| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.74759697 |
| Activation of JNK or Akt and association of JNK and Akt with JNK interacting protein 1 were estimated by immunoprecipitation and immunoblotting . 0.74759697^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Islet brain 1 ( IB 1 ) , a regulator of the pancreatic beta cell function in the rat , is homologous to JIP 1 , a murine inhibitor of c Jun amino terminal kinase ( JNK ) . ^^^ |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Islet brain 1 ( IB 1 ) is the human and rat homologue of JIP 1 , a scaffold protein interacting with the c Jun amino terminal kinase ( JNK ) . ^^^ |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The JNK activation requires the presence of the murine scaffold protein JNK interacting protein 1 ( JIP 1 ) or human Islet brain 1 ( IB 1 ) , which organizes MLK 3 , MKK 7 and JNK for proper signaling specificity . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Islet Brain 1 , also known as JNK interacting protein 1 ( IB1 / JIP 1 ) is a scaffold protein mainly involved in the regulation of the pro apoptotic signalling cascade mediated by c Jun N terminal kinase ( JNK ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Calcium and proteasome dependent degradation of the JNK scaffold protein islet brain 1 . ^^^ This process seems to be facilitated by a reduction in the amount of the islet brain 1 / JNK interacting protein 1 ( IB1 / JIP1 ) , a JNK scaffold with an anti apoptotic effect . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The JNK binding domain of islet brain 1 inhibits IL 1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin secreting cell lines . ^^^ The cell permeable peptide inhibitor of JNK ( JNKI 1 ) , that introduces the JNK binding domain ( JBD ) of the scaffold protein islet brain 1 ( IB 1 ) inside cells , effectively prevents beta cell death caused by this cytokine . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Islet brain 1 ( IB 1 or JIP 1 ) is a scaffold protein that interacts with components of the c Jun N terminal kinase ( JNK ) signal transduction pathway . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Interaction of c Jun amino terminal kinase interacting protein 1 with p 190 rhoGEF and its localization in differentiated neurons . c Jun amino terminal kinase ( JNK ) interacting protein 1 ( JIP 1 ) was originally identified as a cytoplasmic inhibitor of JNK . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| A murine cytoplasmic protein that binds specifically to JNK [ the JNK interacting protein 1 ( JIP 1 ) ] was characterized and cloned . ^^^ JIP 1 caused cytoplasmic retention of JNK and inhibition of JNK regulated gene expression . ^^^ In addition , JIP 1 suppressed the effects of the JNK signaling pathway on cellular proliferation , including transformation by the Bcr Abl oncogene . ^^^ This analysis identifies JIP 1 as a specific inhibitor of the JNK signal transduction pathway and establishes protein targeting as a mechanism that regulates signaling by stress activated MAP kinases . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| MEKK 1 , a specific JNK activator , induced transcription from the uPA promoter in the absence of UV treatment , whereas coexpression of catalytically inactive MEKK 1 ( K432M ) and of cytoplasmic JNK inhibitor JIP 1 inhibited UV induced uPA transcriptional activity . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Expression of wild type Jip 1 , which prevents JNK nuclear translocation , inhibited VEGF induced EC proliferation by 75 % . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| A role for JNK in the induction of the zif 268 gene is indicated , however , by the fact that cotransfection of expression vectors encoding JIP 1 or the JNK binding domain of JIP 1 , which act as dominant negative inhibitors of JNK , partially blocks the NGF mediated induction of a luciferase reporter gene linked to the zif 268 promoter . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have determined the regional expression of transcripts for two modulating genes operating in these pathways , i . e . , the endogenous protein inhibitor of neuronal nitric oxide synthase ( PIN ) , and a cytoplasmic inhibitor of the JNK signal transduction pathway , designated JNK interacting protein 1 ( JIP 1 ) and of the gene for the apoptosis executing protease Caspase 3 in KA treated animals . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The yield of virus in NIH 3T3 cells stably expressing JIP 1 , an inhibitor of JNK translocation to the nucleus , was reduced 70 % compared to that of control cells , in single step growth experiments . