| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.70064051 |
| Physical and functional interactions of human DNA polymerase eta with PCNA . 0.70064051^^^ |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.50586248 |
| Interaction of human DNA polymerase eta with monoubiquitinated PCNA : a possible mechanism for the polymerase switch in response to DNA damage . 0.50586248^^^ |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| Interaction with PCNA is essential for yeast DNA polymerase eta function . ^^^ |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| Proliferating cell nuclear antigen ( PCNA ) has been shown to interact with a variety of DNA polymerases ( pol ) such as pol delta , pol epsilon , pol iota , pol kappa , pol eta , and pol beta . ^^^ |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| XPV cells with non functional p 53 , as a result of transformation by SV 40 or HPV 16 ( E6 / E7 ) , recruit the hMre11 / hRad50 / Nbs1 complex to arrested replication forks , coincident with PCNA , whereas normal transformed cells preferentially use the pol eta bypass replication pathway . ^^^ |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| Pol eta possesses a conserved PCNA binding motif at the C terminal and phosphorylation of this motif might be essential for its interaction with PCNA . ^^^ In this study we examined whether the accumulation of Pol eta in replication foci after DNA damage is dependent on phosphorylation of the PCNA binding motif . ^^^ Our data indicate that ( 1 ) Pol eta is not phosphorylated in response to UV irradiation or MMS treatment , but its diffusional mobility is slightly decreased , and ( 2 ) hRad 18 accumulates in MMS treated cells , and considerable amount of the protein co localizes with detergent insoluble PCNA in replication foci ; these responses are sensitive to staurosporine . ^^^ |
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| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| Several genes have been determined to function in separate branches within this group , including RAD 5 , REV3 / REV7 ( Pol zeta ) , RAD 30 ( Pol eta ) , and POL 30 ( PCNA ) . ^^^ |
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| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| Here , we used the FRAP assay to study the dynamics of the GFP tagged PCNA binding proteins : Flap endonuclease 1 ( Fen 1 ) and DNA polymerase eta ( Pol eta ) . ^^^ The mobilities of focal GFP Pol eta and GFP PCNA did not change after MMS . ^^^ |
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| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| However , whereas the activity of DNA polymerase zeta remains unaffected by ubiquitination of PCNA , ubiquitinated PCNA specifically activates two key enzymes in translesion synthesis : DNA polymerase eta , the yeast Xeroderma pigmentosum ortholog , and Rev 1 , a deoxycytidyl transferase that functions in organizing the mutagenic DNA replication machinery . ^^^ |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| This substitution appears to abolish all DNA damage tolerance activities normally carried out by the RAD6 / RAD18 pathway , including translesion replication by DNA polymerase zeta / Rev1 and DNA polymerase eta , and the error free , recombination dependent component of this pathway , but has little effect on the growth rate , suggesting that G178S may prevent ubiquitination of lysine 164 in PCNA . ^^^ |
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| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| One gene in this region activated reporter gene expression approximately six to eightfold when the reporter gene was under the control of the late promoter of the major capsid protein gene , vp 39 , or the very late promoter of the polyhedrin gene , polh , but not when the reporter gene was under the control of the early promoter of etl , a homolog of proliferating cell nuclear antigen . ^^^ |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| Subcellular localization studies also highlighted an accumulation of nuclei with pol eta foci that correlated with the formation of monoubiquitinated proliferating cell nuclear antigen following treatment with cisplatin , reminiscent of the response to UV irradiation and further indicating a role for pol eta in dealing with cisplatin induced damage . ^^^ |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6FI35 and Q9Y253 |
Pubmed |
SVM Score :0.0 |
| NA |
|