| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.94038411 |
| Direct association between Akt 1 and JIP 1 was observed in primary neurons . 0.94038411^^^ |
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| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Interestingly , inhibited JNK activation in the Myr Akt expressing PC 12 cells is associated with marked induction of JNK interacting protein 1 ( JIP 1 ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Here we have investigated the possibility that JIP 1 may also affect the catalytic activity of Akt 1 , a serine / threonine kinase that has been implicated in multiple cellular processes , including survival and proliferation . ^^^ JIP 1 expression enhanced Akt 1 kinase activity in a dose dependent manner following serum starvation in 293 cells . ^^^ Cellular activation of Akt 1 following stimulation with low concentrations of insulin like growth factor ( IGF 1 ) was elevated in the presence of JIP 1 . ^^^ JIP 1 expression also prolonged Akt 1 stimulation after a short IGF 1 pulse . ^^^ The mechanism of JIP 1 mediated Akt 1 activation involved JIP 1 protein binding to the Akt 1 pleckstrin homology domain , which in turn promoted the phosphorylation of the activation T loop of Akt 1 by phosphoinositide dependent kinase 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Cross talk between JIP 3 and JIP 1 during glucose deprivation : SEK 1 JNK2 and Akt 1 act as mediators . ^^^ JNK 2 phosphorylates JIP 1 on the Thr 103 residue and leads to dissociation of Akt 1 from JIP 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Dissociation of Akt 1 from its negative regulator JIP 1 is mediated through the ASK 1 MEK JNK signal transduction pathway during metabolic oxidative stress : a negative feedback loop . ^^^ The JNK 2 mediated phosphorylation of JIP 1 results in the dissociation of Akt 1 from JIP 1 and subsequently restores Akt 1 enzyme activity . ^^^ Knockdown of SEK 1 leads to the inhibition of JNK activation , JIP 1 JNK2 binding , and the dissociation of Akt 1 from JIP 1 during glucose deprivation . ^^^ Knockdown of JIP 1 also leads to the inhibition of JNK activation , whereas the knockdown of Akt 1 promotes JNK activation during glucose deprivation . ^^^ Altogether , our data demonstrate that Akt 1 participates in a negative regulatory feedback loop by interacting with the JIP 1 scaffold protein . . ^^^ |
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| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.0 |
| In this study , we describe a novel interaction between Akt 1 and JNK interacting protein 1 ( JIP 1 ) . ^^^ We first detected the interaction of Akt 1 and JIP 1 in hippocampus at various time points of ischemia . ^^^ In the basal state , JIP 1 bind to Akt 1 , MLK 3 at maximum while JIP 1 binds to JNK 3 at minimum . ^^^ Ischemia stimulus decreased the Akt 1 JIP 1 interaction and concomitantly increased association between JIP 1 and JNK 3 . ^^^ While MLK 3 binding to JIP 1 decreased , similar to Akt 1 JIP 1 interaction during ischemia . ^^^ |
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| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.0 |
| Activation of JNK or Akt and association of JNK and Akt with JNK interacting protein 1 were estimated by immunoprecipitation and immunoblotting . ^^^ |
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| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UQF2 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
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