| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :1.2393925 |
| BAFF and its close homologue a proliferation inducing ligand ( APRIL ) have both been shown to interact with at least two receptors , B cell maturation antigen ( BCMA ) and transmembrane activator and cyclophilin ligand interactor ( TACI ) , however their relative contribution in transducing BAFF signals in vivo remains unclear . 1.2393925^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.85131574 |
| In addition , NHL B cells express BAFF receptor , which binds BAFF , as well as transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag ( BCMA ) , which bind both BAFF and APRIL . 0.85131574^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.72303711 |
| The autologous interaction between BAFF , APRIL , and their ligands may also be involved in apoptosis inhibition in B CLL . 0.72303711^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.85257556 |
| APRIL binds the receptors B cell maturation antigen ( BCMA ) and TACI with high affinity ; both of these receptors have also been shown to bind BAFF , although BCMA has significantly higher affinity for APRIL than BAFF . 0.85257556^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.67227915 |
| TACI binds two ligands , APRIL and BAFF , with high affinity and contains two cysteine rich domains ( CRDs ) in its extracellular region ; in contrast , BCMA and BR 3 , the other known high affinity receptors for APRIL and BAFF , respectively , contain only a single or partial CRD . 0.67227915^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF , a novel ligand of the tumor necrosis factor family , stimulates B cell growth . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B cells are important in the development of autoimmune disorders by mechanisms involving dysregulated polyclonal B cell activation , production of pathogenic antibodies , and co stimulation of autoreactive T cells . zTNF 4 ( BLyS , BAFF , TALL 1 , THANK ) is a member of the tumour necrosis factor ( TNF ) ligand family that is a potent co activator of B cells in vitro and in vivo . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| APRIL functions via binding to BCMA ( B cell maturation antigen ) and TACI ( transmembrane activator and CAML interactor ) and competes with TALL 1 ( also called BLyS or BAFF ) for receptor binding . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| APRIL and BAFF connect autoimmunity and cancer . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ; also known as TNFSF 20 , BAFF , TALL 1 , zTNF 4 , and THANK ) , a tumor necrosis factor ligand family member , has recently been identified as a factor that promotes expansion and differentiation of the B cell population , leading to increases in serum immunoglobulin levels . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B cell maturation protein , which binds the tumor necrosis factor family members BAFF and APRIL , is dispensable for humoral immune responses . ^^^ BCMA binds two TNF family members , BAFF and APRIL , that stimulate cellular proliferation . ^^^ These data suggest a functional redundancy of BCMA in B cell physiology that is probably due to the presence of TACI , another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL . . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| In a Perspective , Waldschmidt and Noelle discuss new findings showing that the TNF family ligand BAFF and its receptor BAFF R are crucial for selecting transitional B cells into the mature B cell pool ( Thompson et al . , Schiemann et al . ) . . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The B cell activating factor BAFF ( BlyS / TALL 1 / zTNF4 ) is a tumor necrosis factor ( TNF ) related ligand that promotes B cell survival and binds to three receptors ( BCMA , TACI , and the recently described BAFF R ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| T cell costimulation by the TNF ligand BAFF . ^^^ The TNF ligand family member BAFF ( B cell activating factor belonging to the TNF family , also called Blys , TALL 1 , zTNF 4 , or THANK ) is an important survival factor for B cells [ corrected ] . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| However , elucidation of the mechanism of BLyS has proven to be more challenging , because BLyS binds three different TNF receptors ( TACI / BCMA / BAFF R ) and shares overlapping functions with a related TNF ligand , APRIL . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The BAFF structure was further used to generate a homology model of APRIL , a closely related TNF family ligand that also binds to BCMA and TACI , but not BAFF R . ^^^ Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA , TACI and BAFF R . . ^^^ B cell activating factor ( BAFF ) , a ligand belonging to the tumor necrosis factor ( TNF ) family , plays a critical role in regulating survival and activation of peripheral B cell populations and has been associated with autoimmune disease . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Interactions of BAFF ( B cell activating factor ) with BAFF R , one of three BAFF binding receptors that are preferentially expressed on B cells , are essential for B cell development , because defects in either the ligand or the receptor arrest progression from immature type 1 B cells to type 2 cells and mature cells ; B 1 B cells are unaffected . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Dendritic cells , BAFF , and APRIL : innate players in adaptive antibody responses . ^^^ Dendritic cell derived TNF family ligands APRIL and / or BAFF enhance plasmablast survival and differentiation to plasma cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF / BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF kappaB 2 . ^^^ The TNF like ligand BAFF / BLyS is a potent survival factor for B cells . ^^^ Since inhibiting the BR 3 BAFF interaction has therapeutic ramifications , the ligand binding interface of BR 3 was investigated and found to reside within a 26 residue core domain . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF AND APRIL : a tutorial on B cell survival . ^^^ APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| APRIL and B lymphocyte stimulator ( BLyS ; also termed BAFF , TALL 1 , THANK , zTNF 4 ) form a new subfamily of TNF like ligands that are expressed in haematopoietic cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Involvement of BAFF and APRIL in the resistance to apoptosis of B CLL through an autocrine pathway . ^^^ Tumor necrosis factor ( TNF ) superfamily members BAFF , or B cell activation factor of the TNF family , and APRIL , a proliferation inducing ligand , are involved in normal B cell survival and differentiation . ^^^ They interact with 3 receptors : BAFF R , specific to BAFF ; and TACI and BCMA , which are shared by BAFF and APRIL . ^^^ BAFF and APRIL mRNAs and proteins were detected in B CLL leukemic cells and normal blood or tonsil derived B lymphocytes . ^^^ Yet , in contrast to normal B lymphocytes , BAFF and APRIL were expressed at the membranes of leukemic cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor ( TNF ) like ligand BAFF / BLyS ( B cell activating factor of the TNF family / B lymphocyte stimulator ) is a potent B cell survival factor , yet its functional relationship with other B cell surface molecules such as CD 19 and CD 40 is poorly understood . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Importantly , a TACI ( trans membrane activator and CAML interactor ) Fc fusion protein inhibits both macrophage and dendritic cell ( DC ) dependent BCR activated B cell proliferation , indicating a requirement for at least one of the known TACI ligands , BAFF and / or APRIL . ^^^ In addition , BAFF is more than 100 fold more potent than APRIL in enhancing BCR mediated human B cell proliferation . ^^^ Macrophage and dendritic cell dependent regulation of human B cell proliferation requires the TNF family ligand BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF / BLyS receptor 3 comprises a minimal TNF receptor like module that encodes a highly focused ligand binding site . ^^^ Several of the key BAFF binding residues are presented from a beta turn that we have shown previously to be sufficient for ligand binding when transferred to a structured beta hairpin scaffold [ Kayagaki , N . , Yan , M . , Seshasayee , D . , Wang , H . , Lee , W . , French , D . ^^^ The crystal structure of the minimal hairpin peptide , bhpBR 3 , in complex with BAFF reveals intimate packing of the six residue BR 3 turn into a cavity on the ligand surface . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The TNF family members BAFF and APRIL : the growing complexity . ^^^ B cell activating factor belonging to the TNF family ( BAFF ) and apoptosis inducing ligand ( APRIL ) are two related members of the TNF ligand superfamily . ^^^ Therapies designed to inhibit the BAFF and APRIL pathways holds great promise for the future . . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , only one of which , BAFF R , does not cross react with the BAFF related ligand APRIL . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF and APRIL bind to BAFF receptor and TACI and are major B cell survival factors . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Whereas lipopolysaccharide ( LPS ) and B cell activation factor ( BAFF ) mainly activate the type 1 or type 2 pathways , respectively , CD 40 ligand ( CD40L ) strongly activates both . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Three receptors have been identified that bind to BAFF : transmembrane activator , calcium modulator , and cyclophilin ligand interactor ( TACI ) ; B cell maturation Ag ( BCMA ) ; and BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The TNF related ligand , B cell activating factor belonging to the TNF family ( BAFF ) , is necessary for normal B cell development and survival , and specifically binds the receptors transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , B cell maturation Ag ( BCMA ) , and BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Heightened expression of B cell maturation antigen ( BCMA ) , and lowered expression of transmembrane activator and cyclophilin ligand interactor and BAFF receptor in PCs relative to resting B cells suggests a vital role of BCMA in PC survival . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BCMA has been implicated as a receptor for both a proliferation inducing ligand ( APRIL ) and B cell activating factor ( BAFF ) , tumor necrosis factor ligands that bind to multiple tumor necrosis factor receptor and have been reported to play a role in autoimmune disease and cancer . ^^^ The results presented herein provide a dual perspective analysis of BCMA binding to both APRIL and BAFF . ^^^ First , we characterized the binding affinity of monomeric BCMA for its ligands ; BAFF binding affinity ( IC 50 = 8 + / 5 microm ) is about 1000 fold reduced compared with the high affinity interaction of APRIL ( IC 50 = 11 + / 3 nm ) . ^^^ Second , shotgun alanine scanning of BCMA was used to map critical residues for either APRIL or BAFF binding . ^^^ Substitution of Tyr 13 was tolerated for BAFF binding but not APRIL binding . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The TNF family ligand B cell activating factor ( BAFF , BLyS , TALL 1 ) is an essential factor for B cell development . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone . ^^^ Using gene expression profiling , we identified overexpression of 2 receptors for a proliferation inducing ligand ( APRIL ) and B cell activating factor ( BAFF ) in malignant plasma cells compared with normal plasma cells . ^^^ APRIL and BAFF are involved in a variety of tumor and autoimmune diseases , including B cell malignancies . ^^^ We confirmed the expression of BAFF and APRIL receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and calcium modulator and cyclophilin ligand interactor [ TACI ] , and BAFF R ) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients . ^^^ APRIL and BAFF were potent survival factors for exogenous cytokine dependent myeloma cell lines and were autocrine growth factors for the RPMI 8226 and L 363 autonomously growing cell lines . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF [ B cell activating factor belonging to the tumor necrosis factor ( TNF ) family ] is a ligand that is required for peripheral B cell survival and homeostasis . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The B lymphocyte stimulator ( BAFF ) is a novel member of the tumor necrosis factor ( TNF ) ligand family which is important in B lymphocyte maturation and survival . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| We report that the binding of BAFF to BAFF R expressed by a subset of primarily CD 4 ( + ) T cells costimulates T cell activation and allo proliferation in vitro and in vivo , and that mice with a mutation in the BAFF R , or with a targeted deletion of BAFF , show prolonged cardiac allograft survival as compared to wild type or transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) ( / ) controls . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The biochemistry and biology of BAFF , APRIL and their receptors . ^^^ APRIL is a close relative of BAFF and while its biological roles are less well understood , it may have both immune and non immune functions . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor belonging to the TNF family receptor ( BAFF R ) , a member of the TNFR superfamily , plays a role in autoimmunity after ligation with BAFF ligand ( also called TALL 1 , BLyS , THANK , or zTNF 4 ) . ^^^ BAFF / BAFF R interactions are critical for B cell regulation , and signaling from this ligand receptor complex results in NF kappaB activation . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells . ^^^ We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG 1 , IgA , and IgE . ^^^ APRIL and BAFF each engage two receptors , transmembrane activator and calcium modulator and cytophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) , on B cells . ^^^ APRIL and BAFF each engage two receptors , transmembrane activator and calcium modulator and cytophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) , on B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Selectivity of BAFF / BLyS and APRIL for binding to the TNF family receptors BAFFR / BR3 and BCMA . ^^^ BCMA and TACI additionally bind APRIL ( a proliferation inducing ligand ) , the TNF family ligand most homologous to BAFF . ^^^ The binding of BAFF or APRIL to these receptors is highly sensitive to assay dependent avidity effects , likely explaining the widely ranging affinity values reported in the literature . ^^^ BAFF ( B cell activating factor of the TNF family , also known as BlyS and TALL 1 ) , a TNF family cytokine critical for the development and function of B cells , has been reported to bind to three receptors , BCMA ( B cell maturation protein ) , TACI ( transmembrane activator and CAML [ calcium modulator and cyclophilin ligand ] interactor ) , and BAFFR ( BAFF receptor ) , but with widely conflicting values for the affinity and selectivity of binding . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor ( BAFF ) and a proliferation inducing ligand ( APRIL ) have been shown to promote multiple myeloma ( MM ) cell growth . ^^^ We show that the main site of production for BAFF and APRIL is the bone marrow ( BM ) environment , and that production is mainly by monocytes and neutrophils . ^^^ Myeloma cells ( MMCs ) express TACI ( transmembrane activator and calcium modulator and cyclophilin ligand interactor ) , the receptor of BAFF / APRIL , at varying levels . ^^^ Taken together , our findings suggest using gene expression profiling to identify the group of patients who might benefit most from treatment with BAFF / APRIL inhibitors . . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The BAFF / APRIL system : life beyond B lymphocytes . ^^^ B cell activating factor belonging to the TNF family ( BAFF ) and a proliferation inducing ligand ( APRIL ) are two members of the TNF ligand superfamily . ^^^ Studies of BAFF , APRIL and their receptors have highlighted the importance of this ligand / receptor system in regulating B cell homeostasis , tolerance and malignancy . ^^^ Therefore , targeting the BAFF / APRIL system may protect against autoimmunity and lymphoid cancers through the inhibition of pathogenic B and T cell functions . . