| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.52651324 |
| BAFF binds to three receptors , BAFF R , transmembrane activator and CAML interactor ( TACI ) , and B cell maturation antigen ( BCMA ) , but only BAFF R is required for successful survival and maturation of splenic B cells . 0.52651324^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :1.3829912 |
| BAFF and its close homologue a proliferation inducing ligand ( APRIL ) have both been shown to interact with at least two receptors , B cell maturation antigen ( BCMA ) and transmembrane activator and cyclophilin ligand interactor ( TACI ) , however their relative contribution in transducing BAFF signals in vivo remains unclear . 1.3829912^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.5997114 |
| BAFF is known to interact with three receptors , BCMA , TACI and BAFF R , that have distant similarities with other receptors of the TNF family . 0.5997114^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.79358308 |
| In addition , NHL B cells express BAFF receptor , which binds BAFF , as well as transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag ( BCMA ) , which bind both BAFF and APRIL . 0.79358308^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.57439216 |
| TACI binds two ligands , APRIL and BAFF , with high affinity and contains two cysteine rich domains ( CRDs ) in its extracellular region ; in contrast , BCMA and BR 3 , the other known high affinity receptors for APRIL and BAFF , respectively , contain only a single or partial CRD . 0.57439216^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we sequenced the BAFF R gene in 48 patients with common variable immunodeficiency ( CVID ) along with 57 healthy controls . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS interacts with the TNF receptor ( TNFR ) homologue TACI ( transmembrane activator and CAML interactor ) [ 5 ] , and treatment of mice with a TACI Fc fusion protein abolishes germinal center formation after antigenic challenge [ 6 ] . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| APRIL functions via binding to BCMA ( B cell maturation antigen ) and TACI ( transmembrane activator and CAML interactor ) and competes with TALL 1 ( also called BLyS or BAFF ) for receptor binding . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| All MM cells studied expressed one or more of 3 known receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and CAML interactor [ TACI ] , and B cell activating factor receptor [ BAFF R ] ) for BLyS ; however , the pattern of expression was variable . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we have found that the Expi accelerated apoptosis is mediated via BAFF receptor among three known BAFF receptors : BAFF receptor , tumor necrosis factor ( TNF ) receptor homologue TACI ( transmembrane activator and CAML interactor ) , and BCMA ( another TNFR homologue , B cell maturation antigen ) . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Currently , three receptors have been identified that transmit signals upon BLyS and APRIL binding and these include B cell maturation antigen , B cell activating factor receptor , and transmembrane activator and CAML interactor . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Biologic effects of BLyS and APRIL were explored by treating human synovium SCID mouse chimeras with the APRIL and BLyS decoy receptor transmembrane activator and CAML interactor : Fc ( TACI : Fc ) . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We show here that BAFF R and transmembrane activator and CAML interactor ( TACI ) are the major receptors expressed by B 1 cells . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We tested the ability of BLyS to stimulate B lymphocytes obtained from CVID patients . ^^^ These results suggest that BLyS induces proliferative and Ig secretory responses in B lymphocytes isolated from some CVID patients and lend support to its potential use in therapy of this disorder . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The knock out model for BLyS is characterized by an immunological phenotype reminiscent of the human phenotype of common variable immunodeficiency ( CVID ) . ^^^ CVID is characterized by a defective B cell compartment , evidencing the putative importance of BLyS in its pathogenesis . ^^^ In fact , mutations in TACI , one of the three BLyS receptors , are associated with CVID . ^^^ Based on these facts , we hypothesized that BLyS could be a candidate gene for CVID . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We have identified two TNF receptor family members , TACI and BCMA , that bind zTNF 4 . ^^^ These findings demonstrate the involvement of zTNF 4 and its receptors in the development of SLE and identify TACI Ig as a promising treatment of autoimmune disease in humans . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TACI is a TRAF interacting receptor for TALL 1 , a tumor necrosis factor family member involved in B cell regulation . ^^^ Human TACI exhibits high binding affinities to both human and murine TALL 1 . ^^^ Soluble TACI extracellular domain protein specifically blocks TALL 1 mediated B cell proliferation without affecting CD 40 or lipopolysaccharide mediated B cell proliferation in vitro . