| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :1.0754345 |
| Recently , the C terminal region of mammalian REV 1 ( the total 1251 residues in human ) was found to interact with Pol eta , Pol iota , and Pol kappa , as well as with the REV 7 subunit of another TLS enzyme , Pol zeta . 1.0754345^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| In Saccharomyces cerevisiae cells postreplicative translesion synthesis is realized by newly discovered enzymes deoxycytidilmonophosphatetransferase ( encoded by REV 1 gene ) , DNA polymerase zeta ( encoded by REV 3 gene ) , DNA polymerase eta ( encoded by RAD 30 gene ) . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| These are the lesion replicating enzymes pol zeta , pol eta , pol iota , pol kappa , and Rev 1 , and a group of pols called pol theta ; , pol lambda , pol micro , pol sigma , and pol phi that fulfill a variety of other tasks . . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| The Y family of DNA polymerases pol eta , pol iota , pol kappa and rev 1 are specialized for copying DNA lesions and have high rates of error when copying a normal DNA template . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| Based upon phylogenetic relationships , the broad Y family of DNA polymerases can be divided into various subfamilies consisting of UmuC ( polV ) like ; DinB ( polIV / polkappa ) like ; Rev 1 like , Rad30A ( poleta ) like and Rad30B ( poliota ) like polymerases . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| We show too that Rev 1 interacts independently with Rev 7 ( a subunit of a TLS polymerase , Pol zeta ) and with two other Y family polymerases , Pol iota and Pol eta . ^^^ Mouse Pol kappa , Rev 7 , Pol iota and Pol eta each bind to the same approximately 100 amino acid C terminal region of Rev 1 . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| We have investigated the relative roles in vivo of Saccharomyces cerevisiae DNA polymerase eta , DNA polymerase zeta , Rev 1 protein , and the DNA polymerase delta subunit , Pol 32 , in the bypass of an abasic site , T T ( 6 4 ) photoadduct and T T cis syn cyclobutane dimer , by transforming strains deleted for RAD 30 , REV 3 , REV 1 , or POL 32 with duplex plasmids carrying one of these DNA lesions located within a 28 nucleotide single stranded region . ^^^ The relative roles in vivo of Saccharomyces cerevisiae Pol eta , Pol zeta , Rev 1 protein and Pol 32 in the bypass and mutation induction of an abasic site , T T ( 6 4 ) photoadduct and T T cis syn cyclobutane dimer . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| Employing the same two conditions , we now examined the effect of deletions of the genes coding for polymerase eta ( Pol eta ) ( RAD 30 ) and Rev1p ( REV 1 ) . ^^^ In a NER deficient strain background , the increased incidence of stationary phase mutations was only moderately influenced by a lack of Pol eta but completely reduced to wild type level by a knockout of the REV 1 gene . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| However , whereas the activity of DNA polymerase zeta remains unaffected by ubiquitination of PCNA , ubiquitinated PCNA specifically activates two key enzymes in translesion synthesis : DNA polymerase eta , the yeast Xeroderma pigmentosum ortholog , and Rev 1 , a deoxycytidyl transferase that functions in organizing the mutagenic DNA replication machinery . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| A human DNA polymerase eta complex containing Rad 18 , Rad 6 and Rev 1 ; proteomic analysis and targeting of the complex to the chromatin bound fraction of cells undergoing replication fork arrest . ^^^ |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBZ9 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
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