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor of the tumor necrosis factor ( TNF ) family ( BAFF ) and a proliferation inducing ligand ( APRIL ) are closely related ligands within the TNF superfamily that play important roles in B lymphocyte biology . ^^^ In addition , BAFF specifically binds BAFF receptor , whereas the nature of a postulated APRIL specific receptor remains elusive . ^^^ Inhibition of BAFF and APRIL , but not BAFF alone , prevented the survival and / or the migration of newly formed plasma cells to the bone marrow . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Nurselike cells express BAFF and APRIL , which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF 1alpha . ^^^ We examined expression of B cell activating factor of the tumor necrosis factor ( TNF ) family ( BAFF ) and a proliferation inducing ligand ( APRIL ) on chronic lymphocytic leukemia ( CLL ) B cells and nurselike cells ( NLCs ) , which differentiate from CD14+ cells when cultured with CLL B cells . ^^^ NLCs expressed significantly higher levels of APRIL than monocytes and significantly higher levels of BAFF and APRIL than CLL B cells . ^^^ Also , the viability of CLL B cells cultured with NLCs was significantly reduced when CLL B cells were cultured with decoy receptor of B cell maturation antigen ( BCMA ) , which can bind both BAFF and APRIL , but not with BAFF receptor : Fc ( BAFF R : Fc ) , which binds only to BAFF . ^^^ The effect ( s ) of BAFF or APRIL on leukemia cell survival appeared additive and distinct from that of stromal cell derived factor 1alpha ( SDF 1alpha ) , which in contrast to BAFF or APRIL induced leukemia cell phosphorylation of p44 / 42 mitogen activated protein kinase ( extracellular signal regulated kinase 1 / 2 [ ERK1 / 2 ] ) and AKT . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjgren ' s syndrome . ^^^ B cell activating factor ( BAFF ) and a proliferation inducing ligand ( APRIL ) are members of the tumour necrosis factor superfamily . ^^^ We have examined circulating BAFF and APRIL in relation to serological deviations and lymphoid organization in the salivary glands of the chronic , autoimmune disorder Sjgren ' s syndrome . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B cell maturation Ag ( BCMA ) , a member of the TNFR superfamily expressed on B cells , binds to a proliferation inducing ligand ( APRIL ) and B cell activating factor of the TNF family ( BAFF ) but the specific B cell responses regulated by BCMA remain unclear . ^^^ A comparative analysis of hybrid receptors of TNFR 2 fused to the cytoplasmic domains of APRIL / BAFF receptors found that only BCMA , but not transmembrane activator and calcium modulator and cyclophilin ligand interactor or BAFF R , is capable of activating Ag presentation . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Here we review approaches to antagonise members of the CD 28 B7 superfamily as well as the TNF receptor ligand superfamily members , BAFF and APRIL , and their corresponding receptors on B cells ( BAFF R , TACI and BCMA ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The role of APRIL and BAFF in lymphocyte activation . ^^^ The TNF family ligands BAFF ( also called BLyS ) and APRIL regulate lymphocyte survival and activation . ^^^ BAFF binds to three receptors , BAFF R , TACI and BCMA , whereas APRIL interacts with TACI , BCMA and proteoglycans . ^^^ The contribution of BAFF and APRIL to B cell and plasma cell survival , CD 154 ( CD40L ) independent antibody isotype switching , germinal center maintenance , T dependent and T independent antibody responses , and T cell co stimulation are relatively well understood . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The synergy was observed over a wide range of BCR : ligand affinities and involved : 1 ) cooperative effects at promoting early cell cycle progression and viability ; 2 ) BCR : CD 21 coligation promoted increases in BAFF receptors that were highly regulated by IL 4 ; 3 ) reciprocal effects of IL 4 and BAFF at dampening daughter cell apoptosis typical of stimulation by BCR : CD 21 and either cytokine alone ; and 4 ) BAFF sustained expression of antiapoptotic Mcl 1 within replicating lymphoblasts . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| A transmembrane activator and calcium modulating and cyclophilin ligand interactor ( TACI ) Ig fusion protein ( which neutralizes both BAFF and a proliferation inducing ligand ( APRIL ) , another TNF family member ) inhibited Hg induced autoantibody or serum IgE production . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| PURPOSE OF REVIEW : The complex system of the tumour necrosis factor ligands BAFF and APRIL and their three receptors BCMA , TACI and BAFF receptor and its role in B cell development and function is the objective of extensive research . ^^^ SUMMARY : In this review we will discuss recent progress made in the understanding of the BAFF / APRIL TACI / BCMA / BAFF receptor system in relation to the recent discovery that mutations in human TACI cause a primary humoral immunodeficiency . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BAFF is a ligand for three TNF receptor superfamily members : B cell maturation antigen ( BCMA ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , and BAFF receptor ( BAFF R ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Two newly identified tumor necrosis factor ( TNF ) family cytokines , B cell activation factor from the TNF family ( BAFF ) and a proliferation inducing ligand ( APRIL ) , have recently been shown to enhance the maturation and survival of peripheral B cells . ^^^ However , whether BAFF and APRIL are expressed in the bone marrow ( BM ) microenvironment and if these two cytokines modulate early B cell development remain unclear . ^^^ In the present study , we have detected the abundant expression of BAFF and APRIL transcripts in BM non lymphoid cells . ^^^ Low levels of BAFF and APRIL mRNA are also found in developing B cells . ^^^ In cultures , both recombinant BAFF and APRIL significantly promote the survival of precursor B cells whereas only BAFF can suppress apoptosis of immature B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| We found that BAFF and a proliferation inducing ligand ( APRIL ) , which are related , block B cell antigen receptor ( BCR ) induced apoptosis upstream of mitochondrial damage , which is consistent with a role for Bcl 2 family proteins . ^^^ BCR ligation strongly increased expression of the proapoptotic Bcl 2 homology 3 only Bcl 2 protein Bim in both WEHI 231 and splenic B cells , and increases in Bim were reversed by BAFF or APRIL . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| How these receptors are differentially activated is not entirely understood , because the primary ligand BAFF binds to all three . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The TNF family members B cell activating factor of the TNF family ( BAFF ) and its homolog A proliferation inducing ligand ( APRIL ) are B cell survival and differentiation factors and are therefore rational therapeutic targets . ^^^ We compared the effects of BAFF receptor Ig , which blocks only BAFF , with those of transmembrane activator and calcium modulator ligand interactor Ig , which blocks both BAFF and APRIL , in a murine SLE model . ^^^ In contrast , blockade of both BAFF and APRIL , but not blockade of BAFF alone , reduced the serum levels of IgM antibodies , decreased the frequency of plasma cells in the spleen , and inhibited the IgM response to a T cell dependent antigen . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Ligands of the tumor necrosis factor superfamily ( TNFSF ) ( 4 1BBL , APRIL , BAFF , CD27L , CD30L , CD40L , EDA 1 , EDA 2 , FasL , GITRL , LIGHT , lymphotoxin alpha , lymphotoxin alphabeta , OX40L , RANKL , TL1A , TNF , TWEAK , and TRAIL ) bind members of the TNF receptor superfamily ( TNFRSF ) . ^^^ Although human APRIL does not interact with BAFF R , the shorter variant of mouse APRIL exhibits weak but detectable binding to mouse BAFF R . . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| We have developed a simple medium [ termed hESC Cocktail ( HESCO ) ] containing basic fibroblast growth factor , Wnt3a , April ( a proliferation inducing ligand ) / BAFF ( B cell activating factor belonging to TNF ) , albumin , cholesterol , insulin , and transferrin , which is sufficient for hESC self renewal and proliferation . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B Lymphocyte activating factor ( BAFF / BLyS ) is a survival factor for B cells , belonging to the tumor necrosis ligand super family . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| APRIL and BAFF promote increased viability of replicating human B 2 cells via mechanism involving cyclooxygenase 2 . ^^^ By comparing BAFF and a proliferation inducing ligand ( APRIL ) efficacy at different stages in the response ( only BAFF binds BR 3 ; both bind transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag , the early role was attributed to BR 3 , while the later role was attributed to TACI / B cell maturation Ag . ^^^ Importantly , BAFF and APRIL promoted viability of cycling lymphoblasts was associated with sustained expression of cyclooxygenase 2 ( COX 2 ) , the rate limiting enzyme for PGE 2 synthesis , within replicating cells . ^^^ Supernatants of cultures with BAFF and APRIL contained elevated PGE 2 . ^^^ Increased yield of viable progeny was associated with elevated Mcl 1 , suggesting that a BAFF / APRIL > TACI > COX 2 > PGE 2 > Mcl 1 pathway reduces activation related , mitochondrial apoptosis in replicating human B 2 cell clones . . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Antigen pulsed dendritic cells ( DCs ) stimulated production of specific IgA in the absence of T cell help via costimulation by BAFF and / or APRIL , members of the TNF family . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NF kappaB 2 p100 processing has recently been shown to be stimulated by a subset of NF kappaB inducers , including lymphotoxin beta , B cell activating factor and CD 40 ligand , via a novel signalling pathway . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Moreover , BAFF ( 0 100 ng / mL ) increases adhesion of multiple myeloma lines to BMSCs in a dose dependent manner ; conversely , transmembrane activator and calcium modulator and cyclophylin ligand interactor Ig or B cell maturation antigen / Fc blocked BAFF stimulation . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The thymus is a source of B cell survival factors APRIL and BAFF in myasthenia gravis . ^^^ To understand whether factors enhancing B cell survival are increased in MG , we studied the expression of APRIL , BAFF and three of their receptors in the thymus . ^^^ In hyperplastic thymi , macrophages expressed APRIL and BAFF , and germinal center B cells , BAFF R . ^^^ The expression of APRIL and BAFF in MG thymi may reflect the establishment of an environment favorable to B cell survival . . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Role of BAFF and APRIL in human B cell chronic lymphocytic leukaemia . ^^^ Two related members of the tumour necrosis factor family , BAFF ( B cell activating factor of the TNF family ) and APRIL ( a proliferation inducing ligand ) , already known for their crucial role in normal B cell survival , differentiation and apoptosis , were recently shown to be expressed by B CLL cells . ^^^ This review will focus on the role of BAFF and APRIL in the survival of tumoral cells . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Recently members of the TNF superfamily , B cell activating factor ( BAFF ) and a proliferation inducing ligand ( APRIL ) , have been identified along with their receptors , B cell maturation antigen and transmembrane activator and calcium modulator and cyclophilin ligand interactor , and the BAFF specific receptor . ^^^ BAFF is a fundamental B cell survival / maturation factor , and both BAFF and APRIL have been implicated in antibody production . ^^^ We investigated the effect of interfering with BAFF and APRIL mediated signals in an induced model of Graves ' disease by blockade of these factors using soluble decoy receptors . ^^^ Our results are the first to demonstrate attenuation of established hyperthyroidism by therapeutic intervention aimed at autoreactive B cells and indicate that both BAFF and APRIL appear to play important roles in the development and survival of the autoantibody producing cells in this model . . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| In addition , LMP 1 induces B cells to express B cell activating factor of the TNF family and a proliferation inducing ligand , two molecules that mediate B cell survival and T cell independent Ab production . ^^^ B cell activating factor of the TNF family and a proliferation inducing ligand cooperate with LMP 1 to induce Ig class switching because their neutralization by appropriate soluble decoy receptors attenuates CSR in LMP 1 expressing B cells . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) , also referred to as B cell activating factor of the TNF family , is a recently identified tumor necrosis factor ( TNF ) family member shown to be critical for maintenance of normal B cell development and homeostasis and it shares significant homology with another TNF superfamily member , a proliferation inducing ligand ( APRIL ) . ^^^ Currently , three receptors have been identified that transmit signals upon BLyS and APRIL binding and these include B cell maturation antigen , B cell activating factor receptor , and transmembrane activator and CAML interactor . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Interestingly , protein expression of NIK is steadily induced by B cell activating factor or CD 40 ligand , two major physiological inducers of p 100 processing , but not by mitogen phorbol 12 myristate 13 acetate / ionomycin or cytokine tumor necrosis factor alpha , two well known inducers of the canonical NF kappaB signaling . ^^^ Remarkably , both B cell activating factor and CD 40 ligand do not significantly induce expression of NIK at translational or transcriptional level but rather rescue the basally translated NIK protein from undergoing degradation . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) is a recently identified novel member of the tumor necrosis factor ligand superfamily shown to exist in a membrane bound and soluble form . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Interactions of the tumor necrosis factor superfamily members B lymphocyte stimulator ( BLyS ) and a proliferation inducing ligand ( APRIL ) with their receptors transmembrane activator and CAML interactor ( TACI ) and B cell maturation molecule ( BCMA ) on B cells play an important role in the humoral immune response . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Among the novel tumor necrosis factor ligand and receptor superfamily members recently described is B lymphocyte stimulator ( BLyS ; Human Genome Sciences , Rockville , MD ) protein . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) is a newly identified tumor necrosis factor ( TNF ) family member shown to be critical for maintenance of normal B cell development and homeostasis and it shares significant homology with another TNF superfamily member , APRIL . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| This review summarizes the recent progress in immunobiology of the TNF receptor superfamily and focuses on our studies of three critical family members FasL / Fas , TNF related apoptosis inducing ligand ( TRAIL ) / TRAIL Rs , and B lymphocyte stimulator ( BLyS ) / BLyS Rs to demonstrate the therapeutic potential of targeting these receptors for the treatment of autoimmune disease . . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) is a member of the tumor necrosis factor ( TNF ) ligand superfamily that functionally involved in B cell proliferation . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) is a novel member of the TNF ligand superfamily that is important in B cell maturation and survival . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis . ^^^ OBJECTIVE : To determine whether synovial fluid ( SF ) levels and cell surface expression of B lymphocyte stimulator ( BLyS ) protein and SF levels of APRIL are elevated in patients with inflammatory arthritis ( IA ) . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Apoptosis inducing tumor necrosis factor ( TNF ) ligands and receptors have been reported in human placentas , but the expression patterns of family members lacking this function [ a proliferation inducing ligand ( APRIL ) , B lymphocyte stimulator ( BLyS ) , CD30L / CD153 , CD40L / CD154 , TNF related activation induced cytokine , CD27L / CD70 , OX40L , activation inducible TNF receptor ligand ( AITRL ) ] are incompletely documented or unknown . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To assess longitudinal expression of a proliferation inducing ligand ( APRIL ) in patients with systemic lupus erythematosus ( SLE ) and its correlation with B lymphocyte stimulator ( BLyS ) expression , serum anti dsDNA titres , and clinical disease activity . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| METHODS : Blood and SF obtained concomitantly from 91 patients with clinically well defined arthritis were tested for concentrations of total anti GPI IgG , anti GPI IgG subclasses , B lymphocyte stimulator ( BLyS ) , and APRIL by ELISA . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) , a member of the tumor necrosis factor ligand superfamily , has potent costimulatory activity on B cells . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) , a ligand belonging to the tumor necrosis factor ( TNF ) family , plays a critical role in regulating survival and activation of peripheral B cell populations during humeral immune responses . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that B cell dendritic cell ( DC ) interactions via transmembrane activator and calcium modulator and cyclophilin ligand ( CAML ) interactor ( TACI ) and B lymphocyte stimulator ( BLyS ) provide an early signal critical to generate adequate numbers of mature antigen presenting cells ( APCs ) to prime naive CD 8 ( + ) T cells ( CTLs ) in vivo . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The cytokines B lymphocyte stimulator ( BLyS ) and a proliferation inducing ligand ( APRIL ) enhance autoimmune disease by sustaining B cell activation . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) , a relatively recently recognized member of the tumor necrosis factor ligand family ( TNF ) , is a potent cell survival factor expressed in many hematopoietic cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte stimulator ( BLyS ) is a member of the tumor necrosis factor ( TNF ) ligand superfamily . ^^^ |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI . ^^^ Further , the TNF homologue APRIL [ 9 ] , a close relative of BLyS , also bound to BCMA and TACI . ^^^ BLyS or APRIL activated nuclear factor kappaB ( NF kappaB ) through TACI and BCMA , and each ligand stimulated immunoglobulin M ( IgM ) production by peripheral blood B cells . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS . ^^^ We also demonstrate that TACI interacts with nanomolar affinity with the BLyS related tumor necrosis factor homologue APRIL for which no clear in vivo role has been described . ^^^ BLyS and APRIL are capable of signaling through TACI to mediate NF kappaB responses in HEK 293 cells . ^^^ We conclude that TACI is a receptor for BLyS and APRIL and discuss the implications for B cell biology . . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BLyS acts on primary splenic B cells autonomously , and directly cooperates with CD 40 ligand ( CD40L ) in B cell activation in vitro by protecting replicating B cells from apoptosis . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Its biology is complex due to the existence of two ligands , BLyS and APRIL , and a homologous receptor , BCMA , that similarly binds both ligands . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL have similar but distinct biological roles , mediated through two known TNF receptor family members , TACI and BCMA . ^^^ These findings further elucidate the roles of BLyS and APRIL in modulating B cell development and suggest that BLyS is required for the development of most but not all mature B cell populations found in the periphery . . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The TNF related ligands APRIL and BLyS and their cognate receptors BCMA / TACI form a two ligand / two receptor system that has been shown to participate in B and T cell stimulation . ^^^ In contrast to BLyS , which is known to be cleaved from the cell surface , we found that APRIL is processed intracellularly by furin convertase . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Treatment of antigen challenged mice with BR 3 Fc inhibited antibody production , indicating an essential role for BLyS , but not APRIL , in this response . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| The TNF like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA . ^^^ BLyS has been shown to play an important role in B cell homeostasis and autoimmunity , but the biological role of APRIL remains less well defined . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| DCs induce CD 40 independent immunoglobulin class switching through BLyS and APRIL . ^^^ We show here that dendritic cells up regulate BLyS and APRIL upon exposure to interferon alpha , interferon gamma or CD 40 ligand . ^^^ In the presence of interleukin 10 ( IL 10 ) or transforming growth factor beta , BLyS and APRIL induce CSR from C ( mu ) to C ( gamma ) and / or C ( alpha ) genes in B cells , whereas CSR to C ( epsilon ) requires IL 4 . ^^^ By eliciting CD 40 independent Ig class switching and plasmacytoid differentiation , BLyS and APRIL critically link the innate and adaptive immune responses . . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune based rheumatic diseases . ^^^ BLyS and APRIL are two members of the TNF superfamily that are secreted by activated myeloid cells and have costimulatory activity on B cells . ^^^ BLyS and APRIL share two receptors , TACI and BCMA , whereas a third receptor , BAFF R , specifically binds BLyS . ^^^ Both BLyS and APRIL have been described as homotrimeric molecules , a feature common to members of the TNF superfamily . ^^^ In this study , we show that APRIL and BLyS can form active heterotrimeric molecules when coexpressed and that circulating heterotrimers are present in serum samples from patients with systemic immune based rheumatic diseases . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Rescued cDNAs contained Transmembrane Activator and calcium modulator and cyclophilin ligand ( CAML ) Interactor ( TACI ) and B Cell Maturation factor ( BCMA ) sequences , representing two published receptors of BlyS . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| However , several unresolved issues remain , including what is the contributory role of APRIL ( a tumor necrosis factor superfamily member related to BLyS ) in the ' autoimmunogenic ' effects of BLyS , identification of the ' optimal ' BLyS antagonist , and identification of those SLE patients most likely to benefit from BLyS antagonist therapy . . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| APRIL shares two TNF receptor family members , TACI and BCMA , with another TNF homolog , BLyS / BAFF . ^^^ BLyS is involved in regulation of B cell activation and survival and also binds to a third receptor , BR3 / BAFF R , which is not shared with APRIL . ^^^ Recombinant APRIL and BLyS induce accumulation of B cells in mice , while BLyS deficiency results in severe B cell dysfunction . ^^^ Thus , BLyS may be capable of fulfilling APRIL ' s main functions . . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| BLyS and its sister cytokine APRIL ( a proliferation inducing ligand ) act primarily as soluble trimers and serve to regulate the steady state numbers of nearly all B cell compartments . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| These new treatments , which target various steps of the immune response , include : B lymphocyte ( BL ) inhibitors , such as anti CD 20 monoclonal antibodies , BlyS antagonists , and tolerogens that inhibit specific BLs that produce pathogenic antibodies ; inhibitors of costimulation between antigen presenting cells and T lymphocytes ( TL ) , such as monoclonal antibodies against CD 40 ligand and CTLA 4 Ig ( abatecept ) ; TL antagonists , which can inhibit proliferation of autoreactive T cells ; cytokine antagonists ; chemokine and adhesin antagonists , which inhibit trafficking of immunocompetent cells to target organs . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Its carboxy terminus shares approximately 35 % sequence identity with the recently identified APRIL and approximately 20 25 % with TNF , FasL , TRAIL , and lymphotoxin alpha , suggesting that TALL 1 and APRIL belong to a subfamily of the TNF family of ligands . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| Sequence alignments , structural modelling and mutagenesis revealed that one disulphide bridge in BAFF R is critical for determining the binding specificity of the extracellular domain eBAFF R to TALL 1 instead of APRIL , a closely related ligand of TALL 1 , which was confirmed by binding experiments in vitro . . ^^^ Ligand receptor binding revealed by the TNF family member TALL 1 . ^^^ The tumour necrosis factor ( TNF ) ligand TALL 1 and its cognate receptors , BCMA , TACI and BAFF R , were recently identified as members of the TNF superfamily , which are essential factors contributing to B cell maturation . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| TNFRSF 19 did not bind newly cloned TNF ligands , including TWEAK ( HGMW approved symbol TNFSF 12 ) , VEGI / TL1 ( HGMW approved symbol TNFSF 15 ) , TL6 / endokine ( HGMW approved symbol TNFSF 18 ) , APRIL ( HGMW approved symbol TNFSF 13 ) , OPGL ( HGMW approved symbol TNFSF 11 ) , LIGHT ( HGMW approved symbol TNFSF 14 ) , or BAFF / THANK ( HGMW approved symbol TNFSF13B ) by enzyme linked immunosorbent assay and FACS analyses . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| TALL 1 / Blys / BAFF is a member of the tumor necrosis factor ( TNF ) ligand superfamily that is functionally involved in B cell proliferation . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| We and others recently reported tumor necrosis factor ( TNF ) and apoptosis ligand related leukocyte expressed ligand 1 ( TALL 1 ) as a novel member of the TNF ligand family that is functionally involved in B cell proliferation . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| TALL 1 / BAFF / BLyS was recently identified as a member of the tumor necrosis factor ( TNF ) ligand family . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| These experiments indicated that 10 genes , including interleukin ( IL ) 10 , lymphocyte activation gene 1 ( LAG 1 ) , GCP 2 , PBEF , ferritin , PIM 2 , TFG , CD 27 ligand , DUSP 5 , and archain , were up regulated at the mRNA level by TALL 1 stimulation in B lymphoma RPMI 8226 cells and / or primary B lymphocytes . ^^^ |
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| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O75888 |
Pubmed |
SVM Score :0.0 |
| NA |
|