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| An expression cloning approach was employed to identify the receptor for B lymphocyte stimulator ( BLyS ) and identified the tumor necrosis factor receptor superfamily member TACI as a BLyS binding protein . ^^^ Tumor necrosis factor ( TNF ) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS . ^^^ Expression of TACI in HEK293T cells confers on the cells the ability to bind BLyS with subnanomolar affinity . ^^^ Furthermore , a TACI Fc fusion protein recognizes both the cleaved , soluble form of BLyS as well as the membrane BLyS present on the cell surface of a recombinant cell line . ^^^ TACI mRNA is found predominantly in B cells and correlates with BLyS binding in a panel of B cell lines . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We identified a B cell receptor for BLyS through expression cloning as TACI , an orphan TNF receptor homologue of unknown function . ^^^ Binding of BLyS to TACI activated signaling by nuclear factor kappa B ( NF kappa B ) . ^^^ In vitro soluble TACI Fc fusion protein blocked BLyS induced NF kappa B activation in B lymphoma cells and IgM production in peripheral blood B cells . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| These data suggest a functional redundancy of BCMA in B cell physiology that is probably due to the presence of TACI , another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Interactions of the tumor necrosis factor superfamily members B lymphocyte stimulator ( BLyS ) and a proliferation inducing ligand ( APRIL ) with their receptors transmembrane activator and CAML interactor ( TACI ) and B cell maturation molecule ( BCMA ) on B cells play an important role in the humoral immune response . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The TNF like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TALL 1 is a member of the tumor necrosis factor family that binds to BCMA , TACI , and BAFF R , three receptors mostly expressed by mature B lymphocytes . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL share two receptors , TACI and BCMA , whereas a third receptor , BAFF R , specifically binds BLyS . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Finally , three membrane receptors ( TACI , BCMA , and BAFF R ) which bind a newly discovered member of the tumor necrosis factor family named BAFF . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TALL 1 has three receptors , including BCMA , TACI , and BAFF R , which are mostly expressed by B lymphocytes . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Importantly , a TACI ( trans membrane activator and CAML interactor ) Fc fusion protein inhibits both macrophage and dendritic cell ( DC ) dependent BCR activated B cell proliferation , indicating a requirement for at least one of the known TACI ligands , BAFF and / or APRIL . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Rescued cDNAs contained Transmembrane Activator and calcium modulator and cyclophilin ligand ( CAML ) Interactor ( TACI ) and B Cell Maturation factor ( BCMA ) sequences , representing two published receptors of BlyS . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Loss of TACI causes fatal lymphoproliferation and autoimmunity , establishing TACI as an inhibitory BLyS receptor . ^^^ BLys , a key cytokine that sustains B cell maturation and tolerance , binds three receptors : BR 3 , BCMA , and TACI . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TACI Ig neutralizes molecules critical for B cell development and autoimmune disease . impaired B cell maturation in mice lacking BLyS . ^^^ BLyS and APRIL have similar but distinct biological roles , mediated through two known TNF receptor family members , TACI and BCMA . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BCMA ( TNFRSF 17 ) , along with TACI , has recently been demonstrated to be a receptor for BLyS ( TNFSF13B ) . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The B cell activating factor BAFF ( BlyS / TALL 1 / zTNF4 ) is a tumor necrosis factor ( TNF ) related ligand that promotes B cell survival and binds to three receptors ( BCMA , TACI , and the recently described BAFF R ) . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS ( also called BAFF , TALL 1 , THANK , and zTNF 4 ) , a TNF superfamily member , binds two receptors , TACI and BCMA , and regulates humoral immune responses [ 1 7 ] . ^^^ BLyS ( also called BAFF , TALL 1 , THANK , and zTNF 4 ) , a TNF superfamily member , binds two receptors , TACI and BCMA , and regulates humoral immune responses [ 1 7 ] . ^^^ The results from TACI ( / ) and BCMA ( / ) mice suggest the existence of additional receptor ( s ) for BLyS . ^^^ This receptor is unique in that , in contrast to TACI and BCMA , BR 3 only binds BLyS . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF and APRIL bind to BAFF receptor and TACI and are major B cell survival factors . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| They interact with 3 receptors : BAFF R , specific to BAFF ; and TACI and BCMA , which are shared by BAFF and APRIL . ^^^ TACI and BAFF R mRNAs were found in leukemic B cells . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| It binds to three different receptors , BCMA , TACI , and BAFF R , which are all members of the family of TNF receptors . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| RESULTS : LymphoStat B bound with high affinity to human BLyS and inhibited the binding of BLyS to its 3 receptors , TACI , BCMA , and BLyS receptor 3 / BAFF R . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Soluble recombinant chBAFF produced by human 293T cells interacted with the mammalian cell surface receptors TACI , BCMA and BAFF R . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| APRIL shares two TNF receptor family members , TACI and BCMA , with another TNF homolog , BLyS / BAFF . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The tumour necrosis factor ( TNF ) ligand TALL 1 and its cognate receptors , BCMA , TACI and BAFF R , were recently identified as members of the TNF superfamily , which are essential factors contributing to B cell maturation . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We confirmed the expression of BAFF and APRIL receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and calcium modulator and cyclophilin ligand interactor [ TACI ] , and BAFF R ) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Its biological role is mediated by the specific receptors BCMA , TACI and BAFF R . ^^^ Modeling of TACI BAFF complex suggests that both CDRs simultaneously interact with the BAFF dimer in the virus like cage . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF binds three receptors , TACI , BCMA , and BR 3 , with signaling through BR 3 being essential for promoting B cell function . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF exerts its effect by binding to three receptors transmembrane activator of and CAML interactor ( TACI ) , B cell maturation antigen ( BCMA ) , and BAFF receptor ( BAFF R ) . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors ( BCMA , TACI , and BAFF R ) for BLyS ; however , the pattern of expression was variable . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to three receptors , BR 3 , TACI and BCMA . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Three receptors have been identified that bind to BAFF : transmembrane activator , calcium modulator , and cyclophilin ligand interactor ( TACI ) ; B cell maturation Ag ( BCMA ) ; and BAFF R . ^^^ This finding , together with normal or enhanced B cell generation in mice deficient for BCMA or TACI , respectively , suggested that the interaction of BAFF with BAFF R triggers signals essential for the generation and maintenance of mature B cells . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| The TNF related ligand , B cell activating factor belonging to the TNF family ( BAFF ) , is necessary for normal B cell development and survival , and specifically binds the receptors transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , B cell maturation Ag ( BCMA ) , and BAFF R . ^^^ Also , mice lacking both TACI and BCMA simultaneously exhibit no B cell loss , thus confirming that BAFF R is the primary receptor for transmitting the BAFF dependent B cell survival signal . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We report that the binding of BAFF to BAFF R expressed by a subset of primarily CD 4 ( + ) T cells costimulates T cell activation and allo proliferation in vitro and in vivo , and that mice with a mutation in the BAFF R , or with a targeted deletion of BAFF , show prolonged cardiac allograft survival as compared to wild type or transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) ( / ) controls . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| APRIL binds the receptors B cell maturation antigen ( BCMA ) and TACI with high affinity ; both of these receptors have also been shown to bind BAFF , although BCMA has significantly higher affinity for APRIL than BAFF . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TACI and BAFF R mediate isotype switching in B cells . ^^^ APRIL and BAFF each engage two receptors , transmembrane activator and calcium modulator and cytophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) , on B cells . ^^^ To determine the role of these receptors in isotype switching , we examined B cells from mice deficient in TACI , BCMA , and BAFF R . ^^^ The results obtained indicate that both TACI and BAFF R are able to transduce signals that result in isotype switching . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF ( B cell activating factor of the TNF family , also known as BlyS and TALL 1 ) , a TNF family cytokine critical for the development and function of B cells , has been reported to bind to three receptors , BCMA ( B cell maturation protein ) , TACI ( transmembrane activator and CAML [ calcium modulator and cyclophilin ligand ] interactor ) , and BAFFR ( BAFF receptor ) , but with widely conflicting values for the affinity and selectivity of binding . ^^^ BCMA and TACI additionally bind APRIL ( a proliferation inducing ligand ) , the TNF family ligand most homologous to BAFF . ^^^ BAFF ( B cell activating factor of the TNF family , also known as BlyS and TALL 1 ) , a TNF family cytokine critical for the development and function of B cells , has been reported to bind to three receptors , BCMA ( B cell maturation protein ) , TACI ( transmembrane activator and CAML [ calcium modulator and cyclophilin ligand ] interactor ) , and BAFFR ( BAFF receptor ) , but with widely conflicting values for the affinity and selectivity of binding . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Myeloma cells ( MMCs ) express TACI ( transmembrane activator and calcium modulator and cyclophilin ligand interactor ) , the receptor of BAFF / APRIL , at varying levels . ^^^ TACI expression is a good indicator of a BAFF binding receptor . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , BAFF R , TACI and BCMA , whereas APRIL interacts with TACI , BCMA and proteoglycans . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ BAFF R expression increased initially and then decreased with a corresponding induction of TACI and BCMA expression during differentiation to plasma cells ( PCs ) . ^^^ Consistently , blocking of BAFF R alone with specific mAb inhibited GC B cell proliferation and PC generation in the early period of their differentiation , whereas depletion of BAFF with TACI Ig exhibited consistent inhibition throughout the differentiation . ^^^ B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| TACItly changing tunes : farewell to a yin and yang of BAFF receptor and TACI in humoral immunity . ^^^ PURPOSE OF REVIEW : The complex system of the tumour necrosis factor ligands BAFF and APRIL and their three receptors BCMA , TACI and BAFF receptor and its role in B cell development and function is the objective of extensive research . ^^^ Whereas the importance of BAFF / BAFF receptor interactions for B cell survival could be clearly demonstrated , TACI is believed to counteract BAFF activity as a negative regulator in the murine model . ^^^ The recent discovery of genetic defects in the tumour necrosis factor receptor superfamily members TACI and BAFF receptor in patients with common variable immunodeficiency denotes further advances in this field . ^^^ SUMMARY : In this review we will discuss recent progress made in the understanding of the BAFF / APRIL TACI / BCMA / BAFF receptor system in relation to the recent discovery that mutations in human TACI cause a primary humoral immunodeficiency . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BAFF is a ligand for three TNF receptor superfamily members : B cell maturation antigen ( BCMA ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , and BAFF receptor ( BAFF R ) . ^^^ Among them , BAFF R plays the central role in the BAFF system , whereas TACI plays the inhibitory role . ^^^ Furthermore , inhibition of BAFF by TACI Ig and BAFFR Ig has been successful in treating murine models of SLE and rheumatoid arthritis . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Here we review approaches to antagonise members of the CD 28 B7 superfamily as well as the TNF receptor ligand superfamily members , BAFF and APRIL , and their corresponding receptors on B cells ( BAFF R , TACI and BCMA ) . ^^^ Thus , the recent discovery of deletions in the ICOS , BAFF R and TACI genes leading to disturbances in late B cell differentiation and hypogammaglobulinaemia underline the potential impact of targeting these molecules for therapeutic strategies in autoimmune disorders . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that B cell dendritic cell ( DC ) interactions via transmembrane activator and calcium modulator and cyclophilin ligand ( CAML ) interactor ( TACI ) and B lymphocyte stimulator ( BLyS ) provide an early signal critical to generate adequate numbers of mature antigen presenting cells ( APCs ) to prime naive CD 8 ( + ) T cells ( CTLs ) in vivo . ^^^ TACI BLyS signaling via B cell dendritic cell cooperation is required for naive CD8+ T cell priming in vivo . ^^^ BLyS ( high ) peptide pulsed bone marrow derived DCs , used as vaccines in vivo , can not generate CTLs in B cell deficient and TACI deficient mice , strongly supporting a need for B cell DC cooperation through TACI BLyS during CTL first encounter with antigens in vivo . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| A transmembrane activator and calcium modulating and cyclophilin ligand interactor ( TACI ) Ig fusion protein ( which neutralizes both BAFF and a proliferation inducing ligand ( APRIL ) , another TNF family member ) inhibited Hg induced autoantibody or serum IgE production . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Malignant B cells were found to bind soluble BLyS and variably express the receptors BAFF R , TACI , and BCMA . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Antibodies to the receptors BAFF R , BCMA , and TACI were used to define expression of the individual BLyS receptors on subsets of B cells in blood , spleen , and tonsils . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI , BCMA , and BAFF R , which are expressed by mature B cells . ^^^ Syndecan 2 bound TACI but bound neither BAFF R nor BCMA . ^^^ This is the first identification of ligands that selectively activate TACI without simultaneously triggering BCMA or BAFF R . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to 3 TNF R receptors , TACI , BCMA , BAFF R , to regulate B cell survival , differentiation , and proliferation . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| By comparing BAFF and a proliferation inducing ligand ( APRIL ) efficacy at different stages in the response ( only BAFF binds BR 3 ; both bind transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag , the early role was attributed to BR 3 , while the later role was attributed to TACI / B cell maturation Ag . ^^^ Increased yield of viable progeny was associated with elevated Mcl 1 , suggesting that a BAFF / APRIL > TACI > COX 2 > PGE 2 > Mcl 1 pathway reduces activation related , mitochondrial apoptosis in replicating human B 2 cell clones . . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| Regarding BLyS receptor ( s ) expression , freshly isolated monocytes bound low levels of exogenous BLyS and expressed primarily intracellular TACI , and cell surface TACI levels increased following monocyte activation . ^^^ |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14836 and Q9Y275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :1.3829912 |
