins of BAFF R and BCMA as antagonists for BAFF . ^^^ Fc fusion decoy receptors , BCMA Fc and BAFF R Fc , are therapeutic candidates for blocking BAFF . ^^^ While studying their interactions with BAFF , we found that BAFF R Fc is more effective than BCMA Fc for blocking BAFF binding to its receptors . ^^^ We also found that a trimeric BAFF can bind more than one BAFF R Fc but only one BCMA Fc . ^^^ Moreover , we show that , in contrast to monovalent BAFF R Fc , monovalent BCMA does not form stable complexes with BAFF . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| They interact with 3 receptors : BAFF R , specific to BAFF ; and TACI and BCMA , which are shared by BAFF and APRIL . ^^^ Conversely , adding soluble BCMA Fc or anti BAFF and anti APRIL antibodies enhanced B CLL apoptosis . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| It binds to three different receptors , BCMA , TACI , and BAFF R , which are all members of the family of TNF receptors . ^^^ Lupus erythematodes prone mice have elevated blood levels of BAFF , and treatment of these mice with the BAFF decoy receptor ( BCMA Ig ) prevents the onset of this systemic autoimmune disease . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Soluble recombinant chBAFF produced by human 293T cells interacted with the mammalian cell surface receptors TACI , BCMA and BAFF R . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Heightened expression of B cell maturation antigen ( BCMA ) , and lowered expression of transmembrane activator and cyclophilin ligand interactor and BAFF receptor in PCs relative to resting B cells suggests a vital role of BCMA in PC survival . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we have found that the Expi accelerated apoptosis is mediated via BAFF receptor among three known BAFF receptors : BAFF receptor , tumor necrosis factor ( TNF ) receptor homologue TACI ( transmembrane activator and CAML interactor ) , and BCMA ( another TNFR homologue , B cell maturation antigen ) . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BCMA has been implicated as a receptor for both a proliferation inducing ligand ( APRIL ) and B cell activating factor ( BAFF ) , tumor necrosis factor ligands that bind to multiple tumor necrosis factor receptor and have been reported to play a role in autoimmune disease and cancer . ^^^ The results presented herein provide a dual perspective analysis of BCMA binding to both APRIL and BAFF . ^^^ First , we characterized the binding affinity of monomeric BCMA for its ligands ; BAFF binding affinity ( IC 50 = 8 + / 5 microm ) is about 1000 fold reduced compared with the high affinity interaction of APRIL ( IC 50 = 11 + / 3 nm ) . ^^^ Second , shotgun alanine scanning of BCMA was used to map critical residues for either APRIL or BAFF binding . ^^^ Incorporation of the Q25D and R27Y substitutions into BCMA produced a dual specificity variant , since it has comparable binding affinity for both APRIL and BAFF , IC 50 = 350 and 700 nm , respectively . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| We confirmed the expression of BAFF and APRIL receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and calcium modulator and cyclophilin ligand interactor [ TACI ] , and BAFF R ) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Three receptors have been identified that bind to BAFF : transmembrane activator , calcium modulator , and cyclophilin ligand interactor ( TACI ) ; B cell maturation Ag ( BCMA ) ; and BAFF R . ^^^ This finding , together with normal or enhanced B cell generation in mice deficient for BCMA or TACI , respectively , suggested that the interaction of BAFF with BAFF R triggers signals essential for the generation and maintenance of mature B cells . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| The TNF related ligand , B cell activating factor belonging to the TNF family ( BAFF ) , is necessary for normal B cell development and survival , and specifically binds the receptors transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , B cell maturation Ag ( BCMA ) , and BAFF R . ^^^ Also , mice lacking both TACI and BCMA simultaneously exhibit no B cell loss , thus confirming that BAFF R is the primary receptor for transmitting the BAFF dependent B cell survival signal . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| APRIL binds the receptors B cell maturation antigen ( BCMA ) and TACI with high affinity ; both of these receptors have also been shown to bind BAFF , although BCMA has significantly higher affinity for APRIL than BAFF . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| TACI binds two ligands , APRIL and BAFF , with high affinity and contains two cysteine rich domains ( CRDs ) in its extracellular region ; in contrast , BCMA and BR 3 , the other known high affinity receptors for APRIL and BAFF , respectively , contain only a single or partial CRD . ^^^ BCMA complexes that together reveal the mechanism by which TACI engages high affinity ligand binding through a single CRD , and we highlight sources of ligand receptor specificity within the APRIL / BAFF system . . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| APRIL and BAFF each engage two receptors , transmembrane activator and calcium modulator and cytophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) , on B cells . ^^^ To determine the role of these receptors in isotype switching , we examined B cells from mice deficient in TACI , BCMA , and BAFF R . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Also , the viability of CLL B cells cultured with NLCs was significantly reduced when CLL B cells were cultured with decoy receptor of B cell maturation antigen ( BCMA ) , which can bind both BAFF and APRIL , but not with BAFF receptor : Fc ( BAFF R : Fc ) , which binds only to BAFF . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , BAFF R , TACI and BCMA , whereas APRIL interacts with TACI , BCMA and proteoglycans . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ BAFF R expression increased initially and then decreased with a corresponding induction of TACI and BCMA expression during differentiation to plasma cells ( PCs ) . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Here we review approaches to antagonise members of the CD 28 B7 superfamily as well as the TNF receptor ligand superfamily members , BAFF and APRIL , and their corresponding receptors on B cells ( BAFF R , TACI and BCMA ) . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| PURPOSE OF REVIEW : The complex system of the tumour necrosis factor ligands BAFF and APRIL and their three receptors BCMA , TACI and BAFF receptor and its role in B cell development and function is the objective of extensive research . ^^^ SUMMARY : In this review we will discuss recent progress made in the understanding of the BAFF / APRIL TACI / BCMA / BAFF receptor system in relation to the recent discovery that mutations in human TACI cause a primary humoral immunodeficiency . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BAFF is a ligand for three TNF receptor superfamily members : B cell maturation antigen ( BCMA ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , and BAFF receptor ( BAFF R ) . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI , BCMA , and BAFF R , which are expressed by mature B cells . ^^^ Syndecan 2 bound TACI but bound neither BAFF R nor BCMA . ^^^ This is the first identification of ligands that selectively activate TACI without simultaneously triggering BCMA or BAFF R . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| All MM cells studied expressed one or more of 3 known receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and CAML interactor [ TACI ] , and B cell activating factor receptor [ BAFF R ] ) for BLyS ; however , the pattern of expression was variable . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Interactions of the tumor necrosis factor superfamily members B lymphocyte stimulator ( BLyS ) and a proliferation inducing ligand ( APRIL ) with their receptors transmembrane activator and CAML interactor ( TACI ) and B cell maturation molecule ( BCMA ) on B cells play an important role in the humoral immune response . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| B cell maturation Ag ( BCMA ) , a member of the TNFR superfamily expressed on B cells , binds to a proliferation inducing ligand ( APRIL ) and B cell activating factor of the TNF family ( BAFF ) but the specific B cell responses regulated by BCMA remain unclear . ^^^ A comparative analysis of hybrid receptors of TNFR 2 fused to the cytoplasmic domains of APRIL / BAFF receptors found that only BCMA , but not transmembrane activator and calcium modulator and cyclophilin ligand interactor or BAFF R , is capable of activating Ag presentation . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| The TNF like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL share two receptors , TACI and BCMA , whereas a third receptor , BAFF R , specifically binds BLyS . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Rescued cDNAs contained Transmembrane Activator and calcium modulator and cyclophilin ligand ( CAML ) Interactor ( TACI ) and B Cell Maturation factor ( BCMA ) sequences , representing two published receptors of BlyS . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BLys , a key cytokine that sustains B cell maturation and tolerance , binds three receptors : BR 3 , BCMA , and TACI . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| RESULTS : LymphoStat B bound with high affinity to human BLyS and inhibited the binding of BLyS to its 3 receptors , TACI , BCMA , and BLyS receptor 3 / BAFF R . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| APRIL shares two TNF receptor family members , TACI and BCMA , with another TNF homolog , BLyS / BAFF . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Increased expression of BCMA , a weak TNFSF receptor for B lymphocyte stimulator ( BLyS ) , on CD 21 ( low ) B cells was associated with a concomitant reduction in the expression of the more potent BLyS receptor , BAFF R , that resulted in reduced BLyS binding and BLyS mediated survival . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Increased expression of BCMA , a weak TNFSF receptor for B lymphocyte stimulator ( BLyS ) , on CD 21 ( low ) B cells was associated with a concomitant reduction in the expression of the more potent BLyS receptor , BAFF R , that resulted in reduced BLyS binding and BLyS mediated survival . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI . ^^^ Here we report a novel interaction between BLyS and another TNFR homologue , BCMA ( B cell maturation antigen ) [ 7 ] [ 8 ] . ^^^ Further , the TNF homologue APRIL [ 9 ] , a close relative of BLyS , also bound to BCMA and TACI . ^^^ BLyS or APRIL activated nuclear factor kappaB ( NF kappaB ) through TACI and BCMA , and each ligand stimulated immunoglobulin M ( IgM ) production by peripheral blood B cells . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Its biology is complex due to the existence of two ligands , BLyS and APRIL , and a homologous receptor , BCMA , that similarly binds both ligands . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL have similar but distinct biological roles , mediated through two known TNF receptor family members , TACI and BCMA . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BCMA ( TNFRSF 17 ) , along with TACI , has recently been demonstrated to be a receptor for BLyS ( TNFSF13B ) . ^^^ BCMA ( TNFRSF 17 ) , along with TACI , has recently been demonstrated to be a receptor for BLyS ( TNFSF13B ) . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| We found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors ( BCMA , TACI , and BAFF R ) for BLyS ; however , the pattern of expression was variable . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to three receptors , BR 3 , TACI and BCMA . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Generation and characterization of C 305 , a murine neutralizing scFv antibody that can inhibit BLyS binding to its receptor BCMA . ^^^ Neutralizing single chain fragment variable ( scFv ) antibody against BLyS binding to its receptor BCMA has the potential to play a prominent role in autoimmune disease therapy . ^^^ The results indicated that C 305 is the neutralizing scFv antibody that can inhibit BLyS binding to its receptor BCMA . . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Malignant B cells were found to bind soluble BLyS and variably express the receptors BAFF R , TACI , and BCMA . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| Antibodies to the receptors BAFF R , BCMA , and TACI were used to define expression of the individual BLyS receptors on subsets of B cells in blood , spleen , and tonsils . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to 3 TNF R receptors , TACI , BCMA , BAFF R , to regulate B cell survival , differentiation , and proliferation . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| A novel BLyS antagonist peptide designed based on the 3 D complex structure of BCMA and BLyS . ^^^ In this study , a novel BLyS antagonist peptide , PT , was designed based on the modeling 3 D complex structure of BCMA and BLyS . ^^^ The results of competitive ELISA demonstrated that PT could inhibit the binding of BCMA Fc and anti BLyS antibody to BLyS in vitro . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| BLyS , a TNF family member , is crucial for B cell proliferation and differentiation by acting through its three receptors , TACI , BCMA and BAFF R . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| B cell maturation protein is a receptor for the tumor necrosis factor family member TALL 1 . ^^^ Here we show that B cell maturation protein ( BCMA ) , a member of the TNF receptor family that is expressed only by B lymphocytes , specifically binds to TALL 1 . ^^^ A soluble receptor containing the extracellular domain of BCMA blocks the binding of TALL 1 to its receptor on the plasma membrane and inhibits TALL 1 triggered B lymphocyte costimulation . ^^^ Overexpression of BCMA activates NF kappaB , and this activation is potentiated by TALL 1 . ^^^ These data indicate that BCMA is a receptor for TALL 1 and BCMA activates NF kappaB through a TRAF 5 , TRAF 6 , NIK , and IKK dependent pathway . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| TALL 1 is a member of the tumor necrosis factor family that binds to BCMA , TACI , and BAFF R , three receptors mostly expressed by mature B lymphocytes . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| TALL 1 has three receptors , including BCMA , TACI , and BAFF R , which are mostly expressed by B lymphocytes . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| The tumour necrosis factor ( TNF ) ligand TALL 1 and its cognate receptors , BCMA , TACI and BAFF R , were recently identified as members of the TNF superfamily , which are essential factors contributing to B cell maturation . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| We have identified two TNF receptor family members , TACI and BCMA , that bind zTNF 4 . ^^^ |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and Q02223 |
Pubmed |
SVM Score :0.0 |
| NA |
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