| IB1 / JIP 1 interacts with many cellular components including the reelin receptor ApoER 2 , the low density lipoprotein receptor related protein ( LRP ) , kinesin and the Alzheimer ' s amyloid precursor protein . ^^^ However , when stratified on the +766C > T polymorphism of exon 3 of the LRP gene , the IB1 / JIP 1 polymorphism was strongly associated with AD in subjects bearing the CC genotype in the LRP gene . ^^^ Taken together , these data indicate that the increased transcriptional activity in the presence of the G allele of MAPK8IP1 is a risk factor to the onset of in patients bearing the CC genotype of the LRP gene . . ^^^ |