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| When a dominant negative mutant of JNK kinase 2 ( dnJNKK 2 ) , an upstream regulator of JNK , and JNK interacting protein 1 ( JIP 1 ) were expressed in myocytes by recombinant adenovirus , the activation of JNK by simulated MI was reduced 53 % . ^^^ Furthermore , the TNFalpha activated JNK activity in H9c2 cells was completely abolished by dnJNKK 2 and JIP 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Expression of JNK interacting protein 1 ( JIP 1 ) , which facilitates JNK signaling , remained unchanged in post ischemic hippocampal neurons . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The upregulation of growth arrest DNA damage induced gene ( GADD 153 ) , brain specific RING finger protein , JNK interacting protein ( JIP 1 ) , protein kinase A ( PKA ) , and Na+K+ ATPase was studied by quantitative polymerase chain reaction ( PCR ) . ^^^ |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The mouse IB 1 is the rat and human homologue of the Jun interacting protein 1 ( JIP 1 ) which has been recognized as a key player in the regulation of c Jun amino terminal kinase ( JNK ) mitogen activated protein kinase ( MAPK ) pathways . ^^^ |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| There is a protein which inhibits JNK 1 activation , and known as JNK interacting protein 1 ( JIP 1 ) . ^^^ In this study , we investigated change in JNK 1 , phospho JNK , and JIP 1 immunoreactivity in rat brain after transient middle cerebral artery ( MCA ) occlusion . ^^^ This JIP 1 induction got behind the JNK 1 activation , and therefore , may be a vain effort for neurons to survive . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Stable expression of the JNK scaffold protein JIP 1 blocked vinblastine induced phosphorylation of c Jun and ATF 2 , but did not affect Bcl 2 / Bcl 10 ( L ) phosphorylation , confirming a bifurcation in JNK signaling involving both nuclear and non nuclear substrates . ^^^ |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Coexpression of dominant negative versions of kinases of the JNK pathway , such as catalytically inactive forms of MEKK 1 , MKK 7 , and JNKK , and of cytoplasmic JNK inhibitor JIP 1 , as well as treatment of cells with curcumin ( which blocks JNK activation by MNNG ) , inhibited MNNG induced uPA transcriptional activity . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Interestingly , inhibited JNK activation in the Myr Akt expressing PC 12 cells is associated with marked induction of JNK interacting protein 1 ( JIP 1 ) . ^^^ |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| To evaluate the implication of the MAP kinase / ERK kinase ( MEK ) 4 stress activated protein kinase c Jun N terminal protein kinase ( ' JNK SAPK ' ) pathway we overexpressed the N terminal JNK binding domain of the JNK interacting protein 1 ( ' JIP 1 ' ) , demonstrating that activation of JNK is necessary for the insulin inhibitory effect . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Here we have used the JNK binding domain of JNK interacting protein 1 ( JIP 1 ) , a cytosolic scaffold protein that binds to JNK and inhibits its signalling when overexpressed , to assess the contribution of JNK activation to the hypertrophic response . ^^^ However , activation of these reporter genes by PMA , which does not activate JNK significantly in myocytes , was much less affected by overexpression of JIP 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| In addition , direct muscle injection of an adenoviral construct containing the JNK 1 inhibitory protein , JIP 1 , dramatically attenuated the progression of dystrophic myofiber destruction . ^^^ |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Requirement of the JIP 1 scaffold protein for stress induced JNK activation . ^^^ Components of the JNK signaling pathway interact with the JIP 1 scaffold protein . ^^^ However , in response to stress , JIP 1 accumulates in the soma together with activated JNK and phosphorylated c Jun . ^^^ Disruption of the Jip 1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Pax 2 can form a complex with the JNK scaffolding protein JIP 1 , and this interaction is enhanced by activation of the JNK signaling module with the upstream kinase DLK . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Expression of a cytoplasmic inhibitor of the JNK signal transduction pathway , Jip 1 , prevents JNK activity and significantly reduces the extent of apoptosis induced by PBOX 6 . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Jun NH 2 terminal kinase ( JNK ) interacting protein 1 ( JIP 1 ) binds the cytoplasmic domain of the Alzheimer ' s beta amyloid precursor protein ( APP ) . ^^^ Hoping to gain clues about the function of APP , we used the yeast two hybrid system to identify interaction between the AID region of APP and JNK interacting protein 1 ( JIP 1 ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| JIP 1 , one of the scaffold proteins , has been shown to be associated with MLKs , MKK 7 , and JNK [ Whitmarsh , A . ^^^ In addition , LZK induced JNK activation was markedly enhanced when LZK and JNK were co expressed with JIP 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| We have identified a 21 amino acid peptide inhibitor of activated JNKs , based on amino acids 143 163 of the JNK binding domain ( JBD ) of the JNK scaffolding protein , JNK interacting protein 1 ( JIP 1 ) . ^^^ This peptide , 1 JIP ( Inhibitor of JNK based on JIP 1 ) , inhibited JNK activity in vitro toward recombinant c Jun , Elk , and ATF 2 up to 90 % . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Consistent with this finding , transfection of K 562 cells with the JNK scaffold protein , JIP 1 , inhibited JNK activity and apoptosis induced by PBOX 6 . ^^^ JIP 1 specifically scaffolds JNK , MKK 7 , and members of the mixed lineage kinase ( MLK ) family , implicating these kinases upstream of JNK in the apoptotic pathway induced by PBOX 6 in K 562 cells . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Here we describe a novel interaction between Akt 1 and JNK interacting protein 1 ( JIP 1 ) , a JNK pathway scaffold . ^^^ Neuronal exposure to an excitotoxic stimulus decreased the Akt 1 JIP1 interaction and concomitantly increased association between JIP 1 and JNK . ^^^ Akt 1 interaction with JIP 1 inhibited JIP 1 mediated potentiation of JNK activity by decreasing JIP 1 binding to specific JNK pathway kinases . ^^^ These results suggest that Akt 1 binding to JIP 1 acts as a regulatory gate preventing JNK activation , which is released under conditions of excitotoxic injury . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| FHF binding to IB 2 facilitates recruitment of the MAPK p38delta ( SAPK 4 ) , while failing to stimulate binding of JNK , the preferred kinase of the related scaffold IB 1 ( JIP 1 ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Blocking JNK and c Jun action by overexpression of the JNK binding domain of JIP 1 or dominant negative c Jun ablated NRAGE mediated caspase activation and NRAGE induced cell death . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The JNK interacting protein 1 ( JIP 1 ) scaffold protein specifically binds JNK , MAP kinase kinase 7 , and members of the MLK family and is essential for stress mediated JNK activation in neurones . ^^^ Here we report that JIP 1 also binds the dual specificity phosphatases MKP 7 and M3 / 6 via a region independent of its JNK binding domain . ^^^ When MKP 7 is bound to JIP 1 it reduces JNK activation leading to reduced phosphorylation of the JNK target c Jun . ^^^ These results indicate that the JIP 1 scaffold protein modulates JNK signaling via association with both protein kinases and protein phosphatases that target JNK . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Furthermore , expression of a JNK inhibitor , the JNK binding domain of JIP 1 , resulted in resistance to AP 20187 mediated apoptosis in cells expressing FKBP Fas and Daxx . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Coexpression of IB1 / JIP 1 with other components of the c Jun NH 2 terminal kinase ( JNK ) pathway activates the JNK activity ; conversely , selective disruption of IB1 / JIP 1 in mice reduces the stress induced apoptosis of neuronal cells . ^^^ By immunocytochemistry , we first colocalized the presence of IB1 / JIP 1 with JNK and phosphorylated tau in neurofibrillary tangles . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Recruitment of JNK to JIP 1 and JNK dependent JIP 1 phosphorylation regulates JNK module dynamics and activation . ^^^ JIP 1 is a scaffold protein that assembles and facilitates the activation of the mixed lineage kinase dependent JNK module . ^^^ Results of earlier work led us to propose a model for JIP 1 JNK complex regulation that predicts that under basal conditions , JIP 1 maintains DLK in a monomeric , unphosphorylated , and catalytically inactive state . ^^^ Upon appropriate module stimulation , JNK JIP 1 binding affinity increases and DLK JIP 1 affinity decreases . ^^^ Our previous published results suggested the hypothesis that recruitment of JNK to JIP 1 and phosphorylation of JIP 1 by JNK is prerequisite for activation of the JNK module ( Nihalani , D . , Meyer , D . , Pajni , S . , and Holzman , L . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Members of the JNK pathway are organized together by virtue of interactions with JNK interacting protein 1 ( JIP 1 ) , a scaffold protein . ^^^ This study also indicates that JIP 1 expression can exert signaling effects independent of JNK activity . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| In addition , a peptide version of this docking site , as well as a peptide version of the JNK binding site of the JIP 1 scaffold protein , inhibited both MKK4 / JNK binding and MKK 4 mediated phosphorylation of JNK 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| We have recently reported biochemical evidence linking AbetaPP to the JNK signaling cascade by finding that JNK interacting protein 1 ( JIP 1 ) binds AbetaPP . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Overexpression of JNK inhibitor JIP 1 and chemical JNK inhibitors reduce the transactivation capacity of AML 1 ETO on the c jun promoter and the proapoptotic function of AML 1 ETO in U 937 cells . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| We conclude that the IB1 / JIP 1 level in beta cells can control their susceptibility to apoptosis independent of JNK signaling . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Repression of phospho JNK and infarct volume in ischemic brain of JIP 1 deficient mice . ^^^ Mice lacking JIP 1 , a scaffold protein that organizes JNK pathway components , were constructed independently by two groups . ^^^ In contrast , another group ( Whitmarsh et al . [ 2001 ] Genes Dev . 15 : 2421 2432 ) demonstrated that JIP 1 deficient mice were viable and that the JIP 1 null mutation inhibited the kainic acid induced JNK activation and neuronal death . ^^^ The transient focal ischemic insult produced by middle cerebral artery occlusion ( MCAO ) strongly activated JNK in brain of jip 1 ( + / + ) , jip 1 ( + / ) , and jip 1 ( / ) mice . ^^^ Increased JNK activity was sustained for more than 22 hr in jip 1 ( + / + ) and jip 1 ( + / ) , whereas it was repressed rapidly in jip 1 ( / ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Interestingly , when LNCaP cells were stably tranfected with the dominant negative JNK binding domain ( JBD ) of JNK interacting protein 1 ( JIP 1 ) , these cells no longer underwent apoptosis and growth inhibition in the presence of PC SPES . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Krox 20 also up regulates the scaffold protein JNK interacting protein 1 ( JIP 1 ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Structural basis for the selective inhibition of JNK 1 by the scaffolding protein JIP 1 and SP 600125 . ^^^ The c jun N terminal kinase ( JNK ) signaling pathway is regulated by JNK interacting protein 1 ( JIP 1 ) , which is a scaffolding protein assembling the components of the JNK cascade . ^^^ Overexpression of JIP 1 deactivates the JNK pathway selectively by cytoplasmic retention of JNK and thereby inhibits gene expression mediated by JNK , which occurs in the nucleus . ^^^ Here , we report the crystal structure of human JNK 1 complexed with pepJIP 1 , the peptide fragment of JIP 1 , revealing its selectivity for JNK 1 over other MAPKs and the allosteric inhibition mechanism . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| We previously reported that a small peptide based on amino acids 143 153 of the c Jun N terminal kinase ( JNK ) binding domain of JIP 1 functioned as an in vitro inhibitor of JNK activity . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| We have demonstrated previously the presence of critical inhibitory residues within an 11 mer peptide ( TI JIP ) based on the sequence of JNK interacting protein 1 ( JIP 1 ) . ^^^ However , the corresponding region of JNK bound by this JIP 1 based peptide was unknown . ^^^ Therefore , the results of our unbiased reverse two hybrid screening approach have identified residues of JNK responsible for binding JIP 1 based peptides as well as MKK 4 or MKK7 . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| An essential role of the JIP 1 scaffold protein for JNK activation in adipose tissue . ^^^ Here we report that the JNK interacting protein 1 ( JIP 1 ) scaffold protein , which binds components of the JNK signaling module , is essential for JNK activation in the adipose tissue of obese mice . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| A neuroprotective protein , JNK interacting protein 1 ( JIP 1 ) , an inhibitor of JNK mediated apoptosis , was reduced by 6 h hypoxia and markedly decreased by 24 h reoxygenation in CA 1 neurons as was DENN / MADD , which also modulates JNK mediated cell death . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Expression of JNK interacting protein JIP 1 is down regulated in liver from mouse embryos with a disrupted insulin like growth factor 2 gene . ^^^ JNK interacting Protein 1 ( JIP 1 ) is a pivotal scaffolding protein in the JNK signalling pathway . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The axon guidance defect of the corpus callosum in the jsap 1 / brain was correlated with the misplacement of glial sling cells , which reverted to their normal position after the transgenic expression of JNK interacting protein 1 ( JIP 1 ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| IE 1 induced c Jun phosphorylation , and treatment with SP 600125 , a selective JNK inhibitor , as well as overexpression of JNK binding domain of JIP 1 , blocked IE 1 mediated induction of AP 1 and relB promoter activity in NIH 3T3 cells and SMCs . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The c Jun NH 2 terminal kinase ( JNK ) interacting protein ( JIP ) group of scaffold proteins ( JIP 1 , JIP 2 , and JIP 3 ) can interact with components of the JNK signaling pathway and potently activate JNK . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The findings suggested that MKK 7 activation , translocation and binding to JIP 1 were closely associated with reactive oxygen species and might play a pivotal role in the activation of the JNK signaling pathway in brain ischemic injury . . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| We examined if the relative expression of JNK interacting protein 1 ( JIP 1 ) and phosphorylated c Jun N terminal kinase ( JNK ) regulates cell signaling and contributes to selective neuronal vulnerability in response to environmental stress . ^^^ JIP 1 mRNA expression was also down regulated by UV stress and was accompanied by increased JNK and c Jun activation and cell death . ^^^ JIP 1 protein reduction was partially reversed both by inhibitors predominantly of caspase 3 and of the JNK pathway and resulted in significantly increased cell survival . ^^^ Conversely , overexpression of JIP 1 decreased both nuclear translocation of activated JNK , and c Jun phosphorylation induced by either UV irradiation , or the JNK upstream activators , MKK 7 or MEKK 1 . ^^^ JIP 1 overexpression did not facilitate either JNK expression or activation . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The JNK interacting protein JIP 1 and insulin like growth factor 2 genes are co expressed in human embryonic tumours . ^^^ JNK interacting protein 1 ( JIP 1 ) is a pivotal scaffolding protein in the JNK signalling pathway . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Adenovirus mediated overexpression of Flag tagged JNK binding domain ( JBD ) of JNK interacting protein 1 ( JIP 1 ) , an inhibitor of JNK , also inhibited PEITC induced apoptosis in DU 145 cells . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated that the dual specificity phosphatases ( DSPs ) MKP 7 and M3 / 6 bind the scaffold JNK interacting protein 1 ( JIP 1 ) and inactivate the bound subset of JNK ( 1 ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Dissociation of Akt 1 from its negative regulator JIP 1 is mediated through the ASK 1 MEK JNK signal transduction pathway during metabolic oxidative stress : a negative feedback loop . ^^^ The JNK 2 mediated phosphorylation of JIP 1 results in the dissociation of Akt 1 from JIP 1 and subsequently restores Akt 1 enzyme activity . ^^^ Knockdown of SEK 1 leads to the inhibition of JNK activation , JIP 1 JNK2 binding , and the dissociation of Akt 1 from JIP 1 during glucose deprivation . ^^^ Knockdown of JIP 1 also leads to the inhibition of JNK activation , whereas the knockdown of Akt 1 promotes JNK activation during glucose deprivation . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation showed that phosphorylated JNK , but not total JNK , coimmunoprecipitated with JIP 1 protein . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| In this study , we describe a novel interaction between Akt 1 and JNK interacting protein 1 ( JIP 1 ) . ^^^ In the basal state , JIP 1 bind to Akt 1 , MLK 3 at maximum while JIP 1 binds to JNK 3 at minimum . ^^^ Ischemia stimulus decreased the Akt 1 JIP 1 interaction and concomitantly increased association between JIP 1 and JNK 3 . ^^^ These results indicated that Akt 1 interaction with JIP 1 inhibited JIP 1 mediated potentiation of JNK activity by decreasing JIP 1 binding to specific JNK pathway kinases . ^^^ Akt 1 binding to JIP 1 acts as a regulatory gate preventing JNK activation , which is opened under conditions ischemia injury . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| We now show that Notch 1 IC suppresses the scaffold activity of c Jun N terminal kinase ( JNK ) interacting protein 1 ( JIP 1 ) in the JNK signaling pathway . ^^^ Notch 1 IC physically associated with the JNK binding domain of JIP 1 and thereby interfered with the interaction between JIP 1 and JNK . ^^^ JIP 1 mediated the activation of JNK 1 induced by glucose deprivation in mouse embryonic fibroblasts , and ectopic expression of Notch 1 IC inhibited JNK activation and apoptosis triggered by glucose deprivation . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| JNK interacting protein 1 ( JIP 1 ) is a scaffold protein that assembles and facilitates the activation of the mixed lineage kinase dependent JNK module and also establishes an interaction with beta amyloid precursor protein that has been partially characterized . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| APLIP 1 , a kinesin binding JIP 1 / JNK scaffold protein , influences the axonal transport of both vesicles and mitochondria in Drosophila . ^^^ In a genetic screen for Kinesin heavy chain ( Khc ) interacting proteins , we identified APLIP 1 , a neuronally expressed Drosophila homolog of JIP 1 , a JNK scaffolding protein . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Here we reported that Tat JNK binding domain ( JBD ) of JNK interacting protein 1 ( JIP 1 ) , a smaller 11 mer peptide corresponding to residues 153 163 of murine JIP 1 conjugated to Tat peptide , perturbed the assembly of JIP 1 JNK 3 complexes , thus inhibiting the activation of JNK 3 induced by ischemia / reperfusion in the vulnerable hippocampal CA 1 subregion . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Peptide versions of the D sites from MKK 4 or the JIP 1 scaffold protein inhibited MKK 7 JNK binding , suggesting that all three JNK regulators bind to the same region of JNK . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| The B1R JIP 1 complex increases the amount of MAPK bound to JIP 1 ; thus , MKK 7 and TAK 1 either bind with higher affinity or bind more stably to JIP 1 , while there is an increase in the phosphorylation state of JNK bound to JIP 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Promoter inducibility is inhibited by the SAPK / JNK inhibitor , the JNK binding domain of the JNK interacting protein 1 , and Tam 67 ( N terminal deletion mutant of c Jun ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| To inhibit JNK activity in sympathetic neurones we have used two different JNK inhibitors that act by distinct mechanisms : the compound SB 203580 and the JNK binding domain ( JBD ) of JNK interacting protein 1 ( JIP 1 ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Gene transfer of the JNK interacting protein 1 protects dopaminergic neurons in the MPTP model of Parkinson ' s disease . ^^^ In mice , adenoviral gene transfer of the JNK binding domain of JNK interacting protein 1 ( a scaffold protein and inhibitor of JNK ) inhibited this cascade downstream of MKK 4 phosphorylation , blocked JNK , c Jun , and caspase activation , the death of dopaminergic neurons , and the loss of catecholamines in the striatum . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| In addition to known interacting proteins containing a phosphotyrosine interaction domain ( PID ) Fe 65 , Fe65L , Fe65L2 , X 11 , and mDab 1 , we identified , as a novel APP interacting molecule , a PID containing isoform of mouse JNK interacting protein 1 ( JIP 1b ) and its human homolog IB 1 , the established scaffold proteins for JNK . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Here , we show that JNK activation is essential for alpha ( 1 ) AR induced hypertrophy , in that alpha ( 1 ) AR induced hypertrophic responses , such as reorganization of the actin cytoskeleton and increased protein synthesis , could be blocked by expressing the JNK binding domain of JNK interacting protein 1 , a specific inhibitor of JNK . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| JNK interacting protein 1 ( JIP 1 ) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12 0 tetradecanoylphorbol 13 acetate ( TPA ) . 12 0 tetradecanoylphorbol 13 acetate ( TPA ) stimulates protein kinase C ( PKC ) which mediates apoptosis in androgen sensitive LNCaP human prostate cancer cells . ^^^ To explore the possible role that the JNK / c Jun / AP 1 signal pathway has on TPA induced apoptosis in LNCaP cells , we stably transfected the scaffold protein , JNK interacting protein 1 ( JIP 1 ) , which binds to JNK inhibiting its ability to phosphorylate c Jun . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Moreover , the inhibitory effect of ET 1 was suppressed by the c Jun N terminal kinase ( JNK ) inhibitor SP 600125 and the expression of the JNK binding domain of JNK interacting protein 1 , a specific inhibitor of the JNK pathway . ^^^ Using the slice culture system of embryonic brain , we demonstrated that ET 1 and the constitutively active mutant of Galpha q caused the retention of the neural progenitor cells in the intermediate zone and JNK binding domain of JNK interacting protein 1 abrogated the effect of ET 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| Here , we show that apoptotic stimuli increase endogenous cellular levels of pathway components , including POSH , mixed lineage kinases ( MLKs ) , and JNK interacting protein 1 , and that this effect occurs through protein stabilization and requires the presence of POSH as well as activation of MLKs and JNKs . ^^^ |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQF2 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|