| BAFF and its close homologue a proliferation inducing ligand ( APRIL ) have both been shown to interact with at least two receptors , B cell maturation antigen ( BCMA ) and transmembrane activator and cyclophilin ligand interactor ( TACI ) , however their relative contribution in transducing BAFF signals in vivo remains unclear . 1.3829912^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.5997114 |
| BAFF is known to interact with three receptors , BCMA , TACI and BAFF R , that have distant similarities with other receptors of the TNF family . 0.5997114^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.52651324 |
| BAFF binds to three receptors , BAFF R , transmembrane activator and CAML interactor ( TACI ) , and B cell maturation antigen ( BCMA ) , but only BAFF R is required for successful survival and maturation of splenic B cells . 0.52651324^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.79358308 |
| In addition , NHL B cells express BAFF receptor , which binds BAFF , as well as transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag ( BCMA ) , which bind both BAFF and APRIL . 0.79358308^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.57439216 |
| TACI binds two ligands , APRIL and BAFF , with high affinity and contains two cysteine rich domains ( CRDs ) in its extracellular region ; in contrast , BCMA and BR 3 , the other known high affinity receptors for APRIL and BAFF , respectively , contain only a single or partial CRD . 0.57439216^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| APRIL functions via binding to BCMA ( B cell maturation antigen ) and TACI ( transmembrane activator and CAML interactor ) and competes with TALL 1 ( also called BLyS or BAFF ) for receptor binding . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| These data suggest a functional redundancy of BCMA in B cell physiology that is probably due to the presence of TACI , another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL . . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| The B cell activating factor BAFF ( BlyS / TALL 1 / zTNF4 ) is a tumor necrosis factor ( TNF ) related ligand that promotes B cell survival and binds to three receptors ( BCMA , TACI , and the recently described BAFF R ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BLyS ( also called BAFF , TALL 1 , THANK , and zTNF 4 ) , a TNF superfamily member , binds two receptors , TACI and BCMA , and regulates humoral immune responses [ 1 7 ] . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Finally , three membrane receptors ( TACI , BCMA , and BAFF R ) which bind a newly discovered member of the tumor necrosis factor family named BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Importantly , a TACI ( trans membrane activator and CAML interactor ) Fc fusion protein inhibits both macrophage and dendritic cell ( DC ) dependent BCR activated B cell proliferation , indicating a requirement for at least one of the known TACI ligands , BAFF and / or APRIL . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Its biological role is mediated by the specific receptors BCMA , TACI and BAFF R . ^^^ Modeling of TACI BAFF complex suggests that both CDRs simultaneously interact with the BAFF dimer in the virus like cage . . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BAFF binds three receptors , TACI , BCMA , and BR 3 , with signaling through BR 3 being essential for promoting B cell function . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BAFF exerts its effect by binding to three receptors transmembrane activator of and CAML interactor ( TACI ) , B cell maturation antigen ( BCMA ) , and BAFF receptor ( BAFF R ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BAFF and APRIL bind to BAFF receptor and TACI and are major B cell survival factors . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| They interact with 3 receptors : BAFF R , specific to BAFF ; and TACI and BCMA , which are shared by BAFF and APRIL . ^^^ TACI and BAFF R mRNAs were found in leukemic B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| It binds to three different receptors , BCMA , TACI , and BAFF R , which are all members of the family of TNF receptors . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Soluble recombinant chBAFF produced by human 293T cells interacted with the mammalian cell surface receptors TACI , BCMA and BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we have found that the Expi accelerated apoptosis is mediated via BAFF receptor among three known BAFF receptors : BAFF receptor , tumor necrosis factor ( TNF ) receptor homologue TACI ( transmembrane activator and CAML interactor ) , and BCMA ( another TNFR homologue , B cell maturation antigen ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| We confirmed the expression of BAFF and APRIL receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and calcium modulator and cyclophilin ligand interactor [ TACI ] , and BAFF R ) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Three receptors have been identified that bind to BAFF : transmembrane activator , calcium modulator , and cyclophilin ligand interactor ( TACI ) ; B cell maturation Ag ( BCMA ) ; and BAFF R . ^^^ This finding , together with normal or enhanced B cell generation in mice deficient for BCMA or TACI , respectively , suggested that the interaction of BAFF with BAFF R triggers signals essential for the generation and maintenance of mature B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| The TNF related ligand , B cell activating factor belonging to the TNF family ( BAFF ) , is necessary for normal B cell development and survival , and specifically binds the receptors transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , B cell maturation Ag ( BCMA ) , and BAFF R . ^^^ Also , mice lacking both TACI and BCMA simultaneously exhibit no B cell loss , thus confirming that BAFF R is the primary receptor for transmitting the BAFF dependent B cell survival signal . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| We report that the binding of BAFF to BAFF R expressed by a subset of primarily CD 4 ( + ) T cells costimulates T cell activation and allo proliferation in vitro and in vivo , and that mice with a mutation in the BAFF R , or with a targeted deletion of BAFF , show prolonged cardiac allograft survival as compared to wild type or transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) ( / ) controls . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| APRIL binds the receptors B cell maturation antigen ( BCMA ) and TACI with high affinity ; both of these receptors have also been shown to bind BAFF , although BCMA has significantly higher affinity for APRIL than BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| TACI and BAFF R mediate isotype switching in B cells . ^^^ APRIL and BAFF each engage two receptors , transmembrane activator and calcium modulator and cytophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) , on B cells . ^^^ To determine the role of these receptors in isotype switching , we examined B cells from mice deficient in TACI , BCMA , and BAFF R . ^^^ The results obtained indicate that both TACI and BAFF R are able to transduce signals that result in isotype switching . . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BAFF ( B cell activating factor of the TNF family , also known as BlyS and TALL 1 ) , a TNF family cytokine critical for the development and function of B cells , has been reported to bind to three receptors , BCMA ( B cell maturation protein ) , TACI ( transmembrane activator and CAML [ calcium modulator and cyclophilin ligand ] interactor ) , and BAFFR ( BAFF receptor ) , but with widely conflicting values for the affinity and selectivity of binding . ^^^ BCMA and TACI additionally bind APRIL ( a proliferation inducing ligand ) , the TNF family ligand most homologous to BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Myeloma cells ( MMCs ) express TACI ( transmembrane activator and calcium modulator and cyclophilin ligand interactor ) , the receptor of BAFF / APRIL , at varying levels . ^^^ TACI expression is a good indicator of a BAFF binding receptor . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BAFF binds to three receptors , BAFF R , TACI and BCMA , whereas APRIL interacts with TACI , BCMA and proteoglycans . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| B cell activating factor of the tumor necrosis factor family ( BAFF / BLys ) plays a critical role in B cell survival and immune responses through its three receptors : BAFF receptor ( BAFF R / BR3 ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation antigen ( BCMA ) . ^^^ BAFF R expression increased initially and then decreased with a corresponding induction of TACI and BCMA expression during differentiation to plasma cells ( PCs ) . ^^^ Consistently , blocking of BAFF R alone with specific mAb inhibited GC B cell proliferation and PC generation in the early period of their differentiation , whereas depletion of BAFF with TACI Ig exhibited consistent inhibition throughout the differentiation . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| A transmembrane activator and calcium modulating and cyclophilin ligand interactor ( TACI ) Ig fusion protein ( which neutralizes both BAFF and a proliferation inducing ligand ( APRIL ) , another TNF family member ) inhibited Hg induced autoantibody or serum IgE production . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| TACItly changing tunes : farewell to a yin and yang of BAFF receptor and TACI in humoral immunity . ^^^ PURPOSE OF REVIEW : The complex system of the tumour necrosis factor ligands BAFF and APRIL and their three receptors BCMA , TACI and BAFF receptor and its role in B cell development and function is the objective of extensive research . ^^^ Whereas the importance of BAFF / BAFF receptor interactions for B cell survival could be clearly demonstrated , TACI is believed to counteract BAFF activity as a negative regulator in the murine model . ^^^ The recent discovery of genetic defects in the tumour necrosis factor receptor superfamily members TACI and BAFF receptor in patients with common variable immunodeficiency denotes further advances in this field . ^^^ SUMMARY : In this review we will discuss recent progress made in the understanding of the BAFF / APRIL TACI / BCMA / BAFF receptor system in relation to the recent discovery that mutations in human TACI cause a primary humoral immunodeficiency . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BAFF is a ligand for three TNF receptor superfamily members : B cell maturation antigen ( BCMA ) , transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) , and BAFF receptor ( BAFF R ) . ^^^ Among them , BAFF R plays the central role in the BAFF system , whereas TACI plays the inhibitory role . ^^^ Furthermore , inhibition of BAFF by TACI Ig and BAFFR Ig has been successful in treating murine models of SLE and rheumatoid arthritis . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| B lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI , BCMA , and BAFF R , which are expressed by mature B cells . ^^^ Syndecan 2 bound TACI but bound neither BAFF R nor BCMA . ^^^ This is the first identification of ligands that selectively activate TACI without simultaneously triggering BCMA or BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we sequenced the BAFF R gene in 48 patients with common variable immunodeficiency ( CVID ) along with 57 healthy controls . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Here we review approaches to antagonise members of the CD 28 B7 superfamily as well as the TNF receptor ligand superfamily members , BAFF and APRIL , and their corresponding receptors on B cells ( BAFF R , TACI and BCMA ) . ^^^ Thus , the recent discovery of deletions in the ICOS , BAFF R and TACI genes leading to disturbances in late B cell differentiation and hypogammaglobulinaemia underline the potential impact of targeting these molecules for therapeutic strategies in autoimmune disorders . . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Interactions of the tumor necrosis factor superfamily members B lymphocyte stimulator ( BLyS ) and a proliferation inducing ligand ( APRIL ) with their receptors transmembrane activator and CAML interactor ( TACI ) and B cell maturation molecule ( BCMA ) on B cells play an important role in the humoral immune response . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that B cell dendritic cell ( DC ) interactions via transmembrane activator and calcium modulator and cyclophilin ligand ( CAML ) interactor ( TACI ) and B lymphocyte stimulator ( BLyS ) provide an early signal critical to generate adequate numbers of mature antigen presenting cells ( APCs ) to prime naive CD 8 ( + ) T cells ( CTLs ) in vivo . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI . ^^^ BLyS interacts with the TNF receptor ( TNFR ) homologue TACI ( transmembrane activator and CAML interactor ) [ 5 ] , and treatment of mice with a TACI Fc fusion protein abolishes germinal center formation after antigenic challenge [ 6 ] . ^^^ Further , the TNF homologue APRIL [ 9 ] , a close relative of BLyS , also bound to BCMA and TACI . ^^^ BLyS or APRIL activated nuclear factor kappaB ( NF kappaB ) through TACI and BCMA , and each ligand stimulated immunoglobulin M ( IgM ) production by peripheral blood B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| By comparing BAFF and a proliferation inducing ligand ( APRIL ) efficacy at different stages in the response ( only BAFF binds BR 3 ; both bind transmembrane activator and calcium modulator and cyclophilin ligand interactor ( TACI ) and B cell maturation Ag , the early role was attributed to BR 3 , while the later role was attributed to TACI / B cell maturation Ag . ^^^ Increased yield of viable progeny was associated with elevated Mcl 1 , suggesting that a BAFF / APRIL > TACI > COX 2 > PGE 2 > Mcl 1 pathway reduces activation related , mitochondrial apoptosis in replicating human B 2 cell clones . . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| We show here that BAFF R and transmembrane activator and CAML interactor ( TACI ) are the major receptors expressed by B 1 cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| All MM cells studied expressed one or more of 3 known receptors ( B cell maturation antigen [ BCMA ] , transmembrane activator and CAML interactor [ TACI ] , and B cell activating factor receptor [ BAFF R ] ) for BLyS ; however , the pattern of expression was variable . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Currently , three receptors have been identified that transmit signals upon BLyS and APRIL binding and these include B cell maturation antigen , B cell activating factor receptor , and transmembrane activator and CAML interactor . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| An expression cloning approach was employed to identify the receptor for B lymphocyte stimulator ( BLyS ) and identified the tumor necrosis factor receptor superfamily member TACI as a BLyS binding protein . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Loss of TACI causes fatal lymphoproliferation and autoimmunity , establishing TACI as an inhibitory BLyS receptor . ^^^ BLys , a key cytokine that sustains B cell maturation and tolerance , binds three receptors : BR 3 , BCMA , and TACI . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| We tested the ability of BLyS to stimulate B lymphocytes obtained from CVID patients . ^^^ These results suggest that BLyS induces proliferative and Ig secretory responses in B lymphocytes isolated from some CVID patients and lend support to its potential use in therapy of this disorder . . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| RESULTS : LymphoStat B bound with high affinity to human BLyS and inhibited the binding of BLyS to its 3 receptors , TACI , BCMA , and BLyS receptor 3 / BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| APRIL shares two TNF receptor family members , TACI and BCMA , with another TNF homolog , BLyS / BAFF . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| We identified a B cell receptor for BLyS through expression cloning as TACI , an orphan TNF receptor homologue of unknown function . ^^^ Binding of BLyS to TACI activated signaling by nuclear factor kappa B ( NF kappa B ) . ^^^ In vitro soluble TACI Fc fusion protein blocked BLyS induced NF kappa B activation in B lymphoma cells and IgM production in peripheral blood B cells . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| TACI Ig neutralizes molecules critical for B cell development and autoimmune disease . impaired B cell maturation in mice lacking BLyS . ^^^ BLyS and APRIL have similar but distinct biological roles , mediated through two known TNF receptor family members , TACI and BCMA . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BCMA ( TNFRSF 17 ) , along with TACI , has recently been demonstrated to be a receptor for BLyS ( TNFSF13B ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| The TNF like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BLyS and APRIL share two receptors , TACI and BCMA , whereas a third receptor , BAFF R , specifically binds BLyS . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Rescued cDNAs contained Transmembrane Activator and calcium modulator and cyclophilin ligand ( CAML ) Interactor ( TACI ) and B Cell Maturation factor ( BCMA ) sequences , representing two published receptors of BlyS . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| We found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors ( BCMA , TACI , and BAFF R ) for BLyS ; however , the pattern of expression was variable . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to three receptors , BR 3 , TACI and BCMA . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Biologic effects of BLyS and APRIL were explored by treating human synovium SCID mouse chimeras with the APRIL and BLyS decoy receptor transmembrane activator and CAML interactor : Fc ( TACI : Fc ) . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Malignant B cells were found to bind soluble BLyS and variably express the receptors BAFF R , TACI , and BCMA . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Antibodies to the receptors BAFF R , BCMA , and TACI were used to define expression of the individual BLyS receptors on subsets of B cells in blood , spleen , and tonsils . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| BLyS binds to 3 TNF R receptors , TACI , BCMA , BAFF R , to regulate B cell survival , differentiation , and proliferation . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| Regarding BLyS receptor ( s ) expression , freshly isolated monocytes bound low levels of exogenous BLyS and expressed primarily intracellular TACI , and cell surface TACI levels increased following monocyte activation . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| The knock out model for BLyS is characterized by an immunological phenotype reminiscent of the human phenotype of common variable immunodeficiency ( CVID ) . ^^^ CVID is characterized by a defective B cell compartment , evidencing the putative importance of BLyS in its pathogenesis . ^^^ In fact , mutations in TACI , one of the three BLyS receptors , are associated with CVID . ^^^ Based on these facts , we hypothesized that BLyS could be a candidate gene for CVID . ^^^ BLyS , a TNF family member , is crucial for B cell proliferation and differentiation by acting through its three receptors , TACI , BCMA and BAFF R . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| TACI is a TRAF interacting receptor for TALL 1 , a tumor necrosis factor family member involved in B cell regulation . ^^^ Human TACI exhibits high binding affinities to both human and murine TALL 1 . ^^^ Soluble TACI extracellular domain protein specifically blocks TALL 1 mediated B cell proliferation without affecting CD 40 or lipopolysaccharide mediated B cell proliferation in vitro . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| TALL 1 is a member of the tumor necrosis factor family that binds to BCMA , TACI , and BAFF R , three receptors mostly expressed by mature B lymphocytes . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| TALL 1 has three receptors , including BCMA , TACI , and BAFF R , which are mostly expressed by B lymphocytes . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| The tumour necrosis factor ( TNF ) ligand TALL 1 and its cognate receptors , BCMA , TACI and BAFF R , were recently identified as members of the TNF superfamily , which are essential factors contributing to B cell maturation . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| We have identified two TNF receptor family members , TACI and BCMA , that bind zTNF 4 . ^^^ These findings demonstrate the involvement of zTNF 4 and its receptors in the development of SLE and identify TACI Ig as a promising treatment of autoimmune disease in humans . . ^^^ |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y275 and O14836 |
Pubmed |
SVM Score :0.0 |
| NA |
|