| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| TIP49b , a new RuvB like DNA helicase , is included in a complex together with another RuvB like DNA helicase , TIP49a . ^^^ In this study , we isolated a new TIP49a related gene , termed TIP49b , from human and yeast cells . ^^^ TIP49b also resembled RuvB , thus suggesting that TIP49a and TIP49b are included in a gene family . ^^^ Like TIP49a , TIP49b was abundantly expressed in the testis and thymus . ^^^ Most of the enzymatic properties of TIP49b were the same as those of TIP49a , whereas the polarity of TIP49b DNA helicase activity ( 5 ' to 3 ' ) was the opposite to that of TIP49a . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| Moreover , a phylogenetical study suggested that archaeal TIP 49 genes belong to the TIP49b ancestor but not to the TIP49a one and that TIP49a evolved from TIP49b in accordance with divergence of archaea and eukarya . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| Human tip49a and tip49b genes were mapped on 3q21 and 19q13 . 2 , respectively . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| Isolation , molecular characterization , and tissue specific expression of ECP 51 and ECP 54 ( TIP 49 ) , two homologous , interacting erythroid cytosolic proteins . ^^^ We isolated two proteins , ECP 51 and ECP 54 , from human erythrocyte cytosol by affinity chromatography using a peptide of the integral membrane protein stomatin as bait . ^^^ Analysis of the nucleotide sequences revealed that ECP 51 and ECP 54 are homologous ( 44 . 2 % amino acid identity ) and contain ATP binding sites . ^^^ ECP 54 was identified as TIP49 / RUVBL1 / NMP238 , which is a component of a large nuclear protein complex , possibly the RNA polymerase 2 holoenzyme ; ECP 51 is a novel protein . ^^^ The interaction of ECP 51 and ECP 54 with the stomatin peptide and the localization to the nucleus and cytoplasm suggest an additional function for these proteins as chaperone components . . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| Pontin 52 and reptin 52 function as antagonistic regulators of beta catenin signalling activity . ^^^ Here , we report the identification of Reptin 52 as an interacting partner of Pontin 52 . ^^^ Highly homologous to Pontin 52 , Reptin 52 likewise binds beta catenin and TBP . ^^^ These results indicate that the opposite action of Pontin 52 and Reptin 52 on beta catenin mediated transactivation constitutes an additional mechanism for the control of the canonical Wingless / Wnt pathway . . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| This revealed that the binding of 15 . 5K to the box C / D motif is essential for the association of the remaining snoRNP associated proteins , namely , NOP 56 , NOP 58 , fibrillarin , and the nucleoplasmic proteins TIP 48 and TIP 49 . ^^^ Stem 2 of the box C / D motif , in contrast to the U 4 5 ' stem loop , is highly conserved , and we show that this sequence is responsible for the binding of NOP 56 , NOP 58 , fibrillarin , TIP 48 , and TIP 49 , but not of 15 . 5K , to the snoRNA . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| Here , we show that MYC associates with TIP 60 and recruits it to chromatin in vivo with four other components of the TIP 60 complex : TRRAP , p 400 , TIP 48 and TIP 49 . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| In our hands , ectopically expressed E2F1 also bound the unrelated HAT Tip 60 and induced recruitment of five subunits of the Tip 60 complex ( Tip 60 , TRRAP , p 400 , Tip 48 , and Tip 49 ) to target promoters in vivo . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| In Saccharomyces cerevisiae , orthologs of Tip49a and Tip49b , called Rvb 1 and Rvb 2 , respectively , are subunits of two distinct ATP dependent chromatin remodeling complexes , SWR 1 and INO 80 . ^^^ The mammalian Tip49a and Tip49b proteins belong to an evolutionarily conserved family of AAA+ ATPases . ^^^ We recently demonstrated that the mammalian Tip49a and Tip49b proteins are integral subunits of a chromatin remodeling complex bearing striking similarities to the S . cerevisiae SWR 1 complex ( Cai , Y . , Jin , J . , Florens , L . , Swanson , S . ^^^ In this report , we identify a new mammalian Tip49a and Tip49b containing ATP dependent chromatin remodeling complex , which includes orthologs of 8 of the 15 subunits of the S . cerevisiae INO 80 chromatin remodeling complex as well as at least five additional subunits unique to the human INO 80 ( hINO 80 ) complex . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| We identified 2 highly conserved novel Hsp 90 cofactors , termed Tah 1 and Pih 1 , that bind to the chaperone and that also associate physically and functionally with the essential DNA helicases Rvb 1 and Rvb 2 . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| Two of these proteins were identified as TIP 49 and a novel related protein called TIP 48 , both of which are highly conserved in evolution and contain ATPase / helicase motifs . ^^^ TIP 49 and TIP 48 are complexed with c Myc in vivo , and binding is dependent on a c Myc domain essential for oncogenic activity . ^^^ The TIP 49 and TIP 48 ATPase / helicase proteins represent a novel class of cofactors recruited by transcriptional activation domains that function in diverse pathways . . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| We have previously reported the identification and functional characterization of four different c Myc cofactors : TRRAP , hGCN 5 , TIP 49 , and TIP 48 . ^^^ In addition to the human SWI / SNF related BAF complex , BAF 53 forms a complex with TIP 49 and TIP 48 and a separate biochemically distinct complex containing TRRAP and a histone acetyltransferase which does not contain TIP 60 . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| The Rvb1p and Rvb2p ( or TIP 48 and TIP 49 ) nuclear ATP binding proteins are universally conserved in eukaryotes and essential for viability of yeasts . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| We show that both the precursor and mature length nucleoplasmic U 3 snoRNAs are present in larger multiprotein complexes that contain the core box C / D proteins as well as many non snoRNP factors linked to snoRNP assembly ( TIP 48 , TIP 49 , Nopp 140 ) , RNA processing ( TGS 1 , La , LSm 4 , hRrp 46 ) , and subcellular localization ( CRM 1 , PHAX ) . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| Pontin ( Tip 49 ) and Reptin ( Tip 48 ) are highly conserved components of multimeric protein complexes important for chromatin remodelling and transcription . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| Mammalian URI has been shown to associate with key components of the transcriptional machinery , including RPB 5 , a shared subunit of all three RNA polymerases , the ATPases TIP 48 and TIP 49 , which are present in various chromatin remodeling complexes , and human PAF 1 and parafibromin , which are components of a transcription elongation complex . ^^^ |
|
| Interacting proteins: Q9Y265 and Q9Y230 |
Pubmed |
SVM Score :0.0 |
| NA |
|